TTC3 (tetratricopeptide repeat domain 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 7267 |
| Gene name | Tetratricopeptide repeat domain 3 |
| Gene symbol | TTC3 |
| Synonyms (NCBI Gene) |
DCRR1RNF105TPRDIII
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| Chromosome | 21 |
| Chromosome location | 21q22.13 |
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miRNA
miRNA information provided by mirtarbase database.
608
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P53804 | |||||||||||||||
| Protein name | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | |||||||||||||||
| Protein function | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (Pub | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Found in all tissues examined. | |||||||||||||||
| Sequence |
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| Sequence length | 2025 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
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