Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7167
Gene name	Triosephosphate isomerase 1
Gene symbol	TPI1
Synonyms (NCBI Gene)	HEL-S-49TIMTPITPID
Chromosome	12
Chromosome location	12p13.31
Summary	This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121964845	G>C	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs121964846	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs121964847	T>C	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs121964848	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, 5 prime UTR variant, missense variant
rs121964849	A>G	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs121964850	G>T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs587777440	T>C	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs587777441	->G	Pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant, non coding transcript variant, upstream transcript variant
rs1565538350	G>A	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant

546

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000808	hsa-miR-15a-5p	proteomics analysis	18362358
MIRT000807	hsa-miR-16-5p	proteomics analysis	18362358
MIRT049943	hsa-miR-30a-5p	CLASH	23622248
MIRT047515	hsa-miR-10a-5p	CLASH	23622248
MIRT045713	hsa-miR-125a-5p	CLASH	23622248
MIRT044870	hsa-miR-195-5p	CLASH	23622248
MIRT044651	hsa-miR-320a	CLASH	23622248
MIRT043300	hsa-miR-331-3p	CLASH	23622248
MIRT043300	hsa-miR-331-3p	CLASH	23622248
MIRT041278	hsa-miR-193b-3p	CLASH	23622248
MIRT039754	hsa-miR-615-3p	CLASH	23622248
MIRT036219	hsa-miR-320b	CLASH	23622248
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT652249	hsa-miR-649	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT652248	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT652247	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT652246	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT652245	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT652244	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT462271	hsa-miR-4476	PAR-CLIP	23592263
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT462267	hsa-miR-7515	PAR-CLIP	23592263
MIRT462268	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT462266	hsa-miR-3202	PAR-CLIP	23592263
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT462264	hsa-miR-4736	PAR-CLIP	23592263
MIRT462262	hsa-miR-7150	PAR-CLIP	23592263
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462266	hsa-miR-3202	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462271	hsa-miR-4476	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462264	hsa-miR-4736	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462262	hsa-miR-7150	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462267	hsa-miR-7515	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT462268	hsa-miR-873-5p	PAR-CLIP	26701625
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT652249	hsa-miR-649	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT652248	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT652247	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT652246	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT652245	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT652244	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT612207	hsa-miR-4719	HITS-CLIP	23824327
