Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7172
Gene name	Thiopurine S-methyltransferase
Gene symbol	TPMT
Synonyms (NCBI Gene)	TPMTD
Chromosome	6
Chromosome location	6p22.3
Summary	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorph

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1142345	T>C,G	Drug-response, likely-benign, other	Coding sequence variant, missense variant
rs1800460	C>T	Drug-response, likely-benign, other	Coding sequence variant, missense variant
rs1800462	C>G	Drug-response	Coding sequence variant, missense variant
rs1800584	C>T	Drug-response	Splice acceptor variant
rs56019966	C>T	Drug-response, uncertain-significance	Intron variant
rs56161402	C>T	Drug-response	Coding sequence variant, missense variant
rs74423290	G>C	Drug-response	Coding sequence variant, missense variant
rs201695576	T>C	Drug-response	Coding sequence variant, missense variant
rs753545734	C>A,T	Drug-response	Coding sequence variant, missense variant
rs759836180	->T	Drug-response	Coding sequence variant, frameshift variant
rs1256618794	C>A	Drug-response	Coding sequence variant, missense variant

446

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miRTarBase ID	miRNA	Experiments
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT1449867	hsa-miR-3147	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449873	hsa-miR-3609	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449886	hsa-miR-4325	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449895	hsa-miR-4725-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT1449898	hsa-miR-4786-5p	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT1449902	hsa-miR-504	CLIP-seq
MIRT1449903	hsa-miR-508-5p	CLIP-seq
MIRT1449904	hsa-miR-520g	CLIP-seq
MIRT1449905	hsa-miR-520h	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT1449907	hsa-miR-548ah	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT1449911	hsa-miR-767-5p	CLIP-seq
MIRT1449912	hsa-miR-769-5p	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134433	hsa-miR-1262	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2134436	hsa-miR-3140-3p	CLIP-seq
MIRT1449867	hsa-miR-3147	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT2134437	hsa-miR-3169	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT2134438	hsa-miR-34b	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT2134441	hsa-miR-3664-3p	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT2134443	hsa-miR-3919	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT2134444	hsa-miR-3938	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT2134446	hsa-miR-4330	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2134448	hsa-miR-451b	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT2134449	hsa-miR-4695-5p	CLIP-seq
MIRT2134450	hsa-miR-4701-3p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134453	hsa-miR-4756-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2134456	hsa-miR-500a	CLIP-seq
MIRT2134457	hsa-miR-510	CLIP-seq
MIRT2134458	hsa-miR-512-5p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134433	hsa-miR-1262	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2355774	hsa-miR-1293	CLIP-seq
MIRT2355775	hsa-miR-1321	CLIP-seq
MIRT2355776	hsa-miR-135a	CLIP-seq
MIRT2355777	hsa-miR-135b	CLIP-seq
MIRT2355778	hsa-miR-150	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT2355781	hsa-miR-3120-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2355782	hsa-miR-3125	CLIP-seq
