Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7275
Gene name	TUB bipartite transcription factor
Gene symbol	TUB
Synonyms (NCBI Gene)	RDOBrd5
Chromosome	11
Chromosome location	11p15.4
Summary	This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021923	hsa-miR-128-3p	Sequencing	20371350
MIRT022311	hsa-miR-124-3p	Microarray	18668037
MIRT024147	hsa-miR-221-3p	Sequencing	20371350
MIRT047219	hsa-miR-181c-5p	CLASH	23622248
MIRT021923	hsa-miR-128-3p	CLASH	23622248
MIRT044577	hsa-miR-320a	CLASH	23622248
MIRT037636	hsa-miR-744-5p	CLASH	23622248
MIRT036622	hsa-miR-940	CLASH	23622248
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	20371350
MIRT544954	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT544951	hsa-miR-4775	PAR-CLIP	20371350
MIRT544950	hsa-miR-1297	PAR-CLIP	20371350
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT544948	hsa-miR-4465	PAR-CLIP	20371350
MIRT544946	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT544954	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT544951	hsa-miR-4775	PAR-CLIP	21572407
MIRT544950	hsa-miR-1297	PAR-CLIP	21572407
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT544948	hsa-miR-4465	PAR-CLIP	21572407
MIRT544946	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT544954	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT544951	hsa-miR-4775	PAR-CLIP	21572407
MIRT544950	hsa-miR-1297	PAR-CLIP	21572407
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT544948	hsa-miR-4465	PAR-CLIP	21572407
MIRT544946	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT737920	hsa-miR-4692	HITS-CLIP	33718276
MIRT737921	hsa-miR-4514	HITS-CLIP	33718276
MIRT737923	hsa-miR-4742-5p	HITS-CLIP	33718276
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	20371350
MIRT544954	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT544951	hsa-miR-4775	PAR-CLIP	20371350
MIRT544950	hsa-miR-1297	PAR-CLIP	20371350
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT544948	hsa-miR-4465	PAR-CLIP	20371350
MIRT544946	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT544954	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT544951	hsa-miR-4775	PAR-CLIP	21572407
MIRT544950	hsa-miR-1297	PAR-CLIP	21572407
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT544948	hsa-miR-4465	PAR-CLIP	21572407
MIRT544946	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT544955	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT544954	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT544953	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT544952	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT544951	hsa-miR-4775	PAR-CLIP	21572407
MIRT544950	hsa-miR-1297	PAR-CLIP	21572407
