Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7150
Gene name	DNA topoisomerase I
Gene symbol	TOP1
Synonyms (NCBI Gene)	TOPI
Chromosome	20
Chromosome location	20q12
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024385	hsa-miR-215-5p	Microarray	19074876
MIRT026200	hsa-miR-192-5p	Microarray	19074876
MIRT028857	hsa-miR-26b-5p	Microarray	19088304
MIRT030382	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT044929	hsa-miR-186-5p	CLASH	23622248
MIRT042230	hsa-miR-484	CLASH	23622248
MIRT437443	hsa-miR-23a-3p	Luciferase reporter assayqRT-PCRWestern blot	24103454
MIRT437443	hsa-miR-23a-3p	Luciferase reporter assayqRT-PCRWestern blot	24103454
MIRT437443	hsa-miR-23a-3p	FlowLuciferase reporter assayqRT-PCRWestern blot	23158364
MIRT437443	hsa-miR-23a-3p	FlowLuciferase reporter assayqRT-PCRWestern blot	23158364
MIRT153406	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT153406	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT733642	hsa-miR-382-5p	qRT-PCRWestern blotting	34002668
MIRT755616	mmu-miR-92a-3p	qRT-PCRin vitro cullelar assaysCLIP-seq	37094168
MIRT1447045	hsa-miR-101	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT1447047	hsa-miR-1208	CLIP-seq
MIRT1447048	hsa-miR-1224-5p	CLIP-seq
MIRT1447049	hsa-miR-1238	CLIP-seq
MIRT1447050	hsa-miR-1249	CLIP-seq
MIRT1447051	hsa-miR-1254	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447055	hsa-miR-139-5p	CLIP-seq
MIRT1447056	hsa-miR-141	CLIP-seq
MIRT1447057	hsa-miR-144	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT1447059	hsa-miR-153	CLIP-seq
MIRT1447060	hsa-miR-192	CLIP-seq
MIRT1447061	hsa-miR-200a	CLIP-seq
MIRT1447062	hsa-miR-205	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447066	hsa-miR-215	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447074	hsa-miR-27a	CLIP-seq
MIRT1447075	hsa-miR-27b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT1447078	hsa-miR-3116	CLIP-seq
MIRT1447079	hsa-miR-3121-3p	CLIP-seq
MIRT1447080	hsa-miR-3123	CLIP-seq
MIRT1447081	hsa-miR-3124-3p	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447083	hsa-miR-3152-5p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447091	hsa-miR-3529	CLIP-seq
MIRT1447092	hsa-miR-3610	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447096	hsa-miR-3619-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447098	hsa-miR-362-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447100	hsa-miR-3661	CLIP-seq
MIRT1447101	hsa-miR-3672	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447105	hsa-miR-379	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447108	hsa-miR-3915	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447111	hsa-miR-3928	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT1447121	hsa-miR-4326	CLIP-seq
MIRT1447122	hsa-miR-4328	CLIP-seq
MIRT1447123	hsa-miR-433	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447128	hsa-miR-4446-5p	CLIP-seq
MIRT1447129	hsa-miR-4451	CLIP-seq
MIRT1447130	hsa-miR-4463	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447133	hsa-miR-448	CLIP-seq
MIRT1447134	hsa-miR-4520b-3p	CLIP-seq
MIRT1447135	hsa-miR-4528	CLIP-seq
MIRT1447136	hsa-miR-4529-3p	CLIP-seq
MIRT1447137	hsa-miR-4535	CLIP-seq
MIRT1447138	hsa-miR-4539	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT1447140	hsa-miR-4650-3p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447148	hsa-miR-4680-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447150	hsa-miR-4689	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT1447154	hsa-miR-4760-3p	CLIP-seq
MIRT1447155	hsa-miR-4760-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT1447157	hsa-miR-4774-3p	CLIP-seq
MIRT1447158	hsa-miR-4776-5p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447164	hsa-miR-494	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447167	hsa-miR-500b	CLIP-seq
MIRT1447168	hsa-miR-501-5p	CLIP-seq
MIRT1447169	hsa-miR-513a-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT1447171	hsa-miR-526b	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT1447176	hsa-miR-582-5p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT1447178	hsa-miR-631	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447180	hsa-miR-661	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447183	hsa-miR-873	CLIP-seq