MIRT612206	hsa-miR-578	HITS-CLIP	23824327
MIRT462271	hsa-miR-4476	PAR-CLIP	23592263
MIRT462270	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT462269	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT462267	hsa-miR-7515	PAR-CLIP	23592263
MIRT462268	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT462266	hsa-miR-3202	PAR-CLIP	23592263
MIRT462265	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT462263	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT462264	hsa-miR-4736	PAR-CLIP	23592263
MIRT462262	hsa-miR-7150	PAR-CLIP	23592263
MIRT1449306	hsa-miR-1193	CLIP-seq
MIRT1449307	hsa-miR-1237	CLIP-seq
MIRT1449308	hsa-miR-1245b-3p	CLIP-seq
MIRT1449309	hsa-miR-1255b	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449311	hsa-miR-1293	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449313	hsa-miR-1825	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT1449315	hsa-miR-199a-5p	CLIP-seq
MIRT1449316	hsa-miR-199b-5p	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449318	hsa-miR-22	CLIP-seq
MIRT1449319	hsa-miR-2392	CLIP-seq
MIRT1449320	hsa-miR-23a	CLIP-seq
MIRT1449321	hsa-miR-23b	CLIP-seq
MIRT1449322	hsa-miR-23c	CLIP-seq
MIRT1449323	hsa-miR-3126-3p	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449325	hsa-miR-3154	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT1449327	hsa-miR-3166	CLIP-seq
MIRT1449328	hsa-miR-3184	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT1449330	hsa-miR-3605-5p	CLIP-seq
MIRT1449331	hsa-miR-3613-3p	CLIP-seq
MIRT1449332	hsa-miR-3653	CLIP-seq
MIRT1449333	hsa-miR-3714	CLIP-seq
MIRT1449334	hsa-miR-371b-5p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449336	hsa-miR-423-5p	CLIP-seq
MIRT1449337	hsa-miR-425	CLIP-seq
MIRT1449338	hsa-miR-4281	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449340	hsa-miR-4297	CLIP-seq
MIRT1449341	hsa-miR-4303	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449344	hsa-miR-4426	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449347	hsa-miR-4483	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449350	hsa-miR-4493	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449353	hsa-miR-4528	CLIP-seq
MIRT1449354	hsa-miR-4531	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449356	hsa-miR-4647	CLIP-seq
MIRT1449357	hsa-miR-4649-3p	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449359	hsa-miR-4662b	CLIP-seq
MIRT1449360	hsa-miR-4672	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449363	hsa-miR-4699-5p	CLIP-seq
MIRT1449364	hsa-miR-4717-3p	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT1449366	hsa-miR-4757-5p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449368	hsa-miR-5095	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449370	hsa-miR-642a	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449372	hsa-miR-876-3p	CLIP-seq
MIRT1449373	hsa-miR-885-5p	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT2134388	hsa-miR-1224-3p	CLIP-seq
MIRT2134389	hsa-miR-1236	CLIP-seq
MIRT1449307	hsa-miR-1237	CLIP-seq
MIRT2134390	hsa-miR-1260	CLIP-seq
MIRT2134391	hsa-miR-1260b	CLIP-seq
MIRT2134392	hsa-miR-1280	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449311	hsa-miR-1293	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449320	hsa-miR-23a	CLIP-seq
MIRT1449321	hsa-miR-23b	CLIP-seq
