Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7130
Gene name Gene Name - the full gene name approved by the HGNC.
TNF alpha induced protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNFAIP6
Synonyms (NCBI Gene) Gene synonyms aliases
TSG-6, TSG6
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and c
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT573255 hsa-miR-2052 PAR-CLIP 20371350
MIRT573256 hsa-miR-19a-5p PAR-CLIP 20371350
MIRT573254 hsa-miR-19b-1-5p PAR-CLIP 20371350
MIRT573253 hsa-miR-19b-2-5p PAR-CLIP 20371350
MIRT573255 hsa-miR-2052 PAR-CLIP 20371350
Transcription factors
Transcription factor Regulation Reference
CEBPB Activation 7876106
CEBPB Unknown 7935377
CEBPD Activation 23028973
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18042364, 18586671, 22267482, 24501198, 27044744
GO:0005540 Function Hyaluronic acid binding IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006954 Process Inflammatory response TAS 1730767
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600410 11898 ENSG00000123610
Protein
UniProt ID P98066
Protein name Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)
Protein function Major regulator of extracellular matrix organization during tissue remodeling (PubMed:15917224, PubMed:18042364, PubMed:26823460). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves
PDB 1O7B , 1O7C , 2N40 , 2PF5 , 2WNO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00193 Xlink 36 128 Extracellular link domain Domain
PF00431 CUB 135 244 CUB domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (
Sequence
Sequence length 277
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Dermatitis Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 16033404, 17374397
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
31264924
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 34382584
Adenocarcinoma of Lung Associate 38204755
Adenocarcinoma of Lung Stimulate 40776873
Alzheimer Disease Stimulate 30507579
Anal Gland Neoplasms Associate 36521659
Aortic Aneurysm Abdominal Stimulate 29180197
Arthritis Associate 26685054, 37958918, 9237673
Arthritis Psoriatic Associate 11178946
Arthritis Rheumatoid Associate 11178946, 12823853, 15549486, 21162099, 33897688, 34177888, 35353944
Arthritis Rheumatoid Stimulate 37958839