TYMS (thymidylate synthetase)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 7298
Gene name Thymidylate synthetase
Gene symbol TYMS
Synonyms (NCBI Gene)
DKCDHST422TMSTS
Chromosome 18
Chromosome location 18p11.32
Summary Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication an
miRNA miRNA information provided by mirtarbase database.
119
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (119)
miRTarBase ID miRNA Experiments Reference
MIRT001582 hsa-let-7b-5p pSILAC 18668040
MIRT016485 hsa-miR-193b-3p Microarray 20304954
MIRT025487 hsa-miR-34a-5p Proteomics 21566225
MIRT025487 hsa-miR-34a-5p Proteomics 21566225
MIRT029608 hsa-miR-26b-5p Microarray 19088304
Transcription factors Transcription factors information provided by TRRUST V2 database.
10
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (10)
Transcription factor Regulation Reference
CHD8 Unknown 19255092
E2F1 Activation 14618416;9748140
E2F1 Unknown 10914714;14679120
ESR1 Unknown 10875244
SP1 Unknown 10875244;9218479
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (36)
GO ID Ontology Definition Evidence Reference
GO:0000900 Function MRNA regulatory element binding translation repressor activity IDA 1924359
GO:0004799 Function Thymidylate synthase activity IBA
GO:0004799 Function Thymidylate synthase activity IDA 8845352, 11278511, 15093541
GO:0004799 Function Thymidylate synthase activity IEA
GO:0004799 Function Thymidylate synthase activity TAS 1924359
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
188350 12441 ENSG00000176890
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P04818
Protein name Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
Protein function Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de
PDB 1HVY , 1HW3 , 1HW4 , 1HZW , 1I00 , 1JU6 , 1JUJ , 1YPV , 2ONB , 2RD8 , 2RDA , 3EAW , 3EBU , 3ED7 , 3EDW , 3EF9 , 3EGY , 3EHI , 3EJL , 3GG5 , 3GH0 , 3GH2 , 3H9K , 3HB8 , 3N5E , 3N5G , 3OB7 , 4E28 , 4FGT , 4G2O , 4G6W , 4GD7 , 4GYH , 4H1I , 4JEF , 4KPW , 4O1U , 4O1X , 4UP1 , 5HS3 , 5WRN , 5X4W , 5X4X , 5X4Y , 5X5A , 5X5D , 5X5Q , 5X66 , 5X67 , 5X69 , 6OJU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00303 Thymidylat_synt 31 → 313 Thymidylate synthase Domain
Sequence
Sequence length 313
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Pyrimidine metabolism
One carbon pool by folate
Metabolic pathways
Nucleotide metabolism
Antifolate resistance
Folate transport and metabolism 		  Interconversion of nucleotide di- and triphosphates
G1/S-Specific Transcription
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
14
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Dyskeratosis congenita Pathogenic rs2046518776, rs2144335544, rs2144335824, rs2144335968, rs1703168604 RCV002269393
RCV002269395
RCV002269396
RCV002269397
RCV002269398
Dyskeratosis congenita, digenic Pathogenic rs2046518776, rs2144335544, rs2144335824 RCV002285186
RCV002285188
RCV002285189
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
TYMS-related disorder Benign; Likely benign rs3786362, rs1376079761, rs188268314 RCV003919872
RCV003962145
RCV003981241
Show/Hide Text Mining Associations (166)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acidosis Lactic Associate 38098057
Adenocarcinoma Associate 15868929, 19460136, 21205745, 21716147, 23470290, 23803067, 25250715, 26374242, 30823845
Adenocarcinoma Mucinous Inhibit 16012177
Adenocarcinoma Mucinous Associate 20570913
Adenocarcinoma of Lung Associate 16489621, 21321092, 23350714, 27094798, 29895834, 34818974, 34996932, 36311801, 36769342
Adenoma Associate 17971770
Adenoma Pleomorphic Stimulate 26031756
Adenomatous Polyposis Coli Associate 24259968
Adrenal Cortex Neoplasms Associate 28432084
Adrenocortical Carcinoma Associate 28432084