Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7153
Gene name Gene Name - the full gene name approved by the HGNC.	DNA topoisomerase II alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TOP2A
Synonyms (NCBI Gene) Gene synonyms aliases	TOP2, TOP2alpha, TOPIIA, TP2A
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional str

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SNP ID	Visualize variation	Clinical significance	Consequence
rs140672916	C>T	Conflicting-interpretations-of-pathogenicity	Intron variant

Show/Hide all(229)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016473	hsa-miR-193b-3p	Microarray	20304954
MIRT030914	hsa-miR-21-5p	Microarray	18591254
MIRT047766	hsa-miR-7-5p	CLASH	23622248
MIRT045191	hsa-miR-186-5p	CLASH	23622248
MIRT037756	hsa-miR-708-5p	CLASH	23622248
MIRT036474	hsa-miR-1226-3p	CLASH	23622248
MIRT690907	hsa-miR-561-3p	HITS-CLIP	23313552
MIRT690906	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT690905	hsa-miR-5688	HITS-CLIP	23313552
MIRT690904	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT690903	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT690902	hsa-miR-4524b-3p	HITS-CLIP	23313552
MIRT690901	hsa-miR-3668	HITS-CLIP	23313552
MIRT690900	hsa-miR-520d-5p	HITS-CLIP	23313552
MIRT690899	hsa-miR-524-5p	HITS-CLIP	23313552
MIRT690898	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT439403	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439402	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439403	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439402	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT690907	hsa-miR-561-3p	HITS-CLIP	23313552
MIRT690906	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT690905	hsa-miR-5688	HITS-CLIP	23313552
MIRT690904	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT690903	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT690902	hsa-miR-4524b-3p	HITS-CLIP	23313552
MIRT690901	hsa-miR-3668	HITS-CLIP	23313552
MIRT690900	hsa-miR-520d-5p	HITS-CLIP	23313552
MIRT690899	hsa-miR-524-5p	HITS-CLIP	23313552
MIRT690898	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT755819	miR-139-5p	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR, Immunoprecipitaion (IP), Immunohistochemistry (IHC), ChIP-seq	38008711
MIRT756018	hsa-miR-30c-2-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC)	37818158
MIRT1447187	hsa-miR-1253	CLIP-seq
MIRT1447188	hsa-miR-1271	CLIP-seq
MIRT1447189	hsa-miR-1273f	CLIP-seq
MIRT1447190	hsa-miR-1323	CLIP-seq
MIRT1447191	hsa-miR-139-5p	CLIP-seq
MIRT1447192	hsa-miR-143	CLIP-seq
MIRT1447193	hsa-miR-144	CLIP-seq
MIRT1447194	hsa-miR-1587	CLIP-seq
MIRT1447195	hsa-miR-186	CLIP-seq
MIRT1447196	hsa-miR-224	CLIP-seq
MIRT1447197	hsa-miR-2355-5p	CLIP-seq
MIRT1447198	hsa-miR-2964a-5p	CLIP-seq
MIRT1447199	hsa-miR-3117-5p	CLIP-seq
MIRT1447200	hsa-miR-3133	CLIP-seq
MIRT1447201	hsa-miR-3143	CLIP-seq
MIRT1447202	hsa-miR-3161	CLIP-seq
MIRT1447203	hsa-miR-3163	CLIP-seq
MIRT1447204	hsa-miR-3173-3p	CLIP-seq
MIRT1447205	hsa-miR-323-3p	CLIP-seq
MIRT1447206	hsa-miR-330-3p	CLIP-seq
MIRT1447207	hsa-miR-340	CLIP-seq
MIRT1447208	hsa-miR-3614-5p	CLIP-seq
