Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7296
Gene name Gene Name - the full gene name approved by the HGNC.	Thioredoxin reductase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TXNRD1
Synonyms (NCBI Gene) Gene synonyms aliases	GRIM-12, TR, TR1, TRXR1, TXNR, TXNR1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing fla

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001489	hsa-miR-155-5p	pSILAC	18668040
MIRT001489	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT021121	hsa-miR-186-5p	Sequencing	20371350
MIRT025447	hsa-miR-34a-5p	Proteomics	21566225
MIRT029399	hsa-miR-26b-5p	Microarray	19088304
MIRT051614	hsa-let-7e-5p	CLASH	23622248
MIRT041077	hsa-miR-504-5p	CLASH	23622248
MIRT697912	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT565125	hsa-miR-1323	HITS-CLIP	23313552
MIRT565124	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT697910	hsa-miR-4714-3p	HITS-CLIP	23313552
MIRT697911	hsa-miR-219b-5p	HITS-CLIP	23313552
MIRT697909	hsa-miR-124-5p	HITS-CLIP	23313552
MIRT697908	hsa-miR-4672	HITS-CLIP	23313552
MIRT565127	hsa-miR-421	PAR-CLIP	20371350
MIRT565126	hsa-miR-4272	PAR-CLIP	20371350
MIRT565125	hsa-miR-1323	PAR-CLIP	20371350
MIRT565124	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT565123	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT565122	hsa-miR-1206	PAR-CLIP	20371350
MIRT565121	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT565120	hsa-miR-7159-5p	PAR-CLIP	20371350
MIRT565119	hsa-miR-505-3p	PAR-CLIP	20371350
MIRT565118	hsa-miR-1298-5p	PAR-CLIP	20371350
MIRT464905	hsa-miR-409-3p	PAR-CLIP	23592263
MIRT464904	hsa-miR-1257	PAR-CLIP	23592263
MIRT464903	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT464902	hsa-miR-3611	PAR-CLIP	23592263
MIRT697912	hsa-miR-6768-5p	HITS-CLIP	23313552
MIRT565125	hsa-miR-1323	HITS-CLIP	23313552
MIRT565124	hsa-miR-548o-3p	HITS-CLIP	23313552
MIRT697910	hsa-miR-4714-3p	HITS-CLIP	23313552
MIRT697911	hsa-miR-219b-5p	HITS-CLIP	23313552
MIRT697909	hsa-miR-124-5p	HITS-CLIP	23313552
MIRT697908	hsa-miR-4672	HITS-CLIP	23313552
MIRT565127	hsa-miR-421	PAR-CLIP	20371350
MIRT565126	hsa-miR-4272	PAR-CLIP	20371350
MIRT565125	hsa-miR-1323	PAR-CLIP	20371350
MIRT565124	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT565123	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT565122	hsa-miR-1206	PAR-CLIP	20371350
MIRT565121	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT565120	hsa-miR-7159-5p	PAR-CLIP	20371350
MIRT565119	hsa-miR-505-3p	PAR-CLIP	20371350
MIRT565118	hsa-miR-1298-5p	PAR-CLIP	20371350
MIRT464905	hsa-miR-409-3p	PAR-CLIP	23592263
MIRT464904	hsa-miR-1257	PAR-CLIP	23592263
MIRT464903	hsa-miR-5587-5p	PAR-CLIP	23592263
MIRT464902	hsa-miR-3611	PAR-CLIP	23592263
MIRT1465502	hsa-miR-1207-5p	CLIP-seq
MIRT1465503	hsa-miR-1245b-5p	CLIP-seq
MIRT1465504	hsa-miR-1275	CLIP-seq
MIRT1465505	hsa-miR-1295	CLIP-seq
MIRT1465506	hsa-miR-132	CLIP-seq
MIRT1465507	hsa-miR-146b-3p	CLIP-seq
MIRT1465508	hsa-miR-148a	CLIP-seq