MIRT1447184	hsa-miR-885-5p	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447048	hsa-miR-1224-5p	CLIP-seq
MIRT1447050	hsa-miR-1249	CLIP-seq
MIRT1447051	hsa-miR-1254	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447055	hsa-miR-139-5p	CLIP-seq
MIRT2133684	hsa-miR-1470	CLIP-seq
MIRT1447062	hsa-miR-205	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT2133685	hsa-miR-299-3p	CLIP-seq
MIRT1447078	hsa-miR-3116	CLIP-seq
MIRT1447079	hsa-miR-3121-3p	CLIP-seq
MIRT2133686	hsa-miR-3130-3p	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447083	hsa-miR-3152-5p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447091	hsa-miR-3529	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447096	hsa-miR-3619-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447098	hsa-miR-362-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447105	hsa-miR-379	CLIP-seq
MIRT1447108	hsa-miR-3915	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447111	hsa-miR-3928	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT2133687	hsa-miR-3976	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2133688	hsa-miR-4307	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT1447122	hsa-miR-4328	CLIP-seq
MIRT1447123	hsa-miR-433	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447128	hsa-miR-4446-5p	CLIP-seq
MIRT1447129	hsa-miR-4451	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447134	hsa-miR-4520b-3p	CLIP-seq
MIRT2133689	hsa-miR-4522	CLIP-seq
MIRT1447135	hsa-miR-4528	CLIP-seq
MIRT1447136	hsa-miR-4529-3p	CLIP-seq
MIRT1447137	hsa-miR-4535	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2133690	hsa-miR-4648	CLIP-seq
MIRT1447140	hsa-miR-4650-3p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT2133691	hsa-miR-4654	CLIP-seq
MIRT2133692	hsa-miR-4667-3p	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447150	hsa-miR-4689	CLIP-seq
MIRT2133693	hsa-miR-4693-3p	CLIP-seq
MIRT2133694	hsa-miR-4694-3p	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447154	hsa-miR-4760-3p	CLIP-seq
MIRT1447155	hsa-miR-4760-5p	CLIP-seq
MIRT2133695	hsa-miR-4769-5p	CLIP-seq
MIRT1447157	hsa-miR-4774-3p	CLIP-seq
MIRT1447158	hsa-miR-4776-5p	CLIP-seq
MIRT2133696	hsa-miR-4793-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447164	hsa-miR-494	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447167	hsa-miR-500b	CLIP-seq
MIRT1447168	hsa-miR-501-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT2133697	hsa-miR-548c-3p	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2133698	hsa-miR-576-3p	CLIP-seq
MIRT1447176	hsa-miR-582-5p	CLIP-seq
MIRT2133699	hsa-miR-603	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447180	hsa-miR-661	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447183	hsa-miR-873	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447109	hsa-miR-3920	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447112	hsa-miR-3934	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT1447124	hsa-miR-4420	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT1447141	hsa-miR-4652-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT1447146	hsa-miR-4677-3p	CLIP-seq
MIRT1447147	hsa-miR-4679	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447151	hsa-miR-4704-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2133699	hsa-miR-603	CLIP-seq
MIRT1447179	hsa-miR-640	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT1447084	hsa-miR-3153	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447114	hsa-miR-3977	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447144	hsa-miR-4668-5p	CLIP-seq
MIRT1447170	hsa-miR-522	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT2466256	hsa-miR-4670-3p	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT2648610	hsa-miR-1200	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT1447058	hsa-miR-149	CLIP-seq
MIRT2648611	hsa-miR-185	CLIP-seq
MIRT2648612	hsa-miR-203	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT2648613	hsa-miR-3134	CLIP-seq
MIRT2648614	hsa-miR-3140-5p	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT2648615	hsa-miR-3202	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT2648616	hsa-miR-375	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT2648617	hsa-miR-4273	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT2648618	hsa-miR-4306	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT2648619	hsa-miR-4426	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT2648620	hsa-miR-4644	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2648621	hsa-miR-4647	CLIP-seq
