Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	7425
Gene name	VGF nerve growth factor inducible
Gene symbol	VGF
Synonyms (NCBI Gene)	SCG7SgVII
Chromosome	7
Chromosome location	7q22.1
Summary	This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions sh

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miRTarBase ID	miRNA	Experiments	Reference
MIRT491307	hsa-miR-3195	PAR-CLIP	20371350
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT491299	hsa-miR-4488	PAR-CLIP	20371350
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT491297	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT491307	hsa-miR-3195	PAR-CLIP	23592263
MIRT491306	hsa-miR-4479	PAR-CLIP	23592263
MIRT491305	hsa-miR-3960	PAR-CLIP	23592263
MIRT491304	hsa-miR-8072	PAR-CLIP	23592263
MIRT491303	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491302	hsa-miR-663a	PAR-CLIP	23592263
MIRT491301	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT491299	hsa-miR-4488	PAR-CLIP	23592263
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT491297	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491307	hsa-miR-3195	PAR-CLIP	20371350
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT491299	hsa-miR-4488	PAR-CLIP	20371350
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT491297	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT491307	hsa-miR-3195	PAR-CLIP	23592263
MIRT491306	hsa-miR-4479	PAR-CLIP	23592263
MIRT491305	hsa-miR-3960	PAR-CLIP	23592263
MIRT491304	hsa-miR-8072	PAR-CLIP	23592263
MIRT491303	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491302	hsa-miR-663a	PAR-CLIP	23592263
MIRT491301	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491300	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT491299	hsa-miR-4488	PAR-CLIP	23592263
MIRT491298	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT491297	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491296	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT1484239	hsa-miR-1207-5p	CLIP-seq
MIRT1484240	hsa-miR-1270	CLIP-seq
MIRT1484241	hsa-miR-185	CLIP-seq
MIRT1484242	hsa-miR-27a	CLIP-seq
MIRT1484243	hsa-miR-27b	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484245	hsa-miR-3140-3p	CLIP-seq
MIRT1484246	hsa-miR-3154	CLIP-seq
MIRT1484247	hsa-miR-3179	CLIP-seq
MIRT1484248	hsa-miR-3184	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT1484250	hsa-miR-3677-3p	CLIP-seq
MIRT1484251	hsa-miR-3689a-3p	CLIP-seq
MIRT1484252	hsa-miR-3689c	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484254	hsa-miR-3918	CLIP-seq
MIRT1484255	hsa-miR-3919	CLIP-seq
MIRT1484256	hsa-miR-3936	CLIP-seq
MIRT1484257	hsa-miR-423-5p	CLIP-seq
MIRT1484258	hsa-miR-4283	CLIP-seq
MIRT1484259	hsa-miR-4306	CLIP-seq
MIRT1484260	hsa-miR-432	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT1484262	hsa-miR-4446-3p	CLIP-seq
MIRT1484263	hsa-miR-4492	CLIP-seq
MIRT1484264	hsa-miR-4498	CLIP-seq
MIRT1484265	hsa-miR-4531	CLIP-seq
MIRT1484266	hsa-miR-4532	CLIP-seq
MIRT1484267	hsa-miR-4644	CLIP-seq
MIRT1484268	hsa-miR-4688	CLIP-seq
MIRT1484269	hsa-miR-4699-3p	CLIP-seq
MIRT1484270	hsa-miR-4716-3p	CLIP-seq
MIRT1484271	hsa-miR-4723-5p	CLIP-seq
MIRT1484272	hsa-miR-4728-5p	CLIP-seq
MIRT1484273	hsa-miR-4747-3p	CLIP-seq
MIRT1484274	hsa-miR-4763-3p	CLIP-seq
MIRT1484275	hsa-miR-485-5p	CLIP-seq
MIRT1484276	hsa-miR-486-3p	CLIP-seq
MIRT1484277	hsa-miR-513a-5p	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484280	hsa-miR-620	CLIP-seq
MIRT1484281	hsa-miR-762	CLIP-seq
MIRT1484282	hsa-miR-890	CLIP-seq
MIRT1484283	hsa-miR-939	CLIP-seq
MIRT2145772	hsa-miR-1180	CLIP-seq
MIRT1484240	hsa-miR-1270	CLIP-seq
MIRT2145773	hsa-miR-1471	CLIP-seq
