Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7093
Gene name Gene Name - the full gene name approved by the HGNC.	Tolloid like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TLL2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

Show/Hide all(156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT710357	hsa-miR-2277-3p	HITS-CLIP	19536157
MIRT710356	hsa-miR-514a-3p	HITS-CLIP	19536157
MIRT710355	hsa-miR-514b-3p	HITS-CLIP	19536157
MIRT529107	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT529106	hsa-miR-4803	PAR-CLIP	22012620
MIRT529105	hsa-miR-944	PAR-CLIP	22012620
MIRT710357	hsa-miR-2277-3p	HITS-CLIP	19536157
MIRT710356	hsa-miR-514a-3p	HITS-CLIP	19536157
MIRT710355	hsa-miR-514b-3p	HITS-CLIP	19536157
MIRT529107	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT529106	hsa-miR-4803	PAR-CLIP	22012620
MIRT529105	hsa-miR-944	PAR-CLIP	22012620
MIRT1426626	hsa-miR-1289	CLIP-seq
MIRT1426627	hsa-miR-1324	CLIP-seq
MIRT1426628	hsa-miR-298	CLIP-seq
MIRT1426629	hsa-miR-30a	CLIP-seq
MIRT1426630	hsa-miR-30b	CLIP-seq
MIRT1426631	hsa-miR-30c	CLIP-seq
MIRT1426632	hsa-miR-30d	CLIP-seq
MIRT1426633	hsa-miR-30e	CLIP-seq
MIRT1426634	hsa-miR-3121-3p	CLIP-seq
MIRT1426635	hsa-miR-3125	CLIP-seq
MIRT1426636	hsa-miR-3143	CLIP-seq
MIRT1426637	hsa-miR-3158-5p	CLIP-seq
MIRT1426638	hsa-miR-3166	CLIP-seq
MIRT1426639	hsa-miR-3185	CLIP-seq
MIRT1426640	hsa-miR-3198	CLIP-seq
MIRT1426641	hsa-miR-365	CLIP-seq
MIRT1426642	hsa-miR-3662	CLIP-seq
MIRT1426643	hsa-miR-3665	CLIP-seq
MIRT1426644	hsa-miR-3678-3p	CLIP-seq
MIRT1426645	hsa-miR-3681	CLIP-seq
MIRT1426646	hsa-miR-370	CLIP-seq
MIRT1426647	hsa-miR-380	CLIP-seq
MIRT1426648	hsa-miR-3916	CLIP-seq
MIRT1426649	hsa-miR-3924	CLIP-seq
MIRT1426650	hsa-miR-3941	CLIP-seq
MIRT1426651	hsa-miR-4282	CLIP-seq
MIRT1426652	hsa-miR-4289	CLIP-seq
MIRT1426653	hsa-miR-4292	CLIP-seq
MIRT1426654	hsa-miR-4294	CLIP-seq
MIRT1426655	hsa-miR-4308	CLIP-seq
MIRT1426656	hsa-miR-4309	CLIP-seq
MIRT1426657	hsa-miR-433	CLIP-seq
MIRT1426658	hsa-miR-4418	CLIP-seq
MIRT1426659	hsa-miR-4495	CLIP-seq
MIRT1426660	hsa-miR-4520a-3p	CLIP-seq
MIRT1426661	hsa-miR-4633-5p	CLIP-seq
MIRT1426662	hsa-miR-4640-5p	CLIP-seq
MIRT1426663	hsa-miR-4641	CLIP-seq
MIRT1426664	hsa-miR-4654	CLIP-seq
MIRT1426665	hsa-miR-466	CLIP-seq
MIRT1426666	hsa-miR-4672	CLIP-seq
MIRT1426667	hsa-miR-4726-5p	CLIP-seq
MIRT1426668	hsa-miR-4731-3p	CLIP-seq
MIRT1426669	hsa-miR-4736	CLIP-seq
MIRT1426670	hsa-miR-4769-5p	CLIP-seq
MIRT1426671	hsa-miR-4771	CLIP-seq
MIRT1426672	hsa-miR-4793-5p	CLIP-seq
MIRT1426673	hsa-miR-4801	CLIP-seq
MIRT1426674	hsa-miR-4802-3p	CLIP-seq
MIRT1426675	hsa-miR-489	CLIP-seq
MIRT1426676	hsa-miR-509-3-5p	CLIP-seq
MIRT1426677	hsa-miR-509-5p	CLIP-seq
MIRT1426678	hsa-miR-5096	CLIP-seq
MIRT1426679	hsa-miR-532-5p	CLIP-seq
MIRT1426680	hsa-miR-543	CLIP-seq
MIRT1426681	hsa-miR-548a-3p	CLIP-seq
MIRT1426682	hsa-miR-548a-5p	CLIP-seq
MIRT1426683	hsa-miR-548ab	CLIP-seq
MIRT1426684	hsa-miR-548ak	CLIP-seq
MIRT1426685	hsa-miR-548b-5p	CLIP-seq
MIRT1426686	hsa-miR-548c-5p	CLIP-seq
MIRT1426687	hsa-miR-548d-5p	CLIP-seq
MIRT1426688	hsa-miR-548e	CLIP-seq