MIRT2355783	hsa-miR-3127-5p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT2134437	hsa-miR-3169	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT2355784	hsa-miR-3605-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT2355785	hsa-miR-3647-3p	CLIP-seq
MIRT2134441	hsa-miR-3664-3p	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2355786	hsa-miR-378g	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2355787	hsa-miR-3916	CLIP-seq
MIRT2355788	hsa-miR-3926	CLIP-seq
MIRT1449882	hsa-miR-3929	CLIP-seq
MIRT2355789	hsa-miR-410	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT2355790	hsa-miR-4270	CLIP-seq
MIRT1449887	hsa-miR-4419b	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT2355791	hsa-miR-4441	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT1449891	hsa-miR-4478	CLIP-seq
MIRT2355792	hsa-miR-4483	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT1449893	hsa-miR-4649-3p	CLIP-seq
MIRT2134449	hsa-miR-4695-5p	CLIP-seq
MIRT2355793	hsa-miR-4698	CLIP-seq
MIRT2134450	hsa-miR-4701-3p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2355794	hsa-miR-4739	CLIP-seq
MIRT2355795	hsa-miR-4756-5p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449900	hsa-miR-485-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2355796	hsa-miR-495	CLIP-seq
MIRT2134457	hsa-miR-510	CLIP-seq
MIRT2134458	hsa-miR-512-5p	CLIP-seq
MIRT2355797	hsa-miR-548s	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT2355798	hsa-miR-877	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT2396247	hsa-miR-2110	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2396248	hsa-miR-3150a-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2396249	hsa-miR-3175	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT2396250	hsa-miR-4259	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2396251	hsa-miR-4514	CLIP-seq
MIRT2396252	hsa-miR-4692	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2396253	hsa-miR-571	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2396254	hsa-miR-939	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2462208	hsa-miR-1267	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT2355778	hsa-miR-150	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT2462211	hsa-miR-3194-3p	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT2462213	hsa-miR-431	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2462214	hsa-miR-4423-5p	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462216	hsa-miR-4797-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT2462221	hsa-miR-924	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2462208	hsa-miR-1267	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT2649293	hsa-miR-186	CLIP-seq
MIRT2649294	hsa-miR-1915	CLIP-seq
MIRT2649295	hsa-miR-203	CLIP-seq
MIRT2649296	hsa-miR-214	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2649297	hsa-miR-3127-3p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT2649298	hsa-miR-3133	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT2649299	hsa-miR-3158-5p	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2649300	hsa-miR-3189-5p	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT2462211	hsa-miR-3194-3p	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2649301	hsa-miR-3619-5p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2649302	hsa-miR-371-5p	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2649303	hsa-miR-4274	CLIP-seq
MIRT2649304	hsa-miR-4291	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT2462213	hsa-miR-431	CLIP-seq
MIRT2134446	hsa-miR-4330	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT2462214	hsa-miR-4423-5p	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2649305	hsa-miR-4652-3p	CLIP-seq