MIRT2648622	hsa-miR-4662b	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT2648623	hsa-miR-4677-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT2648624	hsa-miR-4747-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT2648625	hsa-miR-4775	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2648626	hsa-miR-590-3p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT2648627	hsa-miR-651	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq
MIRT1447186	hsa-miR-892b	CLIP-seq
MIRT1447046	hsa-miR-1197	CLIP-seq
MIRT2648610	hsa-miR-1200	CLIP-seq
MIRT1447052	hsa-miR-129-5p	CLIP-seq
MIRT1447053	hsa-miR-1297	CLIP-seq
MIRT1447054	hsa-miR-1323	CLIP-seq
MIRT2648611	hsa-miR-185	CLIP-seq
MIRT2648612	hsa-miR-203	CLIP-seq
MIRT1447063	hsa-miR-2053	CLIP-seq
MIRT1447064	hsa-miR-208a	CLIP-seq
MIRT1447065	hsa-miR-208b	CLIP-seq
MIRT1447067	hsa-miR-23a	CLIP-seq
MIRT1447068	hsa-miR-23b	CLIP-seq
MIRT1447069	hsa-miR-23c	CLIP-seq
MIRT1447070	hsa-miR-24	CLIP-seq
MIRT1447071	hsa-miR-2467-5p	CLIP-seq
MIRT1447072	hsa-miR-26a	CLIP-seq
MIRT1447073	hsa-miR-26b	CLIP-seq
MIRT1447076	hsa-miR-296-3p	CLIP-seq
MIRT1447077	hsa-miR-300	CLIP-seq
MIRT2434290	hsa-miR-3129-3p	CLIP-seq
MIRT2648613	hsa-miR-3134	CLIP-seq
MIRT1447082	hsa-miR-3140-3p	CLIP-seq
MIRT2648614	hsa-miR-3140-5p	CLIP-seq
MIRT2441478	hsa-miR-3157-3p	CLIP-seq
MIRT1447085	hsa-miR-3163	CLIP-seq
MIRT1447086	hsa-miR-3183	CLIP-seq
MIRT1447087	hsa-miR-3188	CLIP-seq
MIRT1447088	hsa-miR-3200-5p	CLIP-seq
MIRT1447089	hsa-miR-3201	CLIP-seq
MIRT2648615	hsa-miR-3202	CLIP-seq
MIRT1447090	hsa-miR-338-5p	CLIP-seq
MIRT1447093	hsa-miR-3613-3p	CLIP-seq
MIRT1447094	hsa-miR-361-3p	CLIP-seq
MIRT1447095	hsa-miR-3616-3p	CLIP-seq
MIRT1447097	hsa-miR-3622a-5p	CLIP-seq
MIRT1447099	hsa-miR-3647-3p	CLIP-seq
MIRT1447102	hsa-miR-369-3p	CLIP-seq
MIRT1447103	hsa-miR-374a	CLIP-seq
MIRT1447104	hsa-miR-374b	CLIP-seq
MIRT2648616	hsa-miR-375	CLIP-seq
MIRT1447106	hsa-miR-381	CLIP-seq
MIRT1447107	hsa-miR-382	CLIP-seq
MIRT1447110	hsa-miR-3925-3p	CLIP-seq
MIRT1447113	hsa-miR-3975	CLIP-seq
MIRT1447115	hsa-miR-412	CLIP-seq
MIRT1447116	hsa-miR-4269	CLIP-seq
MIRT2648617	hsa-miR-4273	CLIP-seq
MIRT1447117	hsa-miR-4282	CLIP-seq
MIRT1447118	hsa-miR-4284	CLIP-seq
MIRT1447119	hsa-miR-4287	CLIP-seq
MIRT2441479	hsa-miR-4290	CLIP-seq
MIRT2648618	hsa-miR-4306	CLIP-seq
MIRT1447120	hsa-miR-4316	CLIP-seq
MIRT2648619	hsa-miR-4426	CLIP-seq
MIRT1447125	hsa-miR-4431	CLIP-seq
MIRT1447126	hsa-miR-4432	CLIP-seq
MIRT1447127	hsa-miR-4436b-5p	CLIP-seq
MIRT1447131	hsa-miR-4465	CLIP-seq
MIRT1447132	hsa-miR-4469	CLIP-seq
MIRT2441480	hsa-miR-4635	CLIP-seq
MIRT2648620	hsa-miR-4644	CLIP-seq
MIRT1447139	hsa-miR-4645-5p	CLIP-seq
MIRT2648621	hsa-miR-4647	CLIP-seq
MIRT2648622	hsa-miR-4662b	CLIP-seq
MIRT1447142	hsa-miR-4666-3p	CLIP-seq
MIRT1447143	hsa-miR-4668-3p	CLIP-seq
MIRT1447145	hsa-miR-4673	CLIP-seq
MIRT2648623	hsa-miR-4677-5p	CLIP-seq
MIRT1447149	hsa-miR-4685-3p	CLIP-seq
MIRT1447152	hsa-miR-4723-3p	CLIP-seq
MIRT1447153	hsa-miR-4738-3p	CLIP-seq
MIRT2648624	hsa-miR-4747-5p	CLIP-seq
MIRT1447156	hsa-miR-4766-5p	CLIP-seq
MIRT2648625	hsa-miR-4775	CLIP-seq
MIRT2354861	hsa-miR-4781-3p	CLIP-seq
MIRT1447159	hsa-miR-4789-5p	CLIP-seq
MIRT1447160	hsa-miR-4791	CLIP-seq
MIRT1447161	hsa-miR-485-3p	CLIP-seq
MIRT1447162	hsa-miR-485-5p	CLIP-seq
MIRT1447163	hsa-miR-487a	CLIP-seq
MIRT1447165	hsa-miR-498	CLIP-seq
MIRT1447166	hsa-miR-499-5p	CLIP-seq
MIRT2434291	hsa-miR-548a-3p	CLIP-seq
MIRT2441481	hsa-miR-548ac	CLIP-seq
MIRT2441482	hsa-miR-548ae	CLIP-seq
MIRT2441483	hsa-miR-548aj	CLIP-seq
MIRT2441484	hsa-miR-548am	CLIP-seq
MIRT2441485	hsa-miR-548d-3p	CLIP-seq
MIRT2434292	hsa-miR-548e	CLIP-seq
MIRT2434293	hsa-miR-548f	CLIP-seq
MIRT1447172	hsa-miR-548o	CLIP-seq
MIRT1447173	hsa-miR-548p	CLIP-seq
MIRT2441486	hsa-miR-548x	CLIP-seq
MIRT2441487	hsa-miR-548z	CLIP-seq
MIRT1447174	hsa-miR-549	CLIP-seq
MIRT1447175	hsa-miR-552	CLIP-seq
MIRT2648626	hsa-miR-590-3p	CLIP-seq
MIRT1447177	hsa-miR-629	CLIP-seq
MIRT1447181	hsa-miR-764	CLIP-seq
MIRT1447182	hsa-miR-766	CLIP-seq
MIRT2441488	hsa-miR-874	CLIP-seq
MIRT1447185	hsa-miR-889	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
CEBPB	Unknown	8524227