MIRT1449322	hsa-miR-23c	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449325	hsa-miR-3154	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT1449328	hsa-miR-3184	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT1449332	hsa-miR-3653	CLIP-seq
MIRT2134393	hsa-miR-371-3p	CLIP-seq
MIRT2134394	hsa-miR-371b-3p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT2134395	hsa-miR-3938	CLIP-seq
MIRT1449336	hsa-miR-423-5p	CLIP-seq
MIRT1449338	hsa-miR-4281	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449340	hsa-miR-4297	CLIP-seq
MIRT1449341	hsa-miR-4303	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449347	hsa-miR-4483	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449353	hsa-miR-4528	CLIP-seq
MIRT1449354	hsa-miR-4531	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449357	hsa-miR-4649-3p	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449360	hsa-miR-4672	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449363	hsa-miR-4699-5p	CLIP-seq
MIRT1449364	hsa-miR-4717-3p	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT2134396	hsa-miR-4753-3p	CLIP-seq
MIRT2134397	hsa-miR-4755-3p	CLIP-seq
MIRT1449366	hsa-miR-4757-5p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449368	hsa-miR-5095	CLIP-seq
MIRT2134398	hsa-miR-515-3p	CLIP-seq
MIRT2134399	hsa-miR-519e	CLIP-seq
MIRT2134400	hsa-miR-605	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449370	hsa-miR-642a	CLIP-seq
MIRT2134401	hsa-miR-665	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449372	hsa-miR-876-3p	CLIP-seq
MIRT1449373	hsa-miR-885-5p	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT2134389	hsa-miR-1236	CLIP-seq
MIRT1449307	hsa-miR-1237	CLIP-seq
MIRT1449308	hsa-miR-1245b-3p	CLIP-seq
MIRT1449309	hsa-miR-1255b	CLIP-seq
MIRT1449311	hsa-miR-1293	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT2355666	hsa-miR-1913	CLIP-seq
MIRT1449320	hsa-miR-23a	CLIP-seq
MIRT1449321	hsa-miR-23b	CLIP-seq
MIRT1449322	hsa-miR-23c	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449325	hsa-miR-3154	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT2355667	hsa-miR-3182	CLIP-seq
MIRT1449328	hsa-miR-3184	CLIP-seq
MIRT2355668	hsa-miR-324-3p	CLIP-seq
MIRT1449332	hsa-miR-3653	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT2134395	hsa-miR-3938	CLIP-seq
MIRT1449336	hsa-miR-423-5p	CLIP-seq
MIRT1449337	hsa-miR-425	CLIP-seq
MIRT2355669	hsa-miR-4290	CLIP-seq
MIRT1449340	hsa-miR-4297	CLIP-seq
MIRT1449341	hsa-miR-4303	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449347	hsa-miR-4483	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449357	hsa-miR-4649-3p	CLIP-seq
MIRT1449360	hsa-miR-4672	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449363	hsa-miR-4699-5p	CLIP-seq
MIRT1449364	hsa-miR-4717-3p	CLIP-seq
MIRT2355670	hsa-miR-4727-5p	CLIP-seq
MIRT2134396	hsa-miR-4753-3p	CLIP-seq
MIRT1449366	hsa-miR-4757-5p	CLIP-seq
MIRT2355671	hsa-miR-4768-5p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449368	hsa-miR-5095	CLIP-seq
MIRT1449370	hsa-miR-642a	CLIP-seq
MIRT1449372	hsa-miR-876-3p	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT1449306	hsa-miR-1193	CLIP-seq
MIRT2134388	hsa-miR-1224-3p	CLIP-seq
MIRT2134389	hsa-miR-1236	CLIP-seq
MIRT1449307	hsa-miR-1237	CLIP-seq
MIRT2134390	hsa-miR-1260	CLIP-seq
MIRT2134391	hsa-miR-1260b	CLIP-seq