MIRT1447209	hsa-miR-365	CLIP-seq
MIRT1447210	hsa-miR-3659	CLIP-seq
MIRT1447211	hsa-miR-3673	CLIP-seq
MIRT1447212	hsa-miR-3682-5p	CLIP-seq
MIRT1447213	hsa-miR-371b-5p	CLIP-seq
MIRT1447214	hsa-miR-377	CLIP-seq
MIRT1447215	hsa-miR-3919	CLIP-seq
MIRT1447216	hsa-miR-3929	CLIP-seq
MIRT1447217	hsa-miR-410	CLIP-seq
MIRT1447218	hsa-miR-411	CLIP-seq
MIRT1447219	hsa-miR-4257	CLIP-seq
MIRT1447220	hsa-miR-4280	CLIP-seq
MIRT1447221	hsa-miR-431	CLIP-seq
MIRT1447222	hsa-miR-4419b	CLIP-seq
MIRT1447223	hsa-miR-4478	CLIP-seq
MIRT1447224	hsa-miR-4511	CLIP-seq
MIRT1447225	hsa-miR-4641	CLIP-seq
MIRT1447226	hsa-miR-4645-3p	CLIP-seq
MIRT1447227	hsa-miR-4658	CLIP-seq
MIRT1447228	hsa-miR-4662a-3p	CLIP-seq
MIRT1447229	hsa-miR-4670-3p	CLIP-seq
MIRT1447230	hsa-miR-4674	CLIP-seq
MIRT1447231	hsa-miR-4699-3p	CLIP-seq
MIRT1447232	hsa-miR-4708-5p	CLIP-seq
MIRT1447233	hsa-miR-4724-5p	CLIP-seq
MIRT1447234	hsa-miR-4744	CLIP-seq
MIRT1447235	hsa-miR-4766-5p	CLIP-seq
MIRT1447236	hsa-miR-4770	CLIP-seq
MIRT1447237	hsa-miR-4771	CLIP-seq
MIRT1447238	hsa-miR-4789-3p	CLIP-seq
MIRT1447239	hsa-miR-485-5p	CLIP-seq
MIRT1447240	hsa-miR-543	CLIP-seq
MIRT1447241	hsa-miR-548a-5p	CLIP-seq
MIRT1447242	hsa-miR-548aa	CLIP-seq
MIRT1447243	hsa-miR-548ab	CLIP-seq
MIRT1447244	hsa-miR-548ac	CLIP-seq
MIRT1447245	hsa-miR-548ae	CLIP-seq
MIRT1447246	hsa-miR-548aj	CLIP-seq
MIRT1447247	hsa-miR-548ak	CLIP-seq
MIRT1447248	hsa-miR-548am	CLIP-seq
MIRT1447249	hsa-miR-548b-5p	CLIP-seq
MIRT1447250	hsa-miR-548c-3p	CLIP-seq
MIRT1447251	hsa-miR-548c-5p	CLIP-seq
MIRT1447252	hsa-miR-548d-3p	CLIP-seq
MIRT1447253	hsa-miR-548d-5p	CLIP-seq
MIRT1447254	hsa-miR-548h	CLIP-seq
MIRT1447255	hsa-miR-548i	CLIP-seq
MIRT1447256	hsa-miR-548j	CLIP-seq
MIRT1447257	hsa-miR-548k	CLIP-seq
MIRT1447258	hsa-miR-548l	CLIP-seq
MIRT1447259	hsa-miR-548o	CLIP-seq
MIRT1447260	hsa-miR-548w	CLIP-seq
MIRT1447261	hsa-miR-548x	CLIP-seq
MIRT1447262	hsa-miR-548y	CLIP-seq
MIRT1447263	hsa-miR-548z	CLIP-seq
MIRT1447264	hsa-miR-559	CLIP-seq
MIRT1447265	hsa-miR-570	CLIP-seq
MIRT1447266	hsa-miR-574-5p	CLIP-seq
MIRT1447267	hsa-miR-582-5p	CLIP-seq
MIRT1447268	hsa-miR-635	CLIP-seq
MIRT1447269	hsa-miR-643	CLIP-seq
MIRT1447270	hsa-miR-888	CLIP-seq
MIRT1447271	hsa-miR-96	CLIP-seq
MIRT2133700	hsa-miR-1193	CLIP-seq
MIRT2133701	hsa-miR-1245	CLIP-seq
MIRT1447188	hsa-miR-1271	CLIP-seq
MIRT1447194	hsa-miR-1587	CLIP-seq
MIRT1447195	hsa-miR-186	CLIP-seq
MIRT2133702	hsa-miR-1910	CLIP-seq
MIRT2133703	hsa-miR-21	CLIP-seq
MIRT1447196	hsa-miR-224	CLIP-seq
MIRT2133704	hsa-miR-2276	CLIP-seq
MIRT2133705	hsa-miR-28-3p	CLIP-seq
MIRT1447200	hsa-miR-3133	CLIP-seq
MIRT1447201	hsa-miR-3143	CLIP-seq
MIRT2133706	hsa-miR-3182	CLIP-seq
MIRT1447205	hsa-miR-323-3p	CLIP-seq
MIRT2133707	hsa-miR-3616-5p	CLIP-seq
MIRT2133708	hsa-miR-3647-5p	CLIP-seq
MIRT1447210	hsa-miR-3659	CLIP-seq
MIRT2133709	hsa-miR-3681	CLIP-seq
MIRT2133710	hsa-miR-3691-5p	CLIP-seq
MIRT1447214	hsa-miR-377	CLIP-seq
MIRT2133711	hsa-miR-3909	CLIP-seq
MIRT1447216	hsa-miR-3929	CLIP-seq
MIRT2133712	hsa-miR-409-3p	CLIP-seq
MIRT1447217	hsa-miR-410	CLIP-seq
MIRT1447218	hsa-miR-411	CLIP-seq
MIRT1447220	hsa-miR-4280	CLIP-seq
