Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7381
Gene name Gene Name - the full gene name approved by the HGNC.
Ubiquinol-cytochrome c reductase binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UQCRB
Synonyms (NCBI Gene) Gene synonyms aliases
MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs139283183 A>T Conflicting-interpretations-of-pathogenicity Non coding transcript variant, missense variant, coding sequence variant
rs863224257 T>A Likely-pathogenic 5 prime UTR variant, non coding transcript variant, coding sequence variant, missense variant
rs863224258 C>A,T Likely-pathogenic Non coding transcript variant, stop gained, 3 prime UTR variant, missense variant, coding sequence variant
rs863224259 C>- Pathogenic Frameshift variant, non coding transcript variant, coding sequence variant
rs886043294 TTTT>- Pathogenic 3 prime UTR variant, frameshift variant, non coding transcript variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT042467 hsa-miR-423-3p CLASH 23622248
MIRT640375 hsa-miR-130b-5p HITS-CLIP 23824327
MIRT640374 hsa-miR-942-5p HITS-CLIP 23824327
MIRT640373 hsa-miR-3124-3p HITS-CLIP 23824327
MIRT640372 hsa-miR-627-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IEA
GO:0005743 Component Mitochondrial inner membrane IDA 28844695
GO:0005743 Component Mitochondrial inner membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
191330 12582 ENSG00000156467
Protein
UniProt ID P14927
Protein name Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)
Protein function Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complex
PDB 5XTE , 5XTH , 5XTI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02271 UCR_14kD 8 106 Ubiquinol-cytochrome C reductase complex 14kD subunit Family
Sequence
Sequence length 111
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Thermogenesis
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy
  Respiratory electron transport
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Mitochondrial Complex Deficiency mitochondrial complex III deficiency, mitochondrial complex III deficiency nuclear type 3 N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Altitude Sickness Associate 32299499
Alzheimer Disease Associate 36405716
Carcinoma Hepatocellular Associate 30120311
Colonic Neoplasms Associate 22545919
Colorectal Neoplasms Associate 22545919, 29147009, 32071343
Glioma Associate 37091853
Lymphatic Metastasis Associate 22545919
Mitochondrial Complex III Deficiency Associate 29147009
Neoplasm Metastasis Associate 22545919
Ovarian Neoplasms Associate 22174824