Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	7292
Gene name	TNF superfamily member 4
Gene symbol	TNFSF4
Synonyms (NCBI Gene)	CD134LCD252GP34OX-40LOX4OLTNLG2BTXGP1
Chromosome	1
Chromosome location	1q25.1
Summary	This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene h

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miRTarBase ID	miRNA	Experiments	Reference
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670334	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670333	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670331	hsa-miR-3941	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT670332	hsa-miR-603	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	27418678
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT670334	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT670333	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT670332	hsa-miR-603	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT670331	hsa-miR-3941	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT615655	hsa-miR-8485	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT610653	hsa-miR-4682	HITS-CLIP	23824327
MIRT610652	hsa-miR-3182	HITS-CLIP	23824327
MIRT610651	hsa-miR-4303	HITS-CLIP	23824327
MIRT610650	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT1443526	hsa-miR-10a	CLIP-seq
MIRT1443527	hsa-miR-10b	CLIP-seq
MIRT1443528	hsa-miR-1255a	CLIP-seq
MIRT1443529	hsa-miR-1255b	CLIP-seq
MIRT1443530	hsa-miR-125a-5p	CLIP-seq
MIRT1443531	hsa-miR-125b	CLIP-seq
MIRT1443532	hsa-miR-1273f	CLIP-seq
MIRT1443533	hsa-miR-141	CLIP-seq
MIRT1443534	hsa-miR-143	CLIP-seq
MIRT1443535	hsa-miR-145	CLIP-seq
MIRT1443536	hsa-miR-186	CLIP-seq
MIRT1443537	hsa-miR-1972	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT1443539	hsa-miR-200a	CLIP-seq
MIRT1443540	hsa-miR-2278	CLIP-seq
MIRT1443541	hsa-miR-2682	CLIP-seq
MIRT1443542	hsa-miR-27a	CLIP-seq
MIRT1443543	hsa-miR-27b	CLIP-seq
MIRT1443544	hsa-miR-2964a-5p	CLIP-seq
MIRT1443545	hsa-miR-3120-5p	CLIP-seq
MIRT1443546	hsa-miR-3133	CLIP-seq
MIRT1443547	hsa-miR-3152-5p	CLIP-seq
MIRT1443548	hsa-miR-3177-5p	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT1443550	hsa-miR-3605-5p	CLIP-seq
MIRT1443551	hsa-miR-3908	CLIP-seq
MIRT1443552	hsa-miR-4310	CLIP-seq
MIRT1443553	hsa-miR-4319	CLIP-seq
MIRT1443554	hsa-miR-4324	CLIP-seq
MIRT1443555	hsa-miR-4421	CLIP-seq
MIRT1443556	hsa-miR-4459	CLIP-seq
MIRT1443557	hsa-miR-449c	CLIP-seq
MIRT1443558	hsa-miR-4652-3p	CLIP-seq
MIRT1443559	hsa-miR-4690-5p	CLIP-seq
MIRT1443560	hsa-miR-4708-5p	CLIP-seq
MIRT1443561	hsa-miR-4722-5p	CLIP-seq
MIRT1443562	hsa-miR-4747-5p	CLIP-seq
MIRT1443563	hsa-miR-4770	CLIP-seq
MIRT1443564	hsa-miR-4774-3p	CLIP-seq
MIRT1443565	hsa-miR-513a-5p	CLIP-seq
MIRT1443566	hsa-miR-522	CLIP-seq
MIRT1443567	hsa-miR-634	CLIP-seq
MIRT1443568	hsa-miR-764	CLIP-seq
MIRT1443569	hsa-miR-940	CLIP-seq
MIRT2132730	hsa-miR-1252	CLIP-seq
MIRT2132731	hsa-miR-216b	CLIP-seq
MIRT2132732	hsa-miR-224	CLIP-seq
MIRT2132733	hsa-miR-339-5p	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2132735	hsa-miR-3611	CLIP-seq
MIRT2132736	hsa-miR-4287	CLIP-seq
MIRT2132737	hsa-miR-4420	CLIP-seq
MIRT2132738	hsa-miR-4469	CLIP-seq
MIRT2132739	hsa-miR-4685-3p	CLIP-seq
MIRT2132740	hsa-miR-4713-5p	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2353818	hsa-miR-101	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2353819	hsa-miR-586	CLIP-seq
MIRT2396138	hsa-miR-219-5p	CLIP-seq
MIRT2396139	hsa-miR-4782-3p	CLIP-seq
