TSPAN8 (tetraspanin 8)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7103
Gene name Gene Name - the full gene name approved by the HGNC.
Tetraspanin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSPAN8
Synonyms (NCBI Gene) Gene synonyms aliases
CO-029, TM4SF3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0005178 Function Integrin binding IEA
GO:0005515 Function Protein binding IPI 27180358, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0007283 Process Spermatogenesis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
600769 11855 ENSG00000127324
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID P19075
Protein name Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)
Protein function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:27180357, PubMed:36078095). Participates thereby in diverse biolog
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 8 → 233 Tetraspanin family Family
Tissue specificity TISSUE SPECIFICITY: Gastric, colon, rectal, and pancreatic carcinomas.
Sequence
Sequence length 237
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Acne acne vulgaris N/A N/A GWAS
Asthma Age of onset of childhood onset asthma, Asthma in any disease, Asthma, Asthma (childhood onset), Asthma (adult onset) N/A N/A GWAS
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (29)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 20543560
Ascites Associate 36613908
Asthma Associate 31361310, 40187354
Barrett Esophagus Associate 20543560
Bipolar Disorder Associate 18317468
Carcinogenesis Associate 36613908
Carcinoma Hepatocellular Associate 25556502
Carcinoma Pancreatic Ductal Associate 34163029, 35773268
Colorectal Neoplasms Associate 17912244, 21602532, 22011044, 26993598
Colorectal Neoplasms Inhibit 22679508