MIRT544949	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT544947	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT544948	hsa-miR-4465	PAR-CLIP	21572407
MIRT544946	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT1462907	hsa-miR-134	CLIP-seq
MIRT1462908	hsa-miR-143	CLIP-seq
MIRT1462909	hsa-miR-153	CLIP-seq
MIRT1462910	hsa-miR-2113	CLIP-seq
MIRT1462911	hsa-miR-218	CLIP-seq
MIRT1462912	hsa-miR-2964a-5p	CLIP-seq
MIRT1462913	hsa-miR-3118	CLIP-seq
MIRT1462914	hsa-miR-3150b-3p	CLIP-seq
MIRT1462915	hsa-miR-3164	CLIP-seq
MIRT1462916	hsa-miR-3189-5p	CLIP-seq
MIRT1462917	hsa-miR-3200-5p	CLIP-seq
MIRT1462918	hsa-miR-3614-5p	CLIP-seq
MIRT1462919	hsa-miR-3616-3p	CLIP-seq
MIRT1462920	hsa-miR-3659	CLIP-seq
MIRT1462921	hsa-miR-4303	CLIP-seq
MIRT1462922	hsa-miR-4327	CLIP-seq
MIRT1462923	hsa-miR-448	CLIP-seq
MIRT1462924	hsa-miR-4639-5p	CLIP-seq
MIRT1462925	hsa-miR-4642	CLIP-seq
MIRT1462926	hsa-miR-4649-3p	CLIP-seq
MIRT1462927	hsa-miR-4658	CLIP-seq
MIRT1462928	hsa-miR-4682	CLIP-seq
MIRT1462929	hsa-miR-4721	CLIP-seq
MIRT1462930	hsa-miR-4762-3p	CLIP-seq
MIRT1462931	hsa-miR-4764-5p	CLIP-seq
MIRT1462932	hsa-miR-4770	CLIP-seq
MIRT1462933	hsa-miR-4777-3p	CLIP-seq
MIRT1462934	hsa-miR-4784	CLIP-seq
MIRT1462935	hsa-miR-4799-5p	CLIP-seq
MIRT1462936	hsa-miR-511	CLIP-seq
MIRT1462937	hsa-miR-574-5p	CLIP-seq
MIRT1462938	hsa-miR-603	CLIP-seq
MIRT1462939	hsa-miR-636	CLIP-seq
MIRT1462940	hsa-miR-122	CLIP-seq
MIRT1462941	hsa-miR-124	CLIP-seq
MIRT1462942	hsa-miR-1256	CLIP-seq
MIRT1462943	hsa-miR-1273g	CLIP-seq
MIRT1462944	hsa-miR-128	CLIP-seq
MIRT1462945	hsa-miR-1915	CLIP-seq
MIRT1462946	hsa-miR-19a	CLIP-seq
MIRT1462947	hsa-miR-19b	CLIP-seq
MIRT1462948	hsa-miR-2277-3p	CLIP-seq
MIRT1462949	hsa-miR-299-3p	CLIP-seq
MIRT1462950	hsa-miR-3121-3p	CLIP-seq
MIRT1462951	hsa-miR-3660	CLIP-seq
MIRT1462952	hsa-miR-4289	CLIP-seq
MIRT1462953	hsa-miR-4491	CLIP-seq
MIRT1462954	hsa-miR-4519	CLIP-seq
MIRT1462955	hsa-miR-4526	CLIP-seq
MIRT1462956	hsa-miR-4657	CLIP-seq
MIRT1462957	hsa-miR-4672	CLIP-seq
MIRT1462958	hsa-miR-4685-5p	CLIP-seq
MIRT1462959	hsa-miR-506	CLIP-seq
MIRT1462960	hsa-miR-548an	CLIP-seq
MIRT1462961	hsa-miR-556-5p	CLIP-seq
MIRT737922	hsa-miR-572	CLIP-seq
MIRT1462937	hsa-miR-574-5p	CLIP-seq
MIRT1462962	hsa-miR-581	CLIP-seq
MIRT1462938	hsa-miR-603	CLIP-seq
MIRT1462963	hsa-miR-610	CLIP-seq
MIRT1462964	hsa-miR-645	CLIP-seq
MIRT1462965	hsa-miR-647	CLIP-seq
MIRT1462938	hsa-miR-603	CLIP-seq
MIRT2139288	hsa-miR-3124-3p	CLIP-seq
MIRT2139289	hsa-miR-3173-3p	CLIP-seq
MIRT2139290	hsa-miR-345	CLIP-seq
MIRT2359994	hsa-miR-4272	CLIP-seq
MIRT2359995	hsa-miR-1237	CLIP-seq
MIRT2359996	hsa-miR-1248	CLIP-seq
MIRT2359997	hsa-miR-2467-5p	CLIP-seq
