OC90 (otoconin 90)

Gene

• Entrez ID: 729330
• Gene name: Otoconin 90
• Gene symbol: OC90
• Synonyms (NCBI Gene): PLA2L
• Chromosome: 8
• Chromosome location: 8q24.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1201753	hsa-miR-140-3p	CLIP-seq
MIRT1201754	hsa-miR-1827	CLIP-seq
MIRT1201755	hsa-miR-3185	CLIP-seq
MIRT1201756	hsa-miR-3622b-5p	CLIP-seq
MIRT1201757	hsa-miR-4475	CLIP-seq
MIRT1201758	hsa-miR-4502	CLIP-seq
MIRT1201754	hsa-miR-1827	CLIP-seq
MIRT1201758	hsa-miR-4502	CLIP-seq
MIRT2058226	hsa-miR-4722-5p	CLIP-seq
MIRT2058227	hsa-miR-493	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005543	Function	Phospholipid binding	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0006644	Process	Phospholipid metabolic process	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IEA
GO:0045299	Process	Otolith mineralization	IEA
GO:0045299	Process	Otolith mineralization	ISS
GO:0046470	Process	Phosphatidylcholine metabolic process	IBA
GO:0046470	Process	Phosphatidylcholine metabolic process	IEA
GO:0046471	Process	Phosphatidylglycerol metabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0047498	Function	Calcium-dependent phospholipase A2 activity	IBA
GO:0050482	Process	Arachidonate secretion	IEA

Other IDs

• MIM: 601658
• HGNC: 8100
• e!Ensembl: ENSG00000253117

Protein

• UniProt ID: Q02509
• Protein name: Otoconin-90 (Oc90) (Phospholipase A2 homolog)
• Protein function: Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia tha
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00068	Phospholip_A2_1	76 → 183	Phospholipase A2	Domain
  PF00068	Phospholip_A2_1	305 → 411	Phospholipase A2	Domain

• Sequence:

  MIAFLLTSVLMIPHAGGHPLDTPHLPQELPPGLPNNINITFFSGMFKNVESVAEIFDCLG
  PHFTWLQAVFTNFPVLIQFVNGMKCVAGLCPRDFEDYGCTCRFEMEGLPVDESDSCCFQH
  RRCYEEAAEMDCLQDPAKLSTEVNCVSKKIICESKDNCEHLLCTCDKAAIECLARSSLNS
  SLNLLDTSFCLAQTPETTIKEDLTTLLPRVVPVEPTDTSLTALSGEEAGHDQEGVGAARA
  TSPPGSAEIVATRVTAKIVTLVPAGIKSLGLAVSSVENDPEETTEKACDRFTFLHLGSGD
  NMQVMPQLGEMLFCLTSRCPEEFESYGCYCGQEGRGEPRDDLDRCCLSHHCCLEQVRRLG
  CLLERLPWSPVVCVDHTPKCGGQSLCEKLLCACDQTAAECMTSASFNQSLKSPSRLGCPG
  QPAACEDSLHPVPAAPTLGSSSEEDSEEDPPQEDLGRAKRFLRKSLGPLGIGPLHGR

• Sequence length: 477