Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7425
Gene name Gene Name - the full gene name approved by the HGNC.	VGF nerve growth factor inducible
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	VGF
Synonyms (NCBI Gene) Gene synonyms aliases	SCG7, SgVII
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions sh

Show/Hide all(128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT491307	hsa-miR-3195	PAR-CLIP	20371350
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT491299	hsa-miR-4488	PAR-CLIP	20371350
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT491297	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT491307	hsa-miR-3195	PAR-CLIP	23592263
MIRT491306	hsa-miR-4479	PAR-CLIP	23592263
MIRT491305	hsa-miR-3960	PAR-CLIP	23592263
MIRT491304	hsa-miR-8072	PAR-CLIP	23592263
MIRT491303	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491302	hsa-miR-663a	PAR-CLIP	23592263
MIRT491301	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT491299	hsa-miR-4488	PAR-CLIP	23592263
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT491297	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491307	hsa-miR-3195	PAR-CLIP	20371350
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT491299	hsa-miR-4488	PAR-CLIP	20371350
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT491297	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT491307	hsa-miR-3195	PAR-CLIP	23592263
MIRT491306	hsa-miR-4479	PAR-CLIP	23592263
MIRT491305	hsa-miR-3960	PAR-CLIP	23592263
MIRT491304	hsa-miR-8072	PAR-CLIP	23592263
MIRT491303	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491302	hsa-miR-663a	PAR-CLIP	23592263
MIRT491301	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT491299	hsa-miR-4488	PAR-CLIP	23592263
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT491297	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT1484239	hsa-miR-1207-5p	CLIP-seq
MIRT1484240	hsa-miR-1270	CLIP-seq
MIRT1484241	hsa-miR-185	CLIP-seq
MIRT1484242	hsa-miR-27a	CLIP-seq
MIRT1484243	hsa-miR-27b	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484245	hsa-miR-3140-3p	CLIP-seq
MIRT1484246	hsa-miR-3154	CLIP-seq
MIRT1484247	hsa-miR-3179	CLIP-seq
MIRT1484248	hsa-miR-3184	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT1484250	hsa-miR-3677-3p	CLIP-seq
MIRT1484251	hsa-miR-3689a-3p	CLIP-seq
MIRT1484252	hsa-miR-3689c	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484254	hsa-miR-3918	CLIP-seq
MIRT1484255	hsa-miR-3919	CLIP-seq
MIRT1484256	hsa-miR-3936	CLIP-seq
MIRT1484257	hsa-miR-423-5p	CLIP-seq
MIRT1484258	hsa-miR-4283	CLIP-seq
MIRT1484259	hsa-miR-4306	CLIP-seq
MIRT1484260	hsa-miR-432	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT1484262	hsa-miR-4446-3p	CLIP-seq
MIRT1484263	hsa-miR-4492	CLIP-seq
MIRT1484264	hsa-miR-4498	CLIP-seq
MIRT1484265	hsa-miR-4531	CLIP-seq
MIRT1484266	hsa-miR-4532	CLIP-seq
MIRT1484267	hsa-miR-4644	CLIP-seq
MIRT1484268	hsa-miR-4688	CLIP-seq
MIRT1484269	hsa-miR-4699-3p	CLIP-seq
MIRT1484270	hsa-miR-4716-3p	CLIP-seq
MIRT1484271	hsa-miR-4723-5p	CLIP-seq
MIRT1484272	hsa-miR-4728-5p	CLIP-seq
MIRT1484273	hsa-miR-4747-3p	CLIP-seq
MIRT1484274	hsa-miR-4763-3p	CLIP-seq
MIRT1484275	hsa-miR-485-5p	CLIP-seq
MIRT1484276	hsa-miR-486-3p	CLIP-seq
MIRT1484277	hsa-miR-513a-5p	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484280	hsa-miR-620	CLIP-seq
MIRT1484281	hsa-miR-762	CLIP-seq
MIRT1484282	hsa-miR-890	CLIP-seq
MIRT1484283	hsa-miR-939	CLIP-seq
MIRT2145772	hsa-miR-1180	CLIP-seq
MIRT1484240	hsa-miR-1270	CLIP-seq
MIRT2145773	hsa-miR-1471	CLIP-seq
MIRT1484241	hsa-miR-185	CLIP-seq
MIRT2145774	hsa-miR-2355-5p	CLIP-seq
MIRT1484242	hsa-miR-27a	CLIP-seq
MIRT1484243	hsa-miR-27b	CLIP-seq
MIRT2145775	hsa-miR-296-5p	CLIP-seq
MIRT2145776	hsa-miR-31	CLIP-seq
MIRT2145777	hsa-miR-3126-5p	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484245	hsa-miR-3140-3p	CLIP-seq
MIRT1484248	hsa-miR-3184	CLIP-seq
MIRT2145778	hsa-miR-3191	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT2145779	hsa-miR-3675-5p	CLIP-seq
MIRT2145780	hsa-miR-3688-5p	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484257	hsa-miR-423-5p	CLIP-seq
MIRT1484258	hsa-miR-4283	CLIP-seq
MIRT1484259	hsa-miR-4306	CLIP-seq
MIRT1484260	hsa-miR-432	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT2145781	hsa-miR-4471	CLIP-seq
MIRT1484265	hsa-miR-4531	CLIP-seq
MIRT1484267	hsa-miR-4644	CLIP-seq
MIRT2145782	hsa-miR-4664-3p	CLIP-seq
MIRT1484270	hsa-miR-4716-3p	CLIP-seq
MIRT2145783	hsa-miR-4766-3p	CLIP-seq
MIRT1484275	hsa-miR-485-5p	CLIP-seq
MIRT1484277	hsa-miR-513a-5p	CLIP-seq
MIRT2145784	hsa-miR-548p	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484280	hsa-miR-620	CLIP-seq
MIRT2145785	hsa-miR-671-3p	CLIP-seq
MIRT1484282	hsa-miR-890	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT1484262	hsa-miR-4446-3p	CLIP-seq
MIRT1484263	hsa-miR-4492	CLIP-seq
MIRT1484264	hsa-miR-4498	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484281	hsa-miR-762	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
NPAS3	Unknown	21709683
REST	Unknown	19118055

