TMPRSS2 (transmembrane serine protease 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 7113
Gene name Transmembrane serine protease 2
Gene symbol TMPRSS2
Synonyms (NCBI Gene)
PRSS10
Chromosome 21
Chromosome location 21q22.3
Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to
miRNA miRNA information provided by mirtarbase database.
121
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT734703 hsa-miR-98-5p qRT-PCR 33359190
MIRT734704 hsa-miR-32-3p qRT-PCR 33359190
MIRT734705 hsa-miR-214-3p qRT-PCR 33359190
MIRT1441037 hsa-miR-182 CLIP-seq
MIRT1441038 hsa-miR-3130-3p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
AR Activation 20308527;21761340
AR Unknown 23192983
ERG Unknown 24418414
NKX3-1 Unknown 24418414
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IDA 25122198
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS
GO:0005515 Function Protein binding IPI 21068237, 32296183, 33741941
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602060 11876 ENSG00000184012
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15393
Protein name Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Protein function Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostat
PDB 7MEQ , 7XYD , 7Y0E , 7Y0F , 8HD8 , 8JHZ , 8JI0 , 8S0L , 8S0M , 8S0N , 8V04 , 8V1F , 8VGT , 8Y1D , 8Y1E , 8Y7X , 8Y7Y , 8Y87 , 8Y88 , 8Y89 , 8Y8A , 8Y8B , 8YOY , 8YQQ , 9IZN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15494 SRCR_2 153 → 248 Scavenger receptor cysteine-rich domain Domain
PF00089 Trypsin 256 → 484 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly
Sequence
Sequence length 492
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Influenza A
Coronavirus disease - COVID-19
Transcriptional misregulation in cancer
Prostate cancer 		 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Associated with severe COVID-19 disease Benign rs12329760 RCV003401574
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs781089181, rs781290787 RCV004558016
RCV004558017
Prostate cancer Uncertain significance rs193920966 RCV000149059
TMPRSS2-related disorder Likely benign rs61735795, rs61735791 RCV003904099
RCV003914136
Show/Hide Text Mining Associations (118)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 19151660, 19734849, 21499238, 21677539, 21743434, 24406865, 27272561, 29949537, 32468052, 32705281, 33061814, 33609069, 35049068, 35211754, 36364238
Adenocarcinoma of Lung Associate 31854219, 33061814, 33421977, 35211754, 35960376, 36364238
Adenocarcinoma of Lung Inhibit 34168096, 35170548
amyloidosis IX Associate 30300367
Anxiety Associate 37142998
Asthma Associate 32348692, 32422146, 33413387, 34198852
Brain Diseases Associate 34416267
Breast Neoplasms Associate 25029565, 30792990, 36364238
Breast Neoplasms Stimulate 33421977
Cap Myopathy Associate 17259299, 21178489, 24115221