MIRT1465509	hsa-miR-148b	CLIP-seq
MIRT1465510	hsa-miR-152	CLIP-seq
MIRT1465511	hsa-miR-1827	CLIP-seq
MIRT1465512	hsa-miR-186	CLIP-seq
MIRT1465513	hsa-miR-190	CLIP-seq
MIRT1465514	hsa-miR-190b	CLIP-seq
MIRT1465515	hsa-miR-194	CLIP-seq
MIRT1465516	hsa-miR-205	CLIP-seq
MIRT1465517	hsa-miR-2052	CLIP-seq
MIRT1465518	hsa-miR-212	CLIP-seq
MIRT1465519	hsa-miR-23a	CLIP-seq
MIRT1465520	hsa-miR-23b	CLIP-seq
MIRT1465521	hsa-miR-23c	CLIP-seq
MIRT1465522	hsa-miR-2964a-5p	CLIP-seq
MIRT1465523	hsa-miR-3123	CLIP-seq
MIRT1465524	hsa-miR-3133	CLIP-seq
MIRT1465525	hsa-miR-3142	CLIP-seq
MIRT1465526	hsa-miR-3151	CLIP-seq
MIRT1465527	hsa-miR-3191	CLIP-seq
MIRT1465528	hsa-miR-3614-5p	CLIP-seq
MIRT1465529	hsa-miR-3646	CLIP-seq
MIRT1465530	hsa-miR-3647-3p	CLIP-seq
MIRT1465531	hsa-miR-3676	CLIP-seq
MIRT1465532	hsa-miR-3684	CLIP-seq
MIRT1465533	hsa-miR-374c	CLIP-seq
MIRT1465534	hsa-miR-3927	CLIP-seq
MIRT1465535	hsa-miR-3942-3p	CLIP-seq
MIRT1465536	hsa-miR-4251	CLIP-seq
MIRT1465537	hsa-miR-4265	CLIP-seq
MIRT1465538	hsa-miR-4283	CLIP-seq
MIRT1465539	hsa-miR-4296	CLIP-seq
MIRT1465540	hsa-miR-4311	CLIP-seq
MIRT1465541	hsa-miR-4322	CLIP-seq
MIRT1465542	hsa-miR-4436b-5p	CLIP-seq
MIRT1465543	hsa-miR-4447	CLIP-seq
MIRT1465544	hsa-miR-4450	CLIP-seq
MIRT1465545	hsa-miR-4451	CLIP-seq
MIRT1465546	hsa-miR-4459	CLIP-seq
MIRT1465547	hsa-miR-4468	CLIP-seq
MIRT1465548	hsa-miR-4472	CLIP-seq
MIRT1465549	hsa-miR-4511	CLIP-seq
MIRT1465550	hsa-miR-4525	CLIP-seq
MIRT1465551	hsa-miR-455-3p	CLIP-seq
MIRT1465552	hsa-miR-4649-3p	CLIP-seq
MIRT1465553	hsa-miR-4665-5p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT1465555	hsa-miR-4688	CLIP-seq
MIRT1465556	hsa-miR-4690-5p	CLIP-seq
MIRT1465557	hsa-miR-4695-3p	CLIP-seq
MIRT1465558	hsa-miR-4695-5p	CLIP-seq
MIRT1465559	hsa-miR-4698	CLIP-seq
MIRT1465560	hsa-miR-4699-5p	CLIP-seq
MIRT1465561	hsa-miR-4722-5p	CLIP-seq
MIRT1465562	hsa-miR-4723-5p	CLIP-seq
MIRT1465563	hsa-miR-4736	CLIP-seq
MIRT1465564	hsa-miR-4744	CLIP-seq
MIRT1465565	hsa-miR-4763-3p	CLIP-seq
MIRT1465566	hsa-miR-4772-3p	CLIP-seq
MIRT1465567	hsa-miR-4773	CLIP-seq
MIRT1465568	hsa-miR-4789-3p	CLIP-seq
MIRT1465569	hsa-miR-4802-3p	CLIP-seq
MIRT1465570	hsa-miR-491-5p	CLIP-seq
MIRT1465571	hsa-miR-495	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT1465573	hsa-miR-512-3p	CLIP-seq
MIRT1465574	hsa-miR-518a-5p	CLIP-seq
MIRT1465575	hsa-miR-527	CLIP-seq
MIRT1465576	hsa-miR-539	CLIP-seq
MIRT1465577	hsa-miR-543	CLIP-seq
MIRT1465578	hsa-miR-548aa	CLIP-seq
MIRT1465579	hsa-miR-548o	CLIP-seq
MIRT1465580	hsa-miR-548u	CLIP-seq
MIRT1465581	hsa-miR-552	CLIP-seq
MIRT1465582	hsa-miR-587	CLIP-seq
MIRT1465583	hsa-miR-625	CLIP-seq
MIRT1465584	hsa-miR-634	CLIP-seq
MIRT1465585	hsa-miR-655	CLIP-seq
MIRT1465586	hsa-miR-891b	CLIP-seq
MIRT1465513	hsa-miR-190	CLIP-seq
MIRT1465514	hsa-miR-190b	CLIP-seq
MIRT1465587	hsa-miR-3140-3p	CLIP-seq
MIRT1465588	hsa-miR-4520a-3p	CLIP-seq
MIRT1465589	hsa-miR-4520b-3p	CLIP-seq
MIRT1465590	hsa-miR-4529-3p	CLIP-seq