MIRT2649306	hsa-miR-4672	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT2649307	hsa-miR-4726-3p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2649308	hsa-miR-4758-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT2462216	hsa-miR-4797-5p	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT2649309	hsa-miR-513a-3p	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2649310	hsa-miR-761	CLIP-seq
MIRT1449911	hsa-miR-767-5p	CLIP-seq
MIRT2649311	hsa-miR-922	CLIP-seq
MIRT2462221	hsa-miR-924	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq
MIRT1449857	hsa-miR-10a	CLIP-seq
MIRT1449858	hsa-miR-10b	CLIP-seq
MIRT2134431	hsa-miR-1227	CLIP-seq
MIRT2134432	hsa-miR-1228	CLIP-seq
MIRT2134434	hsa-miR-1268	CLIP-seq
MIRT2134435	hsa-miR-1268b	CLIP-seq
MIRT2355773	hsa-miR-1281	CLIP-seq
MIRT2462209	hsa-miR-129-5p	CLIP-seq
MIRT1449859	hsa-miR-1827	CLIP-seq
MIRT2649294	hsa-miR-1915	CLIP-seq
MIRT2649295	hsa-miR-203	CLIP-seq
MIRT2649296	hsa-miR-214	CLIP-seq
MIRT1449860	hsa-miR-2467-3p	CLIP-seq
MIRT1449861	hsa-miR-25	CLIP-seq
MIRT2355779	hsa-miR-26a	CLIP-seq
MIRT2355780	hsa-miR-26b	CLIP-seq
MIRT1449862	hsa-miR-28-5p	CLIP-seq
MIRT1449863	hsa-miR-3065-5p	CLIP-seq
MIRT1449864	hsa-miR-3122	CLIP-seq
MIRT2649297	hsa-miR-3127-3p	CLIP-seq
MIRT1449865	hsa-miR-3132	CLIP-seq
MIRT1449866	hsa-miR-3139	CLIP-seq
MIRT2462210	hsa-miR-3149	CLIP-seq
MIRT1449868	hsa-miR-3160-3p	CLIP-seq
MIRT1449869	hsa-miR-3168	CLIP-seq
MIRT2649300	hsa-miR-3189-5p	CLIP-seq
MIRT1449870	hsa-miR-3192	CLIP-seq
MIRT1449871	hsa-miR-32	CLIP-seq
MIRT1449872	hsa-miR-339-5p	CLIP-seq
MIRT1449874	hsa-miR-3612	CLIP-seq
MIRT2134439	hsa-miR-3613-3p	CLIP-seq
MIRT2649301	hsa-miR-3619-5p	CLIP-seq
MIRT1449875	hsa-miR-3622a-3p	CLIP-seq
MIRT2134440	hsa-miR-3622a-5p	CLIP-seq
MIRT1449876	hsa-miR-3622b-3p	CLIP-seq
MIRT1449877	hsa-miR-363	CLIP-seq
MIRT1449878	hsa-miR-367	CLIP-seq
MIRT1449879	hsa-miR-3689a-3p	CLIP-seq
MIRT1449880	hsa-miR-3689c	CLIP-seq
MIRT2649302	hsa-miR-371-5p	CLIP-seq
MIRT2134442	hsa-miR-371b-5p	CLIP-seq
MIRT1449881	hsa-miR-3913-5p	CLIP-seq
MIRT2462212	hsa-miR-411	CLIP-seq
MIRT1449883	hsa-miR-421	CLIP-seq
MIRT1449884	hsa-miR-4257	CLIP-seq
MIRT2134445	hsa-miR-4269	CLIP-seq
MIRT2649303	hsa-miR-4274	CLIP-seq
MIRT2649304	hsa-miR-4291	CLIP-seq
MIRT1449885	hsa-miR-4293	CLIP-seq
MIRT1449886	hsa-miR-4325	CLIP-seq
MIRT1449888	hsa-miR-4421	CLIP-seq
MIRT1449889	hsa-miR-4433	CLIP-seq
MIRT1449890	hsa-miR-4459	CLIP-seq
MIRT2134447	hsa-miR-4486	CLIP-seq
MIRT1449892	hsa-miR-4487	CLIP-seq
MIRT2649306	hsa-miR-4672	CLIP-seq
MIRT2462215	hsa-miR-4684-5p	CLIP-seq
MIRT2134451	hsa-miR-4715-3p	CLIP-seq
MIRT1449894	hsa-miR-4722-5p	CLIP-seq
MIRT2649307	hsa-miR-4726-3p	CLIP-seq
MIRT1449896	hsa-miR-4728-5p	CLIP-seq
MIRT2134452	hsa-miR-4735-5p	CLIP-seq
MIRT2649308	hsa-miR-4758-3p	CLIP-seq
MIRT1449897	hsa-miR-4768-3p	CLIP-seq
MIRT2134454	hsa-miR-4775	CLIP-seq
MIRT2134455	hsa-miR-4794	CLIP-seq
MIRT1449899	hsa-miR-4799-5p	CLIP-seq
MIRT2462217	hsa-miR-483-5p	CLIP-seq
MIRT1449901	hsa-miR-490-3p	CLIP-seq
MIRT1449903	hsa-miR-508-5p	CLIP-seq
MIRT1449906	hsa-miR-544b	CLIP-seq
MIRT2462218	hsa-miR-548c-3p	CLIP-seq
MIRT1449908	hsa-miR-558	CLIP-seq
MIRT2134459	hsa-miR-585	CLIP-seq
MIRT2462219	hsa-miR-590-3p	CLIP-seq
MIRT2462220	hsa-miR-593	CLIP-seq
MIRT1449909	hsa-miR-650	CLIP-seq
MIRT1449910	hsa-miR-708	CLIP-seq
MIRT2649310	hsa-miR-761	CLIP-seq
MIRT2649311	hsa-miR-922	CLIP-seq
MIRT1449913	hsa-miR-92a	CLIP-seq
MIRT1449914	hsa-miR-92b	CLIP-seq
MIRT1449915	hsa-miR-940	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
SP1	Unknown	20350137
SP3	Unknown	20350137

