TTC3 (tetratricopeptide repeat domain 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7267 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Tetratricopeptide repeat domain 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TTC3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DCRR1, RNF105, TPRDIII |
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Chromosome
Chromosome number
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21 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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21q22.13 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | P53804 | |||||||||||||||
| Protein name | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | |||||||||||||||
| Protein function | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (Pub | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Found in all tissues examined. | |||||||||||||||
| Sequence |
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| Sequence length | 2025 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||