Show/Hide all (66)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000228	Component	Nuclear chromosome	IDA	9049244
GO:0000932	Component	P-body	IDA	12878161
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	22904072
GO:0001650	Component	Fibrillar center	IDA
GO:0001650	Component	Fibrillar center	IEA
GO:0001651	Component	Dense fibrillar component	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0003677	Function	DNA binding	EXP	11283003
GO:0003677	Function	DNA binding	IDA	17355975
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IMP	10497031
GO:0003682	Function	Chromatin binding	IDA	9049244
GO:0003690	Function	Double-stranded DNA binding	IMP	8631794
GO:0003697	Function	Single-stranded DNA binding	IMP	8631794
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003916	Function	DNA topoisomerase activity	IEA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	14594810
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA
GO:0003917	Function	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IMP	8567649, 8631793, 8631794, 9611241, 14654701, 17355975
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	9611241
GO:0005515	Function	Protein binding	IPI	8567649, 10352183, 12878161, 15448168, 17234752, 17314511, 20195357, 23213405, 26030138, 29248492, 34591642
GO:0005524	Function	ATP binding	IMP	8631793, 9611241
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IDA	9049244, 11016921
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	9049244
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	IMP	14654701
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	9049244
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	IMP	14654701
GO:0005737	Component	Cytoplasm	IEA
GO:0006260	Process	DNA replication	IBA
GO:0006260	Process	DNA replication	IEA
GO:0006265	Process	DNA topological change	IBA
GO:0006265	Process	DNA topological change	IDA	14594810
GO:0006265	Process	DNA topological change	IEA
GO:0006265	Process	DNA topological change	IEA
GO:0006265	Process	DNA topological change	IMP	8567649, 8631793, 8631794, 9611241, 14654701
GO:0006338	Process	Chromatin remodeling	IMP	22904072
GO:0007059	Process	Chromosome segregation	IBA
GO:0007623	Process	Circadian rhythm	IEP	22904072
GO:0008301	Function	DNA binding, bending	EXP	11283003
GO:0009266	Process	Response to temperature stimulus	IEA
GO:0009303	Process	RRNA transcription	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEP	16127745
GO:0010332	Process	Response to gamma radiation	IEA
GO:0012501	Process	Programmed cell death	NAS	17172417
GO:0016853	Function	Isomerase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IMP	9611241
GO:0019904	Function	Protein domain specific binding	IPI	9611241
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0032922	Process	Circadian regulation of gene expression	IMP	22904072
GO:0032993	Component	Protein-DNA complex	IMP	10497031
GO:0040016	Process	Embryonic cleavage	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0071373	Process	Cellular response to luteinizing hormone stimulus	IEA
GO:0097100	Function	Supercoiled DNA binding	IMP	8631793, 9611241, 14654701

