Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7200
Gene name Gene Name - the full gene name approved by the HGNC.
Thyrotropin releasing hormone
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRH
Synonyms (NCBI Gene) Gene synonyms aliases
Pro-TRH, TRF
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1452491 hsa-miR-1343 CLIP-seq
MIRT1452492 hsa-miR-3151 CLIP-seq
MIRT1452493 hsa-miR-4257 CLIP-seq
MIRT1452494 hsa-miR-4447 CLIP-seq
MIRT1452495 hsa-miR-4472 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 11134186;9827656
STAT3 Unknown 11134186
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001692 Process Histamine metabolic process IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613879 12298 ENSG00000170893
Protein
UniProt ID P20396
Protein name Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)]
Protein function As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-sha
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05438 TRH 6 206 Thyrotropin-releasing hormone (TRH) Family
Tissue specificity TISSUE SPECIFICITY: Hypothalamus. Expressed in the hair follicle epithelium (at protein level). {ECO:0000269|PubMed:19825978}.
Sequence
Sequence length 242
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
  Peptide ligand-binding receptors
G alpha (q) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 6350720
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 18206229
Mental retardation Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
Narcolepsy Narcolepsy rs104894574, rs387906655 2845442
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 21063030 ClinVar
Hypothalamic hypothyroidism Hypothalamic hypothyroidism, THYROTROPIN-RELEASING HORMONE DEFICIENCY 20687402 ClinVar
Mental depression Mental Depression, Depressive disorder, Unipolar Depression 19078951, 7798461, 18418668, 25028079, 2543997, 6412261, 6418677, 6461684 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 22491060
Alopecia Areata Associate 39205687
Anxiety Disorders Stimulate 35964359
Breast Neoplasms Associate 25362934
Carcinoma Renal Cell Associate 22610075, 25332168
Carcinoma Squamous Cell Associate 22491060
Combined Pituitary Hormone Deficiency Associate 9745452
Down Syndrome Associate 25362934
Endometrial Neoplasms Associate 29693365
Hyperthyroidism Associate 37876543