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8316220
GO:0006805	Process	Xenobiotic metabolic process	IDA	657528, 18484748
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0008119	Function	Thiopurine S-methyltransferase activity	IBA
GO:0008119	Function	Thiopurine S-methyltransferase activity	IDA	657528, 18484748
GO:0008119	Function	Thiopurine S-methyltransferase activity	IEA
GO:0008119	Function	Thiopurine S-methyltransferase activity	TAS	8316220
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0032259	Process	Methylation	TAS
GO:0042178	Process	Xenobiotic catabolic process	TAS
GO:1904047	Function	S-adenosyl-L-methionine binding	IDA	657528, 18484748

MIM	HGNC	e!Ensembl
187680	12014	ENSG00000137364

P51580

Protein name

Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)

Protein function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed

PDB

2BZG , 2H11

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05724	TPMT	24 → 245	Thiopurine S-methyltransferase (TPMT)	Family

Sequence

MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGK
SGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKV
FKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQY
LLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLY
LLTEK

Sequence length

245

Interactions

View interactions

	KEGG		Reactome
	Drug metabolism - other enzymes		Methylation Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Azathioprine response	drug response; Likely benign	rs56019966	RCV000133448
Chronic lymphocytic leukemia/small lymphocytic lymphoma	drug response	rs1800584	RCV005887486
Thiopurine response	drug response	rs201695576, rs753545734, rs1256618794, rs759836180	RCV000766278 RCV000766277 RCV000766276 RCV000766275
Thiopurine S-methyltransferase deficiency	drug response; Benign; Likely benign; other; Uncertain significance	rs1800462, rs1800460, rs1800584, rs1142345, rs56161402, rs74423290, rs886061256, rs886061266, rs542619563, rs528907381, rs186214874, rs543585967	RCV000013558 RCV000013561 RCV000013560 RCV000013562 RCV000013563 RCV000013564 RCV000310587 RCV000322656 RCV000397029 RCV000398409 RCV000282858 RCV000313781
TPMT-related disorder	drug response; Likely benign; Benign; other	rs56019966, rs1800460, rs760980416	RCV003965083 RCV003914876 RCV003952233

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alopecia	Associate	32372428
Anemia Iron Deficiency	Associate	24385893
Arthralgia	Associate	21961091
Autoimmune Diseases	Associate	15802809, 23377985, 26213853
Bone Marrow Diseases	Associate	23962279
Brain Neoplasms	Associate	19535798
Carcinoma Pancreatic Ductal	Inhibit	30055072
Colitis Ulcerative	Associate	27703193, 29491687, 30452647
Crohn Disease	Associate	27703193, 29206869, 29491687, 32372428
Cyclic neutropenia	Associate	10628931, 15349717, 28914446, 34425754
Death	Associate	32992962
Diabetes Mellitus	Associate	24385893
Dihydropyrimidine Dehydrogenase Deficiency	Associate	32973300
Drug Related Side Effects and Adverse Reactions	Associate	12949626, 15802809, 17617792, 22594254, 22846425, 25614061, 27452984, 30346660, 30452647, 30698675, 32973300, 33348915, 34412101, 35431360, 37857254, 39453028 View all (1 more)
Drug Related Side Effects and Adverse Reactions	Stimulate	33348915
Gastrointestinal Diseases	Associate	22846425
Hearing Loss	Associate	23588304
Heavy Chain Disease	Associate	34365011
Hematologic Diseases	Associate	10354134, 25441457, 32611418, 33958640, 36707393, 9384462
Hematologic Neoplasms	Associate	19034904, 8644731
Hemorrhage	Associate	17978158
Hepatic Veno Occlusive Disease	Associate	33714975
Hepatitis Autoimmune	Associate	33846471
Immune dysfunction with T cell inactivation due to calcium entry defect 2	Associate	27703193
Immune System Diseases	Associate	23407052
Infections	Associate	17617792, 28914446
Inflammatory Bowel Diseases	Associate	16543290, 18482735, 18827410, 23407052, 24142665, 24696613, 25048487, 26213853, 27307154, 28843236, 28914446, 29491687, 30698675, 34521801, 36344599
Leukemia	Associate	15802809, 18482735, 27564568, 30325120, 36344599, 7703493, 9763570
Leukemia Myeloid Acute	Associate	19535798, 23407052, 30325120, 9763570
Leukemia T Cell	Associate	23962279
Leukopenia	Associate	19223932, 24142665, 25108385, 25347948, 32054992, 34425754, 36707393
Lupus Erythematosus Systemic	Associate	16272700
Neoplasms	Associate	18987654, 19034904, 20037211, 29351371, 30055072, 7946931
Neutropenia	Associate	17617792, 20037211, 25347948, 32611418
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	18987654, 22594254, 23377985, 32611418, 32992962, 33958640, 35431360, 7703493, 9763570
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	23252716, 25940902, 30927276, 37248698
Renal Insufficiency	Associate	37239884
Scleroderma Systemic	Associate	37239884
Sepsis	Associate	19223932
Stomach Neoplasms	Associate	35421138
Thiopurine S methyltranferase deficiency	Associate	10997970, 23252704, 27307154, 30806694, 32973300, 8644731
Thiopurine S methyltranferase deficiency	Stimulate	19034904
Thiopurine S methyltranferase deficiency	Inhibit	23252704, 27307154, 7703493
Thrombocytopenia	Associate	25347948

TPMT (thiopurine S-methyltransferase)