TSPAN8 (tetraspanin 8)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7103
Gene name Gene Name - the full gene name approved by the HGNC.
Tetraspanin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSPAN8
Synonyms (NCBI Gene) Gene synonyms aliases
CO-029, TM4SF3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005178 Function Integrin binding IEA
GO:0005515 Function Protein binding IPI 27180358, 32296183
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007283 Process Spermatogenesis IEA
GO:0009986 Component Cell surface IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
600769 11855 ENSG00000127324
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID P19075
Protein name Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)
Protein function Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:27180357, PubMed:36078095). Participates thereby in diverse biolog
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00335 Tetraspanin 8 → 233 Tetraspanin family Family
Tissue specificity TISSUE SPECIFICITY: Gastric, colon, rectal, and pancreatic carcinomas.
Sequence
Sequence length 237
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 23300278, 18372903
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 20052686
Show/Hide Unknown Diseases (7)
Unknown
Disease term Disease name Evidence References Source
Asthma Childhood asthma, Asthma 31036433 ClinVar, GWAS
Coronary heart disease Coronary heart disease 21347282 ClinVar
Diabetes Diabetes GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Show/Hide Text Mining Associations (29)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 20543560
Ascites Associate 36613908
Asthma Associate 31361310, 40187354
Barrett Esophagus Associate 20543560
Bipolar Disorder Associate 18317468
Carcinogenesis Associate 36613908
Carcinoma Hepatocellular Associate 25556502
Carcinoma Pancreatic Ductal Associate 34163029, 35773268
Colorectal Neoplasms Associate 17912244, 21602532, 22011044, 26993598
Colorectal Neoplasms Inhibit 22679508