MIRT2359998	hsa-miR-3188	CLIP-seq
MIRT2359999	hsa-miR-3620	CLIP-seq
MIRT2360000	hsa-miR-362-5p	CLIP-seq
MIRT1462951	hsa-miR-3660	CLIP-seq
MIRT2360001	hsa-miR-3975	CLIP-seq
MIRT1462955	hsa-miR-4526	CLIP-seq
MIRT1462926	hsa-miR-4649-3p	CLIP-seq
MIRT2360002	hsa-miR-4675	CLIP-seq
MIRT2360003	hsa-miR-4722-3p	CLIP-seq
MIRT2360004	hsa-miR-4741	CLIP-seq
MIRT2360005	hsa-miR-485-5p	CLIP-seq
MIRT2360006	hsa-miR-500b	CLIP-seq
MIRT2360007	hsa-miR-501-5p	CLIP-seq
MIRT2360008	hsa-miR-515-5p	CLIP-seq
MIRT2360009	hsa-miR-767-3p	CLIP-seq
MIRT2396481	hsa-miR-1252	CLIP-seq
MIRT2396482	hsa-miR-3158-5p	CLIP-seq
MIRT2396483	hsa-miR-3166	CLIP-seq
MIRT2396484	hsa-miR-338-3p	CLIP-seq
MIRT2396485	hsa-miR-4418	CLIP-seq
MIRT2396486	hsa-miR-4771	CLIP-seq
MIRT2396487	hsa-miR-509-3-5p	CLIP-seq
MIRT2396488	hsa-miR-509-5p	CLIP-seq
MIRT2653148	hsa-miR-1178	CLIP-seq
MIRT2653149	hsa-miR-1205	CLIP-seq
MIRT2359995	hsa-miR-1237	CLIP-seq
MIRT1462942	hsa-miR-1256	CLIP-seq
MIRT2653150	hsa-miR-1258	CLIP-seq
MIRT1462943	hsa-miR-1273g	CLIP-seq
MIRT2653151	hsa-miR-1283	CLIP-seq
MIRT2653152	hsa-miR-1285	CLIP-seq
MIRT2653153	hsa-miR-1291	CLIP-seq
MIRT2653154	hsa-miR-129-3p	CLIP-seq
MIRT1462945	hsa-miR-1915	CLIP-seq
MIRT2653155	hsa-miR-194	CLIP-seq
MIRT2653156	hsa-miR-199a-3p	CLIP-seq
MIRT2653157	hsa-miR-199b-3p	CLIP-seq
MIRT2653158	hsa-miR-204	CLIP-seq
MIRT2653159	hsa-miR-2053	CLIP-seq
MIRT2653160	hsa-miR-211	CLIP-seq
MIRT2653161	hsa-miR-217	CLIP-seq
MIRT2653162	hsa-miR-296-5p	CLIP-seq
MIRT1462949	hsa-miR-299-3p	CLIP-seq
MIRT2653163	hsa-miR-302a	CLIP-seq
MIRT2653164	hsa-miR-302b	CLIP-seq
MIRT2653165	hsa-miR-302c	CLIP-seq
MIRT2653166	hsa-miR-302d	CLIP-seq
MIRT2653167	hsa-miR-302e	CLIP-seq
MIRT2653168	hsa-miR-3064-5p	CLIP-seq
MIRT2139288	hsa-miR-3124-3p	CLIP-seq
MIRT2653169	hsa-miR-3129-5p	CLIP-seq
MIRT2653170	hsa-miR-3130-3p	CLIP-seq
MIRT2653171	hsa-miR-3155	CLIP-seq
MIRT2653172	hsa-miR-3155b	CLIP-seq
MIRT2653173	hsa-miR-3160-5p	CLIP-seq
MIRT2653174	hsa-miR-3173-5p	CLIP-seq
MIRT2653175	hsa-miR-3187-3p	CLIP-seq
MIRT2653176	hsa-miR-3187-5p	CLIP-seq
MIRT2653177	hsa-miR-326	CLIP-seq
MIRT2653178	hsa-miR-330-5p	CLIP-seq
MIRT2653179	hsa-miR-335	CLIP-seq
MIRT2653180	hsa-miR-3611	CLIP-seq
MIRT1462918	hsa-miR-3614-5p	CLIP-seq
MIRT2653181	hsa-miR-3647-3p	CLIP-seq
MIRT2653182	hsa-miR-3658	CLIP-seq
MIRT2653183	hsa-miR-3665	CLIP-seq
MIRT2653184	hsa-miR-3667-5p	CLIP-seq
MIRT2653185	hsa-miR-3685	CLIP-seq
MIRT2653186	hsa-miR-3692	CLIP-seq
MIRT2653187	hsa-miR-371-5p	CLIP-seq
MIRT2653188	hsa-miR-371b-5p	CLIP-seq
MIRT2653189	hsa-miR-372	CLIP-seq
MIRT2653190	hsa-miR-373	CLIP-seq
MIRT2653191	hsa-miR-378g	CLIP-seq
MIRT2653192	hsa-miR-382	CLIP-seq
MIRT2653193	hsa-miR-384	CLIP-seq
