Gene Gene information from NCBI Gene database.
Entrez ID 7171
Gene name Tropomyosin 4
Gene symbol TPM4
Synonyms (NCBI Gene)
BDPLT25HEL-S-108
Chromosome 19
Chromosome location 19p13.12-p13.11
Summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-
miRNA miRNA information provided by mirtarbase database.
1126
miRTarBase ID miRNA Experiments Reference
MIRT002782 hsa-miR-1-3p pSILAC 18668040
MIRT002782 hsa-miR-1-3p Microarray 15685193
MIRT002782 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT002782 hsa-miR-1-3p Proteomics 18668040
MIRT002782 hsa-miR-1-3p Microarray 15685193
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation HDA 16210410
GO:0001725 Component Stress fiber IDA 16236705
GO:0002102 Component Podosome IEA
GO:0003779 Function Actin binding IEA
GO:0005509 Function Calcium ion binding NAS 1836432
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600317 12013 ENSG00000167460
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P67936
Protein name Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
Protein function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by int
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00261 Tropomyosin 12 248 Tropomyosin Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy tha
Sequence
Sequence length 248
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Motor proteins
Cytoskeleton in muscle cells
Hypertrophic cardiomyopathy
Dilated cardiomyopathy
  Striated Muscle Contraction
Smooth Muscle Contraction
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
6
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Bleeding disorder, platelet-type, 25 Pathogenic rs752488156, rs2512689549, rs2090489083 RCV003324880
RCV003324881
RCV003324882
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Abnormal bleeding Uncertain significance rs1229151800 RCV001270581
Hereditary breast ovarian cancer syndrome Uncertain significance rs373696275 RCV001374499
Thrombocytopenia Uncertain significance rs1229151800 RCV001270581
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 36672180
Brain Diseases Associate 36672180
Breast Neoplasms Associate 23812729
Carcinogenesis Associate 17131471, 21119665
Carcinoma Ductal Breast Associate 23812729
Carcinoma Ductal Breast Inhibit 28431393
Carcinoma Hepatocellular Associate 32363617, 33390785, 34850589, 37328795
Carcinoma Renal Cell Associate 15953868
Cardiovascular Diseases Associate 27649540
Colonic Neoplasms Associate 34575979