MIRT2134392	hsa-miR-1280	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449311	hsa-miR-1293	CLIP-seq
MIRT2649227	hsa-miR-1296	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT2355666	hsa-miR-1913	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449319	hsa-miR-2392	CLIP-seq
MIRT1449320	hsa-miR-23a	CLIP-seq
MIRT1449321	hsa-miR-23b	CLIP-seq
MIRT1449322	hsa-miR-23c	CLIP-seq
MIRT2649228	hsa-miR-3134	CLIP-seq
MIRT2649229	hsa-miR-3135	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449325	hsa-miR-3154	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT2355667	hsa-miR-3182	CLIP-seq
MIRT1449328	hsa-miR-3184	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT2355668	hsa-miR-324-3p	CLIP-seq
MIRT1449330	hsa-miR-3605-5p	CLIP-seq
MIRT1449332	hsa-miR-3653	CLIP-seq
MIRT2649230	hsa-miR-3675-5p	CLIP-seq
MIRT2134393	hsa-miR-371-3p	CLIP-seq
MIRT2134394	hsa-miR-371b-3p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT2134395	hsa-miR-3938	CLIP-seq
MIRT1449336	hsa-miR-423-5p	CLIP-seq
MIRT2355669	hsa-miR-4290	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449340	hsa-miR-4297	CLIP-seq
MIRT1449341	hsa-miR-4303	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449344	hsa-miR-4426	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449347	hsa-miR-4483	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT2649231	hsa-miR-4512	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449356	hsa-miR-4647	CLIP-seq
MIRT1449357	hsa-miR-4649-3p	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449359	hsa-miR-4662b	CLIP-seq
MIRT1449360	hsa-miR-4672	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449363	hsa-miR-4699-5p	CLIP-seq
MIRT1449364	hsa-miR-4717-3p	CLIP-seq
MIRT2355670	hsa-miR-4727-5p	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT2134396	hsa-miR-4753-3p	CLIP-seq
MIRT2134397	hsa-miR-4755-3p	CLIP-seq
MIRT1449366	hsa-miR-4757-5p	CLIP-seq
MIRT2355671	hsa-miR-4768-5p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449368	hsa-miR-5095	CLIP-seq
MIRT2134398	hsa-miR-515-3p	CLIP-seq
MIRT2134399	hsa-miR-519e	CLIP-seq
MIRT2134400	hsa-miR-605	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449370	hsa-miR-642a	CLIP-seq
MIRT2134401	hsa-miR-665	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449372	hsa-miR-876-3p	CLIP-seq
MIRT1449373	hsa-miR-885-5p	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq
MIRT1449306	hsa-miR-1193	CLIP-seq
MIRT2134388	hsa-miR-1224-3p	CLIP-seq
MIRT2134389	hsa-miR-1236	CLIP-seq
MIRT1449307	hsa-miR-1237	CLIP-seq
MIRT2134390	hsa-miR-1260	CLIP-seq
MIRT2134391	hsa-miR-1260b	CLIP-seq
MIRT2134392	hsa-miR-1280	CLIP-seq
MIRT1449310	hsa-miR-1285	CLIP-seq
MIRT1449311	hsa-miR-1293	CLIP-seq
MIRT2649227	hsa-miR-1296	CLIP-seq
MIRT1449312	hsa-miR-1587	CLIP-seq
MIRT1449314	hsa-miR-1909	CLIP-seq
MIRT2355666	hsa-miR-1913	CLIP-seq
MIRT1449317	hsa-miR-2114	CLIP-seq
MIRT1449319	hsa-miR-2392	CLIP-seq
MIRT1449320	hsa-miR-23a	CLIP-seq
MIRT1449321	hsa-miR-23b	CLIP-seq
MIRT1449322	hsa-miR-23c	CLIP-seq
MIRT2649228	hsa-miR-3134	CLIP-seq
MIRT2649229	hsa-miR-3135	CLIP-seq
MIRT1449324	hsa-miR-3153	CLIP-seq
MIRT1449325	hsa-miR-3154	CLIP-seq
MIRT1449326	hsa-miR-3157-5p	CLIP-seq
MIRT2355667	hsa-miR-3182	CLIP-seq
MIRT1449328	hsa-miR-3184	CLIP-seq
MIRT1449329	hsa-miR-3187-5p	CLIP-seq
MIRT2355668	hsa-miR-324-3p	CLIP-seq
