Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7114
Gene name Gene Name - the full gene name approved by the HGNC.
Thymosin beta 4 X-linked
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMSB4X
Synonyms (NCBI Gene) Gene synonyms aliases
FX, PTMB4, TB4X, TMSB4
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001845 hsa-miR-1-3p Reporter assay;Other 15951802
MIRT708866 hsa-miR-148a-5p HITS-CLIP 19536157
MIRT708865 hsa-miR-5584-3p HITS-CLIP 19536157
MIRT708864 hsa-miR-4286 HITS-CLIP 19536157
MIRT708863 hsa-miR-6752-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0003723 Function RNA binding HDA 22658674
GO:0003785 Function Actin monomer binding IBA 21873635
GO:0003785 Function Actin monomer binding IDA 1447300, 1999398
GO:0005515 Function Protein binding IPI 17967441, 20706999, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300159 11881 ENSG00000205542
Protein
UniProt ID P62328
Protein name Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]
Protein function Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMe
PDB 3TU5 , 4PL7 , 4PL8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01290 Thymosin 3 41 Thymosin beta-4 family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. {ECO:0000269|PubMed:3500230}.
Sequence
Sequence length 44
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Regulation of actin cytoskeleton   Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
11796754
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 11796754
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17916567
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac disease GWAS
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute On Chronic Liver Failure Associate 35150577
Alzheimer Disease Associate 37788276
Aortic Aneurysm Abdominal Associate 11436088
Astrocytoma Associate 33469081
Brain Neoplasms Associate 33469081, 35328618
Breast Neoplasms Associate 12029440
Calcinosis Cutis Inhibit 25963741
Carcinogenesis Associate 22233609, 23055022, 24141838, 31048733
Carcinoma Ductal Breast Associate 20353910
Carcinoma Hepatocellular Associate 21514425, 24704991