Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7298
Gene name Gene Name - the full gene name approved by the HGNC.	Thymidylate synthetase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TYMS
Synonyms (NCBI Gene) Gene synonyms aliases	DKCD, HST422, TMS, TS
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18p11.32
Summary Summary of gene provided in NCBI Entrez Gene.	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication an

Show/Hide all(119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001582	hsa-let-7b-5p	pSILAC	18668040
MIRT016485	hsa-miR-193b-3p	Microarray	20304954
MIRT025487	hsa-miR-34a-5p	Proteomics	21566225
MIRT025487	hsa-miR-34a-5p	Proteomics	21566225
MIRT029608	hsa-miR-26b-5p	Microarray	19088304
MIRT001582	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT048693	hsa-miR-99a-5p	CLASH	23622248
MIRT044879	hsa-miR-194-5p	CLASH	23622248
MIRT042289	hsa-miR-484	CLASH	23622248
MIRT040968	hsa-miR-18a-3p	CLASH	23622248
MIRT040293	hsa-miR-615-3p	CLASH	23622248
MIRT438242	hsa-miR-433-3p	Luciferase reporter assay, qRT-PCR, Western blot	23915286
MIRT437980	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT437980	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT438242	hsa-miR-433-3p	Luciferase reporter assay, qRT-PCR, Western blot	23915286
MIRT437980	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT437980	hsa-miR-196a-5p	Luciferase reporter assay	24681820
MIRT199238	hsa-miR-203a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25482885
MIRT755700	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, in vitro cullelar assays	35003215
MIRT1465624	hsa-miR-1248	CLIP-seq
MIRT1465625	hsa-miR-192	CLIP-seq
MIRT1465626	hsa-miR-197	CLIP-seq
MIRT1465627	hsa-miR-215	CLIP-seq
MIRT1465628	hsa-miR-3121-5p	CLIP-seq
MIRT1465629	hsa-miR-3133	CLIP-seq
MIRT1465630	hsa-miR-3163	CLIP-seq
MIRT1465631	hsa-miR-338-5p	CLIP-seq
MIRT1465632	hsa-miR-3611	CLIP-seq
MIRT1465633	hsa-miR-362-5p	CLIP-seq
MIRT1465634	hsa-miR-3688-3p	CLIP-seq
MIRT1465635	hsa-miR-369-5p	CLIP-seq
MIRT1465636	hsa-miR-3978	CLIP-seq
MIRT1465637	hsa-miR-433	CLIP-seq
MIRT1465638	hsa-miR-4330	CLIP-seq
MIRT1465639	hsa-miR-4448	CLIP-seq
MIRT1465640	hsa-miR-4469	CLIP-seq
MIRT1465641	hsa-miR-4511	CLIP-seq
MIRT1465642	hsa-miR-4694-5p	CLIP-seq
MIRT1465643	hsa-miR-4795-3p	CLIP-seq
MIRT1465644	hsa-miR-488	CLIP-seq
MIRT1465645	hsa-miR-500b	CLIP-seq
MIRT1465646	hsa-miR-501-5p	CLIP-seq
MIRT1465647	hsa-miR-510	CLIP-seq
MIRT1465648	hsa-miR-512-5p	CLIP-seq
MIRT1465649	hsa-miR-935	CLIP-seq
MIRT2139959	hsa-miR-1202	CLIP-seq