MIRT1447222	hsa-miR-4419b	CLIP-seq
MIRT2133713	hsa-miR-4460	CLIP-seq
MIRT1447223	hsa-miR-4478	CLIP-seq
MIRT2133714	hsa-miR-4646-3p	CLIP-seq
MIRT1447227	hsa-miR-4658	CLIP-seq
MIRT1447228	hsa-miR-4662a-3p	CLIP-seq
MIRT1447229	hsa-miR-4670-3p	CLIP-seq
MIRT1447230	hsa-miR-4674	CLIP-seq
MIRT2133715	hsa-miR-4727-3p	CLIP-seq
MIRT2133716	hsa-miR-4753-3p	CLIP-seq
MIRT2133717	hsa-miR-4768-5p	CLIP-seq
MIRT2133718	hsa-miR-4772-3p	CLIP-seq
MIRT1447238	hsa-miR-4789-3p	CLIP-seq
MIRT2133719	hsa-miR-4795-5p	CLIP-seq
MIRT1447239	hsa-miR-485-5p	CLIP-seq
MIRT1447240	hsa-miR-543	CLIP-seq
MIRT2133720	hsa-miR-544	CLIP-seq
MIRT1447242	hsa-miR-548aa	CLIP-seq
MIRT1447245	hsa-miR-548ae	CLIP-seq
MIRT1447246	hsa-miR-548aj	CLIP-seq
MIRT1447248	hsa-miR-548am	CLIP-seq
MIRT1447261	hsa-miR-548x	CLIP-seq
MIRT2133721	hsa-miR-573	CLIP-seq
MIRT1447266	hsa-miR-574-5p	CLIP-seq
MIRT2133722	hsa-miR-590-5p	CLIP-seq
MIRT2133723	hsa-miR-603	CLIP-seq
MIRT1447268	hsa-miR-635	CLIP-seq
MIRT1447270	hsa-miR-888	CLIP-seq
MIRT2133724	hsa-miR-9	CLIP-seq
MIRT2133725	hsa-miR-924	CLIP-seq
MIRT1447271	hsa-miR-96	CLIP-seq
MIRT2354862	hsa-miR-105	CLIP-seq
MIRT2354863	hsa-miR-1298	CLIP-seq
MIRT1447193	hsa-miR-144	CLIP-seq
MIRT1447194	hsa-miR-1587	CLIP-seq
MIRT2354864	hsa-miR-1827	CLIP-seq
MIRT1447195	hsa-miR-186	CLIP-seq
MIRT1447198	hsa-miR-2964a-5p	CLIP-seq
MIRT1447200	hsa-miR-3133	CLIP-seq
MIRT1447201	hsa-miR-3143	CLIP-seq
MIRT1447203	hsa-miR-3163	CLIP-seq
MIRT1447207	hsa-miR-340	CLIP-seq
MIRT2354865	hsa-miR-34b	CLIP-seq
MIRT1447208	hsa-miR-3614-5p	CLIP-seq
MIRT1447210	hsa-miR-3659	CLIP-seq
MIRT1447212	hsa-miR-3682-5p	CLIP-seq
MIRT1447216	hsa-miR-3929	CLIP-seq
MIRT2133712	hsa-miR-409-3p	CLIP-seq
MIRT1447218	hsa-miR-411	CLIP-seq
MIRT1447219	hsa-miR-4257	CLIP-seq
MIRT1447220	hsa-miR-4280	CLIP-seq
MIRT1447221	hsa-miR-431	CLIP-seq
MIRT1447222	hsa-miR-4419b	CLIP-seq
MIRT1447223	hsa-miR-4478	CLIP-seq
MIRT1447226	hsa-miR-4645-3p	CLIP-seq
MIRT1447227	hsa-miR-4658	CLIP-seq
MIRT2354866	hsa-miR-4659a-3p	CLIP-seq
MIRT2354867	hsa-miR-4659b-3p	CLIP-seq
MIRT1447229	hsa-miR-4670-3p	CLIP-seq
MIRT1447230	hsa-miR-4674	CLIP-seq
MIRT2354868	hsa-miR-4735-5p	CLIP-seq
MIRT1447234	hsa-miR-4744	CLIP-seq
MIRT2354869	hsa-miR-4775	CLIP-seq
MIRT1447239	hsa-miR-485-5p	CLIP-seq
MIRT1447240	hsa-miR-543	CLIP-seq
MIRT1447242	hsa-miR-548aa	CLIP-seq
MIRT1447266	hsa-miR-574-5p	CLIP-seq
MIRT2354870	hsa-miR-590-3p	CLIP-seq
MIRT2354871	hsa-miR-606	CLIP-seq
MIRT1447268	hsa-miR-635	CLIP-seq
MIRT1447269	hsa-miR-643	CLIP-seq
MIRT1447210	hsa-miR-3659	CLIP-seq
MIRT1447216	hsa-miR-3929	CLIP-seq
MIRT1447218	hsa-miR-411	CLIP-seq
MIRT1447219	hsa-miR-4257	CLIP-seq
MIRT1447220	hsa-miR-4280	CLIP-seq
MIRT1447222	hsa-miR-4419b	CLIP-seq
MIRT1447223	hsa-miR-4478	CLIP-seq
MIRT2396208	hsa-miR-4502	CLIP-seq
MIRT1447227	hsa-miR-4658	CLIP-seq
MIRT1447239	hsa-miR-485-5p	CLIP-seq
MIRT1447266	hsa-miR-574-5p	CLIP-seq
MIRT1447268	hsa-miR-635	CLIP-seq
MIRT1447187	hsa-miR-1253	CLIP-seq
MIRT2462139	hsa-miR-3185	CLIP-seq
MIRT2462140	hsa-miR-580	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
ATF1	Unknown	12104051
E2F1	Activation	11313881
UHRF1	Unknown	10646863
YBX1	Unknown	10597187

