Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7307
Gene name Gene Name - the full gene name approved by the HGNC.	U2 small nuclear RNA auxiliary factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	U2AF1
Synonyms (NCBI Gene) Gene synonyms aliases	FP793, RN, RNU2AF1, U2AF35, U2AFBP
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which pl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	24398324
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	24398324
MIRT452698	hsa-miR-3166	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	26701625
MIRT452698	hsa-miR-3166	PAR-CLIP	26701625
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	20371350
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	21572407
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	23446348
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT452698	hsa-miR-3166	PAR-CLIP	24398324
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	24398324
MIRT452698	hsa-miR-3166	PAR-CLIP	23592263
MIRT452699	hsa-miR-1287-3p	PAR-CLIP	23592263
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465954	hsa-miR-297	CLIP-seq
MIRT1465955	hsa-miR-3149	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465958	hsa-miR-4307	CLIP-seq
MIRT1465959	hsa-miR-452	CLIP-seq
MIRT1465960	hsa-miR-4676-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465961	hsa-miR-567	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465959	hsa-miR-452	CLIP-seq
MIRT1465960	hsa-miR-4676-3p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465953	hsa-miR-1283	CLIP-seq
MIRT1465944	hsa-miR-133a	CLIP-seq
MIRT1465945	hsa-miR-133b	CLIP-seq
MIRT2360799	hsa-miR-3127-3p	CLIP-seq
MIRT1465956	hsa-miR-34c-3p	CLIP-seq
MIRT1465946	hsa-miR-3545-3p	CLIP-seq
MIRT1465957	hsa-miR-3622b-5p	CLIP-seq
MIRT1465947	hsa-miR-4705	CLIP-seq
MIRT1465948	hsa-miR-548ag	CLIP-seq
MIRT1465949	hsa-miR-548ai	CLIP-seq
MIRT1465950	hsa-miR-548c-3p	CLIP-seq
MIRT1465951	hsa-miR-582-3p	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq
MIRT1465952	hsa-miR-1273d	CLIP-seq
MIRT1465962	hsa-miR-590-3p	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	32343311
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11551507, 15652350, 16189514, 17577209, 18559666, 20696395, 21460037, 21516116, 21988832, 22365833, 23455924, 23602568, 25416956, 25959826, 28514442, 29892012, 32296183, 32814053, 33961781, 35271311, 39251607
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	11551507
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	1388271
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	1388271
GO:0015030	Component	Cajal body	TAS	1388271
GO:0016607	Component	Nuclear speck	IEA
GO:0016607	Component	Nuclear speck	ISS
GO:0030628	Function	Pre-mRNA 3'-splice site binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0050733	Function	RS domain binding	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0089701	Component	U2AF complex	IBA
GO:0089701	Component	U2AF complex	IDA	1824937, 2531895
GO:0089701	Component	U2AF complex	IEA
GO:0089701	Component	U2AF complex	IPI	11551507

MIM	HGNC	e!Ensembl
191317	12453	ENSG00000160201

Protein

UniProt ID

Q01081

Protein name

Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)

Protein function

Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly med

PDB

1JMT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	13 → 39	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF00076	RRM_1	82 → 141	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00642	zf-CCCH	149 → 175	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

Sequence

MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF

Sequence length

240

Interactions

View interactions

	KEGG		Reactome
	Spliceosome Shigellosis		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination

U2AF1 (U2 small nuclear RNA auxiliary factor 1)