MIRT1449330	hsa-miR-3605-5p	CLIP-seq
MIRT1449332	hsa-miR-3653	CLIP-seq
MIRT2649230	hsa-miR-3675-5p	CLIP-seq
MIRT2134393	hsa-miR-371-3p	CLIP-seq
MIRT2134394	hsa-miR-371b-3p	CLIP-seq
MIRT1449335	hsa-miR-378g	CLIP-seq
MIRT2134395	hsa-miR-3938	CLIP-seq
MIRT1449336	hsa-miR-423-5p	CLIP-seq
MIRT1449338	hsa-miR-4281	CLIP-seq
MIRT2355669	hsa-miR-4290	CLIP-seq
MIRT1449339	hsa-miR-4292	CLIP-seq
MIRT1449340	hsa-miR-4297	CLIP-seq
MIRT1449341	hsa-miR-4303	CLIP-seq
MIRT1449342	hsa-miR-4308	CLIP-seq
MIRT1449343	hsa-miR-4314	CLIP-seq
MIRT1449344	hsa-miR-4426	CLIP-seq
MIRT1449345	hsa-miR-4428	CLIP-seq
MIRT1449346	hsa-miR-4434	CLIP-seq
MIRT1449347	hsa-miR-4483	CLIP-seq
MIRT1449348	hsa-miR-4486	CLIP-seq
MIRT1449349	hsa-miR-4492	CLIP-seq
MIRT1449351	hsa-miR-4498	CLIP-seq
MIRT2649231	hsa-miR-4512	CLIP-seq
MIRT1449352	hsa-miR-4516	CLIP-seq
MIRT1449353	hsa-miR-4528	CLIP-seq
MIRT1449354	hsa-miR-4531	CLIP-seq
MIRT1449355	hsa-miR-4540	CLIP-seq
MIRT1449356	hsa-miR-4647	CLIP-seq
MIRT1449357	hsa-miR-4649-3p	CLIP-seq
MIRT1449358	hsa-miR-4656	CLIP-seq
MIRT1449359	hsa-miR-4662b	CLIP-seq
MIRT1449360	hsa-miR-4672	CLIP-seq
MIRT1449361	hsa-miR-4675	CLIP-seq
MIRT1449362	hsa-miR-4691-3p	CLIP-seq
MIRT1449363	hsa-miR-4699-5p	CLIP-seq
MIRT1449364	hsa-miR-4717-3p	CLIP-seq
MIRT2355670	hsa-miR-4727-5p	CLIP-seq
MIRT1449365	hsa-miR-4741	CLIP-seq
MIRT2134396	hsa-miR-4753-3p	CLIP-seq
MIRT2134397	hsa-miR-4755-3p	CLIP-seq
MIRT1449366	hsa-miR-4757-5p	CLIP-seq
MIRT2355671	hsa-miR-4768-5p	CLIP-seq
MIRT1449367	hsa-miR-4786-3p	CLIP-seq
MIRT1449368	hsa-miR-5095	CLIP-seq
MIRT2134398	hsa-miR-515-3p	CLIP-seq
MIRT2134399	hsa-miR-519e	CLIP-seq
MIRT2134400	hsa-miR-605	CLIP-seq
MIRT1449369	hsa-miR-612	CLIP-seq
MIRT1449370	hsa-miR-642a	CLIP-seq
MIRT2134401	hsa-miR-665	CLIP-seq
MIRT1449371	hsa-miR-762	CLIP-seq
MIRT1449372	hsa-miR-876-3p	CLIP-seq
MIRT1449373	hsa-miR-885-5p	CLIP-seq
MIRT1449374	hsa-miR-935	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004807	Function	Triose-phosphate isomerase activity	IBA
GO:0004807	Function	Triose-phosphate isomerase activity	IDA	18562316
GO:0004807	Function	Triose-phosphate isomerase activity	IEA
GO:0004807	Function	Triose-phosphate isomerase activity	NAS	2876430
GO:0004807	Function	Triose-phosphate isomerase activity	TAS	2579079
GO:0005515	Function	Protein binding	IPI	20849852, 21044950, 23355646, 32814053
GO:0005615	Component	Extracellular space	HDA	16502470, 22664934, 23580065
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006094	Process	Gluconeogenesis	IBA
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0008929	Function	Methylglyoxal synthase activity	IEA
GO:0008929	Function	Methylglyoxal synthase activity	ISS
GO:0016829	Function	Lyase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0019242	Process	Methylglyoxal biosynthetic process	ISS
GO:0019563	Process	Glycerol catabolic process	IBA
GO:0019682	Process	Glyceraldehyde-3-phosphate metabolic process	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19725078
GO:0042803	Function	Protein homodimerization activity	IDA	18562316
GO:0046166	Process	Glyceraldehyde-3-phosphate biosynthetic process	IBA
GO:0046166	Process	Glyceraldehyde-3-phosphate biosynthetic process	IDA	18562316
GO:0061621	Process	Canonical glycolysis	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
190450	12009	ENSG00000111669