MIRT1484241	hsa-miR-185	CLIP-seq
MIRT2145774	hsa-miR-2355-5p	CLIP-seq
MIRT1484242	hsa-miR-27a	CLIP-seq
MIRT1484243	hsa-miR-27b	CLIP-seq
MIRT2145775	hsa-miR-296-5p	CLIP-seq
MIRT2145776	hsa-miR-31	CLIP-seq
MIRT2145777	hsa-miR-3126-5p	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484245	hsa-miR-3140-3p	CLIP-seq
MIRT1484248	hsa-miR-3184	CLIP-seq
MIRT2145778	hsa-miR-3191	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT2145779	hsa-miR-3675-5p	CLIP-seq
MIRT2145780	hsa-miR-3688-5p	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484257	hsa-miR-423-5p	CLIP-seq
MIRT1484258	hsa-miR-4283	CLIP-seq
MIRT1484259	hsa-miR-4306	CLIP-seq
MIRT1484260	hsa-miR-432	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT2145781	hsa-miR-4471	CLIP-seq
MIRT1484265	hsa-miR-4531	CLIP-seq
MIRT1484267	hsa-miR-4644	CLIP-seq
MIRT2145782	hsa-miR-4664-3p	CLIP-seq
MIRT1484270	hsa-miR-4716-3p	CLIP-seq
MIRT2145783	hsa-miR-4766-3p	CLIP-seq
MIRT1484275	hsa-miR-485-5p	CLIP-seq
MIRT1484277	hsa-miR-513a-5p	CLIP-seq
MIRT2145784	hsa-miR-548p	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484280	hsa-miR-620	CLIP-seq
MIRT2145785	hsa-miR-671-3p	CLIP-seq
MIRT1484282	hsa-miR-890	CLIP-seq
MIRT1484244	hsa-miR-3135b	CLIP-seq
MIRT1484249	hsa-miR-3652	CLIP-seq
MIRT1484253	hsa-miR-377	CLIP-seq
MIRT1484261	hsa-miR-4430	CLIP-seq
MIRT1484262	hsa-miR-4446-3p	CLIP-seq
MIRT1484263	hsa-miR-4492	CLIP-seq
MIRT1484264	hsa-miR-4498	CLIP-seq
MIRT1484278	hsa-miR-582-3p	CLIP-seq
MIRT1484279	hsa-miR-603	CLIP-seq
MIRT1484281	hsa-miR-762	CLIP-seq

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Transcription factor	Regulation	Reference
NPAS3	Unknown	21709683
REST	Unknown	19118055

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001541	Process	Ovarian follicle development	IEA
GO:0002021	Process	Response to dietary excess	IEA
GO:0005179	Function	Hormone activity	IBA
GO:0005184	Function	Neuropeptide hormone activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	15706611
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005794	Component	Golgi apparatus	IDA
GO:0006091	Process	Generation of precursor metabolites and energy	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0009409	Process	Response to cold	IEA
GO:0019953	Process	Sexual reproduction	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	17440014
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0033500	Process	Carbohydrate homeostasis	IBA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IBA
GO:0051591	Process	Response to cAMP	IEP	10381005

MIM	HGNC	e!Ensembl
602186	12684	ENSG00000128564

O15240

Protein name

Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]]

Protein function

[Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many ro

PDB

7D13 , 7D16 , 8H0G , 8H0U

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. {ECO:0000269|PubMed:19194657}.

Sequence

MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVR
GARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVR
SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET
AAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGP
LPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG
LAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERES
AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS
QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR
KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPP
GPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQ
EELENYIEHVLLRRP

Sequence length

615

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation NGF-stimulated transcription

VGF (VGF nerve growth factor inducible)