MIRT1426689	hsa-miR-548f	CLIP-seq
MIRT1426690	hsa-miR-548h	CLIP-seq
MIRT1426691	hsa-miR-548i	CLIP-seq
MIRT1426692	hsa-miR-548j	CLIP-seq
MIRT1426693	hsa-miR-548k	CLIP-seq
MIRT1426694	hsa-miR-548l	CLIP-seq
MIRT1426695	hsa-miR-548m	CLIP-seq
MIRT1426696	hsa-miR-548w	CLIP-seq
MIRT1426697	hsa-miR-548y	CLIP-seq
MIRT1426698	hsa-miR-552	CLIP-seq
MIRT1426699	hsa-miR-559	CLIP-seq
MIRT1426700	hsa-miR-660	CLIP-seq
MIRT1426701	hsa-miR-670	CLIP-seq
MIRT1426702	hsa-miR-7	CLIP-seq
MIRT1426703	hsa-miR-877	CLIP-seq
MIRT1426704	hsa-miR-940	CLIP-seq
MIRT2127825	hsa-miR-450b-5p	CLIP-seq
MIRT2127826	hsa-miR-4514	CLIP-seq
MIRT2127827	hsa-miR-4692	CLIP-seq
MIRT2127828	hsa-miR-4696	CLIP-seq
MIRT1426669	hsa-miR-4736	CLIP-seq
MIRT2127829	hsa-miR-498	CLIP-seq
MIRT2127830	hsa-miR-548b-3p	CLIP-seq
MIRT1426704	hsa-miR-940	CLIP-seq
MIRT2349519	hsa-miR-129-5p	CLIP-seq
MIRT2349520	hsa-miR-3173-5p	CLIP-seq
MIRT1426653	hsa-miR-4292	CLIP-seq
MIRT1426655	hsa-miR-4308	CLIP-seq
MIRT2349521	hsa-miR-4327	CLIP-seq
MIRT2127826	hsa-miR-4514	CLIP-seq
MIRT1426662	hsa-miR-4640-5p	CLIP-seq
MIRT2127827	hsa-miR-4692	CLIP-seq
MIRT2349522	hsa-miR-4705	CLIP-seq
MIRT1426667	hsa-miR-4726-5p	CLIP-seq
MIRT1426669	hsa-miR-4736	CLIP-seq
MIRT1426701	hsa-miR-670	CLIP-seq
MIRT1426704	hsa-miR-940	CLIP-seq
MIRT2395844	hsa-miR-1910	CLIP-seq
MIRT2395845	hsa-miR-214	CLIP-seq
MIRT2395846	hsa-miR-3619-5p	CLIP-seq
MIRT2395847	hsa-miR-3909	CLIP-seq
MIRT2395848	hsa-miR-761	CLIP-seq
MIRT2461499	hsa-miR-198	CLIP-seq
MIRT1426635	hsa-miR-3125	CLIP-seq
MIRT1426648	hsa-miR-3916	CLIP-seq
MIRT2461500	hsa-miR-3928	CLIP-seq
MIRT2461501	hsa-miR-4485	CLIP-seq
MIRT2461502	hsa-miR-4539	CLIP-seq
MIRT1426681	hsa-miR-548a-3p	CLIP-seq
MIRT1426688	hsa-miR-548e	CLIP-seq
MIRT1426689	hsa-miR-548f	CLIP-seq
MIRT1426703	hsa-miR-877	CLIP-seq
MIRT2461503	hsa-miR-891b	CLIP-seq
MIRT2642987	hsa-miR-1470	CLIP-seq
MIRT2642988	hsa-miR-3156-3p	CLIP-seq
MIRT1426639	hsa-miR-3185	CLIP-seq
MIRT2642989	hsa-miR-345	CLIP-seq
MIRT2642990	hsa-miR-3664-5p	CLIP-seq
MIRT2642991	hsa-miR-4256	CLIP-seq
MIRT2642992	hsa-miR-4301	CLIP-seq
MIRT2642993	hsa-miR-4469	CLIP-seq
MIRT2642994	hsa-miR-4667-3p	CLIP-seq
MIRT2642995	hsa-miR-4709-3p	CLIP-seq
MIRT2642996	hsa-miR-4753-3p	CLIP-seq
MIRT2642997	hsa-miR-4762-3p	CLIP-seq
MIRT2642998	hsa-miR-4768-5p	CLIP-seq
MIRT2642999	hsa-miR-532-3p	CLIP-seq
MIRT2642987	hsa-miR-1470	CLIP-seq
MIRT2642988	hsa-miR-3156-3p	CLIP-seq
MIRT1426639	hsa-miR-3185	CLIP-seq
MIRT2642989	hsa-miR-345	CLIP-seq
MIRT2642990	hsa-miR-3664-5p	CLIP-seq
MIRT2642991	hsa-miR-4256	CLIP-seq
MIRT2642992	hsa-miR-4301	CLIP-seq
MIRT2642993	hsa-miR-4469	CLIP-seq
MIRT2642994	hsa-miR-4667-3p	CLIP-seq
MIRT2642995	hsa-miR-4709-3p	CLIP-seq
MIRT2642996	hsa-miR-4753-3p	CLIP-seq
MIRT2642997	hsa-miR-4762-3p	CLIP-seq
MIRT2642998	hsa-miR-4768-5p	CLIP-seq
MIRT2642999	hsa-miR-532-3p	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0007275	Process	Multicellular organism development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030154	Process	Cell differentiation	IEA
GO:0048632	Process	Negative regulation of skeletal muscle tissue growth	IEA