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000228	Component	Nuclear chromosome	IDA	9049244
GO:0000287	Function	Magnesium ion binding	IDA	22323612
GO:0000712	Process	Resolution of meiotic recombination intermediates	IBA	21873635
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000793	Component	Condensed chromosome	IEA
GO:0000819	Process	Sister chromatid segregation	IBA	21873635
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0003677	Function	DNA binding	IDA	9049244, 10788521, 12079377
GO:0003682	Function	Chromatin binding	IDA	9049244
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA	16611985
GO:0003918	Function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IMP	12711669
GO:0005080	Function	Protein kinase C binding	IPI	16611985
GO:0005515	Function	Protein binding	IPI	10788521, 12711669, 15965487, 16611985, 17983804, 18790802, 19390626, 20457750, 23652018, 23698369, 26030138
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	9155056, 10788521, 10959840, 16611985
GO:0005654	Component	Nucleoplasm	IDA	8299728, 9049244
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	8299728, 9155056, 17567603
GO:0005730	Component	Nucleolus	IDA	9049244
GO:0005737	Component	Cytoplasm	IDA	9155056
GO:0005814	Component	Centriole	IDA	9049244
GO:0006265	Process	DNA topological change	IDA	22323612
GO:0006265	Process	DNA topological change	IMP	12711669
GO:0006266	Process	DNA ligation	IDA	15491148
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	16611985
GO:0007059	Process	Chromosome segregation	IMP	11136718, 15456904, 15965487
GO:0007143	Process	Female meiotic nuclear division	IEA
GO:0008022	Function	Protein C-terminus binding	IPI	10666337, 15965487
GO:0008094	Function	DNA-dependent ATPase activity	IDA	12079377
GO:0008301	Function	DNA binding, bending	IDA	22323612
GO:0009330	Component	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IDA	10473615
GO:0019899	Function	Enzyme binding	IPI	10959840, 17567603
GO:0030263	Process	Apoptotic chromosome condensation	IBA	21873635
GO:0030263	Process	Apoptotic chromosome condensation	IDA	10959840
GO:0032991	Component	Protein-containing complex	IDA	16611985
GO:0040016	Process	Embryonic cleavage	IEA
GO:0042752	Process	Regulation of circadian rhythm	ISS
GO:0042803	Function	Protein homodimerization activity	IPI	10473615
GO:0042826	Function	Histone deacetylase binding	IPI	11062478, 11136718
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16611985
GO:0043130	Function	Ubiquitin binding	IMP	15965487
GO:0045870	Process	Positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP	16712776
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	10473615
GO:0048511	Process	Rhythmic process	IEA
GO:1905463	Process	Negative regulation of DNA duplex unwinding	IMP	12711669
GO:1990904	Component	Ribonucleoprotein complex	IDA	12711669