MIRT2396140	hsa-miR-483-3p	CLIP-seq
MIRT2396141	hsa-miR-578	CLIP-seq
MIRT2441449	hsa-miR-1270	CLIP-seq
MIRT2441450	hsa-miR-1299	CLIP-seq
MIRT2441451	hsa-miR-4290	CLIP-seq
MIRT2441452	hsa-miR-4683	CLIP-seq
MIRT2441453	hsa-miR-4687-5p	CLIP-seq
MIRT2441454	hsa-miR-4782-5p	CLIP-seq
MIRT2441455	hsa-miR-516b	CLIP-seq
MIRT2441456	hsa-miR-620	CLIP-seq
MIRT2462104	hsa-miR-103b	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2462105	hsa-miR-376c	CLIP-seq
MIRT2647893	hsa-miR-122	CLIP-seq
MIRT2132730	hsa-miR-1252	CLIP-seq
MIRT1443528	hsa-miR-1255a	CLIP-seq
MIRT1443529	hsa-miR-1255b	CLIP-seq
MIRT2441449	hsa-miR-1270	CLIP-seq
MIRT2647894	hsa-miR-1273g	CLIP-seq
MIRT2441450	hsa-miR-1299	CLIP-seq
MIRT2647895	hsa-miR-138	CLIP-seq
MIRT2647896	hsa-miR-147	CLIP-seq
MIRT2647897	hsa-miR-153	CLIP-seq
MIRT2647898	hsa-miR-188-5p	CLIP-seq
MIRT1443537	hsa-miR-1972	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT1443540	hsa-miR-2278	CLIP-seq
MIRT2647899	hsa-miR-2467-3p	CLIP-seq
MIRT2647900	hsa-miR-2467-5p	CLIP-seq
MIRT1443541	hsa-miR-2682	CLIP-seq
MIRT1443545	hsa-miR-3120-5p	CLIP-seq
MIRT2647901	hsa-miR-3134	CLIP-seq
MIRT1443547	hsa-miR-3152-5p	CLIP-seq
MIRT2647902	hsa-miR-3160-3p	CLIP-seq
MIRT1443548	hsa-miR-3177-5p	CLIP-seq
MIRT2647903	hsa-miR-3188	CLIP-seq
MIRT2647904	hsa-miR-3202	CLIP-seq
MIRT1443549	hsa-miR-329	CLIP-seq
MIRT2132733	hsa-miR-339-5p	CLIP-seq
MIRT2647905	hsa-miR-3591-5p	CLIP-seq
MIRT1443550	hsa-miR-3605-5p	CLIP-seq
MIRT2132734	hsa-miR-3606	CLIP-seq
MIRT2647906	hsa-miR-3617	CLIP-seq
MIRT2647907	hsa-miR-3678-3p	CLIP-seq
MIRT1443551	hsa-miR-3908	CLIP-seq
MIRT2647908	hsa-miR-3911	CLIP-seq
MIRT2647909	hsa-miR-3915	CLIP-seq
MIRT2647910	hsa-miR-3928	CLIP-seq
MIRT2647911	hsa-miR-3975	CLIP-seq
MIRT2647912	hsa-miR-4280	CLIP-seq
MIRT2441451	hsa-miR-4290	CLIP-seq
MIRT1443552	hsa-miR-4310	CLIP-seq
MIRT2647913	hsa-miR-4316	CLIP-seq
MIRT1443555	hsa-miR-4421	CLIP-seq
MIRT2647914	hsa-miR-4426	CLIP-seq
MIRT1443556	hsa-miR-4459	CLIP-seq
MIRT2647915	hsa-miR-4476	CLIP-seq
MIRT1443557	hsa-miR-449c	CLIP-seq
MIRT2647916	hsa-miR-4533	CLIP-seq
MIRT2647917	hsa-miR-4534	CLIP-seq
MIRT2647918	hsa-miR-4633-3p	CLIP-seq
MIRT2647919	hsa-miR-4647	CLIP-seq
MIRT1443558	hsa-miR-4652-3p	CLIP-seq
MIRT2647920	hsa-miR-4662b	CLIP-seq
MIRT2441452	hsa-miR-4683	CLIP-seq
MIRT2441453	hsa-miR-4687-5p	CLIP-seq
MIRT1443559	hsa-miR-4690-5p	CLIP-seq
MIRT2647921	hsa-miR-4719	CLIP-seq
MIRT1443561	hsa-miR-4722-5p	CLIP-seq
MIRT1443562	hsa-miR-4747-5p	CLIP-seq
MIRT1443564	hsa-miR-4774-3p	CLIP-seq
MIRT2647922	hsa-miR-4777-5p	CLIP-seq
MIRT2441454	hsa-miR-4782-5p	CLIP-seq
MIRT2132741	hsa-miR-4786-3p	CLIP-seq
MIRT2647923	hsa-miR-4786-5p	CLIP-seq
MIRT2647924	hsa-miR-4789-3p	CLIP-seq
MIRT2647925	hsa-miR-4802-3p	CLIP-seq
MIRT2647926	hsa-miR-485-5p	CLIP-seq
MIRT2441455	hsa-miR-516b	CLIP-seq
MIRT2647927	hsa-miR-518d-5p	CLIP-seq
MIRT2647928	hsa-miR-519b-5p	CLIP-seq
MIRT2647929	hsa-miR-519c-5p	CLIP-seq
MIRT2647930	hsa-miR-520c-5p	CLIP-seq
MIRT2647931	hsa-miR-526a	CLIP-seq
MIRT2647932	hsa-miR-548q	CLIP-seq
MIRT2441456	hsa-miR-620	CLIP-seq
MIRT1443567	hsa-miR-634	CLIP-seq
MIRT2647933	hsa-miR-641	CLIP-seq
MIRT2647934	hsa-miR-644	CLIP-seq
MIRT1443568	hsa-miR-764	CLIP-seq
MIRT2647935	hsa-miR-769-5p	CLIP-seq
MIRT1443569	hsa-miR-940	CLIP-seq
MIRT1443538	hsa-miR-198	CLIP-seq
MIRT2647909	hsa-miR-3915	CLIP-seq
MIRT2647910	hsa-miR-3928	CLIP-seq
MIRT2647914	hsa-miR-4426	CLIP-seq
MIRT2647919	hsa-miR-4647	CLIP-seq
MIRT2647920	hsa-miR-4662b	CLIP-seq
MIRT2647921	hsa-miR-4719	CLIP-seq

