SCGB1A1 (secretoglobin family 1A member 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 7356
Gene name Secretoglobin family 1A member 1
Gene symbol SCGB1A1
Synonyms (NCBI Gene)
CC10CC16CCPBPCCSPUGBUP-1UP1
Chromosome 11
Chromosome location 11q12.3
Summary This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defec
miRNA miRNA information provided by mirtarbase database.
12
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (12)
miRTarBase ID miRNA Experiments Reference
MIRT1329344 hsa-miR-1273g CLIP-seq
MIRT1329345 hsa-miR-299-5p CLIP-seq
MIRT1329346 hsa-miR-4708-5p CLIP-seq
MIRT1329347 hsa-miR-4709-3p CLIP-seq
MIRT2097669 hsa-miR-2110 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (32)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0005515 Function Protein binding IPI 16423471, 18243143, 21516116, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IDA 21805676
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
192020 12523 ENSG00000149021
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11684
Protein name Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)
Protein function Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
PDB 7VF3 , 7VG7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01099 Uteroglobin 1 → 90 Uteroglobin family Domain
Tissue specificity TISSUE SPECIFICITY: Club cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Sequence
Sequence length 91
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Chronic obstructive pulmonary disease association; Established risk allele rs3741240 RCV001328408
Inherited susceptibility to asthma Uncertain significance rs41364547 RCV000013040
Show/Hide Text Mining Associations (61)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Lung Injury Associate 32184583
Adenocarcinoma of Lung Associate 39364403
Airway Obstruction Associate 17624750
Airway Remodeling Associate 17624750
Arthritis Rheumatoid Associate 20037209
Asthma Associate 31322430, 32762031, 36352422, 9643286
Asthma Inhibit 36066606
Atrophy Stimulate 34928497
Breast Neoplasms Associate 14521461
Bronchial Hyperreactivity Associate 28146340