Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	716
Gene name Gene Name - the full gene name approved by the HGNC.	Complement C1s
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	C1S
Synonyms (NCBI Gene) Gene synonyms aliases	EDSPD2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	EDSPD2
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in thi

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs121909582	C>T	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs886040974	TGT>-	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, inframe indel
rs886040975	T>C	Pathogenic-likely-pathogenic, pathogenic	Coding sequence variant, missense variant

Show/Hide all(207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018885	hsa-miR-335-5p	Microarray	18185580
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT609887	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT609887	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT609887	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	27418678
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	27418678
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	27418678
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	27418678
MIRT609889	hsa-miR-4435	HITS-CLIP	27418678
MIRT609889	hsa-miR-4435	HITS-CLIP	27418678
MIRT609889	hsa-miR-4435	HITS-CLIP	27418678
MIRT609889	hsa-miR-4435	HITS-CLIP	27418678
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	27418678
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	27418678
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	27418678
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	27418678
MIRT609892	hsa-miR-548s	HITS-CLIP	27418678
MIRT609892	hsa-miR-548s	HITS-CLIP	27418678
MIRT609892	hsa-miR-548s	HITS-CLIP	27418678
MIRT609892	hsa-miR-548s	HITS-CLIP	27418678
MIRT609890	hsa-miR-588	HITS-CLIP	27418678
MIRT609890	hsa-miR-588	HITS-CLIP	27418678
MIRT609890	hsa-miR-588	HITS-CLIP	27418678
MIRT609890	hsa-miR-588	HITS-CLIP	27418678
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT609892	hsa-miR-548s	HITS-CLIP	23824327
MIRT609891	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT609890	hsa-miR-588	HITS-CLIP	23824327
MIRT609889	hsa-miR-4435	HITS-CLIP	23824327
MIRT609888	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT609887	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT842575	hsa-miR-3189-5p	CLIP-seq
MIRT842576	hsa-miR-371b-3p	CLIP-seq
MIRT842577	hsa-miR-4758-3p	CLIP-seq
MIRT842578	hsa-miR-1276	CLIP-seq
MIRT842579	hsa-miR-3125	CLIP-seq
MIRT842580	hsa-miR-3916	CLIP-seq
MIRT842581	hsa-miR-4261	CLIP-seq
MIRT842582	hsa-miR-4311	CLIP-seq
MIRT842583	hsa-miR-4496	CLIP-seq
MIRT842584	hsa-miR-583	CLIP-seq
MIRT842585	hsa-miR-618	CLIP-seq
MIRT1545927	hsa-miR-548ag	CLIP-seq
MIRT1545928	hsa-miR-548ai	CLIP-seq
MIRT1545927	hsa-miR-548ag	CLIP-seq
MIRT1545928	hsa-miR-548ai	CLIP-seq
MIRT842578	hsa-miR-1276	CLIP-seq
MIRT2491652	hsa-miR-1283	CLIP-seq
MIRT2491653	hsa-miR-1297	CLIP-seq
