Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7155
Gene name	DNA topoisomerase II beta
Gene symbol	TOP2B
Synonyms (NCBI Gene)	BILUTOPIIBtop2beta
Chromosome	3
Chromosome location	3p24.2
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional str

Show/Hide all (1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs886039770	G>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant

145

Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029687	hsa-miR-26b-5p	Microarray	19088304
MIRT708527	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT708526	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT708525	hsa-miR-1248	HITS-CLIP	19536157
MIRT708524	hsa-miR-1290	HITS-CLIP	19536157
MIRT708523	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT708522	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT708521	hsa-miR-450b-3p	HITS-CLIP	19536157
MIRT708520	hsa-miR-769-3p	HITS-CLIP	19536157
MIRT708519	hsa-miR-6728-5p	HITS-CLIP	19536157
MIRT708518	hsa-miR-5089-5p	HITS-CLIP	19536157
MIRT708517	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT708516	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT708527	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT708526	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT708525	hsa-miR-1248	HITS-CLIP	19536157
MIRT708524	hsa-miR-1290	HITS-CLIP	19536157
MIRT708523	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT708522	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT708521	hsa-miR-450b-3p	HITS-CLIP	19536157
MIRT708520	hsa-miR-769-3p	HITS-CLIP	19536157
MIRT708519	hsa-miR-6728-5p	HITS-CLIP	19536157
MIRT708518	hsa-miR-5089-5p	HITS-CLIP	19536157
MIRT708517	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT708516	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT756214	hsa-miR-9-3p	Luciferase reporter assayWestern blottingqRT-PCR	36410793
MIRT756215	hsa-miR-9-5p	Luciferase reporter assayWestern blottingqRT-PCR	36410793
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447277	hsa-miR-140-3p	CLIP-seq
MIRT1447278	hsa-miR-1537	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447286	hsa-miR-4251	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447288	hsa-miR-4329	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447292	hsa-miR-4698	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447299	hsa-miR-548ac	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447301	hsa-miR-548d-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447305	hsa-miR-548z	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447277	hsa-miR-140-3p	CLIP-seq
MIRT1447278	hsa-miR-1537	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT1447299	hsa-miR-548ac	CLIP-seq
MIRT1447301	hsa-miR-548d-3p	CLIP-seq
MIRT1447305	hsa-miR-548z	CLIP-seq
MIRT1447272	hsa-miR-101	CLIP-seq
MIRT1447275	hsa-miR-1283	CLIP-seq
MIRT1447276	hsa-miR-1324	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT2354872	hsa-miR-3137	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT2354873	hsa-miR-3613-3p	CLIP-seq
MIRT1447287	hsa-miR-4275	CLIP-seq
MIRT1447290	hsa-miR-4645-3p	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT2354874	hsa-miR-4703-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447296	hsa-miR-499-3p	CLIP-seq
MIRT1447297	hsa-miR-499a-3p	CLIP-seq
MIRT2354875	hsa-miR-513a-3p	CLIP-seq
MIRT2354876	hsa-miR-579	CLIP-seq
MIRT2354877	hsa-miR-607	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447279	hsa-miR-23a	CLIP-seq
MIRT1447280	hsa-miR-23b	CLIP-seq
MIRT1447281	hsa-miR-23c	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT2648628	hsa-miR-2113	CLIP-seq
MIRT2648629	hsa-miR-218	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT2648630	hsa-miR-653	CLIP-seq
MIRT2648631	hsa-miR-9	CLIP-seq
MIRT1447273	hsa-miR-1253	CLIP-seq
MIRT1447274	hsa-miR-1276	CLIP-seq
MIRT1447282	hsa-miR-297	CLIP-seq
MIRT1447283	hsa-miR-3145-3p	CLIP-seq
MIRT1447284	hsa-miR-3177-3p	CLIP-seq
MIRT1447285	hsa-miR-3919	CLIP-seq
MIRT1447289	hsa-miR-4511	CLIP-seq
MIRT1447291	hsa-miR-4668-3p	CLIP-seq
MIRT1447293	hsa-miR-4731-3p	CLIP-seq
MIRT1447294	hsa-miR-4796-5p	CLIP-seq
MIRT1447295	hsa-miR-4801	CLIP-seq
MIRT1447298	hsa-miR-548a-3p	CLIP-seq
MIRT1447300	hsa-miR-548b-3p	CLIP-seq
MIRT1447302	hsa-miR-548e	CLIP-seq
MIRT1447303	hsa-miR-548f	CLIP-seq
MIRT1447304	hsa-miR-548g	CLIP-seq
MIRT1447306	hsa-miR-567	CLIP-seq
MIRT2648630	hsa-miR-653	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000712	Process	Resolution of meiotic recombination intermediates	IBA
GO:0000792	Component	Heterochromatin	IDA	9049244
GO:0000819	Process	Sister chromatid segregation	IBA
GO:0001764	Process	Neuron migration	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	9049244
GO:0003682	Function	Chromatin binding	IEA
GO:0003916	Function	DNA topoisomerase activity	IEA
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IBA
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	10684600
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IMP	31409799, 32128574
GO:0005515	Function	Protein binding	IPI	10473615, 10666337, 11062478, 11136718, 16611985, 17567603, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9049244, 9155056, 17567603
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	9049244
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	9049244
GO:0005730	Component	Nucleolus	IDA	8299728, 9155056
GO:0005829	Component	Cytosol	IDA	9049244
GO:0006259	Process	DNA metabolic process	IEA
GO:0006265	Process	DNA topological change	IDA	10684600
GO:0006265	Process	DNA topological change	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0030183	Process	B cell differentiation	IMP	31409799, 32128574
GO:0030900	Process	Forebrain development	IEA
GO:0043021	Function	Ribonucleoprotein complex binding	IEA
GO:0045870	Process	Positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	IEA
GO:0045870	Process	Positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP	16712776
GO:0046872	Function	Metal ion binding	IEA
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071318	Process	Cellular response to ATP	IEA
GO:0090398	Process	Cellular senescence	IEA
GO:1990904	Component	Ribonucleoprotein complex	ISS
GO:2001034	Process	Positive regulation of double-strand break repair via nonhomologous end joining	IEA

