TXN (thioredoxin)

Gene

• Entrez ID: 7295
• Gene name: Thioredoxin
• Gene symbol: TXN
• Synonyms (NCBI Gene): TRDX, TRX, TRX1, TXN1, Trx80
• Chromosome: 9
• Chromosome location: 9q31.3
• Summary: The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. Th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046747	hsa-miR-222-3p	CLASH	23622248
MIRT045602	hsa-miR-149-5p	CLASH	23622248
MIRT035966	hsa-miR-1301-3p	CLASH	23622248
MIRT441782	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT441781	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT441780	hsa-miR-889-5p	PAR-CLIP	22100165
MIRT441779	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT441782	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT441781	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT441780	hsa-miR-889-5p	PAR-CLIP	22100165
MIRT441779	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT441782	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT441781	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT441780	hsa-miR-889-5p	PAR-CLIP	22100165
MIRT441779	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT441782	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT441781	hsa-miR-6882-5p	PAR-CLIP	22100165
MIRT441780	hsa-miR-889-5p	PAR-CLIP	22100165
MIRT441779	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT1464896	hsa-miR-409-3p	CLIP-seq
MIRT1464897	hsa-miR-4307	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT1464896	hsa-miR-409-3p	CLIP-seq
MIRT1464897	hsa-miR-4307	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT1464896	hsa-miR-409-3p	CLIP-seq
MIRT1464897	hsa-miR-4307	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT2653928	hsa-miR-3652	CLIP-seq
MIRT2653929	hsa-miR-3942-3p	CLIP-seq
MIRT2653930	hsa-miR-4430	CLIP-seq
MIRT2653931	hsa-miR-4505	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq
MIRT1464895	hsa-miR-1279	CLIP-seq
MIRT2653928	hsa-miR-3652	CLIP-seq
MIRT2653930	hsa-miR-4430	CLIP-seq
MIRT2653931	hsa-miR-4505	CLIP-seq
MIRT1464898	hsa-miR-629	CLIP-seq
MIRT1464899	hsa-miR-654-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HSF2	Unknown	9374530
JUN	Unknown	12414792
PPARD	Activation	18048767

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004791	Function	Thioredoxin-disulfide reductase activity	TAS
GO:0005515	Function	Protein binding	IPI	9108029, 10814541, 11118054, 15246877, 15480426, 15657067, 17260951, 17557078, 17606900, 19690162, 19805025, 20029029, 21145461, 21771788, 21988832, 24658140, 24976139, 25402766, 28514442, 31980649, 32296183, 32814053
GO:0005576	Component	Extracellular region	IDA	1332947
GO:0005634	Component	Nucleus	IDA	9108029
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	9108029
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006662	Process	Glycerol ether metabolic process	IEA
GO:0009314	Process	Response to radiation	IDA	9108029, 11118054
GO:0015035	Function	Protein disulfide oxidoreductase activity	IDA	2176490, 17182577, 19032234
GO:0015037	Function	Peptide disulfide oxidoreductase activity	IEA
GO:0032148	Process	Activation of protein kinase B activity	IC	22492997
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IGI	22492997
GO:0042803	Function	Protein homodimerization activity	IDA	9369469, 17260951
GO:0043388	Process	Positive regulation of DNA binding	IDA	11118054
GO:0045454	Process	Cell redox homeostasis	IDA	2176490
GO:0045454	Process	Cell redox homeostasis	IMP	9108029
GO:0046826	Process	Negative regulation of protein export from nucleus	IEA
GO:0047134	Function	Protein-disulfide reductase activity	IDA	17182577
GO:0051897	Process	Positive regulation of protein kinase B signaling	IC	22492997
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071731	Process	Response to nitric oxide	IMP	16408020, 17606900
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:1903206	Process	Negative regulation of hydrogen peroxide-induced cell death	IGI	22492997
GO:2000170	Process	Positive regulation of peptidyl-cysteine S-nitrosylation	IMP	9108029, 16408020, 17606900