MIM	HGNC	e!Ensembl
126430	11989	ENSG00000131747

Protein

UniProt ID

P11388

Protein name

DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)

Protein function

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (Pu

PDB

1ZXM , 1ZXN , 4FM9 , 4R1F , 5GWK , 5NNE , 6ZY5 , 6ZY6 , 6ZY7 , 6ZY8 , 8W50

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02518	HATPase_c	76 → 225	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
PF00204	DNA_gyraseB	266 → 430	DNA gyrase B	Domain
PF01751	Toprim	456 → 572	Toprim domain	Family
PF16898	TOPRIM_C	573 → 711	C-terminal associated domain of TOPRIM	Family
PF00521	DNA_topoisoIV	713 → 1172	DNA gyrase/topoisomerase IV, subunit A	Family
PF08070	DTHCT	1430 → 1522	DTHCT (NUC029) region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056). {ECO:0000

Sequence

MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

Sequence length

1531

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins

Show/Hide Causal Diseases (10)

Disease term	Disease name	dbSNP ID	References
Causal
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	16762588
Adrenocortical carcinoma	Adrenocortical carcinoma	rs121912656, rs28934874, rs121912662, rs786202525, rs121912664, rs397516435, rs121913343, rs587780070, rs121912666, rs55832599, rs587782144, rs587782272, rs587782529, rs587782620, rs587782664 View all (30 more)	23533247
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	22204715, 12006526, 11583189, 16234514
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	12006526, 16234514, 22204715, 11583189
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499 View all (13 more)	18402387
Leukemia	leukemia, Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	15833037, 27903959
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	27602772
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	12006526, 11583189, 22204715, 16234514
Neuroblastoma	Neuroblastoma	rs113994087, rs113994089, rs281864719, rs863225285, rs863225284, rs863225283, rs281864720, rs863225282, rs863225281, rs1057519698, rs915983602, rs1469271544	18671248, 16682295
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17363613

Show/Hide Text Mining Associations (202)