MIRT1465564	hsa-miR-4744	CLIP-seq
MIRT1465580	hsa-miR-548u	CLIP-seq
MIRT1555294	hsa-miR-3974	CLIP-seq
MIRT1555295	hsa-miR-4457	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT1465566	hsa-miR-4772-3p	CLIP-seq
MIRT1555296	hsa-miR-548a-3p	CLIP-seq
MIRT1555297	hsa-miR-548e	CLIP-seq
MIRT1555298	hsa-miR-548f	CLIP-seq
MIRT1557243	hsa-miR-3121-3p	CLIP-seq
MIRT1465587	hsa-miR-3140-3p	CLIP-seq
MIRT1557244	hsa-miR-3685	CLIP-seq
MIRT1557245	hsa-miR-384	CLIP-seq
MIRT1465588	hsa-miR-4520a-3p	CLIP-seq
MIRT1465589	hsa-miR-4520b-3p	CLIP-seq
MIRT1465590	hsa-miR-4529-3p	CLIP-seq
MIRT1557246	hsa-miR-548c-3p	CLIP-seq
MIRT1465529	hsa-miR-3646	CLIP-seq
MIRT2139947	hsa-miR-4645-5p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT2139948	hsa-miR-4673	CLIP-seq
MIRT2139949	hsa-miR-4755-3p	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT1465577	hsa-miR-543	CLIP-seq
MIRT2360610	hsa-miR-103b	CLIP-seq
MIRT2360611	hsa-miR-1207-3p	CLIP-seq
MIRT2360612	hsa-miR-125a-5p	CLIP-seq
MIRT2360613	hsa-miR-125b	CLIP-seq
MIRT1465517	hsa-miR-2052	CLIP-seq
MIRT2360614	hsa-miR-2117	CLIP-seq
MIRT1465519	hsa-miR-23a	CLIP-seq
MIRT1465520	hsa-miR-23b	CLIP-seq
MIRT1465521	hsa-miR-23c	CLIP-seq
MIRT2360615	hsa-miR-3124-3p	CLIP-seq
MIRT2360616	hsa-miR-3136-3p	CLIP-seq
MIRT1465526	hsa-miR-3151	CLIP-seq
MIRT1465532	hsa-miR-3684	CLIP-seq
MIRT2360617	hsa-miR-376c	CLIP-seq
MIRT1465534	hsa-miR-3927	CLIP-seq
MIRT1465536	hsa-miR-4251	CLIP-seq
MIRT2360618	hsa-miR-4277	CLIP-seq
MIRT2360619	hsa-miR-4319	CLIP-seq
MIRT1465543	hsa-miR-4447	CLIP-seq
MIRT1465545	hsa-miR-4451	CLIP-seq
MIRT1465548	hsa-miR-4472	CLIP-seq
MIRT2360620	hsa-miR-4514	CLIP-seq
MIRT2360621	hsa-miR-4532	CLIP-seq
MIRT2139947	hsa-miR-4645-5p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT2139948	hsa-miR-4673	CLIP-seq
MIRT2360622	hsa-miR-4692	CLIP-seq
MIRT1465557	hsa-miR-4695-3p	CLIP-seq
MIRT2360623	hsa-miR-4732-3p	CLIP-seq
MIRT2360624	hsa-miR-4753-3p	CLIP-seq
MIRT2139949	hsa-miR-4755-3p	CLIP-seq
MIRT1465570	hsa-miR-491-5p	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT1465574	hsa-miR-518a-5p	CLIP-seq
MIRT1465575	hsa-miR-527	CLIP-seq
MIRT1465576	hsa-miR-539	CLIP-seq
MIRT2360625	hsa-miR-544b	CLIP-seq
MIRT1465581	hsa-miR-552	CLIP-seq
MIRT1465584	hsa-miR-634	CLIP-seq
MIRT2360626	hsa-miR-663b	CLIP-seq
MIRT2360627	hsa-miR-670	CLIP-seq
MIRT1465586	hsa-miR-891b	CLIP-seq
MIRT1465566	hsa-miR-4772-3p	CLIP-seq
MIRT1465586	hsa-miR-891b	CLIP-seq
MIRT2396547	hsa-miR-1205	CLIP-seq
MIRT2360611	hsa-miR-1207-3p	CLIP-seq
MIRT2396548	hsa-miR-1286	CLIP-seq
MIRT1465506	hsa-miR-132	CLIP-seq
MIRT2360614	hsa-miR-2117	CLIP-seq
MIRT1465518	hsa-miR-212	CLIP-seq
MIRT2360618	hsa-miR-4277	CLIP-seq
MIRT2396549	hsa-miR-4436a	CLIP-seq
MIRT1465551	hsa-miR-455-3p	CLIP-seq
MIRT1465561	hsa-miR-4722-5p	CLIP-seq
MIRT2360624	hsa-miR-4753-3p	CLIP-seq
MIRT1465567	hsa-miR-4773	CLIP-seq
MIRT1465530	hsa-miR-3647-3p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT2434410	hsa-miR-549	CLIP-seq
MIRT2434411	hsa-miR-203	CLIP-seq