MIRT2139960	hsa-miR-1206	CLIP-seq
MIRT1465624	hsa-miR-1248	CLIP-seq
MIRT2139961	hsa-miR-1298	CLIP-seq
MIRT1465626	hsa-miR-197	CLIP-seq
MIRT2139962	hsa-miR-203	CLIP-seq
MIRT2139963	hsa-miR-3150a-5p	CLIP-seq
MIRT2139964	hsa-miR-3150b-5p	CLIP-seq
MIRT2139965	hsa-miR-3688-5p	CLIP-seq
MIRT2139966	hsa-miR-375	CLIP-seq
MIRT2139967	hsa-miR-3972	CLIP-seq
MIRT2139968	hsa-miR-4279	CLIP-seq
MIRT2139969	hsa-miR-4304	CLIP-seq
MIRT2139970	hsa-miR-4654	CLIP-seq
MIRT2139971	hsa-miR-4690-3p	CLIP-seq
MIRT2139972	hsa-miR-4744	CLIP-seq
MIRT2139973	hsa-miR-4769-5p	CLIP-seq
MIRT2139974	hsa-miR-4776-3p	CLIP-seq
MIRT2139975	hsa-miR-548c-3p	CLIP-seq
MIRT2139976	hsa-miR-548u	CLIP-seq
MIRT1465649	hsa-miR-935	CLIP-seq
MIRT2139959	hsa-miR-1202	CLIP-seq
MIRT2139960	hsa-miR-1206	CLIP-seq
MIRT1465624	hsa-miR-1248	CLIP-seq
MIRT2139961	hsa-miR-1298	CLIP-seq
MIRT1465626	hsa-miR-197	CLIP-seq
MIRT2139962	hsa-miR-203	CLIP-seq
MIRT1465629	hsa-miR-3133	CLIP-seq
MIRT2139963	hsa-miR-3150a-5p	CLIP-seq
MIRT2139964	hsa-miR-3150b-5p	CLIP-seq
MIRT1465634	hsa-miR-3688-3p	CLIP-seq
MIRT2139965	hsa-miR-3688-5p	CLIP-seq
MIRT2139966	hsa-miR-375	CLIP-seq
MIRT2139967	hsa-miR-3972	CLIP-seq
MIRT1465636	hsa-miR-3978	CLIP-seq
MIRT2139968	hsa-miR-4279	CLIP-seq
MIRT2360655	hsa-miR-4310	CLIP-seq
MIRT1465638	hsa-miR-4330	CLIP-seq
MIRT1465641	hsa-miR-4511	CLIP-seq
MIRT2139970	hsa-miR-4654	CLIP-seq
MIRT2360656	hsa-miR-4666-5p	CLIP-seq
MIRT2139973	hsa-miR-4769-5p	CLIP-seq
MIRT2139974	hsa-miR-4776-3p	CLIP-seq
MIRT2360657	hsa-miR-4777-3p	CLIP-seq
MIRT1465643	hsa-miR-4795-3p	CLIP-seq
MIRT1465649	hsa-miR-935	CLIP-seq
MIRT2396553	hsa-miR-129-5p	CLIP-seq
MIRT1465635	hsa-miR-369-5p	CLIP-seq
MIRT2396554	hsa-miR-4307	CLIP-seq
MIRT1465637	hsa-miR-433	CLIP-seq
MIRT2396555	hsa-miR-4639-5p	CLIP-seq
MIRT2360656	hsa-miR-4666-5p	CLIP-seq
MIRT2396556	hsa-miR-499-3p	CLIP-seq
MIRT2396557	hsa-miR-499a-3p	CLIP-seq
MIRT2139959	hsa-miR-1202	CLIP-seq
MIRT1465625	hsa-miR-192	CLIP-seq
MIRT1465627	hsa-miR-215	CLIP-seq
MIRT1465628	hsa-miR-3121-5p	CLIP-seq
MIRT1465631	hsa-miR-338-5p	CLIP-seq
MIRT1465633	hsa-miR-362-5p	CLIP-seq
MIRT2139965	hsa-miR-3688-5p	CLIP-seq
MIRT2139967	hsa-miR-3972	CLIP-seq
MIRT1465639	hsa-miR-4448	CLIP-seq
MIRT2139974	hsa-miR-4776-3p	CLIP-seq
MIRT1465645	hsa-miR-500b	CLIP-seq
MIRT1465646	hsa-miR-501-5p	CLIP-seq
MIRT2139975	hsa-miR-548c-3p	CLIP-seq
MIRT1465649	hsa-miR-935	CLIP-seq
MIRT2139959	hsa-miR-1202	CLIP-seq
MIRT2139965	hsa-miR-3688-5p	CLIP-seq
MIRT2139967	hsa-miR-3972	CLIP-seq
MIRT2139974	hsa-miR-4776-3p	CLIP-seq
MIRT2139975	hsa-miR-548c-3p	CLIP-seq
MIRT1465649	hsa-miR-935	CLIP-seq

