Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7112
Gene name Gene Name - the full gene name approved by the HGNC.
Thymopoietin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMPO
Synonyms (NCBI Gene) Gene synonyms aliases
CMD1T, LAP2, LEMD4, PRO0868, TP
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q23.1
Summary Summary of gene provided in NCBI Entrez Gene.
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expre
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs138295270 G>A Conflicting-interpretations-of-pathogenicity, uncertain-significance Coding sequence variant, intron variant, missense variant
rs200420073 C>A Conflicting-interpretations-of-pathogenicity Missense variant, 5 prime UTR variant, coding sequence variant
rs200923649 A>G Conflicting-interpretations-of-pathogenicity Missense variant, 5 prime UTR variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024489 hsa-miR-215-5p Microarray 19074876
MIRT026410 hsa-miR-192-5p Microarray 19074876
MIRT048728 hsa-miR-96-5p CLASH 23622248
MIRT044781 hsa-miR-320a CLASH 23622248
MIRT044336 hsa-miR-106b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
EGR1 Activation 19747485
SP1 Activation 19747485
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 17284516
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 16247757, 17474147, 29568061, 32296183, 32707033
GO:0005521 Function Lamin binding IEA
GO:0005521 Function Lamin binding TAS 8530026
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
188380 11875 ENSG00000120802
Protein
UniProt ID P42166
Protein name Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
Protein function May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; TP and TP5 may play a role in T-cell development and
PDB 1GJJ , 1H9E , 1H9F , 8FN7 , 8FND , 8FNG , 8FNH , 8FNJ , 8FNL , 8FNM , 8FNN , 8FNO , 8FNP , 8FNQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08198 Thymopoietin 2 49 Thymopoietin protein Family
PF03020 LEM 111 150 LEM domain Domain
PF11560 LAP2alpha 461 693 Lamina-associated polypeptide 2 alpha Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Sequence
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK
GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL
LDQLVKYGVNPGPIVGTTRKLYEKKLLKLR
EQGTESRSSTPLPTISSSAENTRQNGSNDS
DRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFPEISTRPPLGSTELQA
AKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEH
SAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKAL
EESESSQLISPPLAQAIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQET
EFLSPPRKVPRLSEKSVEERDSGSFVAFQNIPGSELMSSFAKTVVSHSLTTLGLEVAKQS
QHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEI
LGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA
AQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKI
NLASKNKLASTPFKGGTLFGGEVCKVIKKRGNK
H
Sequence length 694
UniProt ID P42167
Protein name Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
Protein function May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control o
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08198 Thymopoietin 2 49 Thymopoietin protein Family
PF03020 LEM 111 150 LEM domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Sequence
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK
GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL
LDQLVKYGVNPGPIVGTTRKLYEKKLLKLR
EQGTESRSSTPLPTISSSAENTRQNGSNDS
DRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQAGITETEWTSGSSKG
GPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTG
NFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGIS
ASCRRPIKGAAGRPLELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLF
VVVAVFLFLVYQAMETNQVNPFSNFLHVDPRKSN
Sequence length 454
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Nuclear Envelope Breakdown
Initiation of Nuclear Envelope (NE) Reformation
Depolymerisation of the Nuclear Lamina
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy N/A N/A ClinVar
cardiomyopathy Cardiomyopathy N/A N/A ClinVar
Cardiomyopathy Primary dilated cardiomyopathy N/A N/A ClinVar
Dilated Cardiomyopathy Dilated cardiomyopathy 1T, Dilated Cardiomyopathy, Dominant, familial isolated dilated cardiomyopathy N/A N/A ClinVar, GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30587197
Breast Neoplasms Associate 25837847
Breast Neoplasms Stimulate 27756319
Cardiomyopathy Dilated Associate 31277123, 36362411
Colorectal Neoplasms Associate 33422939
Esophageal Squamous Cell Carcinoma Associate 35760875
Glioblastoma Associate 27756319
Lung Neoplasms Stimulate 27756319
Neoplasm Metastasis Associate 35760875
Neoplasms Associate 25837847