UMPS (uridine monophosphate synthetase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7372 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Uridine monophosphate synthetase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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UMPS |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ODC, OPRT |
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Chromosome
Chromosome number
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3 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q21.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a uridine 5`-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosp |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | P11172 | |||||||||||||||
| Protein name | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)] | |||||||||||||||
| Protein function | Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the t | |||||||||||||||
| PDB | 2EAW , 2JGY , 2P1F , 2QCC , 2QCD , 2QCE , 2QCF , 2QCG , 2QCH , 2QCL , 2QCM , 2QCN , 2V30 , 2WNS , 3BGG , 3BGJ , 3BK0 , 3BVJ , 3DBP , 3EWU , 3EWW , 3EWX , 3EWY , 3EWZ , 3EX1 , 3EX2 , 3EX3 , 3EX4 , 3EX6 , 3G3D , 3G3M , 3L0K , 3L0N , 3MI2 , 3MO7 , 3MW7 , 4HIB , 4HKP , 6YVK , 6YVL , 6YVM , 6YVN , 6YVO , 6YWT , 6YWU , 6ZWY , 6ZWZ , 6ZX0 , 6ZX1 , 6ZX2 , 6ZX3 | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 480 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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