UBE2V2 (ubiquitin conjugating enzyme E2 V2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 7336 |
| Gene name | Ubiquitin conjugating enzyme E2 V2 |
| Gene symbol | UBE2V2 |
| Synonyms (NCBI Gene) |
DDVIT1DDVit-1EDAF-1EDPF-1EDPF1MMS2UEV-2UEV2
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| Chromosome | 8 |
| Chromosome location | 8q11.21 |
| Summary | Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic |
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miRNA
miRNA information provided by mirtarbase database.
537
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q15819 | ||||||||||
| Protein name | Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein) | ||||||||||
| Protein function | Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by t | ||||||||||
| PDB | 1J74 , 1J7D , 1ZGU , 3VON , 4NR3 , 4NRG , 4NRI , 4ONL , 4ONM , 4ONN , 4ORH , 5AIT , 7BBD , 7BBF , 8WR5 , 9BIV | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269|PubMed:9199207, ECO:0000269|PubMed:9705497}. | ||||||||||
| Sequence |
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| Sequence length | 145 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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