Transcription factors

Show/Hide all(10)

Transcription factor	Regulation	Reference
CHD8	Unknown	19255092
E2F1	Activation	14618416;9748140
E2F1	Unknown	10914714;14679120
ESR1	Unknown	10875244
SP1	Unknown	10875244;9218479
TFCP2	Unknown	16973241;19622726
TFDP1	Activation	14618416
TP53	Repression	21351099
USF1	Unknown	12782596
YBX1	Repression	17072343

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IDA	1924359
GO:0004799	Function	Thymidylate synthase activity	IBA
GO:0004799	Function	Thymidylate synthase activity	IDA	8845352, 11278511, 15093541
GO:0004799	Function	Thymidylate synthase activity	IEA
GO:0004799	Function	Thymidylate synthase activity	TAS	1924359
GO:0005542	Function	Folic acid binding	IC	15093541
GO:0005634	Component	Nucleus	IDA	21876188
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	21876188
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	21876188
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	21876188
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	21876188
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006231	Process	DTMP biosynthetic process	IBA
GO:0006231	Process	DTMP biosynthetic process	IDA	8845352, 11278511, 15093541
GO:0006231	Process	DTMP biosynthetic process	IEA
GO:0006235	Process	DTTP biosynthetic process	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0009165	Process	Nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016741	Function	Transferase activity, transferring one-carbon groups	IEA
GO:0017148	Process	Negative regulation of translation	IDA	1924359
GO:0032259	Process	Methylation	IEA
GO:0035999	Process	Tetrahydrofolate interconversion	IDA	15093541
GO:0035999	Process	Tetrahydrofolate interconversion	IEA
GO:0046653	Process	Tetrahydrofolate metabolic process	IEA
GO:0071897	Process	DNA biosynthetic process	IC	15093541
GO:1990825	Function	Sequence-specific mRNA binding	IDA	1924359

MIM	HGNC	e!Ensembl
188350	12441	ENSG00000176890

Protein

UniProt ID

P04818

Protein name

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

Protein function

Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de

PDB

1HVY , 1HW3 , 1HW4 , 1HZW , 1I00 , 1JU6 , 1JUJ , 1YPV , 2ONB , 2RD8 , 2RDA , 3EAW , 3EBU , 3ED7 , 3EDW , 3EF9 , 3EGY , 3EHI , 3EJL , 3GG5 , 3GH0 , 3GH2 , 3H9K , 3HB8 , 3N5E , 3N5G , 3OB7 , 4E28 , 4FGT , 4G2O , 4G6W , 4GD7 , 4GYH , 4H1I , 4JEF , 4KPW , 4O1U , 4O1X , 4UP1 , 5HS3 , 5WRN , 5X4W , 5X4X , 5X4Y , 5X5A , 5X5D , 5X5Q , 5X66 , 5X67 , 5X69 , 6OJU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00303	Thymidylat_synt	31 → 313	Thymidylate synthase	Domain