P60174

Protein name

Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)

Protein function

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562

PDB

1HTI , 1KLG , 1KLU , 1WYI , 2IAM , 2IAN , 2JK2 , 2VOM , 4BR1 , 4E41 , 4POC , 4POD , 4UNK , 4UNL , 4ZVJ , 6C2G , 6D43 , 6NLH , 6UP1 , 6UP5 , 6UP8 , 6UPF , 7RDE , 7SX1 , 7T0Q , 7UXB , 7UXV , 9F69 , 9FFC

Family and domains

Pfam

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Accession	ID	Position in sequence	Description	Type
PF00121	TIM	44 → 282	Triosephosphate isomerase	Domain

Sequence

MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKI
AVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAE
GLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE
FVDIINAKQ

Sequence length

249

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Fructose and mannose metabolism Inositol phosphate metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids		Glycolysis Gluconeogenesis

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Triosephosphate isomerase deficiency	Pathogenic; Likely pathogenic	rs587777440, rs587777441, rs2138094606, rs121964845, rs121964848, rs121964849, rs121964850	RCV000123389 RCV000123390 RCV002272749 RCV000013284 RCV000013289 RCV000013290 RCV000013291 RCV003990811

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs115061797	RCV005893148
Clear cell carcinoma of kidney	Benign	rs115061797	RCV005893149
Ovarian serous cystadenocarcinoma	Benign	rs115061797	RCV005893151
Sarcoma	Benign	rs115061797	RCV005893150
Thymoma	Benign	rs115061797	RCV005893153
TPI1-related disorder	Uncertain significance; Likely benign; Benign	rs143000041, rs782014411, rs1337396876, rs370863694, rs141972556, rs61747602	RCV004758848 RCV003929605 RCV003971531 RCV003957609 RCV003967902 RCV004731054
TRIOSEPHOSPHATE ISOMERASE MANCHESTER	Uncertain significance	rs121964846	RCV000013285
Uterine carcinosarcoma	Benign	rs115061797	RCV005893152
Uterine corpus endometrial carcinoma	Benign	rs115061797	RCV005893154

Show/Hide Text Mining Associations (53)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Achalasia Addisonianism Alacrimia syndrome	Inhibit	22226179
Adenocarcinoma of Lung	Stimulate	35126788
Adenocarcinoma of Lung	Associate	35246510, 37335089, 38130074
Alzheimer Disease	Associate	18752637, 36809524
Anemia Hemolytic	Associate	2876430
Anemia Hemolytic Congenital	Inhibit	10556207
Anemia Hemolytic Congenital Nonspherocytic	Associate	8503454
Aortic Aneurysm Abdominal	Associate	22226179
Breast Neoplasms	Associate	16048908, 22664934
Carcinoma Hepatocellular	Associate	38134103
Cell Transformation Neoplastic	Associate	32802869
Colorectal Neoplasms	Associate	25206290, 32802869
Colorectal Neoplasms	Inhibit	31708650
Diabetes Mellitus Type 1	Associate	18840520
Diabetes Mellitus Type 2	Inhibit	35712251
Diarrhea	Stimulate	30392450
Gardner Syndrome	Associate	22554281
Genetic Diseases Inborn	Inhibit	2876430
Genital Neoplasms Female	Associate	23504277
Giardiasis	Associate	29502512
Glioma	Associate	34573317
Glyceraldehyde 3 phosphate dehydrogenase deficiency	Associate	8503454
Hypoalphalipoproteinemias	Associate	7816830
Hypoxia	Stimulate	27765905
Immunologic Deficiency Syndromes	Associate	6946452
Latent Autoimmune Diabetes in Adults	Associate	8503454
Lung Neoplasms	Associate	12644837, 35126788, 35246510
Lung Neoplasms	Stimulate	19116456
Lymphatic Metastasis	Associate	28489783
Lymphoma T Cell Peripheral	Associate	30291111
Melanoma	Associate	10049939
Metabolism Inborn Errors	Inhibit	11698297
Myasthenia Gravis	Associate	35802752
Nasopharyngeal Carcinoma	Associate	33102573
Neoplasm Metastasis	Associate	23504277, 35126788, 38130074
Neoplasms	Associate	10049939, 19407367, 28489783, 29629840, 32679775, 35126788, 35246510, 38130074, 39201484
Neoplasms	Stimulate	11254220
Neoplasms	Inhibit	23504277
Neuroblastoma	Associate	27765905
Neuromuscular Diseases	Associate	10556207, 2876430, 8503454
Osteoarthritis	Associate	15146421
Pierre Robin Syndrome	Associate	22554281
Prostatic Neoplasms	Associate	35242214
Prostatitis	Associate	11254220
Ribose 5 Phosphate Isomerase Deficiency	Associate	28341520, 34167376
Ribose 5 Phosphate Isomerase Deficiency	Inhibit	2876430, 7816830
Sarcoma Ewing	Associate	34233293
Squamous Cell Carcinoma of Head and Neck	Associate	38102653
Stomach Neoplasms	Associate	26911362, 28489783
Thymoma	Associate	35802752
Triosephosphate Isomerase Deficiency	Associate	10556207, 11698297, 35315486
Triosephosphate Isomerase Deficiency	Inhibit	11698297, 8503454
Uterine Cervical Neoplasms	Associate	23504277

TPI1 (triosephosphate isomerase 1)