TM4SF4 (transmembrane 4 L six family member 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7104
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane 4 L six family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TM4SF4
Synonyms (NCBI Gene) Gene synonyms aliases
ILTMP, il-TMP
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
miRTarBase ID miRNA Experiments Reference
MIRT2461538 hsa-miR-1298 CLIP-seq
MIRT2461539 hsa-miR-219-1-3p CLIP-seq
MIRT2461540 hsa-miR-4272 CLIP-seq
MIRT2461541 hsa-miR-571 CLIP-seq
MIRT2461542 hsa-miR-664 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0016020 Component Membrane IBA
GO:0016020 Component Membrane IEA
GO:0042246 Process Tissue regeneration IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606567 11856 ENSG00000169903
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID P48230
Protein name Transmembrane 4 L6 family member 4 (Intestine and liver tetraspan membrane protein) (IL-TMP)
Protein function Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05805 L6_membrane 1 → 191 L6 membrane protein Family
Tissue specificity TISSUE SPECIFICITY: Jejunum and liver.
Sequence
Sequence length 202
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Cholecystitis Cholecystitis N/A N/A GWAS
Cholelithiasis Cholelithiasis N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Gout Gout N/A N/A GWAS
Show/Hide Text Mining Associations (8)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 32972043
Carcinoma Hepatocellular Stimulate 22236579
Carcinoma Hepatocellular Associate 22236579, 39999090
Colorectal Neoplasms Associate 22011044, 28687755, 37535601
Liver Failure Stimulate 22236579
Lung Neoplasms Stimulate 32972043
Neoplasm Metastasis Associate 22011044
Neoplasms Associate 22011044