MIM	HGNC	e!Ensembl
126431	11990	ENSG00000077097

Q02880

Protein name

DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

Protein function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Pl

PDB

3QX3 , 4G0U , 4G0V , 4G0W , 4J3N , 5GWI , 5GWJ , 5ZAD , 5ZEN , 5ZQF , 5ZRF , 7QFN , 7QFO , 7YQ8 , 7ZBG , 8KE7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02518	HATPase_c	97 → 246	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
PF00204	DNA_gyraseB	287 → 451	DNA gyrase B	Domain
PF01751	Toprim	477 → 592	Toprim domain	Family
PF16898	TOPRIM_C	594 → 732	C-terminal associated domain of TOPRIM	Family
PF00521	DNA_topoisoIV	734 → 1190	DNA gyrase/topoisomerase IV, subunit A	Family
PF08070	DTHCT	1508 → 1610	DTHCT (NUC029) region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma,

Sequence

MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSG
PDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVE
SQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKK
KKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTS
SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD
DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK
SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS
SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV
DFAMFN

Sequence length

1626

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance		SUMOylation of DNA replication proteins

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autism spectrum disorder	Pathogenic	rs886039770	RCV000256202
B-cell immunodeficiency, distal limb anomalies, and urogenital malformations	Pathogenic	rs2125376009, rs2125377904, rs2125377898	RCV001775185 RCV001775186 RCV001775188

