TMPRSS2 (transmembrane serine protease 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7113
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane serine protease 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMPRSS2
Synonyms (NCBI Gene) Gene synonyms aliases
PRSS10
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(121)
miRTarBase ID miRNA Experiments Reference
MIRT734703 hsa-miR-98-5p qRT-PCR 33359190
MIRT734704 hsa-miR-32-3p qRT-PCR 33359190
MIRT734705 hsa-miR-214-3p qRT-PCR 33359190
MIRT1441037 hsa-miR-182 CLIP-seq
MIRT1441038 hsa-miR-3130-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
AR Activation 20308527;21761340
AR Unknown 23192983
ERG Unknown 24418414
NKX3-1 Unknown 24418414
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(25)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IDA 25122198
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS
GO:0005515 Function Protein binding IPI 21068237, 32296183, 33741941
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602060 11876 ENSG00000184012
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O15393
Protein name Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Protein function Plasma membrane-anchored serine protease that cleaves at arginine residues (PubMed:32703818, PubMed:35676539, PubMed:37990007, PubMed:38964328). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostat
PDB 7MEQ , 7XYD , 7Y0E , 7Y0F , 8HD8 , 8JHZ , 8JI0 , 8S0L , 8S0M , 8S0N , 8V04 , 8V1F , 8VGT , 8Y1D , 8Y1E , 8Y7X , 8Y7Y , 8Y87 , 8Y88 , 8Y89 , 8Y8A , 8Y8B , 8YOY , 8YQQ , 9IZN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15494 SRCR_2 153 → 248 Scavenger receptor cysteine-rich domain Domain
PF00089 Trypsin 256 → 484 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly
Sequence
Sequence length 492
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Influenza A
Coronavirus disease - COVID-19
Transcriptional misregulation in cancer
Prostate cancer 		 
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer, Prostate cancer (late onset) N/A N/A GWAS
Show/Hide Text Mining Associations (118)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 19151660, 19734849, 21499238, 21677539, 21743434, 24406865, 27272561, 29949537, 32468052, 32705281, 33061814, 33609069, 35049068, 35211754, 36364238
Adenocarcinoma of Lung Associate 31854219, 33061814, 33421977, 35211754, 35960376, 36364238
Adenocarcinoma of Lung Inhibit 34168096, 35170548
amyloidosis IX Associate 30300367
Anxiety Associate 37142998
Asthma Associate 32348692, 32422146, 33413387, 34198852
Brain Diseases Associate 34416267
Breast Neoplasms Associate 25029565, 30792990, 36364238
Breast Neoplasms Stimulate 33421977
Cap Myopathy Associate 17259299, 21178489, 24115221