Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7270
Gene name Gene Name - the full gene name approved by the HGNC.	Transcription termination factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TTF1
Synonyms (NCBI Gene) Gene synonyms aliases	TTF-1, TTF-I
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q34.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box termina

Show/Hide all(61)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020919	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT439140	hsa-let-7c-5p	3'LIFE	25074381
MIRT439140	hsa-let-7c-5p	3'LIFE	25074381
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT1462030	hsa-miR-197	CLIP-seq
MIRT1462031	hsa-miR-1972	CLIP-seq
MIRT1462032	hsa-miR-24	CLIP-seq
MIRT1462033	hsa-miR-3125	CLIP-seq
MIRT1462034	hsa-miR-3916	CLIP-seq
MIRT1462035	hsa-miR-412	CLIP-seq
MIRT1462036	hsa-miR-4284	CLIP-seq
MIRT1462037	hsa-miR-4650-5p	CLIP-seq
MIRT1462038	hsa-miR-4680-5p	CLIP-seq
MIRT1462039	hsa-miR-4716-5p	CLIP-seq
MIRT1462040	hsa-miR-4772-3p	CLIP-seq
MIRT1462041	hsa-miR-4781-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT1462043	hsa-miR-520a-5p	CLIP-seq
MIRT1462044	hsa-miR-525-5p	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT1462032	hsa-miR-24	CLIP-seq
MIRT1462036	hsa-miR-4284	CLIP-seq
MIRT1462040	hsa-miR-4772-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT2462626	hsa-miR-150	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT2462626	hsa-miR-150	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT2653015	hsa-miR-1244	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT2462626	hsa-miR-150	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT2653016	hsa-miR-4703-3p	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq
MIRT2653015	hsa-miR-1244	CLIP-seq
MIRT1462029	hsa-miR-1343	CLIP-seq
MIRT2462626	hsa-miR-150	CLIP-seq
MIRT1462045	hsa-miR-1976	CLIP-seq
MIRT1462046	hsa-miR-4279	CLIP-seq
MIRT1462047	hsa-miR-4722-3p	CLIP-seq
MIRT1462042	hsa-miR-498	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	28169274
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	7597036
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006353	Process	DNA-templated transcription termination	IEA
GO:0006353	Process	DNA-templated transcription termination	NAS	7597036
GO:0006360	Process	Transcription by RNA polymerase I	IEA
GO:0006361	Process	Transcription initiation at RNA polymerase I promoter	IEA
GO:0006363	Process	Termination of RNA polymerase I transcription	IBA
GO:0006363	Process	Termination of RNA polymerase I transcription	IEA
GO:0006363	Process	Termination of RNA polymerase I transcription	ISS
GO:0008156	Process	Negative regulation of DNA replication	IEA

MIM	HGNC	e!Ensembl
600777	12397	ENSG00000125482

Protein

UniProt ID

Q15361

Protein name

Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I)

Protein function

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13921	Myb_DNA-bind_6	620 → 677		Domain

Sequence

MEGESSRFEIHTPVSDKKKKKCSIHKERPQKHSHEIFRDSSLVNEQSQITRRKKRKKDFQ
HLISSPLKKSRICDETANATSTLKKRKKRRYSALEVDEEAGVTVVLVDKENINNTPKHFR
KDVDVVCVDMSIEQKLPRKPKTDKFQVLAKSHAHKSEALHSKVREKKNKKHQRKAASWES
QRARDTLPQSESHQEESWLSVGPGGEITELPASAHKNKSKKKKKKSSNREYETLAMPEGS
QAGREAGTDMQESQPTVGLDDETPQLLGPTHKKKSKKKKKKKSNHQEFEALAMPEGSQVG
SEVGADMQESRPAVGLHGETAGIPAPAYKNKSKKKKKKSNHQEFEAVAMPESLESAYPEG
SQVGSEVGTVEGSTALKGFKESNSTKKKSKKRKLTSVKRARVSGDDFSVPSKNSESTLFD
SVEGDGAMMEEGVKSRPRQKKTQACLASKHVQEAPRLEPANEEHNVETAEDSEIRYLSAD
SGDADDSDADLGSAVKQLQEFIPNIKDRATSTIKRMYRDDLERFKEFKAQGVAIKFGKFS
VKENKQLEKNVEDFLALTGIESADKLLYTDRYPEEKSVITNLKRRYSFRLHIGRNIARPW
KLIYYRAKKMFDVNNYKGRYSEGDTEKLKMYHSLLGNDWKTIGEMVARSSLSVALKFSQI
SSQRNRGAWSKSETRKLIKAVEEVILKKMSPQELKEVDSKLQENPESCLSIVREKLYKGI
SWVEVEAKVQTRNWMQCKSKWTEILTKRMTNGRRIYYGMNALRAKVSLIERLYEINVEDT
NEIDWEDLASAIGDVPPSYVQTKFSRLKAVYVPFWQKKTFPEIIDYLYETTLPLLKEKLE
KMMEKKGTKIQTPAAPKQVFPFRDIFYYEDDSEGEDIEKESEGQAPCMAHACNSSTLGGQ
GRWII

Sequence length

905

Interactions

View interactions

	KEGG		Reactome
	Thyroid hormone synthesis		Surfactant metabolism RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination

TTF1 (transcription termination factor 1)