MIRT1465530	hsa-miR-3647-3p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT2434410	hsa-miR-549	CLIP-seq
MIRT1465511	hsa-miR-1827	CLIP-seq
MIRT2441573	hsa-miR-4316	CLIP-seq
MIRT2441574	hsa-miR-3672	CLIP-seq
MIRT2654181	hsa-miR-105	CLIP-seq
MIRT2654182	hsa-miR-124	CLIP-seq
MIRT2654183	hsa-miR-1297	CLIP-seq
MIRT2654184	hsa-miR-1298	CLIP-seq
MIRT2654185	hsa-miR-140-3p	CLIP-seq
MIRT1465507	hsa-miR-146b-3p	CLIP-seq
MIRT1465511	hsa-miR-1827	CLIP-seq
MIRT2654186	hsa-miR-188-5p	CLIP-seq
MIRT2434411	hsa-miR-203	CLIP-seq
MIRT2654187	hsa-miR-204	CLIP-seq
MIRT2654188	hsa-miR-211	CLIP-seq
MIRT2654189	hsa-miR-2276	CLIP-seq
MIRT2654190	hsa-miR-26a	CLIP-seq
MIRT2654191	hsa-miR-26b	CLIP-seq
MIRT2654192	hsa-miR-302f	CLIP-seq
MIRT2654193	hsa-miR-3164	CLIP-seq
MIRT2654194	hsa-miR-3173-5p	CLIP-seq
MIRT2654195	hsa-miR-324-5p	CLIP-seq
MIRT2654196	hsa-miR-330-3p	CLIP-seq
MIRT1465528	hsa-miR-3614-5p	CLIP-seq
MIRT1465529	hsa-miR-3646	CLIP-seq
MIRT2654197	hsa-miR-3652	CLIP-seq
MIRT2654198	hsa-miR-3667-3p	CLIP-seq
MIRT2441574	hsa-miR-3672	CLIP-seq
MIRT2654199	hsa-miR-3692	CLIP-seq
MIRT2654200	hsa-miR-369-3p	CLIP-seq
MIRT2654201	hsa-miR-374a	CLIP-seq
MIRT2654202	hsa-miR-374b	CLIP-seq
MIRT1465533	hsa-miR-374c	CLIP-seq
MIRT2654203	hsa-miR-3926	CLIP-seq
MIRT2654204	hsa-miR-3941	CLIP-seq
MIRT1555294	hsa-miR-3974	CLIP-seq
MIRT2654205	hsa-miR-4299	CLIP-seq
MIRT2654206	hsa-miR-4422	CLIP-seq
MIRT2654207	hsa-miR-4430	CLIP-seq
MIRT2654208	hsa-miR-4446-5p	CLIP-seq
MIRT1555295	hsa-miR-4457	CLIP-seq
MIRT2654209	hsa-miR-4463	CLIP-seq
MIRT2654210	hsa-miR-4465	CLIP-seq
MIRT2654211	hsa-miR-4480	CLIP-seq
MIRT2654212	hsa-miR-4505	CLIP-seq
MIRT2654213	hsa-miR-4645-3p	CLIP-seq
MIRT2139947	hsa-miR-4645-5p	CLIP-seq
MIRT1465552	hsa-miR-4649-3p	CLIP-seq
MIRT2654214	hsa-miR-466	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT2139948	hsa-miR-4673	CLIP-seq
MIRT2654215	hsa-miR-4710	CLIP-seq
MIRT2654216	hsa-miR-4717-3p	CLIP-seq
MIRT2654217	hsa-miR-4722-3p	CLIP-seq
MIRT2654218	hsa-miR-4742-5p	CLIP-seq
MIRT2139949	hsa-miR-4755-3p	CLIP-seq
MIRT2654219	hsa-miR-4755-5p	CLIP-seq
MIRT1465566	hsa-miR-4772-3p	CLIP-seq
MIRT1465568	hsa-miR-4789-3p	CLIP-seq
MIRT2654220	hsa-miR-4792	CLIP-seq
MIRT2654221	hsa-miR-487a	CLIP-seq
MIRT2654222	hsa-miR-490-5p	CLIP-seq
MIRT1465571	hsa-miR-495	CLIP-seq
MIRT2654223	hsa-miR-506	CLIP-seq
MIRT2654224	hsa-miR-544	CLIP-seq
MIRT1555296	hsa-miR-548a-3p	CLIP-seq
MIRT1465578	hsa-miR-548aa	CLIP-seq
MIRT1555297	hsa-miR-548e	CLIP-seq
MIRT1555298	hsa-miR-548f	CLIP-seq
MIRT1465579	hsa-miR-548o	CLIP-seq
MIRT2654225	hsa-miR-548s	CLIP-seq
MIRT2434410	hsa-miR-549	CLIP-seq
MIRT2654226	hsa-miR-562	CLIP-seq
MIRT2654227	hsa-miR-580	CLIP-seq
MIRT2654228	hsa-miR-617	CLIP-seq
MIRT2654229	hsa-miR-623	CLIP-seq
MIRT1465585	hsa-miR-655	CLIP-seq
MIRT2654230	hsa-miR-874	CLIP-seq
MIRT2654231	hsa-miR-875-5p	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT2654181	hsa-miR-105	CLIP-seq
MIRT2694550	hsa-miR-1224-5p	CLIP-seq
