Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7188
Gene name Gene Name - the full gene name approved by the HGNC.
TNF receptor associated factor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRAF5
Synonyms (NCBI Gene) Gene synonyms aliases
MGC:39780, RNF84
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.3
Summary Summary of gene provided in NCBI Entrez Gene.
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF protei
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs756183569 AGAG>- Likely-pathogenic Frameshift variant, coding sequence variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT553425 hsa-miR-8485 PAR-CLIP 21572407
MIRT553424 hsa-miR-329-3p PAR-CLIP 21572407
MIRT553423 hsa-miR-362-3p PAR-CLIP 21572407
MIRT553422 hsa-miR-603 PAR-CLIP 21572407
MIRT553421 hsa-miR-4789-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IBA 21873635
GO:0005164 Function Tumor necrosis factor receptor binding IBA 21873635
GO:0005515 Function Protein binding IPI 9153189, 9162022, 15121867, 21516116, 21822258, 22493164, 25241761, 25416956, 27107012, 28514442, 32296183, 32814053
GO:0005813 Component Centrosome IDA 21399614
GO:0005829 Component Cytosol IDA 15121867
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602356 12035 ENSG00000082512
Protein
UniProt ID O00463
Protein name TNF receptor-associated factor 5 (RING finger protein 84)
Protein function Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably
PDB 7L3L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00097 zf-C3HC4 45 83 Zinc finger, C3HC4 type (RING finger) Domain
PF02176 zf-TRAF 128 183 TRAF-type zinc finger Family
PF02176 zf-TRAF 183 241 TRAF-type zinc finger Family
Tissue specificity TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Sequence
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
GHRFCQHCILSLRELNTVPICPV
DKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
QN
HEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
H
EHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
DTLFLKVAVDLTDLEDL
Sequence length 557
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  NF-kappa B signaling pathway
Necroptosis
NOD-like receptor signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Shigellosis
Human cytomegalovirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Viral carcinogenesis
Small cell lung cancer
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Glioma Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
19578366
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 38088510
Arthritis Rheumatoid Associate 17277003
Atherosclerosis Associate 37330462
Autoimmune Diseases Associate 24020968, 24416204
Behcet Syndrome Associate 24416204
Carcinoma Hepatocellular Associate 30021196, 37366426
Carcinoma Ovarian Epithelial Associate 34983361
Colitis Stimulate 23329887
Colitis Ulcerative Associate 23329887
Colorectal Neoplasms Associate 29328486