UBE2L3 (ubiquitin conjugating enzyme E2 L3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7332 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Ubiquitin conjugating enzyme E2 L3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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UBE2L3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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E2-F1, L-UBC, UBCH7, UbcM4 |
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Chromosome
Chromosome number
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22 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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22q11.21 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjuga |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | P68036 | ||||||||||
| Protein name | Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3) | ||||||||||
| Protein function | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with | ||||||||||
| PDB | 1C4Z , 1FBV , 3SQV , 3SY2 , 4Q5E , 4Q5H , 5HPT , 5TTE , 5UDH , 6CP2 , 6DJW , 6DJX , 6N13 , 6XXU , 7B5L , 7B5N , 7OIK , 7V8F , 8EAZ , 8EB0 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous, with highest expression in testis. | ||||||||||
| Sequence |
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| Sequence length | 154 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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