Disease Name	Relationship Type	References
Associations from Text Mining
Abdominal Injuries	Associate	36656469
Achalasia Addisonianism Alacrimia syndrome	Associate	35792986
Acromegaly	Associate	25692206
Acute Aortic Syndrome	Associate	31721906
Adenocarcinoma	Associate	19250538, 19670330, 20557373, 27814385, 28081737, 31180040, 8398710, 8780403
Adenocarcinoma of Lung	Associate	28355294, 31074380, 32149105, 32323809, 32578582, 33126397, 33361736, 34304612, 35778520, 37985446, 8398710
Adenocarcinoma of Lung	Stimulate	33398330
Adenoma	Associate	8780403
Adenoma Pleomorphic	Stimulate	19250538
Adenomatous Polyposis Coli	Associate	20368985
Adrenocortical Carcinoma	Associate	23533247, 28432084, 32147961, 32373071, 35185794, 38053725
Aneuploidy	Associate	20368985, 21595939, 32057913, 8669491
Anophthalmia with pulmonary hypoplasia	Associate	39358545
Aortic Dissection	Associate	31721906
Astrocytoma	Associate	12937144, 23737970, 30520434, 32647207, 33642282, 36115056
Ataxia Telangiectasia	Associate	23163762, 2836804
Barrett Esophagus	Associate	20557373
Blindness	Stimulate	15510606
Brain Neoplasms	Associate	29923182
Breast Neoplasms	Associate	10702400, 10854209, 11304576, 11583189, 15628907, 15887027, 15987433, 16097435, 17511886, 17922046, 18332872, 18413646, 18702822, 19176392, 19401546 View all (61 more)
Breast Neoplasms	Inhibit	23201559
Breast Neoplasms Male	Associate	24080492
Burkitt Lymphoma	Associate	2163884
Calcinosis Cutis	Associate	36656469
Carcinogenesis	Associate	12001123, 30672125, 33765507, 35058360, 35394699
Carcinogenesis	Stimulate	29651323
Carcinoma	Associate	16033110
Carcinoma Acinar Cell	Associate	15696124
Carcinoma Adenoid Cystic	Associate	19250538, 31914060, 37861550
Carcinoma Basal Cell	Associate	34856000
Carcinoma Ductal Breast	Associate	16097435, 20069504, 7745115
Carcinoma Embryonal	Associate	12237772
Carcinoma Hepatocellular	Stimulate	15765123, 36299605
Carcinoma Hepatocellular	Associate	22539975, 25695068, 26722553, 29658607, 29843214, 29977454, 30341252, 30702595, 31043166, 31811111, 31822116, 32627011, 32685486, 32722976, 33157984 View all (21 more)
Carcinoma Large Cell	Associate	34453496
Carcinoma Medullary	Associate	19539329
Carcinoma Non Small Cell Lung	Associate	11115510, 12001123, 21067592, 21455636, 22190510, 24135250, 24165483, 28355294, 30832674, 31746439, 31797573, 31805030, 31816603, 31901017, 33099907 View all (6 more)
Carcinoma Ovarian Epithelial	Associate	25846551, 27315793
Carcinoma Ovarian Epithelial	Inhibit	36799490
Carcinoma Renal Cell	Associate	21461646, 24388441, 28260099, 31422942, 32986937, 34606125, 34872567, 35778520, 35896362, 9393588
Carcinoma Small Cell	Associate	18520795
Carcinoma Squamous Cell	Stimulate	12001123, 24135250
Carcinoma Squamous Cell	Associate	29578153, 36352434, 37985446
Carcinosarcoma	Associate	32114514
Cardiotoxicity	Associate	16803541
Cavernous Sinus Thrombosis	Associate	30074233
Chemical and Drug Induced Liver Injury	Associate	37114547
Cholangiocarcinoma	Associate	31545466, 32040444, 32344256
Cholangiocarcinoma	Stimulate	37114547
Colorectal Neoplasms	Associate	11862483, 16882699, 19083133, 24752576, 25333365, 25550888, 25746763, 25777966, 26040697, 26867764, 26947016, 28072746, 28816939, 31072339, 31137244 View all (4 more)
Colorectal Neoplasms	Stimulate	29651323
Congenital contractural arachnodactyly	Associate	32344256
COVID 19	Associate	35958619, 36389792, 36856850, 38301615
Cytomegalovirus Infections	Associate	14695446
Death	Associate	18506140, 21681601, 23092535, 24388441, 24403186
Death	Inhibit	37067901
Diabetes Mellitus	Stimulate	25815791
Disease Resistance	Associate	24752576
DNA Virus Infections	Associate	26317544
Down Syndrome	Associate	21856934
Drug Hypersensitivity	Associate	23163762
Drug Related Side Effects and Adverse Reactions	Associate	12105221, 32041867, 7710929, 7713987, 9556152
Drug Related Side Effects and Adverse Reactions	Inhibit	24995306
