Gene Gene information from NCBI Gene database.
Entrez ID 7145
Gene name Tensin 1
Gene symbol TNS1
Synonyms (NCBI Gene)
MST091MST122MST127MSTP091MSTP122MSTP127MXRA6PPP1R155TNS
Chromosome 2
Chromosome location 2q35
Summary The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in
miRNA miRNA information provided by mirtarbase database.
1266
miRTarBase ID miRNA Experiments Reference
MIRT019227 hsa-miR-335-5p Microarray 18185580
MIRT027785 hsa-miR-98-5p Microarray 19088304
MIRT724982 hsa-miR-4464 HITS-CLIP 19536157
MIRT724981 hsa-miR-4748 HITS-CLIP 19536157
MIRT724980 hsa-miR-1237-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003779 Function Actin binding IEA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0005515 Function Protein binding IPI 17190795, 24728074
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600076 11973 ENSG00000079308
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HBL0
Protein name Tensin-1 (EC 3.1.3.-)
Protein function May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix depo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10409 PTEN_C2 179 306 C2 domain of PTEN tumour-suppressor protein Domain
PF00017 SH2 1463 1557 SH2 domain Domain
PF08416 PTB 1598 1734 Phosphotyrosine-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: In the lung, detected in the alveolar septa (at protein level) (PubMed:28005397). Ubiquitous (PubMed:11023826). {ECO:0000269|PubMed:11023826, ECO:0000269|PubMed:28005397}.
Sequence
MSVSRTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL
SERRPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRI
GVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMN
NKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGL
LLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKV
EFVFSY
GPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFSGHRDDGMEEVVGHTQGP
LDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLSVSSDSGNSTASTKTDKTDE
PVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSAVPSSGRHV
VPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSSLDGVTNTSEGGYPEALSPL
TNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQEGLAGYQREGPHPAW
PQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQQQQQQQQQP
RPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLMLDLE
PASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAP
RASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLP
GLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASD
GQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTS
PSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGVTRRRIQPEEDEGKVVVRLSE
EPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSS
PILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTV
GSSYSSPDYSLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAI
NPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLH
NKVATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRH
VAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQG
SPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKY
SMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLA
MKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQH
SII
PLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISK
ATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMK
TEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQK
R
Sequence length 1735
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
74
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
TNS1-related disorder Benign; Likely benign; Uncertain significance rs61746994, rs140104262, rs149122582, rs200822159, rs148888599, rs201977904, rs13419876, rs3796028, rs3796032, rs181839905, rs1364641, rs377079698, rs3796033, rs3796026, rs10211238
View all (57 more)
RCV003975919
RCV003919164
RCV003919794
RCV003919830
RCV003914714
RCV003929859
RCV003931854
RCV003974310
RCV003974365
RCV003974422
RCV003974690
RCV003904274
RCV003979682
RCV003979809
RCV003984651
RCV003984773
RCV003982338
RCV003982383
RCV003982415
RCV003982541
RCV003911983
RCV003964464
RCV003974025
RCV003977228
RCV003982284
RCV003977256
RCV003897285
RCV003911856
RCV003924602
RCV003941904
RCV003927347
RCV003952060
RCV003954313
RCV003954899
RCV003914665
RCV003931811
RCV003927098
RCV003917252
RCV003932296
RCV003932300
RCV003924406
RCV003949278
RCV003969251
RCV003922189
RCV003922195
RCV003926775
RCV003927010
RCV003931985
RCV003947017
RCV003956697
RCV003954415
RCV003979262
RCV003979303
RCV003974782
RCV003981870
RCV003982002
RCV003982127
RCV003971750
RCV003971439
RCV003971462
RCV003976571
RCV003966831
RCV003972162
RCV003926112
RCV003933276
RCV003935857
RCV003925938
RCV003933268
RCV003978294
RCV003935989
RCV003972831
RCV003916167
RCV003932974
RCV003950833
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33628780
Airway Obstruction Associate 31831813
Alzheimer Disease Associate 40220916
Asthma Associate 24388013
Bicuspid Aortic Valve Disease Associate 36071494
Breast Neoplasms Associate 23317273
Carcinoma Non Small Cell Lung Associate 33269380
Carcinoma Renal Cell Associate 34491407
Carcinoma Transitional Cell Associate 31805718
Colonic Neoplasms Associate 32315285