Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	710
Gene name Gene Name - the full gene name approved by the HGNC.	Serpin family G member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SERPING1
Synonyms (NCBI Gene) Gene synonyms aliases	C1IN, C1INH, C1NH, HAE1, HAE2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	HAE1
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It i

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SNP ID	Visualize variation	Clinical significance	Consequence
rs28940870	C>A,T	Pathogenic, not-provided	Coding sequence variant, missense variant
rs112565881	G>A,T	Pathogenic	Splice donor variant
rs121907947	G>A	Pathogenic	Coding sequence variant, missense variant
rs121907948	G>A,C,T	Not-provided, pathogenic	Coding sequence variant, missense variant
rs121907949	T>A	Pathogenic	Coding sequence variant, missense variant
rs121907950	C>T	Pathogenic	Coding sequence variant, missense variant
rs121907951	C>G	Pathogenic	Coding sequence variant, stop gained
rs201363394	C>T	Pathogenic	Coding sequence variant, missense variant
rs281875170	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs606231141	->TGT	Pathogenic	Coding sequence variant, inframe indel
rs763451792	T>C,G	Pathogenic	Missense variant, coding sequence variant
rs778625408	G>A,T	Pathogenic	Missense variant, coding sequence variant, stop gained
rs886041353	G>A	Pathogenic	Splice acceptor variant
rs922149386	C>T	Pathogenic	Stop gained, coding sequence variant
rs956390201	G>A,C	Pathogenic	Missense variant, coding sequence variant
rs978962357	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520366	A>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1064793350	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1064793792	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064793917	AGTTCCA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1085307611	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554994665	G>T	Likely-pathogenic	Intron variant
rs1554994909	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554995260	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1554995271	A>TCAGTGTCGTG	Pathogenic	Coding sequence variant, inframe indel, stop gained
rs1554995774	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1554995860	C>G	Pathogenic	Coding sequence variant, stop gained
rs1554996817	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554996819	->A	Pathogenic	Coding sequence variant, stop gained
rs1554996833	GA>-	Pathogenic, likely-pathogenic	Coding sequence variant, frameshift variant
rs1554996859	CAAGTTCC>A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1565168898	A>C,G	Pathogenic	Missense variant, initiator codon variant
rs1565169419	A>T	Pathogenic	Coding sequence variant, stop gained
rs1565169621	TACC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1565170287	ATCC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1565170364	TC>AA	Pathogenic	Coding sequence variant, stop gained
rs1565171906	C>T	Pathogenic	Coding sequence variant, stop gained
rs1565173309	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1565173405	T>A	Pathogenic	Coding sequence variant, stop gained
rs1565174105	C>T	Pathogenic	Coding sequence variant, stop gained
rs1590821401	G>-	Likely-pathogenic	Coding sequence variant, splice donor variant
rs1590822296	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1590822371	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1590822588	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1590822719	AGACCAACATGG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1590822739	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1590823884	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1590826571	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1590826703	T>C	Pathogenic	Coding sequence variant, missense variant
rs1590829609	C>T	Pathogenic	Coding sequence variant, stop gained
rs1590829616	GCTGCAGCTCTCCCA>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1590829685	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1590829763	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1590831385	->GAACTGAC	Pathogenic	Coding sequence variant, inframe insertion, stop gained
rs1590831432	C>T	Pathogenic	Coding sequence variant, missense variant
rs1590831492	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1590831545	G>A	Pathogenic	Coding sequence variant, stop gained

