Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7226
Gene name Gene Name - the full gene name approved by the HGNC.	Transient receptor potential cation channel subfamily M member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRPM2
Synonyms (NCBI Gene) Gene synonyms aliases	EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to ce

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miRTarBase ID	miRNA	Experiments	Reference
MIRT042627	hsa-miR-423-3p	CLASH	23622248
MIRT1457298	hsa-miR-1269	CLIP-seq
MIRT1457299	hsa-miR-1269b	CLIP-seq
MIRT1457300	hsa-miR-1288	CLIP-seq
MIRT1457301	hsa-miR-1324	CLIP-seq
MIRT1457302	hsa-miR-1909	CLIP-seq
MIRT1457303	hsa-miR-3616-3p	CLIP-seq
MIRT1457304	hsa-miR-3660	CLIP-seq
MIRT1457305	hsa-miR-4271	CLIP-seq
MIRT1457306	hsa-miR-4293	CLIP-seq
MIRT1457307	hsa-miR-4433	CLIP-seq
MIRT1457308	hsa-miR-4459	CLIP-seq
MIRT1457309	hsa-miR-4515	CLIP-seq
MIRT1457310	hsa-miR-4526	CLIP-seq
MIRT1457311	hsa-miR-4632	CLIP-seq
MIRT1457312	hsa-miR-4645-3p	CLIP-seq
MIRT1457313	hsa-miR-4721	CLIP-seq
MIRT1457314	hsa-miR-4725-3p	CLIP-seq
MIRT1457315	hsa-miR-4740-5p	CLIP-seq
MIRT1457316	hsa-miR-4768-3p	CLIP-seq
MIRT1457317	hsa-miR-4786-3p	CLIP-seq
MIRT1457318	hsa-miR-544b	CLIP-seq
MIRT1457319	hsa-miR-671-5p	CLIP-seq
MIRT2137124	hsa-miR-1286	CLIP-seq
MIRT2137125	hsa-miR-3155	CLIP-seq
MIRT2137126	hsa-miR-3155b	CLIP-seq
MIRT2137127	hsa-miR-3677-5p	CLIP-seq
MIRT2137128	hsa-miR-4323	CLIP-seq
MIRT2137129	hsa-miR-4435	CLIP-seq
MIRT2137130	hsa-miR-4436a	CLIP-seq
MIRT2137131	hsa-miR-4514	CLIP-seq
MIRT2137132	hsa-miR-4645-5p	CLIP-seq
MIRT2137133	hsa-miR-4673	CLIP-seq
MIRT2137134	hsa-miR-4692	CLIP-seq
MIRT2137135	hsa-miR-4755-3p	CLIP-seq
MIRT2137136	hsa-miR-484	CLIP-seq
MIRT2357943	hsa-miR-4771	CLIP-seq
MIRT2357944	hsa-miR-499a-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	IEA
GO:0001659	Process	Temperature homeostasis	ISS
GO:0002407	Process	Dendritic cell chemotaxis	IEA
GO:0002407	Process	Dendritic cell chemotaxis	ISS
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005261	Function	Monoatomic cation channel activity	IMP	27068538
GO:0005262	Function	Calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	TAS	9806837
GO:0005272	Function	Sodium channel activity	IEA
GO:0005384	Function	Manganese ion transmembrane transporter activity	IEA
GO:0005509	Function	Calcium ion binding	IDA	30467180
GO:0005509	Function	Calcium ion binding	IMP	19171771
GO:0005764	Component	Lysosome	IDA	27068538
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	27333281, 30467180
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	19171771
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	9806837
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	TAS	9806837
GO:0006828	Process	Manganese ion transport	IEA
GO:0009408	Process	Response to heat	IEA
GO:0014074	Process	Response to purine-containing compound	IMP	19171771
GO:0015278	Function	Intracellularly gated calcium channel activity	IMP	27068538
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IMP	27383051
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	27068538
GO:0033194	Process	Response to hydroperoxide	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046873	Function	Metal ion transmembrane transporter activity	IEA
GO:0047631	Function	ADP-ribose diphosphatase activity	IDA	30467180
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IMP	27068538
GO:0051209	Process	Release of sequestered calcium ion into cytosol	ISS
GO:0051289	Process	Protein homotetramerization	IDA	30467180
GO:0051489	Process	Regulation of filopodium assembly	IMP	27068538
GO:0055085	Process	Transmembrane transport	IEA
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	27068538
GO:0070588	Process	Calcium ion transmembrane transport	IDA	25620041, 27333281, 28775320, 29745897, 30467180
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0071277	Process	Cellular response to calcium ion	IMP	19171771
GO:0071421	Process	Manganese ion transmembrane transport	IEA
GO:0071502	Process	Cellular response to temperature stimulus	IEA
GO:0071502	Process	Cellular response to temperature stimulus	ISS
GO:0071577	Process	Zinc ion transmembrane transport	IMP	27068538
GO:0072571	Function	Mono-ADP-D-ribose binding	IDA	30467180
GO:0097028	Process	Dendritic cell differentiation	IEA
GO:0097028	Process	Dendritic cell differentiation	ISS
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IEA
GO:0097553	Process	Calcium ion transmembrane import into cytosol	IMP	19171771, 27068538
GO:0098703	Process	Calcium ion import across plasma membrane	IEA
GO:0098703	Process	Calcium ion import across plasma membrane	ISS
GO:0099604	Function	Ligand-gated calcium channel activity	IBA
GO:0099604	Function	Ligand-gated calcium channel activity	IDA	19171771, 25620041, 27333281, 28775320, 29745897, 30467180
GO:0099604	Function	Ligand-gated calcium channel activity	IEA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

MIM	HGNC	e!Ensembl
603749	12339	ENSG00000142185

Protein

UniProt ID

O94759

Protein name

Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor

Protein function

[Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:12594222, PubMed:15561722, PubMed:1660

PDB

6MIX , 6MIZ , 6MJ2 , 6PUO , 6PUR , 6PUS , 6PUU , 7VQ1 , 7VQ2 , 8E6Q , 8E6R , 8E6S , 8E6T , 8E6U , 8E6V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18139	LSDAT_euk	140 → 408	SLOG in TRPM	Family
PF00520	Ion_trans	797 → 1060	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:115

Sequence

MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLS
SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQ
EMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF
NMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIG
VATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP
LRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVA
DVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR
EGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWK
PSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVL
VEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQ
GVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILK
ELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQL
ALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQD
VGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV
CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILS
LDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNE
RRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAF
PEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAA
PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQ
KQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTAQALHWIVRTLRA
SGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNE
KVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ
AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLP
LSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWI
ETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFG
AHY

Sequence length

1503

Interactions

View interactions

	KEGG		Reactome
	NOD-like receptor signaling pathway Oxytocin signaling pathway		TRP channels Neutrophil degranulation

TRPM2 (transient receptor potential cation channel subfamily M member 2)