Gene Gene information from NCBI Gene database.
Entrez ID 7114
Gene name Thymosin beta 4 X-linked
Gene symbol TMSB4X
Synonyms (NCBI Gene)
FXPTMB4TB4XTMSB4
Chromosome X
Chromosome location Xp22.2
Summary This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome
miRNA miRNA information provided by mirtarbase database.
537
miRTarBase ID miRNA Experiments Reference
MIRT001845 hsa-miR-1-3p Reporter assay;Other 15951802
MIRT708866 hsa-miR-148a-5p HITS-CLIP 19536157
MIRT708865 hsa-miR-5584-3p HITS-CLIP 19536157
MIRT708864 hsa-miR-4286 HITS-CLIP 19536157
MIRT708863 hsa-miR-6752-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003779 Function Actin binding IEA
GO:0003785 Function Actin monomer binding IBA
GO:0003785 Function Actin monomer binding IDA 1999398
GO:0003785 Function Actin monomer binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300159 11881 ENSG00000205542
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62328
Protein name Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)]
Protein function Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMe
PDB 3TU5 , 4PL7 , 4PL8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01290 Thymosin 3 41 Thymosin beta-4 family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. {ECO:0000269|PubMed:3500230}.
Sequence
Sequence length 44
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Regulation of actin cytoskeleton   Platelet degranulation