MIM	HGNC	e!Ensembl
606743	11844	ENSG00000095587

Protein

UniProt ID

Q9Y6L7

Protein name

Tolloid-like protein 2 (EC 3.4.24.-)

Protein function

Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01400	Astacin	157 → 350	Astacin (Peptidase family M12A)	Domain
PF00431	CUB	351 → 460	CUB domain	Domain
PF00431	CUB	464 → 573	CUB domain	Domain
PF14670	FXa_inhibition	580 → 616		Domain
PF00431	CUB	620 → 729	CUB domain	Domain
PF07645	EGF_CA	732 → 771	Calcium-binding EGF domain	Domain
PF00431	CUB	776 → 885	CUB domain	Domain
PF00431	CUB	889 → 1002	CUB domain	Domain

Sequence

MPRATALGALVSLLLLLPLPRGAGGLGERPDATADYSELDGEEGTEQQLEHYHDPCKAAV
FWGDIALDEDDLKLFHIDKARDWTKQTVGATGHSTGGLEEQASESSPDTTAMDTGTKEAG
KDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIF
KQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIV
AHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMH
YARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTG
NFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAP
LLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNY
PDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCG
YEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYK
CACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISL
QFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTV
SKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKI
SSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGP
DSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTK
ELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSS
APRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQDALHMKK

Sequence length

1015

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Attention Deficit Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder	GWAS
Dementia	Dementia	GWAS
Insomnia	Insomnia	GWAS
Takayasu Arteritis	Takayasu Arteritis	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	40158169
Dysbiosis	Associate	36291689
Melanoma Cutaneous Malignant	Associate	28796414
Muscular Atrophy Spinal	Associate	31888525
Neoplasms	Associate	30770791, 33390848, 40158169
Pulmonary Disease Chronic Obstructive	Associate	36291689

TLL2 (tolloid like 2)