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Transcription factor	Regulation	Reference
HDAC11	Activation	21239696

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0001819	Process	Positive regulation of cytokine production	IBA
GO:0002215	Process	Defense response to nematode	ISS
GO:0002526	Process	Acute inflammatory response	ISS
GO:0002639	Process	Positive regulation of immunoglobulin production	ISS
GO:0002726	Process	Positive regulation of T cell cytokine production	ISS
GO:0002819	Process	Regulation of adaptive immune response	ISS
GO:0002830	Process	Positive regulation of type 2 immune response	ISS
GO:0002891	Process	Positive regulation of immunoglobulin mediated immune response	ISS
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	7913952
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	16905106
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	17166734
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	NAS	18397322
GO:0005886	Component	Plasma membrane	TAS	7913952
GO:0006954	Process	Inflammatory response	IBA
GO:0006955	Process	Immune response	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	TAS	7913952
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	7913952
GO:0009615	Process	Response to virus	ISS
GO:0009986	Component	Cell surface	IDA	18397322
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0032689	Process	Negative regulation of type II interferon production	ISS
GO:0032700	Process	Negative regulation of interleukin-17 production	IDA	18501882
GO:0032722	Process	Positive regulation of chemokine production	ISS
GO:0032729	Process	Positive regulation of type II interferon production	IDA	18501882
GO:0032733	Process	Positive regulation of interleukin-10 production	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	ISS
GO:0032736	Process	Positive regulation of interleukin-13 production	ISS
GO:0032753	Process	Positive regulation of interleukin-4 production	IDA	18501882
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	20844189
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	IBA
GO:0032813	Function	Tumor necrosis factor receptor superfamily binding	ISS
GO:0035709	Process	Memory T cell activation	ISS
GO:0035712	Process	T-helper 2 cell activation	ISS
GO:0035713	Process	Response to nitrogen dioxide	ISS
GO:0042102	Process	Positive regulation of T cell proliferation	IBA
GO:0043372	Process	Positive regulation of CD4-positive, alpha-beta T cell differentiation	ISS
GO:0043382	Process	Positive regulation of memory T cell differentiation	ISS
GO:0045590	Process	Negative regulation of regulatory T cell differentiation	ISS
GO:0045626	Process	Negative regulation of T-helper 1 cell differentiation	ISS
GO:0045630	Process	Positive regulation of T-helper 2 cell differentiation	ISS
GO:0046641	Process	Positive regulation of alpha-beta T cell proliferation	ISS
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0050729	Process	Positive regulation of inflammatory response	IDA	20844189
GO:0050871	Process	Positive regulation of B cell activation	ISS
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	20844189
GO:0071380	Process	Cellular response to prostaglandin E stimulus	IDA	19029446
GO:1900281	Process	Positive regulation of CD4-positive, alpha-beta T cell costimulation	ISS
GO:2000572	Process	Positive regulation of interleukin-4-dependent isotype switching to IgE isotypes	ISS

MIM	HGNC	e!Ensembl
603594	11934	ENSG00000117586

P23510

Protein name

Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)

Protein function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

PDB

2HEV

Family and domains

Sequence

MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQ
SIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQ
KDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEF
CVL

Sequence length

183

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction		TNFs bind their physiological receptors

TNFSF4 (TNF superfamily member 4)