MIRT2653194	hsa-miR-3976	CLIP-seq
MIRT2653195	hsa-miR-4274	CLIP-seq
MIRT1462952	hsa-miR-4289	CLIP-seq
MIRT2653196	hsa-miR-4302	CLIP-seq
MIRT2396485	hsa-miR-4418	CLIP-seq
MIRT2653197	hsa-miR-4436b-5p	CLIP-seq
MIRT2653198	hsa-miR-4473	CLIP-seq
MIRT2653199	hsa-miR-4486	CLIP-seq
MIRT1462953	hsa-miR-4491	CLIP-seq
MIRT2653200	hsa-miR-4496	CLIP-seq
MIRT2653201	hsa-miR-451b	CLIP-seq
MIRT2653202	hsa-miR-4529-5p	CLIP-seq
MIRT2653203	hsa-miR-4535	CLIP-seq
MIRT1462924	hsa-miR-4639-5p	CLIP-seq
MIRT2653204	hsa-miR-4640-5p	CLIP-seq
MIRT1462956	hsa-miR-4657	CLIP-seq
MIRT2653205	hsa-miR-4667-3p	CLIP-seq
MIRT1462957	hsa-miR-4672	CLIP-seq
MIRT2653206	hsa-miR-4687-3p	CLIP-seq
MIRT2653207	hsa-miR-4687-5p	CLIP-seq
MIRT2653208	hsa-miR-4694-3p	CLIP-seq
MIRT2653209	hsa-miR-4698	CLIP-seq
MIRT2653210	hsa-miR-4726-5p	CLIP-seq
MIRT2653211	hsa-miR-4732-3p	CLIP-seq
MIRT2653212	hsa-miR-4755-5p	CLIP-seq
MIRT1462933	hsa-miR-4777-3p	CLIP-seq
MIRT1462935	hsa-miR-4799-5p	CLIP-seq
MIRT2653213	hsa-miR-484	CLIP-seq
MIRT2653214	hsa-miR-492	CLIP-seq
MIRT2396487	hsa-miR-509-3-5p	CLIP-seq
MIRT2396488	hsa-miR-509-5p	CLIP-seq
MIRT2653215	hsa-miR-512-3p	CLIP-seq
MIRT2653216	hsa-miR-513a-3p	CLIP-seq
MIRT2653217	hsa-miR-519a	CLIP-seq
MIRT2653218	hsa-miR-519b-3p	CLIP-seq
MIRT2653219	hsa-miR-519c-3p	CLIP-seq
MIRT2653220	hsa-miR-520a-3p	CLIP-seq
MIRT2653221	hsa-miR-520b	CLIP-seq
MIRT2653222	hsa-miR-520c-3p	CLIP-seq
MIRT2653223	hsa-miR-520d-3p	CLIP-seq
MIRT2653224	hsa-miR-520e	CLIP-seq
MIRT2653225	hsa-miR-520f	CLIP-seq
MIRT2653226	hsa-miR-548a-3p	CLIP-seq
MIRT2653227	hsa-miR-548e	CLIP-seq
MIRT2653228	hsa-miR-548f	CLIP-seq
MIRT2653229	hsa-miR-556-3p	CLIP-seq
MIRT2653230	hsa-miR-570	CLIP-seq
MIRT1462962	hsa-miR-581	CLIP-seq
MIRT2653231	hsa-miR-612	CLIP-seq
MIRT2653232	hsa-miR-623	CLIP-seq
MIRT1462964	hsa-miR-645	CLIP-seq
MIRT2653233	hsa-miR-648	CLIP-seq
MIRT2653234	hsa-miR-657	CLIP-seq
MIRT2653235	hsa-miR-668	CLIP-seq
MIRT2653236	hsa-miR-888	CLIP-seq
MIRT2653237	hsa-miR-892b	CLIP-seq
MIRT1462942	hsa-miR-1256	CLIP-seq
MIRT2653150	hsa-miR-1258	CLIP-seq
MIRT1462943	hsa-miR-1273g	CLIP-seq
MIRT2653151	hsa-miR-1283	CLIP-seq
MIRT2653152	hsa-miR-1285	CLIP-seq
MIRT2653153	hsa-miR-1291	CLIP-seq
MIRT2653154	hsa-miR-129-3p	CLIP-seq
MIRT1462945	hsa-miR-1915	CLIP-seq
MIRT2653155	hsa-miR-194	CLIP-seq
MIRT2653158	hsa-miR-204	CLIP-seq
MIRT2653160	hsa-miR-211	CLIP-seq
MIRT2653161	hsa-miR-217	CLIP-seq
MIRT2653162	hsa-miR-296-5p	CLIP-seq
MIRT2653168	hsa-miR-3064-5p	CLIP-seq
MIRT2139288	hsa-miR-3124-3p	CLIP-seq
MIRT2653170	hsa-miR-3130-3p	CLIP-seq
MIRT2653171	hsa-miR-3155	CLIP-seq
MIRT2653172	hsa-miR-3155b	CLIP-seq
MIRT2653175	hsa-miR-3187-3p	CLIP-seq