Endometrial Neoplasms	Associate	16803541, 32555395
Ependymoma	Associate	30649797
Esophageal Neoplasms	Associate	32443386
Fibrosis	Associate	31811111
Friedreich Ataxia 1	Associate	40432442
Gallbladder Neoplasms	Associate	18204862, 28728050, 32925281
Gastrointestinal Stromal Tumors	Associate	33266502
Glioblastoma	Associate	12937144, 15494095, 21904904, 23737970, 32647207, 39528802, 8172796
Glioma	Associate	10344108, 23736022, 28106765, 33537815, 33765507, 33892537, 35012441, 37901992, 9330528
Glomerulonephritis	Stimulate	11012894
Glomerulonephritis IGA	Associate	38301615
Glomerulonephritis Membranous	Inhibit	11012894
Glycogen Storage Disease Type IIb	Associate	18520795
Granulosa cell tumor of the ovary	Associate	23956975
Hashimoto Disease	Associate	32603365
Heart Defects Congenital	Associate	25205790
Hematuria	Associate	26981592
Hepatitis B	Associate	29587760, 33376723
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25695068
Hypertension Pulmonary	Associate	10971522
Idiopathic Pulmonary Fibrosis	Associate	10971522
Inflammation	Associate	37861550
Isodicentric Chromosome 15 Syndrome	Associate	25786458
Laron Syndrome	Associate	16556661
Leukemia	Associate	16357944, 17332311, 23041231, 23163762, 25140305, 26163765, 28385713, 7756657, 8634439, 8639880, 8948668, 9808573
Leukemia Biphenotypic Acute	Associate	11406628, 22615413
Leukemia Myeloid	Associate	9633900, 9763573
Leukemia Myeloid Acute	Associate	17332311, 19127593, 19458360, 19530238, 22615413, 23163762, 24327541, 25786458, 31138411, 32218491, 34405474, 35807446, 7904487, 8260707, 8948668, 9226152, 9808573 View all (2 more)
Leukemia Prolymphocytic T Cell	Associate	1355660
Leukemia Promyelocytic Acute	Associate	10203104, 15829534, 19884644, 29447373
Leukemia T Cell	Associate	9633900
Light Fixation Seizure Syndrome	Associate	28432084
Liposarcoma	Associate	18820673, 21335544, 22300273
Liver Cirrhosis	Associate	37861550
Lung Neoplasms	Associate	10879730, 29578153, 31816603, 32831194, 35178291, 39331864, 9765623
Lupus Erythematosus Systemic	Associate	34079550, 36726984, 37072474
Lupus Nephritis	Stimulate	11012894
Lymphatic Metastasis	Stimulate	16097435, 32925281
Lymphatic Metastasis	Associate	28816939, 33832110, 37378945, 38561479
Lymphoma	Associate	19530238, 9155056
Lymphoma Large B Cell Diffuse	Associate	28690315, 37072474
Lymphoma Non Hodgkin	Associate	18927283, 36945359
Mandibuloacral dysplasia with type A lipodystrophy	Stimulate	18927283
Medulloblastoma	Associate	29869738
Melanoma	Inhibit	10646909
Melanoma	Associate	16116595, 20543820, 28026870, 37384650
Meningioma	Associate	12204057, 21157382, 37880655
Meningioma	Stimulate	28301542
Mesothelioma	Associate	25393473
Mesothelioma Malignant	Associate	33032291, 37172528
Mucocutaneous Lymph Node Syndrome	Associate	40455761
Multiple Myeloma	Associate	10691864, 18062937, 39769169
Myelodysplastic Syndromes	Associate	9763573
Nasal Polyps	Associate	18544048
Nasopharyngeal Carcinoma	Associate	23897556
Necrosis	Associate	37861550
Nemaline myopathy 5	Associate	15816547
Neoplasm Invasiveness	Associate	23398928
Neoplasm Metastasis	Associate	16556665, 32925281, 33982765, 37114547, 37985446, 38561479, 7745115
Neoplasm Metastasis	Stimulate	29587760, 37980167
Neoplasm Metastasis	Inhibit	36195266
Neoplasms	Associate	10070864, 10879730, 10940316, 11473732, 11862483, 12001123, 12769819, 12838312, 12915875, 15510606, 15668283, 15816547, 15886298, 15887027, 16533424 View all (121 more)
Neoplasms	Inhibit	12044890, 21878638, 35792986, 7947097
Neoplasms	Stimulate	15043465, 19083133, 21338529, 26560244, 30672125, 33807717, 36299605
Neoplasms Cystic Mucinous and Serous	Associate	27315793
Nephritis Interstitial	Inhibit	11012894
Neuroblastoma	Associate	26575016
Neurodegenerative Diseases	Associate	40229714
Neuroendocrine Tumors	Associate	31937620
Neurofibroma	Associate	28813519
Neurofibrosarcoma	Associate	15255999, 18522746, 24040940, 28813519