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018847	hsa-miR-335-5p	Microarray	18185580
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT611745	hsa-miR-5695	HITS-CLIP	19536157
MIRT611744	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT611743	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT611741	hsa-miR-3672	HITS-CLIP	19536157
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT611739	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT611745	hsa-miR-5695	HITS-CLIP	19536157
MIRT611743	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT611739	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT641421	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT641420	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT641419	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT620861	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620860	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620859	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620856	hsa-miR-4284	HITS-CLIP	23824327
MIRT620855	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT620854	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT620853	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT620852	hsa-miR-4507	HITS-CLIP	23824327
MIRT620851	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT620861	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620860	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620859	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620858	hsa-miR-635	HITS-CLIP	23824327
MIRT620857	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT620856	hsa-miR-4284	HITS-CLIP	23824327
MIRT620855	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT620854	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT620853	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT620852	hsa-miR-4507	HITS-CLIP	23824327
MIRT620851	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT542324	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542323	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542322	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT542321	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542320	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT542319	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT542318	hsa-miR-661	PAR-CLIP	21572407
MIRT542317	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542315	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542316	hsa-miR-7703	PAR-CLIP	21572407
MIRT542314	hsa-miR-1262	PAR-CLIP	21572407
MIRT542313	hsa-miR-4701-3p	PAR-CLIP	21572407
MIRT542312	hsa-miR-6736-5p	PAR-CLIP	21572407
MIRT542311	hsa-miR-498	PAR-CLIP	21572407
MIRT542310	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT611745	hsa-miR-5695	HITS-CLIP	19536157
MIRT611744	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT611743	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT611741	hsa-miR-3672	HITS-CLIP	19536157
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT611739	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT611745	hsa-miR-5695	HITS-CLIP	19536157
MIRT611743	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT611739	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT641421	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT641420	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT641419	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT620861	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620860	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620859	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620856	hsa-miR-4284	HITS-CLIP	23824327
MIRT620855	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT620854	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT620853	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT620852	hsa-miR-4507	HITS-CLIP	23824327
MIRT620851	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT620861	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT620860	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT620859	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT620858	hsa-miR-635	HITS-CLIP	23824327
MIRT620857	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT620856	hsa-miR-4284	HITS-CLIP	23824327
MIRT620855	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT620854	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT620853	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT620852	hsa-miR-4507	HITS-CLIP	23824327
MIRT620851	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT611746	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT611745	hsa-miR-5695	HITS-CLIP	23824327
MIRT611744	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT611743	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT611742	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT611741	hsa-miR-3672	HITS-CLIP	23824327
MIRT611740	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT611739	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT542324	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542323	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542322	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT542321	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542320	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT542319	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT542318	hsa-miR-661	PAR-CLIP	21572407
MIRT542317	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542315	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542316	hsa-miR-7703	PAR-CLIP	21572407
MIRT542314	hsa-miR-1262	PAR-CLIP	21572407
MIRT542313	hsa-miR-4701-3p	PAR-CLIP	21572407
MIRT542312	hsa-miR-6736-5p	PAR-CLIP	21572407
MIRT542311	hsa-miR-498	PAR-CLIP	21572407
MIRT542310	hsa-miR-1273g-3p	PAR-CLIP	21572407

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001869	Process	Negative regulation of complement activation, lectin pathway	IDA	10946292
GO:0002576	Process	Platelet degranulation	TAS
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA	21873635
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IDA	11527969
GO:0005515	Function	Protein binding	IPI	10570951, 10946292, 16237761, 22046132, 22483117, 25910212
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0007597	Process	Blood coagulation, intrinsic pathway	TAS
GO:0008015	Process	Blood circulation	TAS	2365061, 2563376
GO:0010951	Process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0030449	Process	Regulation of complement activation	TAS
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0042730	Process	Fibrinolysis	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28675934
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
606860	1228	ENSG00000149131

Protein

UniProt ID

P05155

Protein name

Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)

Protein function

Serine protease inhibitor, which acrs as a regulator of the classical complement pathway (PubMed:10946292, PubMed:11527969, PubMed:3458172, PubMed:6416294). Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases (P

PDB

2OAY , 5DU3 , 5DUQ , 7AKV , 8W18

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00079	Serpin	144 → 498	Serpin (serine protease inhibitor)	Domain

Sequence

MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG
SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ
VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS
RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK
TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP
QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD
FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV
LWDQQHKFPVFMGRVYDPRA

Sequence length

500

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades Pertussis		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Angioedema	Angioedemas, Hereditary, Hereditary Angioedema Type II, Hereditary Angioedema Types I and II, Hereditary Angioedema Type I, Acquired angioedema, Hereditary angioedema type 1, Hereditary angioedema type 2	rs28940870, rs1554996819, rs1554996817, rs112565881, rs2135304804, rs121907951, rs281875174, rs281875178, rs281875168, rs281875170, rs281875171, rs1554995255, rs1554995860, rs886041353, rs978962357 View all (36 more)	9734886, 23634741, 23406939, 7883978, 19477491, 23866957, 23844784, 24456027, 18387221, 15806011, 1644161, 2118657, 29753808, 8172583, 28194776 View all (12 more)
Complement component deficiency	Complement Component 4, Partial Deficiency Of, Complement deficiency disease	rs387906509, rs1467298230, rs1022194067, rs774370086, rs121964922, rs372345940, rs121913052, rs121913053, rs460897, rs121913054, rs121913056, rs121913058, rs796052138, rs41286844, rs121909592 View all (29 more)	7883978
Hereditary c1 esterase inhibitor deficiency	Hereditary C1 esterase inhibitor deficiency - deficient factor, Hereditary C1 esterase inhibitor deficiency - dysfunctional factor	rs121907947, rs28940870, rs121907949, rs606231141	24456027
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27935865
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Peripheral axonal neuropathy	Peripheral axonal neuropathy		ClinVar
Neuroticism	Neuroticism		GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Insomnia	Insomnia		GWAS

