TSPAN8 (tetraspanin 8)

Gene Gene information from NCBI Gene database.
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID 7103
Gene name Tetraspanin 8
Gene symbol TSPAN8
Synonyms (NCBI Gene)
CO-029TM4SF3
Chromosome 12
Chromosome location 12q21.1
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005178 Function Integrin binding IEA
GO:0005515 Function Protein binding IPI 27180358, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0007283 Process Spermatogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
600769 11855 ENSG00000127324
Protein Protein information from UniProt database.
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P19075
Protein name Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)
Protein function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:27180357, PubMed:36078095). Participates thereby in diverse biolog
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 8 → 233 Tetraspanin family Family
Tissue specificity TISSUE SPECIFICITY: Gastric, colon, rectal, and pancreatic carcinomas.
Sequence
Sequence length 237
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Breast ductal adenocarcinoma Uncertain significance rs869025229 RCV000207126
Show/Hide Text Mining Associations (29)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 20543560
Ascites Associate 36613908
Asthma Associate 31361310, 40187354
Barrett Esophagus Associate 20543560
Bipolar Disorder Associate 18317468
Carcinogenesis Associate 36613908
Carcinoma Hepatocellular Associate 25556502
Carcinoma Pancreatic Ductal Associate 34163029, 35773268
Colorectal Neoplasms Associate 17912244, 21602532, 22011044, 26993598
Colorectal Neoplasms Inhibit 22679508