TNFAIP6 (TNF alpha induced protein 6)

Gene

• Entrez ID: 7130
• Gene name: TNF alpha induced protein 6
• Gene symbol: TNFAIP6
• Synonyms (NCBI Gene): TSG-6, TSG6
• Chromosome: 2
• Chromosome location: 2q23.3
• Summary: The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT573255	hsa-miR-2052	PAR-CLIP	20371350
MIRT573256	hsa-miR-19a-5p	PAR-CLIP	20371350
MIRT573254	hsa-miR-19b-1-5p	PAR-CLIP	20371350
MIRT573253	hsa-miR-19b-2-5p	PAR-CLIP	20371350
MIRT573255	hsa-miR-2052	PAR-CLIP	20371350
MIRT573256	hsa-miR-19a-5p	PAR-CLIP	20371350
MIRT573254	hsa-miR-19b-1-5p	PAR-CLIP	20371350
MIRT573253	hsa-miR-19b-2-5p	PAR-CLIP	20371350
MIRT2647470	hsa-miR-137	CLIP-seq
MIRT2647471	hsa-miR-23a	CLIP-seq
MIRT2647472	hsa-miR-23b	CLIP-seq
MIRT2647473	hsa-miR-23c	CLIP-seq
MIRT2647474	hsa-miR-3160-5p	CLIP-seq
MIRT2647475	hsa-miR-337-3p	CLIP-seq
MIRT2647476	hsa-miR-3647-3p	CLIP-seq
MIRT2647477	hsa-miR-3685	CLIP-seq
MIRT2647478	hsa-miR-384	CLIP-seq
MIRT2647479	hsa-miR-3924	CLIP-seq
MIRT2647480	hsa-miR-4446-5p	CLIP-seq
MIRT2647481	hsa-miR-4517	CLIP-seq
MIRT2647482	hsa-miR-4654	CLIP-seq
MIRT2647483	hsa-miR-4712-3p	CLIP-seq
MIRT2647484	hsa-miR-4755-5p	CLIP-seq
MIRT2647485	hsa-miR-4769-5p	CLIP-seq
MIRT2647486	hsa-miR-561	CLIP-seq
MIRT2647487	hsa-miR-579	CLIP-seq
MIRT2647470	hsa-miR-137	CLIP-seq
MIRT2647471	hsa-miR-23a	CLIP-seq
MIRT2647472	hsa-miR-23b	CLIP-seq
MIRT2647473	hsa-miR-23c	CLIP-seq
MIRT2647474	hsa-miR-3160-5p	CLIP-seq
MIRT2647475	hsa-miR-337-3p	CLIP-seq
MIRT2647476	hsa-miR-3647-3p	CLIP-seq
MIRT2647477	hsa-miR-3685	CLIP-seq
MIRT2647478	hsa-miR-384	CLIP-seq
MIRT2647479	hsa-miR-3924	CLIP-seq
MIRT2647480	hsa-miR-4446-5p	CLIP-seq
MIRT2647481	hsa-miR-4517	CLIP-seq
MIRT2647482	hsa-miR-4654	CLIP-seq
MIRT2647483	hsa-miR-4712-3p	CLIP-seq
MIRT2647484	hsa-miR-4755-5p	CLIP-seq
MIRT2647485	hsa-miR-4769-5p	CLIP-seq
MIRT2647486	hsa-miR-561	CLIP-seq
MIRT2647487	hsa-miR-579	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPB	Activation	7876106
CEBPB	Unknown	7935377
CEBPD	Activation	23028973

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001550	Process	Ovarian cumulus expansion	IEA
GO:0001550	Process	Ovarian cumulus expansion	ISS
GO:0001968	Function	Fibronectin binding	IDA	18042364
GO:0005509	Function	Calcium ion binding	IDA	26468290
GO:0005515	Function	Protein binding	IPI	16771708, 18042364, 18586671, 22267482, 24501198, 26468290, 27044744
GO:0005540	Function	Hyaluronic acid binding	IDA	26468290, 26823460
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005540	Function	Hyaluronic acid binding	TAS	1730767
GO:0005576	Component	Extracellular region	IDA	1730767
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006954	Process	Inflammatory response	TAS	1730767
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	TAS	1730767
GO:0007267	Process	Cell-cell signaling	TAS	1730767
GO:0016787	Function	Hydrolase activity	IEA
GO:0030212	Process	Hyaluronan metabolic process	IDA	20463016, 26468290
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	IDA	16771708
GO:0045668	Process	Negative regulation of osteoblast differentiation	IDA	16771708, 18586671
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	18586671
GO:0046872	Function	Metal ion binding	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IBA
GO:0050728	Process	Negative regulation of inflammatory response	IDA	21569482
GO:0090024	Process	Negative regulation of neutrophil chemotaxis	IDA	24501198
GO:0106435	Function	Carboxylesterase activity	IDA	16873769, 20463016
GO:1903911	Process	Positive regulation of receptor clustering	IDA	26823460
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS
GO:1905590	Process	Fibronectin fibril organization	IDA	18042364

Other IDs

• MIM: 600410
• HGNC: 11898
• e!Ensembl: ENSG00000123610

Protein

• UniProt ID: P98066
• Protein name: Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)
• Protein function: Major regulator of extracellular matrix organization during tissue remodeling (PubMed:15917224, PubMed:18042364, PubMed:26823460). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves
• PDB: 1O7B, 1O7C, 2N40, 2PF5, 2WNO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00193	Xlink	36 → 128	Extracellular link domain	Domain
  PF00431	CUB	135 → 244	CUB domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (
• Sequence:

  MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEF
  EGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRS
  ERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDF
  DLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGF
  QIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL

• Sequence length: 277

Pathways

Reactome:

Neutrophil degranulation