CCR2 (C-C motif chemokine receptor 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
729230
Gene name Gene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCR2
Synonyms (NCBI Gene) Gene synonyms aliases
CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, PCLUD
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PCLUD
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rh
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(41)
miRTarBase ID miRNA Experiments Reference
MIRT018230 hsa-miR-335-5p Microarray 18185580
MIRT037379 hsa-miR-744-3p CLASH 23622248
MIRT527319 hsa-miR-618 PAR-CLIP 22012620
MIRT527318 hsa-miR-532-5p PAR-CLIP 22012620
MIRT527316 hsa-miR-4539 PAR-CLIP 22012620
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
NFKB1 Activation 19156404
RELA Activation 19156404
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(68)
GO ID Ontology Definition Evidence Reference
GO:0001974 Process Blood vessel remodeling ISS
GO:0002407 Process Dendritic cell chemotaxis TAS 16621978
GO:0002724 Process Regulation of T cell cytokine production ISS
GO:0002827 Process Positive regulation of T-helper 1 type immune response ISS
GO:0002829 Process Negative regulation of type 2 immune response ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601267 1603 ENSG00000121807
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P41597
Protein name C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Protein function Key functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855). Its binding with CCL2 on monocytes and macropha
PDB 2MLO , 2MLQ , 5T1A , 7P8X , 7XA3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 59 → 305 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed by monocytes and IL2-activated NK cells (PubMed:9058802). Abundantly expressed on CD14+/CD16- monocytes and weakly on CD14+/CD16+ monocytes, type 2 dendritic cells (DCs) and plasmacytoid DCs (at protein level) (PubMed:3815785
Sequence
Sequence length 374
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway 		  Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 17374397
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)		 14609568
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac disease GWAS
Rheumatoid arthritis Rheumatoid arthritis GWAS
Show/Hide Text Mining Associations (215)
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 31281837
Acquired Immunodeficiency Syndrome Associate 10486323, 11752157, 17786209, 18391751, 20531015, 20537184, 23880174, 24098976
Acquired Immunodeficiency Syndrome Inhibit 21739027
Acute Coronary Syndrome Associate 35563407
Adenocarcinoma Associate 32509861
Adenocarcinoma of Lung Associate 32337264, 32873769, 33949150, 34187403, 34863300, 35029906, 38111060
Adjustment Disorders Associate 37500699
Aggressive Periodontitis Associate 21264360
Alzheimer Disease Associate 22607625, 29352259
Alzheimer Disease Inhibit 23380586