MIRT2654182	hsa-miR-124	CLIP-seq
MIRT2694551	hsa-miR-1273f	CLIP-seq
MIRT2654183	hsa-miR-1297	CLIP-seq
MIRT2654184	hsa-miR-1298	CLIP-seq
MIRT2654185	hsa-miR-140-3p	CLIP-seq
MIRT2694552	hsa-miR-143	CLIP-seq
MIRT1465507	hsa-miR-146b-3p	CLIP-seq
MIRT1465511	hsa-miR-1827	CLIP-seq
MIRT2654186	hsa-miR-188-5p	CLIP-seq
MIRT2434411	hsa-miR-203	CLIP-seq
MIRT2654187	hsa-miR-204	CLIP-seq
MIRT2654188	hsa-miR-211	CLIP-seq
MIRT2654189	hsa-miR-2276	CLIP-seq
MIRT2654190	hsa-miR-26a	CLIP-seq
MIRT2654191	hsa-miR-26b	CLIP-seq
MIRT2654192	hsa-miR-302f	CLIP-seq
MIRT2654193	hsa-miR-3164	CLIP-seq
MIRT2654194	hsa-miR-3173-5p	CLIP-seq
MIRT2654195	hsa-miR-324-5p	CLIP-seq
MIRT2654196	hsa-miR-330-3p	CLIP-seq
MIRT1465528	hsa-miR-3614-5p	CLIP-seq
MIRT2654197	hsa-miR-3652	CLIP-seq
MIRT2654198	hsa-miR-3667-3p	CLIP-seq
MIRT2441574	hsa-miR-3672	CLIP-seq
MIRT2654199	hsa-miR-3692	CLIP-seq
MIRT2654200	hsa-miR-369-3p	CLIP-seq
MIRT2654201	hsa-miR-374a	CLIP-seq
MIRT2654202	hsa-miR-374b	CLIP-seq
MIRT1465533	hsa-miR-374c	CLIP-seq
MIRT2654203	hsa-miR-3926	CLIP-seq
MIRT2654204	hsa-miR-3941	CLIP-seq
MIRT1555294	hsa-miR-3974	CLIP-seq
MIRT2654205	hsa-miR-4299	CLIP-seq
MIRT2441573	hsa-miR-4316	CLIP-seq
MIRT2654206	hsa-miR-4422	CLIP-seq
MIRT2654207	hsa-miR-4430	CLIP-seq
MIRT2654208	hsa-miR-4446-5p	CLIP-seq
MIRT1555295	hsa-miR-4457	CLIP-seq
MIRT2654209	hsa-miR-4463	CLIP-seq
MIRT2654210	hsa-miR-4465	CLIP-seq
MIRT2654211	hsa-miR-4480	CLIP-seq
MIRT2654212	hsa-miR-4505	CLIP-seq
MIRT2654213	hsa-miR-4645-3p	CLIP-seq
MIRT2139947	hsa-miR-4645-5p	CLIP-seq
MIRT1465552	hsa-miR-4649-3p	CLIP-seq
MIRT2654214	hsa-miR-466	CLIP-seq
MIRT1465554	hsa-miR-4668-3p	CLIP-seq
MIRT2139948	hsa-miR-4673	CLIP-seq
MIRT2694553	hsa-miR-4708-5p	CLIP-seq
MIRT2654215	hsa-miR-4710	CLIP-seq
MIRT2654216	hsa-miR-4717-3p	CLIP-seq
MIRT2654217	hsa-miR-4722-3p	CLIP-seq
MIRT2654218	hsa-miR-4742-5p	CLIP-seq
MIRT2694554	hsa-miR-4751	CLIP-seq
MIRT2139949	hsa-miR-4755-3p	CLIP-seq
MIRT2654219	hsa-miR-4755-5p	CLIP-seq
MIRT2694555	hsa-miR-4770	CLIP-seq
MIRT1465566	hsa-miR-4772-3p	CLIP-seq
MIRT1465568	hsa-miR-4789-3p	CLIP-seq
MIRT2654220	hsa-miR-4792	CLIP-seq
MIRT2654221	hsa-miR-487a	CLIP-seq
MIRT2654222	hsa-miR-490-5p	CLIP-seq
MIRT1465571	hsa-miR-495	CLIP-seq
MIRT1465572	hsa-miR-500a	CLIP-seq
MIRT2654223	hsa-miR-506	CLIP-seq
MIRT2654224	hsa-miR-544	CLIP-seq
MIRT1555296	hsa-miR-548a-3p	CLIP-seq
MIRT1465578	hsa-miR-548aa	CLIP-seq
MIRT1555297	hsa-miR-548e	CLIP-seq
MIRT1555298	hsa-miR-548f	CLIP-seq
MIRT1465579	hsa-miR-548o	CLIP-seq
MIRT2654225	hsa-miR-548s	CLIP-seq
MIRT2434410	hsa-miR-549	CLIP-seq
MIRT2654226	hsa-miR-562	CLIP-seq
MIRT2654227	hsa-miR-580	CLIP-seq
MIRT2654228	hsa-miR-617	CLIP-seq
MIRT2654229	hsa-miR-623	CLIP-seq
MIRT1465585	hsa-miR-655	CLIP-seq
MIRT2654230	hsa-miR-874	CLIP-seq
MIRT2654231	hsa-miR-875-5p	CLIP-seq
MIRT2441574	hsa-miR-3672	CLIP-seq
MIRT2654209	hsa-miR-4463	CLIP-seq
MIRT2654213	hsa-miR-4645-3p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
POU2F1	Unknown	11375392

