Gene Gene information from NCBI Gene database.
Entrez ID 7336
Gene name Ubiquitin conjugating enzyme E2 V2
Gene symbol UBE2V2
Synonyms (NCBI Gene)
DDVIT1DDVit-1EDAF-1EDPF-1EDPF1MMS2UEV-2UEV2
Chromosome 8
Chromosome location 8q11.21
Summary Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic
miRNA miRNA information provided by mirtarbase database.
537
miRTarBase ID miRNA Experiments Reference
MIRT024376 hsa-miR-215-5p Microarray 19074876
MIRT026382 hsa-miR-192-5p Microarray 19074876
MIRT029206 hsa-miR-26b-5p Microarray 19088304
MIRT051590 hsa-let-7e-5p CLASH 23622248
MIRT363925 hsa-miR-106a-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination TAS 10089880
GO:0000729 Process DNA double-strand break processing IMP 17349954
GO:0005515 Function Protein binding IPI 11473255, 16129784, 16786304, 19549727, 27173435, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 16129784
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603001 12495 ENSG00000169139
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15819
Protein name Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Protein function Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by t
PDB 1J74 , 1J7D , 1ZGU , 3VON , 4NR3 , 4NRG , 4NRI , 4ONL , 4ONM , 4ONN , 4ORH , 5AIT , 7BBD , 7BBF , 8WR5 , 9BIV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00179 UQ_con 14 144 Ubiquitin-conjugating enzyme Domain
Tissue specificity TISSUE SPECIFICITY: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269|PubMed:9199207, ECO:0000269|PubMed:9705497}.
Sequence
Sequence length 145
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Shigellosis   Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EYE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 37755128
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Associate 32420374
★☆☆☆☆
Found in Text Mining only
Lymphatic Metastasis Associate 37755128
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 37755128
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 24072219, 27422711, 37755128
★☆☆☆☆
Found in Text Mining only
Osteoporosis Associate 34555052
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 34429120
★☆☆☆☆
Found in Text Mining only
Smoke Inhalation Injury Associate 34555052
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Associate 22559327
★☆☆☆☆
Found in Text Mining only