TXN (thioredoxin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7295
Gene name Gene Name - the full gene name approved by the HGNC.
Thioredoxin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TXN
Synonyms (NCBI Gene) Gene synonyms aliases
TRDX, TRX, TRX1, TXN1, Trx80
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q31.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. Th
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(52)
miRTarBase ID miRNA Experiments Reference
MIRT046747 hsa-miR-222-3p CLASH 23622248
MIRT045602 hsa-miR-149-5p CLASH 23622248
MIRT035966 hsa-miR-1301-3p CLASH 23622248
MIRT441782 hsa-miR-3121-3p PAR-CLIP 22100165
MIRT441781 hsa-miR-6882-5p PAR-CLIP 22100165
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
HSF2 Unknown 9374530
JUN Unknown 12414792
PPARD Activation 18048767
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0004791 Function Thioredoxin-disulfide reductase (NADPH) activity TAS
GO:0005515 Function Protein binding IPI 9108029, 10814541, 11118054, 15246877, 15480426, 15657067, 17260951, 17557078, 17606900, 19690162, 19805025, 20029029, 21145461, 21771788, 21988832, 24658140, 24976139, 25402766, 28514442, 31980649, 32296183, 32814053
GO:0005576 Component Extracellular region IDA 1332947
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
187700 12435 ENSG00000136810
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P10599
Protein name Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Protein function Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the rever
PDB 1AIU , 1AUC , 1CQG , 1CQH , 1ERT , 1ERU , 1ERV , 1ERW , 1M7T , 1MDI , 1MDJ , 1MDK , 1TRS , 1TRU , 1TRV , 1TRW , 2HSH , 2HXK , 2IFQ , 2IIY , 3E3E , 3KD0 , 3M9J , 3M9K , 3QFA , 3QFB , 3TRX , 4LL1 , 4LL4 , 4OO4 , 4OO5 , 4POK , 4POL , 4POM , 4PUF , 4TRX , 5DQY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 2 → 103 Thioredoxin Domain
Sequence
Sequence length 105
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  NOD-like receptor signaling pathway
Parkinson disease
Salmonella infection
Fluid shear stress and atherosclerosis 		  Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Pelvic Organ Prolapse Pelvic organ prolapse N/A N/A GWAS
Show/Hide Text Mining Associations (120)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Injuries Stimulate 21362081
Actinic cheilitis Associate 28183007
Acute Coronary Syndrome Associate 34082767
Adenocarcinoma of Lung Stimulate 40349025
Altitude Sickness Associate 33393624
Amyotrophic Lateral Sclerosis Stimulate 11279269
Arterial Occlusive Diseases Associate 30188935
Arthritis Psoriatic Associate 16622521
Arthritis Reactive Stimulate 10555039
Arthritis Rheumatoid Stimulate 10555039