Show/Hide Text Mining Associations (72)

Disease Name	Relationship Type	References
Associations from Text Mining
Abdominal Pain	Associate	27725554, 32066472, 32351099
Acidosis Renal Tubular	Associate	33932403
Acquired angioedema	Associate	31397881
Adenocarcinoma of Lung	Associate	35733175
Adrenocortical Carcinoma	Associate	20231622
Airway Obstruction	Associate	23661661, 32066472
Angioedema	Associate	15356535, 25401373, 36787826, 6976242
Angioedema	Inhibit	23661661
Angioedemas Hereditary	Associate	11315937, 12773530, 15356535, 1611187, 16617246, 18035804, 18250972, 1885769, 1902490, 20955596, 2318974, 23437219, 24850548, 25053016, 26535898 View all (35 more)
Angioedemas Hereditary	Inhibit	15607116, 18460017, 37620742
Arterial Occlusive Diseases	Associate	36515245
Arthritis Rheumatoid	Associate	21385363, 37426666
Bipolar Disorder	Associate	30379966
Blood Coagulation Disorders	Associate	33730015, 37003465
Brain Ischemia	Associate	31434864
Breast Neoplasms	Associate	37109602
Cardiomyopathies	Associate	31434864
Colorectal Neoplasms	Associate	32660089
Complement Component C1s Deficiency	Associate	26154504, 26535898, 2890659, 29166502, 31959500, 37620742
Coronary Aneurysm	Associate	36515245
Coronary Disease	Associate	36515245
COVID 19	Associate	35733175, 36072597, 36696180, 37051252
Delayed Cranial Ossification due to CBFB Haploinsufficiency	Associate	16617246
Depressive Disorder	Associate	35870967
Diabetic Nephropathies	Associate	32778679
Edema	Associate	11315937, 20955596, 30530986, 32351099
Genetic Diseases Inborn	Associate	32351099, 38340462
Glioblastoma	Associate	33009892
Glioma	Associate	33009892
Glomerulonephritis IGA	Associate	30356754
Gray Platelet Syndrome	Inhibit	28707765
HAIR AN syndrome	Stimulate	32974878
Hereditary Angioedema Type III	Associate	26154504, 28194776, 34331949, 36787826, 37301409, 37620742, 38340462
Hereditary Angioedema Type III	Inhibit	37114700
Hereditary Angioedema Types I and II	Associate	23437219, 23940538, 2478540, 25053016, 30118244, 30398465, 30530986, 30918175, 32351099, 34838707, 36587848, 36858856, 9519866
Hereditary Angioedema Types I and II	Inhibit	24850548
Hypoxia Brain	Associate	33009892
Immunologic Deficiency Syndromes	Associate	34910083
Impotence Vasculogenic	Associate	36515245
Inflammation	Associate	2112412, 2478540, 36596079
Iron Overload	Associate	39272138
Jeune syndrome	Associate	32066472
Laryngeal Edema	Associate	32351099
Latent Tuberculosis	Associate	32179338
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Associate	37301409
Leukemia Myeloid Acute	Associate	27473565
Lung Diseases	Associate	32179338
Lymphatic Metastasis	Associate	33658651
Lymphoma Non Hodgkin	Associate	30398465, 34790823
Macular Degeneration	Associate	18842294, 19169411, 19607829, 20161815, 20606025, 21526158, 25800435
Melanoma	Associate	22032772
Mitochondrial Diseases	Associate	39272138
Mouth Diseases	Associate	28707765
Muscular Dystrophy Duchenne	Stimulate	36596079
Neoplasms Plasma Cell	Inhibit	30530986
Neoplastic Syndromes Hereditary	Associate	21375555
Osteosarcoma	Associate	29760609
Panic Disorder	Associate	32351099
Primary Immunodeficiency Diseases	Associate	35553639
Protein Deficiency	Associate	15607116
Pulmonary Embolism	Associate	37003465
Retinal Neoplasms	Associate	19607829
Schizophrenia	Associate	30379966
Severe Acute Respiratory Syndrome	Associate	33730015
Skin Diseases	Associate	32066472
Skin Diseases Vesiculobullous	Associate	32351099
Stomatitis Aphthous	Associate	21478439
Syndrome	Associate	33643312
Thrombosis	Associate	34668383
Tuberculosis	Associate	32179338, 36007657
Venous Thromboembolism	Inhibit	37003465
Venous Thrombosis	Associate	37003465

SERPING1 (serpin family G member 1)