MIRT2653176	hsa-miR-3187-5p	CLIP-seq
MIRT2653177	hsa-miR-326	CLIP-seq
MIRT2653178	hsa-miR-330-5p	CLIP-seq
MIRT2653179	hsa-miR-335	CLIP-seq
MIRT2653180	hsa-miR-3611	CLIP-seq
MIRT1462918	hsa-miR-3614-5p	CLIP-seq
MIRT2653181	hsa-miR-3647-3p	CLIP-seq
MIRT2653185	hsa-miR-3685	CLIP-seq
MIRT2653187	hsa-miR-371-5p	CLIP-seq
MIRT2653191	hsa-miR-378g	CLIP-seq
MIRT2653192	hsa-miR-382	CLIP-seq
MIRT2653193	hsa-miR-384	CLIP-seq
MIRT2653194	hsa-miR-3976	CLIP-seq
MIRT2653195	hsa-miR-4274	CLIP-seq
MIRT1462952	hsa-miR-4289	CLIP-seq
MIRT2396485	hsa-miR-4418	CLIP-seq
MIRT2653199	hsa-miR-4486	CLIP-seq
MIRT2653200	hsa-miR-4496	CLIP-seq
MIRT2653201	hsa-miR-451b	CLIP-seq
MIRT2653202	hsa-miR-4529-5p	CLIP-seq
MIRT2653203	hsa-miR-4535	CLIP-seq
MIRT2653205	hsa-miR-4667-3p	CLIP-seq
MIRT1462957	hsa-miR-4672	CLIP-seq
MIRT2653206	hsa-miR-4687-3p	CLIP-seq
MIRT2653207	hsa-miR-4687-5p	CLIP-seq
MIRT2653208	hsa-miR-4694-3p	CLIP-seq
MIRT2653212	hsa-miR-4755-5p	CLIP-seq
MIRT2653213	hsa-miR-484	CLIP-seq
MIRT2653214	hsa-miR-492	CLIP-seq
MIRT2396487	hsa-miR-509-3-5p	CLIP-seq
MIRT2396488	hsa-miR-509-5p	CLIP-seq
MIRT2653226	hsa-miR-548a-3p	CLIP-seq
MIRT2653227	hsa-miR-548e	CLIP-seq
MIRT2653228	hsa-miR-548f	CLIP-seq
MIRT2653229	hsa-miR-556-3p	CLIP-seq
MIRT2653230	hsa-miR-570	CLIP-seq
MIRT1462962	hsa-miR-581	CLIP-seq
MIRT2653231	hsa-miR-612	CLIP-seq
MIRT2653232	hsa-miR-623	CLIP-seq
MIRT1462964	hsa-miR-645	CLIP-seq
MIRT2653236	hsa-miR-888	CLIP-seq
MIRT2653237	hsa-miR-892b	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001664	Function	G protein-coupled receptor binding	IDA	28154160
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IDA	28154160
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	11000483
GO:0005737	Component	Cytoplasm	IDA	28154160
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	11000483
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005929	Component	Cilium	IBA
GO:0005929	Component	Cilium	IDA	28154160
GO:0006909	Process	Phagocytosis	IEA
GO:0006910	Process	Phagocytosis, recognition	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0042073	Process	Intraciliary transport	IDA	28154160
GO:0044877	Function	Protein-containing complex binding	IDA	20889716
GO:0045494	Process	Photoreceptor cell maintenance	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IDA	19837063
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0061512	Process	Protein localization to cilium	IBA
GO:0061512	Process	Protein localization to cilium	IEA
GO:0097500	Process	Receptor localization to non-motile cilium	IEA
GO:0120160	Function	Intraciliary transport particle A binding	IDA	28154160
GO:1903546	Process	Protein localization to photoreceptor outer segment	IEA