Nevus Epithelioid and Spindle Cell	Associate	20543820
Non functioning pancreatic endocrine tumor	Associate	15043465
Non Muscle Invasive Bladder Neoplasms	Associate	26981592
Obesity	Associate	29330624
Oligodendroglioma	Associate	33244057
Osteoarthritis	Associate	36700234
Osteolysis	Stimulate	37980167
Osteoporosis	Associate	38169377
Osteosarcoma	Associate	34156352
Ovarian Diseases	Associate	23029477, 23388101, 34414458
Ovarian Neoplasms	Associate	10070864, 16533424, 17433065, 18506140, 19270648, 23029477, 23214297, 23388101, 28728050, 31729978, 31987036, 32693821, 34253236, 34414458, 35047055, 35735060, 7713987, 8172796, 9119751 View all (4 more)
Paget Disease Extramammary	Associate	31899853
Paget's Disease Mammary	Associate	31899853
Pancreatic Neoplasms	Associate	12136248, 19393226, 32537471, 33613108, 37604837
Pancreatoblastoma	Associate	15696124
Papilloma Inverted	Associate	18544048
Papillomavirus Infections	Stimulate	34268934
Pelvic Organ Prolapse	Associate	27818488
Peripheral Nervous System Neoplasms	Associate	25769404
Personality Disorders	Associate	21157382
Pituitary Neoplasms	Associate	25692206, 30074233
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	8780403, 9808573
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	1355660, 21824431, 22627319
Prodromal Symptoms	Associate	29587760
Prostatic Neoplasms	Associate	16556661, 23251544, 23398928, 26560244, 31967940, 33091733, 33630978, 34198380, 35409038, 36124532, 36245843, 37184661, 38179769
Prostatic Neoplasms	Stimulate	33527765
Prostatitis	Associate	16556661
Pulmonary Arterial Hypertension	Associate	36072642
Rapidly progressive glomerulonephritis with pulmonary hemorrhage	Stimulate	11012894
Rectal Neoplasms	Associate	38012642
Renal Insufficiency Chronic	Inhibit	11012894
Respiratory Distress Syndrome	Associate	27090785, 33904373
Respiratory Tract Infections	Associate	28755093
Retinal Dysplasia	Associate	20557373
Retinoblastoma	Associate	32443297, 33217867
Salivary Duct Calculi	Stimulate	19250538
Salivary Gland Neoplasms	Associate	19250538
Sarcoma	Associate	33266502
Sarcoma	Inhibit	34550531
Sarcoma Ewing	Associate	15886298
Scleroderma Systemic	Associate	10971522
Seminoma	Associate	31545448, 9155056
Sepsis	Associate	27090785, 33904373
Sertoli Cell Only Syndrome	Associate	37500704
Sjogren's Syndrome	Associate	35958619
Sleep Deprivation	Associate	20419121, 40229714, 7947097
Sleep Wake Disorders	Associate	40229714
Small Cell Lung Carcinoma	Associate	12044890, 18520795, 21455636, 24058603, 29290260, 29845250, 7947097, 8980384, 9652763, 9765623
Small Cell Lung Carcinoma	Stimulate	33186389, 34825846
Squamous Cell Carcinoma of Head and Neck	Associate	10744048, 25719218, 31109699, 34268934, 37378945
Squamous Cell Carcinoma of Head and Neck	Stimulate	37667354
Squamous Intraepithelial Lesions	Stimulate	25189639
Squamous Intraepithelial Lesions	Associate	33413211, 36352434
Status Asthmaticus	Associate	34088958
Stomach Diseases	Associate	8780403
Stomach Neoplasms	Associate	19061514, 24326092, 25550836, 25684949, 25743022, 25778705, 25815791, 27314292, 28056823, 28078605, 28460635, 29772796, 32902196
Thyroid Carcinoma Anaplastic	Associate	30213925, 31183379, 33025856, 33455115, 35405742
Thyroid Neoplasms	Associate	16033110
Triple Negative Breast Neoplasms	Associate	26051240, 27799773, 30583686
Tuberculosis Multidrug Resistant	Associate	11434876, 22190510, 25304659, 26947016, 28816939, 9652763
Tuberculosis Multidrug Resistant	Inhibit	7640209
Urethral Neoplasms	Associate	28755093, 9477189
Urinary Bladder Neoplasms	Associate	11304849, 23495258, 26981592, 27473264, 29532898, 39456780, 7734314
Uterine Cervical Neoplasms	Associate	32181600, 33302814, 33413211, 34705880
Uterine Cervical Neoplasms	Stimulate	33023625
Uterine Cervicitis	Associate	33413211, 34705880
Wilms Tumor	Associate	16556665, 26274016, 30155617
Wolf Hirschhorn Syndrome	Stimulate	35394699

TOP2A (DNA topoisomerase II alpha)