Other IDs

• MIM: 187700
• HGNC: 12435
• e!Ensembl: ENSG00000136810

Protein

• UniProt ID: P10599
• Protein name: Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
• Protein function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the rever
• PDB: 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1M7T, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK, 2IFQ, 2IIY, 3E3E, 3KD0, 3M9J, 3M9K, 3QFA, 3QFB, 3TRX, 4LL1, 4LL4, 4OO4, 4OO5, 4POK, 4POL, 4POM, 4PUF, 4TRX, 5DQY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00085	Thioredoxin	2 → 103	Thioredoxin	Domain

• Sequence:

  MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
  DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

• Sequence length: 105

Pathways

KEGG:

NOD-like receptor signaling pathway
Parkinson disease
Salmonella infection
Fluid shear stress and atherosclerosis

Reactome:

Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	30396169
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	30396169
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	30396169

Unknown
Disease term	Disease name	Evidence	References	Source
Pelvic Organ Prolapse	Pelvic Organ Prolapse			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Abdominal Injuries	Stimulate	21362081
Actinic cheilitis	Associate	28183007
Acute Coronary Syndrome	Associate	34082767
Adenocarcinoma of Lung	Stimulate	40349025
Altitude Sickness	Associate	33393624
Amyotrophic Lateral Sclerosis	Stimulate	11279269
Arterial Occlusive Diseases	Associate	30188935
Arthritis Psoriatic	Associate	16622521
Arthritis Reactive	Stimulate	10555039
Arthritis Rheumatoid	Stimulate	10555039
Arthritis Rheumatoid	Associate	28914370, 30853960
Asthma	Associate	39531229
Astrocytoma	Associate	12744469
Atherosclerosis	Associate	16207716
Atherosclerosis	Inhibit	24086714
Autistic Disorder	Associate	22051046
beta Thalassemia	Associate	30521599
Brain Neoplasms	Associate	32418115
Breast Neoplasms	Associate	16159878, 16712525, 16868544, 17555594, 19620238, 21963718, 22342720, 22975630, 25416100, 26760912, 32444848, 33768386, 34979986
Breast Neoplasms	Stimulate	19566940
Burkitt Lymphoma	Associate	2172979
Cafe au Lait Spots	Associate	9475178
Carcinogenesis	Associate	24793768, 28183007
Carcinoma Hepatocellular	Associate	17346424, 25004829
Carcinoma Non Small Cell Lung	Associate	32925168, 33812801, 40349025
Carcinoma Renal Cell	Associate	34859284
Carcinoma Squamous Cell	Associate	28183007
Carcinoma Squamous Cell	Stimulate	40349025
Celiac Disease	Associate	24130874
Chromosome Disorders	Associate	9475178
Colorectal Neoplasms	Associate	27613835, 29383839, 34979986
Colorectal Neoplasms	Stimulate	36147458
COVID 19	Associate	34186206, 35390032
Cryptogenic Organizing Pneumonia	Associate	21088339
Cushing Syndrome	Associate	23691179
Diabetes Mellitus	Associate	22445099, 29751399, 37232340
Diabetes Mellitus Type 2	Associate	24689038
Diabetic Nephropathies	Associate	40076459
Diabetic Retinopathy	Associate	37232340
Dyskeratosis Congenita	Associate	29055871
Endometrial Neoplasms	Associate	36807337
Endometriosis	Associate	20172870, 33572677
Esophageal Neoplasms	Associate	26692290
Fanconi Anemia	Associate	9475178
Fibrosarcoma	Associate	16024017
Gallbladder Neoplasms	Associate	22882193
Glioblastoma	Associate	28345125, 30248944, 39684695
Glioma	Associate	36106447
Glucose Intolerance	Inhibit	24689038