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0001707	Process	Mesoderm formation	IEA
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	IBA
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	IDA	8577704
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	IEA
GO:0004791	Function	Thioredoxin-disulfide reductase (NADPH) activity	TAS	9671710
GO:0005515	Function	Protein binding	IPI	15199063, 19820694, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	NAS	8921404
GO:0007369	Process	Gastrulation	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016668	Function	Oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	IEA
GO:0042802	Function	Identical protein binding	IDA	8577704
GO:0045454	Process	Cell redox homeostasis	IBA
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0050137	Function	NADPH peroxidase activity	IDA	10849437
GO:0050137	Function	NADPH peroxidase activity	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0071949	Function	FAD binding	IDA	8577704
GO:0098869	Process	Cellular oxidant detoxification	IEA

MIM	HGNC	e!Ensembl
601112	12437	ENSG00000198431

Protein

UniProt ID

Q16881

Protein name

Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Perox

Protein function

Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-t

PDB

2CFY , 2J3N , 2ZZ0 , 2ZZB , 2ZZC , 3QFA , 3QFB , 7X1R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00462	Glutaredoxin	68 → 130	Glutaredoxin	Domain
PF07992	Pyr_redox_2	163 → 500	Pyridine nucleotide-disulphide oxidoreductase	Domain
PF02852	Pyr_redox_dim	520 → 633	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. {ECO:0000269|PubMed:18042542}.; TISSUE SPECIFICITY: [Isof