Sequence

MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV

Sequence length

313

Interactions

View interactions

	KEGG		Reactome
	Pyrimidine metabolism One carbon pool by folate Metabolic pathways Nucleotide metabolism Antifolate resistance Folate transport and metabolism		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (166)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acidosis Lactic	Associate	38098057
Adenocarcinoma	Associate	15868929, 19460136, 21205745, 21716147, 23470290, 23803067, 25250715, 26374242, 30823845
Adenocarcinoma Mucinous	Inhibit	16012177
Adenocarcinoma Mucinous	Associate	20570913
Adenocarcinoma of Lung	Associate	16489621, 21321092, 23350714, 27094798, 29895834, 34818974, 34996932, 36311801, 36769342
Adenoma	Associate	17971770
Adenoma Pleomorphic	Stimulate	26031756
Adenomatous Polyposis Coli	Associate	24259968
Adrenal Cortex Neoplasms	Associate	28432084
Adrenocortical Carcinoma	Associate	28432084
Alzheimer Disease	Associate	37819172
Anemia	Associate	19648163, 27191954
Anodontia	Associate	15646842
Arthritis Rheumatoid	Associate	19571519, 25279663, 25687398
Astrocytoma	Associate	15265232
Barrett Esophagus	Associate	19460136
Biliary Tract Neoplasms	Associate	11676864
Birth Weight	Associate	35631247
Breast Neoplasms	Associate	16723031, 17385677, 17695507, 18669903, 20571234, 23217244, 24166930, 25598430, 26109344, 28349820, 29228969, 33030246, 33832110, 34048185
Calcinosis Cutis	Associate	19105824, 29394274
Carcinogenesis	Associate	17971770
Carcinoma Adenosquamous	Associate	22996376
Carcinoma Hepatocellular	Associate	17659576, 28713155, 31291332, 32513905, 37051625
Carcinoma Large Cell	Associate	34453496
Carcinoma Non Small Cell Lung	Associate	10622537, 15785747, 15868929, 16334126, 16880781, 17695427, 18442042, 19811498, 20384633, 21716147, 22551903, 22866924, 23350714, 23470290, 23717468 View all (18 more)
Carcinoma Pancreatic Ductal	Associate	37432996
Carcinoma Renal Cell	Associate	37033923
Carcinoma Small Cell	Associate	21321092
Carcinoma Squamous Cell	Stimulate	16955506, 21321092, 26031756
Carcinoma Squamous Cell	Associate	22134068, 22996376, 23350714, 23470290, 31642613, 32810931
Cardiomyopathies	Associate	22448752
Cholangiocarcinoma	Associate	15884115, 22912546, 26374242, 30538221
Chromosome Aberrations	Associate	25762627
Chromosome Disorders	Associate	25366766
Colonic Neoplasms	Associate	10744679, 15646842, 18203297, 18618519, 20515563, 9223329
Colorectal Neoplasms	Associate	10097112, 11038045, 11058126, 11139611, 11278511, 11300331, 11484952, 11501504, 11556832, 11747337, 11896073, 12373601, 12453856, 12460463, 12870370 View all (81 more)
Colorectal Neoplasms	Stimulate	18652704
Colorectal Neoplasms	Inhibit	29085228
Congenital disorder of glycosylation type 1B	Associate	33569057
Conotruncal cardiac defects	Associate	19493349, 21254360, 22887475, 24535845
Coronary Artery Disease	Associate	20962453, 37628769
COVID 19	Associate	35958619, 37033923, 37486005
Death	Associate	19154585, 21460376, 28932083
Diabetes Gestational	Associate	35631247
Diarrhea	Associate	20306339
Dihydropyrimidine Dehydrogenase Deficiency	Associate	33608662
Disease	Associate	28932083, 35038823
Disease Resistance	Associate	15884115
Dissection Thoracic Aorta	Associate	31380418
DNA Virus Infections	Associate	9771948
Down Syndrome	Associate	20868477
Drug Related Side Effects and Adverse Reactions	Associate	17609664, 18790783, 19811498, 20628391, 20819423, 22496803, 22867891, 23736036, 25167226, 27913567, 28222070, 29145602, 36952646
Drug Related Side Effects and Adverse Reactions	Inhibit	9771948
Dyskeratosis Congenita	Associate	35931051
Endocrine System Diseases	Associate	36952646
Endometrial Neoplasms	Associate	19190136
Episodic Ataxia	Associate	31786878
Esophageal Neoplasms	Associate	21196216
Esophageal Squamous Cell Carcinoma	Associate	19750576, 21196216
Fever	Inhibit	38350654
Folate Malabsorption Hereditary	Associate	34502300, 35631247
Fragile X Syndrome	Associate	2931977
Gallbladder Neoplasms	Associate	16619549
Gastro enteropancreatic neuroendocrine tumor	Associate	18281538
Gastrointestinal Diseases	Associate	32344632
Gastrointestinal Neoplasms	Associate	10622537, 14716816, 18507058, 18652704, 31648989, 33608662
Genetic Diseases Inborn	Associate	30122583, 38098057
Glioblastoma	Associate	21365010
Glioma	Associate	30305647, 37901992
Graft vs Host Disease	Associate	16920564
Hand Foot Syndrome	Associate	29145602, 31601265, 33285053
Head and Neck Neoplasms	Associate	10206306, 23276522, 33369477
Hematologic Diseases	Associate	20306339, 27191954, 29906295
Hematologic Neoplasms	Associate	29906295
Hemorrhage	Associate	36952646