Gout	Stimulate	10555039
Heart Diseases	Inhibit	37232340
Heart Failure	Stimulate	12547991
Heart Failure	Associate	32481311
Hepatoblastoma	Associate	26210445
Hyperglycemia	Associate	17555594
Hyperostosis corticalis deformans juvenilis	Associate	1607673
Hyperoxia	Associate	25106706
Hyperpigmentation	Associate	9475178
Hypertension	Associate	22016650
Hypoxia	Associate	14742261, 17959730, 33493155
Hypoxia	Stimulate	16513844, 22342720, 28914370
Hypoxia Brain	Associate	14742261
Idiopathic Pulmonary Fibrosis	Stimulate	21088339
Immune System Diseases	Associate	38147024
Infections	Associate	9811703
Inflammation	Associate	19655254, 23068965, 26779447, 33524223, 39766355
Leukemia	Associate	2172979
Leukemia Lymphocytic Chronic B Cell	Associate	10666220, 18024398
Leukemia Lymphoma Adult T Cell	Associate	1398748
Leukemia Monocytic Acute	Associate	28270496
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26460262
Leukemia Myeloid Acute	Associate	27158980
Lung Diseases Interstitial	Associate	21088339
Lung Neoplasms	Associate	33760130, 34939468, 38013118, 40349025
Lymphoma	Associate	18422776
Lymphoma Large B Cell Diffuse	Associate	22447839
Medulloblastoma	Associate	32418115
Melanoma	Associate	24008424
Mesothelioma Malignant	Associate	38013118
Multiple Myeloma	Associate	21910912, 25945832, 32820006
Nasopharyngeal Carcinoma	Associate	28107202
Necrosis	Associate	12744469
Neoplasm Metastasis	Stimulate	25004829
Neoplasm Metastasis	Associate	26760912, 28107202
Neoplasm Metastasis	Inhibit	34859284
Neoplasms	Associate	10464265, 12744469, 14742261, 16024017, 16159878, 17572693, 20955789, 21069338, 21487522, 21963718, 22342720, 22342995, 22882193, 24342878, 25004829, 25391429, 26210445, 26692290, 28183007, 30140002, 31541631, 32673292, 32925168, 34785721, 34859284, 35344158, 37944440, 40349025, 8805557
Neoplasms	Stimulate	16513844
Neoplasms	Inhibit	22248473, 27158980
Neuroblastoma	Associate	14500366, 21704743, 25231459
Obesity	Associate	21593104, 29459183
Obesity Abdominal	Associate	26329592
Osteosarcoma	Associate	12032145
Ovarian Neoplasms	Associate	25483711
Parkinson Disease	Associate	34732784
Pemphigus	Associate	33868574
Postural Orthostatic Tachycardia Syndrome	Associate	40022872
Pre Eclampsia	Associate	36587441
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	27158980
Preeclamptic toxemia	Associate	36587441
Premature Birth	Associate	23068965
Progeroid syndrome neonatal	Inhibit	24799429
Prostatic Neoplasms	Associate	17030815, 20955789, 24269899, 28391184, 29089489, 29697282, 35508713
Prostatic Neoplasms Castration Resistant	Associate	29089489
Pulmonary Disease Chronic Obstructive	Associate	33493155, 39349929, 39766355
Pulmonary Fibrosis	Associate	37944440
Radiation Injuries	Associate	22003958, 33768386
Reperfusion Injury	Associate	14742261
Sarcoma Ewing	Associate	15581626
Sepsis	Associate	40613196
Severe Acute Respiratory Syndrome	Associate	39766355
Skin Diseases	Associate	9475178
Sleep Apnea Obstructive	Associate	19581829
Sleep Apnea Obstructive	Inhibit	30159112
Stomach Neoplasms	Associate	16513844, 23112551
Stomach Neoplasms	Stimulate	24793768
Tertiary Lymphoid Structures	Associate	28107202
Trochlear Nerve Diseases	Associate	29843669
Urticaria Solar	Associate	1607673
Uterine Cervical Neoplasms	Associate	14742261, 26439985, 26758418
Werner Syndrome	Associate	24799429