Sequence

MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG

Sequence length

649

Interactions

View interactions

	KEGG		Reactome
	Selenocompound metabolism Pathways in cancer Hepatocellular carcinoma		PPARA activates gene expression Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dementia	Dementia	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (63)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acute Coronary Syndrome	Associate	34082767
Adenocarcinoma in Situ	Associate	31568004
Adenocarcinoma of Lung	Associate	20920480, 34996932, 35325730, 37335087
Alzheimer Disease	Associate	36928034, 37621137
Antley Bixler Syndrome Phenotype	Associate	35889519
Atherosclerosis	Associate	36754152
Breast Neoplasms	Associate	20584310, 23216744, 24278290, 29162888, 36335879
Breast Neoplasms	Stimulate	26760912, 31430859
Carcinoma Hepatocellular	Associate	28536696, 33188160, 36378050, 37181805, 38025761, 38097352, 38308689, 40465781
Carcinoma Non Small Cell Lung	Associate	23959471, 33812801
Carcinoma Squamous Cell	Associate	31568004
CD59 Deficiency	Associate	33280050
Cognition Disorders	Associate	31601260
Cognitive Dysfunction	Associate	31601260
Colorectal Neoplasms	Associate	20098717, 22615972, 31027226, 32596335
Depressive Disorder Major	Associate	36928034
Diabetes Gestational	Associate	35669396
Diabetes Mellitus Type 2	Associate	18229449
Drug Related Side Effects and Adverse Reactions	Associate	20098717, 20920480
Endometriosis	Associate	32679649
Epilepsy	Associate	39849427
Epilepsy Familial Mesial Temporal Lobe	Inhibit	19499324
Esophageal Squamous Cell Carcinoma	Associate	34999996, 35703190
Familial Primary Pulmonary Hypertension	Associate	34722766
Glioblastoma	Stimulate	28345125
Glioblastoma	Associate	36555352, 37834393
Glomerulonephritis Membranous	Associate	20920480
Hearing Loss	Associate	35322580
Hereditary leiomyomatosis and renal cell cancer	Associate	33931688
Hypoxia	Stimulate	26743692, 33493155
Hypoxia Brain	Inhibit	37892173
Idiopathic Pulmonary Fibrosis	Stimulate	20483575
IgA Vasculitis	Associate	33280050
Inflammation	Associate	31568004, 8999974
Intervertebral Disc Degeneration	Associate	36814575
Kashin Beck Disease	Associate	33455417
Kidney Diseases	Stimulate	18229449
Lung Diseases	Associate	20920480
Lung Neoplasms	Associate	20920480
Lymphoma	Associate	18422776
Melanoma	Inhibit	37892173
Mitochondrial Diseases	Associate	20920480, 36358916
Multiple Myeloma	Associate	25945832, 26743692
Myocardial Infarction	Associate	34799616
Neoplasm Metastasis	Associate	26760912, 36335879
Neoplasms	Associate	16175400, 20584310, 20920480, 22629368, 27093577, 28417283, 28536696, 30653260, 33706760, 38308689
Neuroblastoma	Associate	26464515
Neurodegenerative Diseases	Associate	37269647
Nevus	Associate	27920018
Obesity	Associate	21593104, 34684477
Optic Atrophy Hereditary Leber	Associate	36358916
Osteoarthritis	Associate	33455417
Osteosarcoma	Associate	31920141
Ovarian Neoplasms	Associate	29910195
Periodic fever familial autosomal dominant	Associate	31568004
Pre Eclampsia	Associate	36343018
Prostatic Neoplasms	Associate	23133653, 34125740
Prurigo	Associate	37245863
Pulmonary Disease Chronic Obstructive	Associate	33493155, 35441963
Smoke Inhalation Injury	Associate	31568004
Tinnitus	Associate	35322580
Tuberculosis Multidrug Resistant	Associate	27706680
Urinary Bladder Neoplasms	Associate	16175400

TXNRD1 (thioredoxin reductase 1)