Hereditary Sensory and Autonomic Neuropathies	Associate	27191954
Hypoxia	Inhibit	28713155
Inflammation	Inhibit	30544400
Laryngeal Neoplasms	Associate	23838799
Leukemia	Associate	15251465, 21159649, 26438060
Leukemia Lymphocytic Chronic B Cell	Associate	18945750
Leukemia Lymphoma Adult T Cell	Associate	26438060
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	16920564
Leukemia T Cell	Associate	9369939
Lipodystrophy	Associate	21282454, 23468971
Liver Diseases	Associate	33931971
Lung Diseases	Associate	29895834, 32810931
Lung Diseases Interstitial	Stimulate	38302188
Lung Neoplasms	Associate	20384633, 20628382, 21321092, 23372658, 25536611, 26745074, 28835573, 32638267, 35499292
Lung Neoplasms	Stimulate	27387303
Lymphatic Metastasis	Associate	16489621, 21347782, 33832110
Lymphoma Follicular	Associate	16410450
Lymphoma Large B Cell Diffuse	Associate	15198953, 18042267
Lymphoma Non Hodgkin	Inhibit	15198953
Lymphoma Non Hodgkin	Associate	15198953, 18042267
Lymphoma Non Hodgkin	Stimulate	25384508
Medulloblastoma	Associate	29869738
Melanoma	Associate	17611626, 18677108, 23249808, 8394020
Mesothelioma	Associate	19662092, 28945836
Mesothelioma Malignant	Associate	21970874, 28415584, 35461395, 36708568
Microsatellite Instability	Associate	20515563
Neoplasm Invasiveness	Associate	12165018
Neoplasm Metastasis	Associate	11484952, 11896073, 12165018, 15040806, 18985814, 19052026, 20727737, 29394274, 30054102, 34818974
Neoplasm Residual	Associate	18087284
Neoplasms	Associate	11058126, 11161374, 11278511, 11300331, 11501504, 11556832, 12085207, 12147691, 12354935, 12460463, 12592379, 12870370, 15265232, 15330198, 15354215 View all (85 more)
Neoplasms	Stimulate	25581782
Neoplasms Cystic Mucinous and Serous	Stimulate	15655543
Nervous System Diseases	Associate	29145602
Neural Tube Defects	Associate	22903727
Neurologic Manifestations	Associate	36952646
Neutropenia	Associate	27191954
NOG Related Symphalangism Spectrum Disorder	Associate	23968134, 24277474
Oculocutaneous albinism type 2	Associate	33569057
Oropharyngeal Neoplasms	Associate	19221247, 23054206
Osteochondritis	Associate	31758856
Osteoporosis	Associate	29534533
Osteoporotic Fractures	Associate	29534533
Ovarian Neoplasms	Associate	20570913, 23056627
Palmer Pagon syndrome	Associate	20306339
Pancreatic Neoplasms	Associate	20306339, 21487324, 29229329, 34632851
Pancreatic Neoplasms	Stimulate	31861032
Pancreatitis	Associate	23468971
Papilloma	Associate	23826176
Papillomavirus Infections	Associate	23826176
Paresthesia	Associate	29145602
Penile Neoplasms	Associate	26935231
Peripheral Nervous System Diseases	Associate	23468971
Personality Disorders	Inhibit	15785747
Pleural Effusion Malignant	Associate	18507058
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	11986237, 36952646
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	36769342
Premature Birth	Associate	35631247
Prostatic Neoplasms	Associate	25762627
Proteinuria	Associate	27191954
Rectal Neoplasms	Associate	17016487, 18087284, 18286688, 19491899, 21205745, 21347782, 23968134, 24455740, 27423551, 28932083, 34207124
Rectal Neoplasms	Stimulate	25532759
Retinal Dysplasia	Associate	19460136
Retinoblastoma	Inhibit	17510060
Retroperitoneal liposarcoma	Associate	32627015
Sarcoma	Associate	25984907, 9565579
Sarcoma Kaposi	Associate	12239332
Sick Sinus Syndrome	Associate	11300331
Sjogren's Syndrome	Associate	35958619
Skin Diseases	Associate	29421402
Small Cell Lung Carcinoma	Stimulate	18281538
Small Cell Lung Carcinoma	Associate	20107425, 29845250
Spinal Dysraphism	Associate	19683694
Squamous Cell Carcinoma of Head and Neck	Associate	17596206, 21460376, 25186767, 30803213
Stomach Diseases	Associate	29906295
Stomach Neoplasms	Associate	11161374, 12085207, 15244514, 15330198, 15354215, 16317430, 17201138, 17211470, 17322540, 17695481, 17854149, 18362936, 18442042, 20857529, 21931799 View all (9 more)
Stomach Neoplasms	Stimulate	18652704
Stomatitis	Associate	22448752, 23652803
Tertiary Lymphoid Structures	Associate	12655514, 17695507
Thrombocytopenia	Associate	27191954, 29145602
Thymoma	Stimulate	27387303
Thyroid Neoplasms	Associate	35528004
Triple Negative Breast Neoplasms	Associate	27107440, 31641220, 34053447
Triple Negative Breast Neoplasms	Stimulate	33030246
Turcot syndrome	Stimulate	24800948
Turcot syndrome	Associate	27821793
Urinary Bladder Neoplasms	Associate	12165018, 20425122
Uterine Cervical Dysplasia	Associate	31642613
Uterine Cervical Neoplasms	Associate	17605297, 32181600, 33302814
Uterine Cervicitis	Associate	32295543
Venous Thrombosis	Associate	27191954
Vomiting	Associate	20306339

TYMS (thymidylate synthetase)