TRPC4 (transient receptor potential cation channel subfamily C member 4)

Gene

• Entrez ID: 7223
• Gene name: Transient receptor potential cation channel subfamily C member 4
• Gene symbol: TRPC4
• Synonyms (NCBI Gene): HTRP-4, HTRP4, TRP4
• Chromosome: 13
• Chromosome location: 13q13.3
• Summary: This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029916	hsa-miR-26b-5p	Microarray	19088304
MIRT533452	hsa-miR-33a-5p	PAR-CLIP	22012620
MIRT533450	hsa-miR-33b-5p	PAR-CLIP	22012620
MIRT533449	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT533452	hsa-miR-33a-5p	PAR-CLIP	22012620
MIRT533450	hsa-miR-33b-5p	PAR-CLIP	22012620
MIRT533449	hsa-miR-140-3p	PAR-CLIP	22012620
MIRT1457242	hsa-miR-18a	CLIP-seq
MIRT1457243	hsa-miR-18b	CLIP-seq
MIRT1457244	hsa-miR-300	CLIP-seq
MIRT1457245	hsa-miR-381	CLIP-seq
MIRT1457246	hsa-miR-4729	CLIP-seq
MIRT1457247	hsa-miR-4735-3p	CLIP-seq
MIRT1457248	hsa-miR-4761-5p	CLIP-seq
MIRT1457249	hsa-miR-624	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15757897, 16254212, 20164195
GO:0005886	Component	Plasma membrane	IDA	16254212
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005901	Component	Caveola	IEA
GO:0005911	Component	Cell-cell junction	IDA	19996314
GO:0006816	Process	Calcium ion transport	TAS	8646775
GO:0006828	Process	Manganese ion transport	IBA	21873635
GO:0008013	Function	Beta-catenin binding	IPI	19996314
GO:0009986	Component	Cell surface	IDA	19996314
GO:0014051	Process	Gamma-aminobutyric acid secretion	IEA
GO:0015279	Function	Store-operated calcium channel activity	IBA	21873635
GO:0015279	Function	Store-operated calcium channel activity	IMP	16254212
GO:0016323	Component	Basolateral plasma membrane	IDA	19996314
GO:0030863	Component	Cortical cytoskeleton	IDA	16254212
GO:0034703	Component	Cation channel complex	IBA	21873635
GO:0034704	Component	Calcium channel complex	IDA	20164195
GO:0045296	Function	Cadherin binding	IPI	19996314
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0070509	Process	Calcium ion import	IDA	19996314
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IBA	21873635

Other IDs

• MIM: 603651
• HGNC: 12336
• e!Ensembl: ENSG00000133107

Protein

• UniProt ID: Q9UBN4
• Protein name: Short transient receptor potential channel 4 (TrpC4) (Trp-related protein 4) (hTrp-4) (hTrp4)
• Protein function: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a hom
• PDB: 8WPL, 8WPM, 8WPN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08344	TRP_2	176 → 238	Transient receptor ion channel II	Family
  PF00520	Ion_trans	362 → 632	Ion transport protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. {E
• Sequence:

  MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
  PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
  CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
  YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
  VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
  KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
  MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
  FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
  YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
  FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
  PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAA
  MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSADSDEK
  SDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVT
  DIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIP
  GLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYD
  LNLPDTVTHEDYVTTRL

• Sequence length: 977

Pathways

KEGG:

Axon guidance
GnRH secretion

Reactome:

TRP channels

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999

Unknown
Disease term	Disease name	Evidence	References	Source
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alkalosis	Associate	17074721
Atrial Fibrillation	Stimulate	28839241
Autistic Disorder	Associate	39766876
Brain Edema	Associate	39189437
Carcinoma Basal Cell	Associate	36674553
Carcinoma Non Small Cell Lung	Associate	23840757
Carcinoma Squamous Cell	Associate	36674553
Cardiovascular Diseases	Associate	30423812
Endometriosis	Associate	30134548
Glioma	Associate	39189437
Heart Septal Defects Ventricular	Associate	30423812
Hypoxia	Stimulate	12909593
Leukoplakia Oral	Associate	27255271
Lung Neoplasms	Associate	23840757
Neoplasm Metastasis	Associate	36674553
Neoplasms	Associate	36674553
Primary Myelofibrosis	Associate	24603752