UCP1 (uncoupling protein 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7350
Gene name Gene Name - the full gene name approved by the HGNC.
Uncoupling protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UCP1
Synonyms (NCBI Gene) Gene synonyms aliases
SLC25A7, UCP
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak.
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT510004 hsa-miR-548at-5p PAR-CLIP 20371350
MIRT510003 hsa-miR-4251 PAR-CLIP 20371350
MIRT510002 hsa-miR-539-5p PAR-CLIP 20371350
MIRT510001 hsa-miR-4668-5p PAR-CLIP 20371350
MIRT510004 hsa-miR-548at-5p PAR-CLIP 20371350
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
PPARA Repression 11875072
VDR Unknown 23906633
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002024 Process Diet induced thermogenesis IEA
GO:0005739 Component Mitochondrion IDA 9054939
GO:0005743 Component Mitochondrial inner membrane ISS
GO:0005743 Component Mitochondrial inner membrane TAS
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
113730 12517 ENSG00000109424
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P25874
Protein name Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)
Protein function Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the re
PDB 8G8W , 8HBV , 8HBW , 8J1N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00153 Mito_carr 10 → 107 Mitochondrial carrier protein Family
PF00153 Mito_carr 110 → 206 Mitochondrial carrier protein Family
PF00153 Mito_carr 210 → 300 Mitochondrial carrier protein Family
Tissue specificity TISSUE SPECIFICITY: Brown adipose tissue. {ECO:0000269|PubMed:3165741}.
Sequence
Sequence length 307
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  PPAR signaling pathway
Apelin signaling pathway
Thermogenesis
Huntington disease 		  The fatty acid cycling model
The proton buffering model
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Cardiomyopathy, Dilated, Cardiomyopathy, Familial Idiopathic rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)		 26670611
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)		 15592485
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 26670611 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 26670611 ClinVar
Myocardial infarction Myocardial Failure 26670611 ClinVar
Show/Hide Text Mining Associations (44)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 34067093
Atelosteogenesis type 2 Associate 29077154
Atrial Fibrillation Inhibit 29077154
Bone Neoplasms Associate 21355075
Breast Neoplasms Associate 23257779, 32819314
Carcinogenesis Associate 35090503
Carcinoma Renal Cell Associate 31545449
Carotid Stenosis Associate 22087257
Colonic Neoplasms Associate 36254139
Coronary Artery Disease Associate 27542888