Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7224
Gene name Gene Name - the full gene name approved by the HGNC.	Transient receptor potential cation channel subfamily C member 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRPC5
Synonyms (NCBI Gene) Gene synonyms aliases	PPP1R159, TRP5
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective

Show/Hide all(53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038711	hsa-miR-29b-2-5p	CLASH	23622248
MIRT438273	hsa-miR-320a	Luciferase reporter assay, qRT-PCR, Western blot	25159093
MIRT438273	hsa-miR-320a	Luciferase reporter assay, qRT-PCR, Western blot	25159093
MIRT533448	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT533446	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT533447	hsa-miR-4643	PAR-CLIP	22012620
MIRT533445	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT533444	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT533443	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT533442	hsa-miR-1913	PAR-CLIP	22012620
MIRT533441	hsa-miR-324-3p	PAR-CLIP	22012620
MIRT533439	hsa-miR-4313	PAR-CLIP	22012620
MIRT533440	hsa-miR-3941	PAR-CLIP	22012620
MIRT533438	hsa-miR-4672	PAR-CLIP	22012620
MIRT533437	hsa-miR-466	PAR-CLIP	22012620
MIRT533436	hsa-miR-6509-3p	PAR-CLIP	22012620
MIRT533435	hsa-miR-4436b-5p	PAR-CLIP	22012620
MIRT533448	hsa-miR-32-3p	PAR-CLIP	22012620
MIRT533446	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT533447	hsa-miR-4643	PAR-CLIP	22012620
MIRT533445	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT533444	hsa-miR-181a-2-3p	PAR-CLIP	22012620
MIRT533443	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT533442	hsa-miR-1913	PAR-CLIP	22012620
MIRT533441	hsa-miR-324-3p	PAR-CLIP	22012620
MIRT533439	hsa-miR-4313	PAR-CLIP	22012620
MIRT533440	hsa-miR-3941	PAR-CLIP	22012620
MIRT533438	hsa-miR-4672	PAR-CLIP	22012620
MIRT533437	hsa-miR-466	PAR-CLIP	22012620
MIRT533436	hsa-miR-6509-3p	PAR-CLIP	22012620
MIRT533435	hsa-miR-4436b-5p	PAR-CLIP	22012620
MIRT1457251	hsa-miR-1193	CLIP-seq
MIRT1457252	hsa-miR-147b	CLIP-seq
MIRT1457253	hsa-miR-2392	CLIP-seq
MIRT1457254	hsa-miR-3605-5p	CLIP-seq
MIRT1457255	hsa-miR-873	CLIP-seq
MIRT2137099	hsa-miR-1288	CLIP-seq
MIRT2137100	hsa-miR-138	CLIP-seq
MIRT2137101	hsa-miR-3144-5p	CLIP-seq
MIRT2137102	hsa-miR-3191	CLIP-seq
MIRT2137103	hsa-miR-3199	CLIP-seq
MIRT2137104	hsa-miR-3671	CLIP-seq
MIRT2137105	hsa-miR-4456	CLIP-seq
MIRT2137106	hsa-miR-4652-5p	CLIP-seq
MIRT2137107	hsa-miR-491-5p	CLIP-seq
MIRT2137108	hsa-miR-541	CLIP-seq
MIRT2137109	hsa-miR-607	CLIP-seq
MIRT2137110	hsa-miR-628-5p	CLIP-seq
MIRT2137111	hsa-miR-654-5p	CLIP-seq
MIRT2357911	hsa-miR-1323	CLIP-seq
MIRT2357912	hsa-miR-548o	CLIP-seq
MIRT2651471	hsa-miR-374a	CLIP-seq
MIRT2651472	hsa-miR-374b	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005262	Function	Calcium channel activity	IDA	20164195
GO:0005515	Function	Protein binding	IPI	20164195, 32110987
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006816	Process	Calcium ion transport	TAS	10493832
GO:0006828	Process	Manganese ion transport	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007399	Process	Nervous system development	TAS	10493832
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	IEA
GO:0015279	Function	Store-operated calcium channel activity	IBA	21873635
GO:0030182	Process	Neuron differentiation	IEA
GO:0030276	Function	Clathrin binding	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0034703	Component	Cation channel complex	IBA	21873635
GO:0034704	Component	Calcium channel complex	IDA	20164195
GO:0042805	Function	Actinin binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0050774	Process	Negative regulation of dendrite morphogenesis	IEA
GO:0051117	Function	ATPase binding	IEA
GO:0051402	Process	Neuron apoptotic process	ISS
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IBA	21873635
GO:0070782	Process	Phosphatidylserine exposure on apoptotic cell surface	ISS
GO:1902630	Process	Regulation of membrane hyperpolarization	IEA

MIM	HGNC	e!Ensembl
300334	12337	ENSG00000072315

Protein

UniProt ID

Q9UL62

Protein name

Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)

Protein function

Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1

PDB

6YSN , 7D4P , 7D4Q , 7E4T , 7WDB , 7X6C , 7X6I , 8GVW , 8GVX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	36 → 126	Ankyrin repeats (3 copies)	Repeat
PF08344	TRP_2	176 → 238	Transient receptor ion channel II	Family
PF00520	Ion_trans	363 → 636	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. {ECO:0000269|PubMed:9687496}.

Sequence

MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
WGDGQEEQVTTRL

Sequence length

973

Interactions

View interactions

	KEGG		Reactome
	Axon guidance GnRH secretion		TRP channels

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Hypertension	Hypertensive disease	rs13306026	17351372

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Neurodevelopmental Disorders	neurodevelopmental disorder			GenCC

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	32205467
Atrial Fibrillation	Associate	28839241
Autism Spectrum Disorder	Associate	36323681
Breast Neoplasms	Associate	28032400, 37174704
Colorectal Neoplasms	Associate	29463225
Congenital Hyperinsulinism	Associate	23869231
Glioma	Associate	18211288, 39189437
Intellectual Disability	Associate	15254149, 36323681
Intracranial Hemorrhage Hypertensive	Inhibit	21957871
Neoplasms	Associate	28032400
Thyroid Cancer Papillary	Associate	37733241

TRPC5 (transient receptor potential cation channel subfamily C member 5)