INS-IGF2 (INS-IGF2 readthrough)

Gene

• Entrez ID: 723961
• Gene name: INS-IGF2 readthrough
• Gene symbol: INS-IGF2
• Synonyms (NCBI Gene): INSIGF
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5` region and to the IGF2 gene in the 3` region. One transcript is predicted to encode a protein which shares the N-terminus with the INS pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1067729	hsa-miR-1205	CLIP-seq
MIRT1067730	hsa-miR-2467-5p	CLIP-seq
MIRT1067731	hsa-miR-3183	CLIP-seq
MIRT1067732	hsa-miR-3188	CLIP-seq
MIRT1067733	hsa-miR-3975	CLIP-seq
MIRT1067734	hsa-miR-4259	CLIP-seq
MIRT1067735	hsa-miR-4260	CLIP-seq
MIRT1067736	hsa-miR-4283	CLIP-seq
MIRT1067737	hsa-miR-4489	CLIP-seq
MIRT1067738	hsa-miR-4505	CLIP-seq
MIRT1067739	hsa-miR-4649-3p	CLIP-seq
MIRT1067740	hsa-miR-4656	CLIP-seq
MIRT1067741	hsa-miR-4723-3p	CLIP-seq
MIRT1067742	hsa-miR-4731-5p	CLIP-seq
MIRT1067743	hsa-miR-485-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005158	Function	Insulin receptor binding	IBA
GO:0005179	Function	Hormone activity	IBA
GO:0005179	Function	Hormone activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0007165	Process	Signal transduction	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: F8WCM5
• Protein name: Insulin, isoform 2 (INS-IGF2 readthrough transcript protein)
• PDB: 7YQ3, 7YQ4, 7YQ5, 8GUY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00049	Insulin	28 → 168	Insulin/IGF/Relaxin family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in pancreas, eye and, to a lower extent, in limb. {ECO:0000269|PubMed:16531418}.
• Sequence:

  MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
  LQASALSLSSSTSTWPEGLDATARAPPALVVTANIGQAGGSSSRQFRQRALGTSDSPVLF
  IHCPGAAGTAQGLEYRGRRVTTELVWEEVDSSPQPQGSESLPAQPPAQPAPQPEPQQARE
  PSPEVSCCGLWPRRPQRSQN

• Sequence length: 200

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Maturity-onset diabetes of the young type 10	Pathogenic	rs145038693	RCV001197790