MIRT2491654	hsa-miR-130a	CLIP-seq
MIRT2491655	hsa-miR-130b	CLIP-seq
MIRT2491656	hsa-miR-186	CLIP-seq
MIRT2491657	hsa-miR-188-5p	CLIP-seq
MIRT2491658	hsa-miR-26a	CLIP-seq
MIRT2491659	hsa-miR-26b	CLIP-seq
MIRT2491660	hsa-miR-301a	CLIP-seq
MIRT2491661	hsa-miR-301b	CLIP-seq
MIRT842579	hsa-miR-3125	CLIP-seq
MIRT842575	hsa-miR-3189-5p	CLIP-seq
MIRT2491662	hsa-miR-3190	CLIP-seq
MIRT2491663	hsa-miR-338-5p	CLIP-seq
MIRT2491664	hsa-miR-339-5p	CLIP-seq
MIRT2491665	hsa-miR-3666	CLIP-seq
MIRT842576	hsa-miR-371b-3p	CLIP-seq
MIRT842580	hsa-miR-3916	CLIP-seq
MIRT2491666	hsa-miR-4255	CLIP-seq
MIRT842581	hsa-miR-4261	CLIP-seq
MIRT2491667	hsa-miR-4295	CLIP-seq
MIRT842582	hsa-miR-4311	CLIP-seq
MIRT2491668	hsa-miR-4465	CLIP-seq
MIRT842583	hsa-miR-4496	CLIP-seq
MIRT2491669	hsa-miR-454	CLIP-seq
MIRT2491670	hsa-miR-4671-3p	CLIP-seq
MIRT2491671	hsa-miR-4694-3p	CLIP-seq
MIRT2491672	hsa-miR-4696	CLIP-seq
MIRT842577	hsa-miR-4758-3p	CLIP-seq
MIRT2491673	hsa-miR-522	CLIP-seq
MIRT1545927	hsa-miR-548ag	CLIP-seq
MIRT1545928	hsa-miR-548ai	CLIP-seq
MIRT2491674	hsa-miR-580	CLIP-seq
MIRT842584	hsa-miR-583	CLIP-seq
MIRT842578	hsa-miR-1276	CLIP-seq
MIRT2491652	hsa-miR-1283	CLIP-seq
MIRT2491653	hsa-miR-1297	CLIP-seq
MIRT2491654	hsa-miR-130a	CLIP-seq
MIRT2491655	hsa-miR-130b	CLIP-seq
MIRT2491656	hsa-miR-186	CLIP-seq
MIRT2491657	hsa-miR-188-5p	CLIP-seq
MIRT2491658	hsa-miR-26a	CLIP-seq
MIRT2491659	hsa-miR-26b	CLIP-seq
MIRT2491660	hsa-miR-301a	CLIP-seq
MIRT2491661	hsa-miR-301b	CLIP-seq
MIRT842579	hsa-miR-3125	CLIP-seq
MIRT2676788	hsa-miR-3153	CLIP-seq
MIRT842575	hsa-miR-3189-5p	CLIP-seq
MIRT2491662	hsa-miR-3190	CLIP-seq
MIRT2491663	hsa-miR-338-5p	CLIP-seq
MIRT2491664	hsa-miR-339-5p	CLIP-seq
MIRT2491665	hsa-miR-3666	CLIP-seq
MIRT842576	hsa-miR-371b-3p	CLIP-seq
MIRT842580	hsa-miR-3916	CLIP-seq
MIRT2491666	hsa-miR-4255	CLIP-seq
MIRT842581	hsa-miR-4261	CLIP-seq
MIRT2491667	hsa-miR-4295	CLIP-seq
MIRT842582	hsa-miR-4311	CLIP-seq
MIRT2491668	hsa-miR-4465	CLIP-seq
MIRT842583	hsa-miR-4496	CLIP-seq
MIRT2491669	hsa-miR-454	CLIP-seq
MIRT2491670	hsa-miR-4671-3p	CLIP-seq
MIRT2491671	hsa-miR-4694-3p	CLIP-seq
MIRT2491672	hsa-miR-4696	CLIP-seq
MIRT842577	hsa-miR-4758-3p	CLIP-seq
MIRT2491673	hsa-miR-522	CLIP-seq
MIRT1545927	hsa-miR-548ag	CLIP-seq
MIRT1545928	hsa-miR-548ai	CLIP-seq
MIRT2491674	hsa-miR-580	CLIP-seq
MIRT842584	hsa-miR-583	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IDA	11527969
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	2387866, 12788922, 17996945, 25910212, 28514442, 31749804, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006508	Process	Proteolysis	IEA
GO:0006956	Process	Complement activation	TAS
GO:0006958	Process	Complement activation, classical pathway	TAS
GO:0030449	Process	Regulation of complement activation	TAS
GO:0042802	Function	Identical protein binding	IPI	2387866, 12788922
GO:0045087	Process	Innate immune response	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
120580	1247	ENSG00000182326

