Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7347
Gene name Gene Name - the full gene name approved by the HGNC.	Ubiquitin C-terminal hydrolase L3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UCHL3
Synonyms (NCBI Gene) Gene synonyms aliases	UCH-L3
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. T

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019702	hsa-miR-375	Microarray	20215506
MIRT047087	hsa-miR-183-5p	CLASH	23622248
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT717174	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT717173	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT717172	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT717171	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT717169	hsa-miR-4534	HITS-CLIP	19536157
MIRT717170	hsa-miR-8082	HITS-CLIP	19536157
MIRT717168	hsa-miR-3134	HITS-CLIP	19536157
MIRT717167	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT717166	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT717165	hsa-miR-5093	HITS-CLIP	19536157
MIRT717164	hsa-miR-4633-5p	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT520283	hsa-miR-8485	PAR-CLIP	21572407
MIRT520282	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT520281	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT520280	hsa-miR-603	PAR-CLIP	21572407
MIRT520279	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT520278	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT520277	hsa-miR-875-5p	PAR-CLIP	21572407
MIRT520276	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520274	hsa-miR-3941	PAR-CLIP	21572407
MIRT520275	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT520273	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT528099	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT528098	hsa-miR-548p	PAR-CLIP	22012620
MIRT528097	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT528096	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT528095	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT528094	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT528093	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT528092	hsa-miR-2117	PAR-CLIP	22012620
MIRT528091	hsa-miR-513c-5p	PAR-CLIP	22012620
MIRT528090	hsa-miR-514b-5p	PAR-CLIP	22012620
MIRT528089	hsa-miR-4273	PAR-CLIP	22012620
MIRT528088	hsa-miR-7156-5p	PAR-CLIP	22012620
MIRT520283	hsa-miR-8485	PAR-CLIP	23446348
MIRT520282	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT520281	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT520280	hsa-miR-603	PAR-CLIP	23446348
MIRT520279	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT520278	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT520277	hsa-miR-875-5p	PAR-CLIP	23446348
MIRT520276	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520274	hsa-miR-3941	PAR-CLIP	23446348
MIRT520275	hsa-miR-3144-3p	PAR-CLIP	23446348
MIRT520273	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT717174	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT717173	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT717172	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT717171	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT717169	hsa-miR-4534	HITS-CLIP	19536157
MIRT717170	hsa-miR-8082	HITS-CLIP	19536157
MIRT717168	hsa-miR-3134	HITS-CLIP	19536157
MIRT717167	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT717166	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT717165	hsa-miR-5093	HITS-CLIP	19536157
MIRT717164	hsa-miR-4633-5p	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT709706	hsa-miR-606	HITS-CLIP	19536157
MIRT520283	hsa-miR-8485	PAR-CLIP	21572407
MIRT520282	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT520281	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT520280	hsa-miR-603	PAR-CLIP	21572407
MIRT520279	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT520278	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT520277	hsa-miR-875-5p	PAR-CLIP	21572407
MIRT520276	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT520274	hsa-miR-3941	PAR-CLIP	21572407
MIRT520275	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT520273	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT528099	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT528098	hsa-miR-548p	PAR-CLIP	22012620
MIRT528097	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT528096	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT528095	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT528094	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT528093	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT528092	hsa-miR-2117	PAR-CLIP	22012620
MIRT528091	hsa-miR-513c-5p	PAR-CLIP	22012620
MIRT528090	hsa-miR-514b-5p	PAR-CLIP	22012620
MIRT528089	hsa-miR-4273	PAR-CLIP	22012620
MIRT528088	hsa-miR-7156-5p	PAR-CLIP	22012620
MIRT520283	hsa-miR-8485	PAR-CLIP	23446348
MIRT520282	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT520281	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT520280	hsa-miR-603	PAR-CLIP	23446348
MIRT520279	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT520278	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT520277	hsa-miR-875-5p	PAR-CLIP	23446348
MIRT520276	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT520274	hsa-miR-3941	PAR-CLIP	23446348
MIRT520275	hsa-miR-3144-3p	PAR-CLIP	23446348
MIRT520273	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1472393	hsa-miR-183	CLIP-seq
MIRT1472394	hsa-miR-3647-3p	CLIP-seq
MIRT1472395	hsa-miR-3919	CLIP-seq
MIRT1472396	hsa-miR-4282	CLIP-seq
MIRT1472397	hsa-miR-4684-3p	CLIP-seq
MIRT1472398	hsa-miR-518a-5p	CLIP-seq
MIRT1472399	hsa-miR-527	CLIP-seq
MIRT2142306	hsa-miR-369-3p	CLIP-seq
MIRT2142307	hsa-miR-374c	CLIP-seq
MIRT2142308	hsa-miR-4328	CLIP-seq
MIRT1472397	hsa-miR-4684-3p	CLIP-seq
MIRT1472398	hsa-miR-518a-5p	CLIP-seq
MIRT1472399	hsa-miR-527	CLIP-seq
MIRT2142309	hsa-miR-582-5p	CLIP-seq
MIRT2142310	hsa-miR-655	CLIP-seq
MIRT1472394	hsa-miR-3647-3p	CLIP-seq
MIRT1472395	hsa-miR-3919	CLIP-seq
MIRT1472396	hsa-miR-4282	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IBA	21873635
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IDA	9521656, 19047059
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	TAS	2530630
GO:0005515	Function	Protein binding	IPI	21453705, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0008233	Function	Peptidase activity	IDA	21762696
GO:0016567	Process	Protein ubiquitination	TAS
GO:0016579	Process	Protein deubiquitination	IBA	21873635
GO:0016579	Process	Protein deubiquitination	IDA	9521656, 19047059
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0019784	Function	NEDD8-specific protease activity	TAS
GO:0030163	Process	Protein catabolic process	IDA	21762696
GO:0043130	Function	Ubiquitin binding	IDA	19154770
GO:0043687	Process	Post-translational protein modification	TAS

MIM	HGNC	e!Ensembl
603090	12515	ENSG00000118939

Protein

UniProt ID

P15374

Protein name

Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)

Protein function

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiq

PDB

1UCH , 1XD3 , 6ISU , 6QML , 7YV4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01088	Peptidase_C12	6 → 214	Ubiquitin carboxyl-terminal hydrolase, family 1	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and testis. {ECO:0000269|PubMed:9790970}.

Sequence

MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITE
KYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLK
KFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHL
YELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA

Sequence length

230

Interactions

View interactions

	Reactome
			UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetic Retinopathy	Diabetic Retinopathy			GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	32546741
Bipolar Disorder	Inhibit	39600279
Breast Neoplasms	Associate	16734731, 27941124, 35053210
Carcinogenesis	Associate	32546741, 36813921
Carcinoma Hepatocellular	Stimulate	32486284
Carcinoma Non Small Cell Lung	Associate	32546741, 35918714
Chordoma	Associate	24503940
Diabetic Retinopathy	Associate	23562823
Infertility Male	Associate	27780264
Inflammation	Associate	23562823
Neoplasm Metastasis	Associate	36813921
Neoplasms	Associate	16734731, 27941124, 32486284, 32546741
Neurodegenerative Diseases	Associate	16537382, 29898404
Rhabdomyosarcoma	Associate	29898404
Spinocerebellar ataxia autosomal recessive 1	Associate	29898404
Stomach Neoplasms	Associate	37460253
Thyroid Carcinoma Anaplastic	Associate	36813921

UCHL3 (ubiquitin C-terminal hydrolase L3)