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001541	Process	Ovarian follicle development	IEA
GO:0002021	Process	Response to dietary excess	IEA
GO:0003674	Function	Molecular_function	ND
GO:0005179	Function	Hormone activity	IBA	21873635
GO:0005184	Function	Neuropeptide hormone activity	IEA
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	15706611
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0006091	Process	Generation of precursor metabolites and energy	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0009409	Process	Response to cold	IEA
GO:0019953	Process	Sexual reproduction	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	17440014
GO:0032868	Process	Response to insulin	IEA
GO:0033500	Process	Carbohydrate homeostasis	IBA	21873635
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0048167	Process	Regulation of synaptic plasticity	IBA	21873635
GO:0051591	Process	Response to cAMP	IEP	10381005

MIM	HGNC	e!Ensembl
602186	12684	ENSG00000128564

Protein

UniProt ID

O15240

Protein name

Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]]

Protein function

[Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many ro

PDB

7D13 , 7D16 , 8H0G , 8H0U

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. {ECO:0000269|PubMed:19194657}.

Sequence

MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVR
GARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVR
SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET
AAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGP
LPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG
LAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERES
AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS
QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR
KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPP
GPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQ
EELENYIEHVLLRRP

Sequence length

615

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation NGF-stimulated transcription

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder		18983874, 20631166, 18815270, 22990943	ClinVar

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	37742030
Alzheimer Disease	Associate	22046305, 26270474, 30578620, 32301581, 36776048
Alzheimer Disease	Stimulate	26142708
Alzheimer Disease	Inhibit	32366888, 36912488
Amyotrophic Lateral Sclerosis	Inhibit	32174778
Anhedonia	Associate	24934694
Autistic Disorder	Associate	33893496
Bipolar Disorder	Associate	24934694
Brain Diseases	Associate	21838886
Breast Neoplasms	Associate	19228724, 24277232, 24927296
Carcinoma Basal Cell	Associate	24830820
Carcinoma Non Small Cell Lung	Stimulate	29209432
Colorectal Neoplasms	Associate	33413474
Diabetes Mellitus	Stimulate	22808091
Diabetes Mellitus Type 2	Associate	22808091, 26337083
Endocrine System Diseases	Associate	24277232
Frontotemporal Dementia	Associate	32576262, 34838088
Hydrocephalus Normal Pressure	Associate	34360799
Intellectual Disability	Inhibit	24934694
Lewy Body Disease	Associate	32552841
Lung Neoplasms	Associate	29209432
Mental Disorders	Associate	24934694, 33893496
Neoplasms	Associate	19228724, 29209432, 32588760
Neurodegenerative Diseases	Associate	26142708
Obesity	Associate	26337083
Ovarian Neoplasms	Associate	24086249
Pain	Associate	24646654
Parkinson Disease	Associate	33481347, 35732154
Prostatic Neoplasms	Associate	31682594, 35466393
Seminoma	Associate	22068818
Thyroid Neoplasms	Associate	32588760
Urinary Bladder Neoplasms	Associate	24830820

VGF (VGF nerve growth factor inducible)