Protein

UniProt ID

P09871

Protein name

Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain (Complement C1s subcomponent chain A); Complement C1s subcomponent light chain (Complement C1s subcompo

Protein function

Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive

PDB

1ELV , 1NZI , 4J1Y , 4LMF , 4LOR , 4LOS , 4LOT , 6F1C , 6F1H , 8GMN , 8TYP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00431	CUB	16 → 127	CUB domain	Domain
PF14670	FXa_inhibition	135 → 171		Domain
PF00431	CUB	175 → 287	CUB domain	Domain
PF00084	Sushi	294 → 354	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	359 → 421	Sushi repeat (SCR repeat)	Domain
PF00089	Trypsin	438 → 675	Trypsin	Domain

Sequence

MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIE
LSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF
TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF
VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTP
NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK
CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN
REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVK
MGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV
EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG
TYGLYTRVKNYVDWIMKTMQENSTPRED

Sequence length

688

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades Pertussis Staphylococcus aureus infection Coronavirus disease - COVID-19 Systemic lupus erythematosus		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade

Show/Hide Causal Diseases (9)

Disease term	Disease name	dbSNP ID	References
Causal
Angioedema	Hereditary Angioedema Type II, Hereditary Angioedema Types I and II, Hereditary Angioedema Type I	rs28940870, rs1554996819, rs1554996817, rs112565881, rs2135304804, rs121907951, rs281875174, rs281875178, rs281875168, rs281875170, rs281875171, rs1554995255, rs1554995860, rs886041353, rs978962357 View all (36 more)	3184114
Autoimmune diseases	Autoimmune Diseases	rs869025224	11390518
Complement component deficiency	Complement Component C1s Deficiency, Complement deficiency disease	rs387906509, rs1467298230, rs1022194067, rs774370086, rs121964922, rs372345940, rs121913052, rs121913053, rs460897, rs121913054, rs121913056, rs121913058, rs796052138, rs41286844, rs121909592 View all (29 more)	20727163
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778
Ehlers-danlos syndrome	Ehlers-Danlos Syndrome, Type VIII	rs121917817, rs121917818, rs28937869, rs764070148, rs144556766, rs121913550, rs121913552, rs80338764, rs121912933, rs786205103, rs786205104, rs121912930, rs397509369, rs113485686, rs121912914 View all (490 more)	27745832
Periodontal ehlers-danlos syndrome	EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2	rs886040974, rs886040975, rs1057518645, rs760277934, rs769707492, rs1057515579, rs1057518646, rs1057518643, rs1057519026, rs1057519025, rs1057519580, rs1057519579, rs1057519578, rs1057519577, rs1057519576, rs1060499554 View all (1 more)	28306225, 27745832
Immunodeficiency	Immunodeficiency due to a classical component pathway complement deficiency	rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs121918314, rs587776713, rs137852678, rs587776714, rs128620188, rs2147483647, rs1569556522, rs137853331, rs137853332, rs179363866 View all (256 more)
Periodontal ehlers-danlos syndrome	Periodontal Ehlers-Danlos syndrome	rs886040974, rs886040975, rs1057518645, rs760277934, rs769707492, rs1057515579, rs1057518646, rs1057518643, rs1057519026, rs1057519025, rs1057519580, rs1057519579, rs1057519578, rs1057519577, rs1057519576, rs1060499554 View all (1 more)
Periodontitis	Periodontitis	rs28937571, rs104894211, rs587777534

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Ehlers-Danlos Syndrome	Ehlers-Danlos syndrome, periodontal type 1, Ehlers-Danlos syndrome, periodontal type 2, Ehlers-Danlos syndrome, periodontitis type			GenCC

Show/Hide Text Mining Associations (41)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	26950848, 40037332
Angioedemas Hereditary	Associate	2026621, 3965500
Bipolar Disorder	Associate	39616737
Blood Coagulation Disorders	Associate	27613243
Carcinoma Squamous Cell	Associate	31049937
Chronic Disease	Associate	35218958
Complement Component C1s Deficiency	Associate	11390518
Complement Component C1s Deficiency	Inhibit	37209807
Coronary Artery Disease	Associate	38049831
Dystonic Disorders	Associate	31049937
Ehlers Danlos Syndrome	Associate	31921203
Ehlers Danlos syndrome type 3	Associate	31749804
Ehlers Danlos Syndrome Type VIII	Associate	27745832, 31749804, 31921203, 36960056
Emphysema	Associate	33535173
Endometriosis	Associate	11779588
Epidermolysis Bullosa Dystrophica	Associate	31049937
Epilepsy	Associate	26742644
Frontotemporal Dementia	Associate	32792518
Glioblastoma	Associate	34180136, 39179711
Glioma	Associate	39179711
Hashimoto Disease	Associate	37209807
Histiocytic Necrotizing Lymphadenitis	Associate	37209807
Inflammation	Associate	2478540, 29545349, 36596079, 39616737
Keratosis Actinic	Inhibit	31049937
Leukemia Lymphocytic Chronic B Cell	Associate	35501457
Lupus Erythematosus Systemic	Associate	30707351, 35964089, 37209807
Lymphatic Metastasis	Associate	33658651
Lymphoma Non Hodgkin	Associate	27745832
Macular Degeneration	Associate	37099020
Multiple Sclerosis	Associate	37406976
Muscular Dystrophy Duchenne	Associate	36596079
Musculoskeletal Diseases	Associate	27745832
Neoplasms	Associate	31049937, 31881847, 39179711
Neoplasms Squamous Cell	Associate	31049937
Ovarian Neoplasms	Associate	20969748
Periodontitis	Associate	31921203
Pulmonary Disease Chronic Obstructive	Associate	33535173
Schizophrenia	Associate	39616737
Thromboembolism	Associate	29166502
Thyroiditis Autoimmune	Associate	37209807
Venous Thromboembolism	Associate	39179711

C1S (complement C1s)