Gene Gene information from NCBI Gene database.
Entrez ID 7323
Gene name Ubiquitin conjugating enzyme E2 D3
Gene symbol UBE2D3
Synonyms (NCBI Gene)
E2(17)KB3UBC4/5UBCH5C
Chromosome 4
Chromosome location 4q24
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
miRNA miRNA information provided by mirtarbase database.
692
miRTarBase ID miRNA Experiments Reference
MIRT020637 hsa-miR-155-5p Proteomics 18668040
MIRT027292 hsa-miR-101-3p Sequencing 20371350
MIRT027590 hsa-miR-98-5p Microarray 19088304
MIRT032304 hsa-let-7b-5p Proteomics 18668040
MIRT038113 hsa-miR-423-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SNAI2 Repression 21044962
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS
GO:0000166 Function Nucleotide binding IEA
GO:0000209 Process Protein polyubiquitination IDA 14765125, 16522193
GO:0004842 Function Ubiquitin-protein transferase activity IDA 14765125, 16522193, 20061386, 20347421, 21532592, 28685749
GO:0004842 Function Ubiquitin-protein transferase activity TAS 8090726
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602963 12476 ENSG00000109332
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61077
Protein name Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzym
Protein function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:15247280, PubMed:15496420, PubMed:18284575, PubMed:20061386, PubMed:21532592, PubMed:28322253). In vitro catalyzes 'Lys-11'-, as well as 'Lys-4
PDB 1X23 , 2FUH , 3L1Z , 3RPG , 3UGB , 4BVU , 4R8P , 4S3O , 5EGG , 5IFR , 6CP0 , 6T7F , 7JZV , 7LYB , 8AMS , 8GRQ , 8SMW , 8SMX , 8SMY , 8SMZ , 8SN0 , 8SN1 , 8SN2 , 8SN3 , 8SN4 , 8SN5 , 8SN6 , 8SN7 , 8SN8 , 8SN9 , 8SNA , 8U14 , 8UPF , 8UQ8 , 8UQ9 , 8UQA , 8UQB , 8UQC , 8UQD , 8UQE , 8X7I , 8X7J , 8X7K , 9IPU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00179 UQ_con 5 142 Ubiquitin-conjugating enzyme Domain
Sequence
Sequence length 147
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Polycomb repressive complex
Ubiquitin mediated proteolysis
Protein processing in endoplasmic reticulum
Shigellosis
  Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 34416429
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Associate 34416429
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 21044962, 23741361
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 38041015
★☆☆☆☆
Found in Text Mining only
Meibomitis Associate 17889501
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 21044962
★☆☆☆☆
Found in Text Mining only
Neoplasms Stimulate 34440306
★☆☆☆☆
Found in Text Mining only
Osteosarcoma Associate 34440306
★☆☆☆☆
Found in Text Mining only
Thyroid Neoplasms Associate 35546566
★☆☆☆☆
Found in Text Mining only