MIM	HGNC	e!Ensembl
601197	12406	ENSG00000166402

P50607

Protein name

Tubby protein homolog

Protein function

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Cou

PDB

1S31

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16322	Tub_N	29 → 237	Tubby N-terminal	Family
PF01167	Tub	257 → 501	Tub family	Domain

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRR
ARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQG
GAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQD
LRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAP
EQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLA
GRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLES
GTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTE
SIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTM
DYNYPLCALQAFAIALSSFDSKLACE

Sequence length

506

Interactions

View interactions

193

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Retinal dystrophy and obesity	Pathogenic; Likely pathogenic	rs727502810, rs1589996458	RCV000149873 RCV000991211

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autism spectrum disorder	association	rs769088023	RCV001291501
Cervical cancer	Conflicting classifications of pathogenicity	rs150402974	RCV005909405
Clear cell carcinoma of kidney	Uncertain significance	rs145623562	RCV005913604
Retinal dystrophy	Uncertain significance; Conflicting classifications of pathogenicity	rs369363661, rs147246689, rs1040410003, rs370188104	RCV004815450 RCV004817119 RCV001073609 RCV004813914
Thymoma	Likely benign	rs201501899	RCV005912712
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs200511292	RCV005908995
TUB-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs199688428, rs751661721, rs767402711, rs762696992, rs371203227, rs759795167, rs1370693176, rs144484513, rs749961508, rs776764692, rs775236651, rs1944231934, rs771147672, rs369363661, rs565455543 View all (136 more)	RCV004743400 RCV003953663 RCV003399100 RCV003416209 RCV003898314 RCV003416196 RCV004743404 RCV003399107 RCV003918868 RCV004743418 RCV004743421 RCV003399122 RCV003393986 RCV003898340 RCV003405611 RCV004743438 RCV003399161 RCV004743445 RCV004743469 RCV003973228 RCV004743454 RCV003938678 RCV003908559 RCV003938669 RCV003394039 RCV003908582 RCV003930932 RCV003965861 RCV003955973 RCV003908630 RCV003900518 RCV003938741 RCV003938808 RCV003900556 RCV003938811 RCV004743516 RCV003908681 RCV003938897 RCV003940949 RCV004743655 RCV003416588 RCV004743647 RCV003418227 RCV003941176 RCV003401950 RCV004744188 RCV003401792 RCV003941204 RCV004744206 RCV003913424 RCV004743616 RCV004744198 RCV004728854 RCV003418288 RCV003401863 RCV003407882 RCV004743641 RCV003948827 RCV004743620 RCV004744182 RCV003895980 RCV003978858 RCV003913664 RCV003978547 RCV004744316 RCV004744234 RCV003913791 RCV004744327 RCV004744271 RCV003408217 RCV003953863 RCV003966265 RCV003903717 RCV003403859 RCV004744380 RCV004744383 RCV003961085 RCV004744394 RCV003961108 RCV004744412 RCV003898492 RCV004744426 RCV004744430 RCV004744434 RCV003395520 RCV004744459 RCV004744524 RCV003898671 RCV004744529 RCV004744533 RCV004741517 RCV004741570 RCV003417053 RCV003402633 RCV003393103 RCV003399487 RCV003391587 RCV003412138 RCV003412148 RCV003392836 RCV004741733 RCV003966710 RCV003896529 RCV003896558 RCV003896961 RCV003909420 RCV003981598 RCV003894409 RCV003984501 RCV003927202 RCV003983527 RCV003983661 RCV003916110 RCV003960851 RCV003895447 RCV003975613 RCV003948398 RCV003910774 RCV003968208 RCV003912871 RCV004743203 RCV003903030 RCV003903145 RCV003906090 RCV003413884 RCV003413843 RCV003928685 RCV003928689 RCV003963004 RCV004726804 RCV003918651 RCV003906164 RCV003396732 RCV003974950 RCV003963134 RCV004743322 RCV004743325 RCV003405394 RCV003908447 RCV003898198 RCV003393878 RCV004743340 RCV003938567 RCV003405415 RCV003405428 RCV003405418 RCV003393900 RCV004743344 RCV004743341 RCV003918786 RCV003945935 RCV003908461 RCV003928798 RCV003416175 RCV003953646 RCV003898296 RCV004743389
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs150402974	RCV005909406

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Cataract Age Related Nuclear	Associate	32337810
Ciliopathies	Associate	36498982
Colonic Neoplasms	Associate	36181111
Cone Dystrophy	Associate	24375934
Deafness	Associate	16643894
Dehydration	Associate	36380055
Hearing Loss Sensorineural	Associate	18183286
Insulin Resistance	Associate	18183286
Leber Congenital Amaurosis	Associate	16643894
Obesity	Associate	16443771, 16643894, 18183286, 24375934, 33983957
Retinal Degeneration	Associate	16643894
Retinal Diseases	Associate	36498982
Retinal Dystrophies	Associate	24375934, 36498982
Retinitis Pigmentosa	Associate	16643894, 36650547
Squamous Cell Carcinoma of Head and Neck	Associate	31198983

TUB (TUB bipartite transcription factor)