TLR5 (toll like receptor 5)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 7100
Gene name Toll like receptor 5
Gene symbol TLR5
Synonyms (NCBI Gene)
MELIOSSLE1SLEB1TIL3
Chromosome 1
Chromosome location 1q41
Summary This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are express
SNPs SNP information provided by dbSNP.
2
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (2)
SNP ID Visualize variation Clinical significance Consequence
rs2072493 T>A,C Risk-factor Coding sequence variant, missense variant
rs5744168 G>A Risk-factor, protective Coding sequence variant, stop gained
miRNA miRNA information provided by mirtarbase database.
62
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (62)
miRTarBase ID miRNA Experiments Reference
MIRT451800 hsa-miR-6783-5p PAR-CLIP 23592263
MIRT451799 hsa-miR-3185 PAR-CLIP 23592263
MIRT451798 hsa-miR-4645-3p PAR-CLIP 23592263
MIRT451797 hsa-miR-3184-5p PAR-CLIP 23592263
MIRT451796 hsa-miR-423-5p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0002224 Process Toll-like receptor signaling pathway IBA
GO:0002224 Process Toll-like receptor signaling pathway IEA
GO:0002376 Process Immune system process IEA
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0005149 Function Interleukin-1 receptor binding IPI 12925853
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603031 11851 ENSG00000187554
Protein Protein information from UniProt database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60602
Protein name Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Protein function Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molec
PDB 3J0A , 8AR2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 79 → 131 Leucine rich repeat Repeat
PF13855 LRR_8 288 → 348 Leucine rich repeat Repeat
PF13855 LRR_8 491 → 538 Leucine rich repeat Repeat
PF01582 TIR 692 → 858 TIR domain Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781). {ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:184
Sequence 
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKE
KEKKKDNNIPLQTVATIS
Sequence length 858
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
Inflammatory bowel disease 		  Toll Like Receptor 5 (TLR5) Cascade
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (13)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign; Likely benign rs5744175 RCV005891020
Cervical cancer Benign; Likely benign rs5744175 RCV005891021
Clear cell carcinoma of kidney Benign; Likely benign rs5744175 RCV005891022
Colon adenocarcinoma Benign; Likely benign rs5744175 RCV005891019
Show/Hide Text Mining Associations (109)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 37273234
Adenoma Associate 35636682
Agnosia Associate 28856441
Aicardi Syndrome Associate 26888781
Alzheimer Disease Associate 17652175
Appendicitis Associate 24336024
Arthritis Rheumatoid Associate 21179534, 22661088, 26440629, 31376255, 33482886, 37796367
Arthritis Rheumatoid Stimulate 31396542
Asthma Associate 29486764
Astrocytoma Associate 29912993