|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7112
|
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Thymopoietin |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TMPO |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CMD1T, LAP2, LEMD4, PRO0868, TP |
|
Chromosome
Chromosome number
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12 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q23.1 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expre |
| UniProt ID |
P42166
|
| Protein name |
Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] |
| Protein function |
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; TP and TP5 may play a role in T-cell development and |
| PDB |
1GJJ
,
1H9E
,
1H9F
,
8FN7
,
8FND
,
8FNG
,
8FNH
,
8FNJ
,
8FNL
,
8FNM
,
8FNN
,
8FNO
,
8FNP
,
8FNQ
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF08198
|
Thymopoietin |
2 → 49 |
Thymopoietin protein |
Family |
|
PF03020
|
LEM |
111 → 150 |
LEM domain |
Domain |
|
PF11560
|
LAP2alpha |
461 → 693 |
Lamina-associated polypeptide 2 alpha |
Family |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver. |
| Sequence |
|
| Sequence length |
694 |
| UniProt ID |
P42167
|
| Protein name |
Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] |
| Protein function |
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control o |
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF08198
|
Thymopoietin |
2 → 49 |
Thymopoietin protein |
Family |
|
PF03020
|
LEM |
111 → 150 |
LEM domain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver. |
| Sequence |
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL LDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDS DRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKG GPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTG NFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLF VVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
|
|
| Sequence length |
454 |
| Interactions |
View interactions
|
|
Unknown
Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
|
| Disease merge term |
Disease name |
Evidence |
References |
Source |
| arrhythmogenic right ventricular cardiomyopathy |
Arrhythmogenic right ventricular cardiomyopathy |
N/A |
N/A |
ClinVar |
| cardiomyopathy |
Cardiomyopathy |
N/A |
N/A |
ClinVar |
| Cardiomyopathy |
Primary dilated cardiomyopathy |
N/A |
N/A |
ClinVar |
| Dilated Cardiomyopathy |
Dilated cardiomyopathy 1T, Dilated Cardiomyopathy, Dominant, familial isolated dilated cardiomyopathy |
N/A |
N/A |
ClinVar, GenCC |
| Hypertrophic Cardiomyopathy |
Primary familial hypertrophic cardiomyopathy, Hypertrophic cardiomyopathy 25 |
N/A |
N/A |
ClinVar |
| Hypertrophic cardiomyopathy |
hypertrophic cardiomyopathy |
N/A |
N/A |
GenCC, ClinVar |
| Loeys-Dietz Syndrome |
Loeys-Dietz syndrome 2 |
N/A |
N/A |
ClinVar |
| Long QT Syndrome |
long qt syndrome |
N/A |
N/A |
ClinVar |
| Myopathy |
dilated cardiomyopathy |
N/A |
N/A |
GenCC |
|
|
Associations from Text Mining
Disease associations identified through Pubtator
|
| Disease Name |
Relationship Type |
References |
| Adenocarcinoma of Lung |
Associate
|
30587197 |
| Breast Neoplasms |
Associate
|
25837847 |
| Breast Neoplasms |
Stimulate
|
27756319 |
| Cardiomyopathy Dilated |
Associate
|
31277123, 36362411 |
| Colorectal Neoplasms |
Associate
|
33422939 |
| Esophageal Squamous Cell Carcinoma |
Associate
|
35760875 |
| Glioblastoma |
Associate
|
27756319 |
| Lung Neoplasms |
Stimulate
|
27756319 |
| Neoplasm Metastasis |
Associate
|
35760875 |
| Neoplasms |
Associate
|
25837847 |
| Neoplasms |
Stimulate
|
27756319 |
| Non alcoholic Fatty Liver Disease |
Associate
|
28902428 |
| Sarcoma Myeloid |
Associate
|
25877407 |
| Uterine Cervical Neoplasms |
Associate
|
36614304 |
| Wilms Tumor |
Associate
|
32597194 |
|