MIM	HGNC	e!Ensembl
126420	11986	ENSG00000198900

P11387

Protein name

DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)

Protein function

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a targ

PDB

1A31 , 1A35 , 1A36 , 1EJ9 , 1K4S , 1K4T , 1LPQ , 1NH3 , 1R49 , 1RR8 , 1RRJ , 1SC7 , 1SEU , 1T8I , 1TL8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02919	Topoisom_I_N	215 → 429	Eukaryotic DNA topoisomerase I, DNA binding fragment	Family
PF01028	Topoisom_I	432 → 665	Eukaryotic DNA topoisomerase I, catalytic core	Domain
PF14370	Topo_C_assoc	695 → 765	C-terminal topoisomerase domain	Family

Tissue specificity

TISSUE SPECIFICITY: Endothelial cells. {ECO:0000269|PubMed:19168442}.

Sequence

MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

Sequence length

765

Interactions

View interactions

	Reactome
			SUMOylation of DNA replication proteins

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
DNA topoisomerase I, camptothecin-resistant	Pathogenic	rs121434562	RCV000018262

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs267607131, rs267607132	-
Autism spectrum disorder	association	rs2034059953	RCV001291503
TOP1-related disorder	Likely benign; Benign	rs764208638, rs368613261, rs147984700, rs61756256, rs550250396	RCV003914685 RCV003912167 RCV003944229 RCV003920648 RCV003925783

Show/Hide Text Mining Associations (56)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Lung Injury	Associate	34002668
Adenocarcinoma	Stimulate	28355294
Adenocarcinoma Bronchiolo Alveolar	Associate	31383554
Ataxia Telangiectasia	Associate	23626666, 30679601
Ataxia Telangiectasia	Stimulate	25032865
Breast Neoplasms	Associate	12833450, 20215517, 25885574, 31783818, 33144457, 37913680
Carcinoma Non Small Cell Lung	Associate	28355294, 33099907
Carcinoma Ovarian Epithelial	Associate	27315793
Carcinoma Renal Cell	Associate	33062672
Cardiovascular Diseases	Associate	40102901
Colonic Neoplasms	Associate	9321666
Colorectal Neoplasms	Associate	16127745, 19584232, 20164542, 21636699, 23110915, 23577133, 23836376, 25777966, 25885574, 27029323, 28077117, 35053185, 37353483
Crisponi syndrome	Associate	21628532
Diabetes Mellitus Type 1	Associate	33083497
Drug Related Side Effects and Adverse Reactions	Associate	26668189
Drug Related Side Effects and Adverse Reactions	Inhibit	34008967
Emphysema	Associate	31383554
Fanconi Anemia	Associate	21478670, 24130054
Hepatitis C	Associate	36405960
HIV Infections	Associate	36405960
Immunologic Deficiency Syndromes	Associate	26578593
Inflammation	Associate	35957613, 40102901
Kidney Neoplasms	Inhibit	19584232
Leukemia	Associate	23085462
Leukemia Lymphoma Adult T Cell	Associate	35041720
Leukemia Myeloid Acute	Associate	29781401
Lung Neoplasms	Associate	28355294
Lung Neoplasms	Inhibit	35794238
Medulloblastoma	Associate	29869738
Melanoma	Associate	33631697, 34560251
Mental Disorders	Associate	28850114
Microcephaly	Associate	37916443
Mitochondrial Diseases	Associate	31383554
Myelodysplastic Syndromes	Associate	10556215
Neoplasms	Associate	19584232, 21834757, 23110915, 23577133, 25253693, 27107440, 27825117, 27825797, 29869738, 30148840, 31196001, 32075943, 32152270, 32513688, 33144457 View all (9 more)
Neoplasms Cystic Mucinous and Serous	Associate	27315793
Nerve Degeneration	Associate	17706468
Neuroblastoma	Associate	34465595
Neurodegenerative Diseases	Associate	25032865, 26578593, 30679601
Neutropenia	Associate	19604089
Osteoarthritis	Associate	32788627
Ovarian Neoplasms	Associate	35197484
Pancreatic Neoplasms	Associate	37831776
Poisoning	Associate	15471886
Prostatic Neoplasms	Associate	35349486
Prostatic Neoplasms Castration Resistant	Associate	35349486
Rectal Neoplasms	Associate	23110915, 23577133
Reinjuries	Associate	21628532
Small Cell Lung Carcinoma	Associate	22344449, 33848478, 35794238, 35957613
Spinocerebellar ataxia autosomal recessive with axonal neuropathy	Associate	26578593
Spinocerebellar Degenerations	Associate	24335147
Syndrome	Associate	26578593
T cell immunodeficiency primary	Associate	36405960
Translocation Genetic	Associate	10556215
Triple Negative Breast Neoplasms	Associate	27107440, 32075943
Turcot syndrome	Associate	25777966

TOP1 (DNA topoisomerase I)