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs1703159290	RCV005921077
Cervical cancer	Likely benign	rs568934329	RCV005912914
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Likely benign	rs56986587	RCV005867018
Colon adenocarcinoma	Benign; Likely benign	rs377277487, rs56986587	RCV005867124 RCV005869730
Familial cancer of breast	Likely benign	rs1703159290	RCV005921076
Familial pancreatic carcinoma	Likely benign	rs56986587	RCV005867017
Gastric cancer	Likely benign	rs1179455501	RCV005921144
Lung cancer	Uncertain significance	rs758347808	RCV005924026
Malignant tumor of esophagus	Likely benign	rs1703159290	RCV005921078
Neurodevelopmental disorder	Uncertain significance	rs1266305512	RCV003389163
Nonpapillary renal cell carcinoma	Likely benign	rs56986587	RCV005867015
Ovarian cancer	Likely benign	rs56986587	RCV005867016
Ovarian serous cystadenocarcinoma	Likely benign	rs1703159290	RCV005921080
Sarcoma	Likely benign; Uncertain significance	rs568934329, rs1703159290, rs753537537	RCV005912915 RCV005921079 RCV005928330
See cases	Uncertain significance	rs2125351347, rs2125385266	RCV001731178 RCV001784136
TOP2B-related disorder	Likely benign; Benign; Uncertain significance; Conflicting classifications of pathogenicity	rs56986587, rs777837072, rs2125345556, rs114586748, rs370757931, rs370638500, rs760755554, rs773139821, rs375477555, rs2470335206, rs368895676, rs1200820514, rs368409004, rs187350468	RCV003938723 RCV003973225 RCV003973281 RCV003920979 RCV003980419 RCV003938855 RCV003921077 RCV003921169 RCV003966128 RCV003418329 RCV003968680 RCV003951304 RCV003913772 RCV003911220 RCV003923447 RCV003971052 RCV003951176 RCV004753650 RCV003391312 RCV003408454 RCV003397819 RCV003956631 RCV003901401 RCV003971518 RCV003918842
TOP2B-related neurodevelopmental disorder	Uncertain significance	rs774627996	RCV002275577
Uterine corpus endometrial carcinoma	Likely benign	rs568934329	RCV005912916

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Stimulate	28355294
Adenomatous Polyposis Coli	Associate	31663907
Astrocytoma	Associate	36503484
Autism Spectrum Disorder	Associate	31953910, 36450898
Autistic Disorder	Associate	26612825
Carcinoma Hepatocellular	Associate	15526362
Carcinoma Non Small Cell Lung	Associate	28355294, 9765623
Carcinoma Ovarian Epithelial	Associate	25846551
Carcinoma Renal Cell	Associate	34784933
Cardiotoxicity	Associate	26237429, 27142468, 31399497
Cell Transformation Viral	Associate	27974636
Chromosome Xp11.3 Deletion Syndrome	Associate	34784933
Colorectal Neoplasms	Associate	25009397, 37453058
Developmental Disabilities	Associate	31953910
Drug Related Side Effects and Adverse Reactions	Associate	12105221, 26237429, 34576262
Inflammation	Associate	32218491
Leukemia	Associate	22894901, 38508753
Leukemia Biphenotypic Acute	Associate	22615413
Leukemia Myeloid Acute	Associate	10233413, 23696245, 32218491, 7904487
Leukemia Promyelocytic Acute	Associate	18212063
Lung Neoplasms	Associate	10879730, 8398710
Multiple Myeloma	Associate	33375771
Neoplasms	Associate	10879730, 15526362, 16807458, 18596031, 37406101, 7797575, 8664122, 9155056
Neuroblastoma	Associate	20886683, 35831557
Neurodegenerative Diseases	Associate	29695291
Ovarian Neoplasms	Associate	10070864, 21542140
Pathological Conditions Anatomical	Associate	26612825
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22627319
Prostatic Intraepithelial Neoplasia	Associate	20601956
Prostatic Neoplasms	Associate	20601956, 28055971
Schizophrenia	Associate	26612825
Small Cell Lung Carcinoma	Associate	8980384
Translocation Genetic	Associate	22894901

TOP2B (DNA topoisomerase II beta)