TK1 (thymidine kinase 1)

Gene

• Entrez ID: 7083
• Gene name: Thymidine kinase 1
• Gene symbol: TK1
• Synonyms (NCBI Gene): TK2
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encod

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016357	hsa-miR-193b-3p	Microarray	20304954
MIRT029423	hsa-miR-26b-5p	Microarray	19088304
MIRT048356	hsa-miR-103a-3p	CLASH	23622248
MIRT038616	hsa-miR-186-3p	CLASH	23622248
MIRT723919	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT723918	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT723917	hsa-miR-3924	HITS-CLIP	19536157
MIRT723916	hsa-miR-675-3p	HITS-CLIP	19536157
MIRT695302	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT695301	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT695300	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT695299	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT695298	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT695297	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT695296	hsa-miR-181a-2-3p	HITS-CLIP	23313552
MIRT695295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695294	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT048356	hsa-miR-103a-3p	HITS-CLIP	23313552
MIRT695293	hsa-miR-107	HITS-CLIP	23313552
MIRT695292	hsa-miR-4775	HITS-CLIP	23313552
MIRT695291	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695290	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT695289	hsa-miR-6833-5p	HITS-CLIP	23313552
MIRT695288	hsa-miR-4752	HITS-CLIP	23313552
MIRT695287	hsa-miR-2113	HITS-CLIP	23313552
MIRT695286	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT695285	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT723919	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT723918	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT723917	hsa-miR-3924	HITS-CLIP	19536157
MIRT723916	hsa-miR-675-3p	HITS-CLIP	19536157
MIRT695302	hsa-miR-497-3p	HITS-CLIP	23313552
MIRT695301	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT695300	hsa-miR-4724-5p	HITS-CLIP	23313552
MIRT695299	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT695298	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT695297	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT695296	hsa-miR-181a-2-3p	HITS-CLIP	23313552
MIRT695295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT695294	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT048356	hsa-miR-103a-3p	HITS-CLIP	23313552
MIRT695293	hsa-miR-107	HITS-CLIP	23313552
MIRT695292	hsa-miR-4775	HITS-CLIP	23313552
MIRT695291	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT695290	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT695289	hsa-miR-6833-5p	HITS-CLIP	23313552
MIRT695288	hsa-miR-4752	HITS-CLIP	23313552
MIRT695287	hsa-miR-2113	HITS-CLIP	23313552
MIRT695286	hsa-miR-5010-3p	HITS-CLIP	23313552
MIRT695285	hsa-miR-4799-5p	HITS-CLIP	23313552
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425876	hsa-miR-3120-3p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425880	hsa-miR-3190	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425884	hsa-miR-421	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425886	hsa-miR-4261	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425890	hsa-miR-4283	CLIP-seq
MIRT1425891	hsa-miR-4290	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425896	hsa-miR-4326	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425905	hsa-miR-4489	CLIP-seq
MIRT1425906	hsa-miR-4493	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT1425909	hsa-miR-4530	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425912	hsa-miR-4691-3p	CLIP-seq
MIRT1425913	hsa-miR-4709-5p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425915	hsa-miR-4725-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq
MIRT1425920	hsa-miR-4753-5p	CLIP-seq
MIRT1425921	hsa-miR-4761-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425923	hsa-miR-4800-5p	CLIP-seq
MIRT1425924	hsa-miR-486-3p	CLIP-seq
MIRT1425925	hsa-miR-504	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT1425928	hsa-miR-548v	CLIP-seq
MIRT1425929	hsa-miR-646	CLIP-seq
MIRT1425930	hsa-miR-711	CLIP-seq
MIRT1425931	hsa-miR-760	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT2127628	hsa-miR-103a	CLIP-seq
MIRT2127629	hsa-miR-1207-5p	CLIP-seq
MIRT2127630	hsa-miR-122	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT2127631	hsa-miR-1266	CLIP-seq
MIRT2127632	hsa-miR-1285	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT2127633	hsa-miR-3187-5p	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT2127634	hsa-miR-34a	CLIP-seq
MIRT2127635	hsa-miR-34c-5p	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT2127636	hsa-miR-3652	CLIP-seq
MIRT2127637	hsa-miR-3690	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425884	hsa-miR-421	CLIP-seq
MIRT2127638	hsa-miR-4254	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425890	hsa-miR-4283	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT2127639	hsa-miR-4300	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425896	hsa-miR-4326	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT2127640	hsa-miR-4430	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425905	hsa-miR-4489	CLIP-seq
MIRT2127641	hsa-miR-4496	CLIP-seq
MIRT2127642	hsa-miR-449a	CLIP-seq
MIRT2127643	hsa-miR-449b	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT2127644	hsa-miR-4505	CLIP-seq
MIRT2127645	hsa-miR-4514	CLIP-seq
MIRT2127646	hsa-miR-4518	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT2127647	hsa-miR-4529-5p	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT2127648	hsa-miR-4645-5p	CLIP-seq
MIRT2127649	hsa-miR-4673	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT2127650	hsa-miR-4692	CLIP-seq
MIRT1425913	hsa-miR-4709-5p	CLIP-seq
MIRT2127651	hsa-miR-4712-5p	CLIP-seq
MIRT2127652	hsa-miR-4715-3p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT2127653	hsa-miR-4728-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT2127654	hsa-miR-4763-3p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT2127655	hsa-miR-612	CLIP-seq
MIRT2127656	hsa-miR-617	CLIP-seq
MIRT1425931	hsa-miR-760	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT2127657	hsa-miR-770-5p	CLIP-seq
MIRT2127658	hsa-miR-885-3p	CLIP-seq
MIRT2127659	hsa-miR-920	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425858	hsa-let-7a	CLIP-seq
MIRT1425859	hsa-let-7b	CLIP-seq
MIRT1425860	hsa-let-7c	CLIP-seq
MIRT1425861	hsa-let-7d	CLIP-seq
MIRT1425862	hsa-let-7e	CLIP-seq
MIRT1425863	hsa-let-7f	CLIP-seq
MIRT1425864	hsa-let-7g	CLIP-seq
MIRT1425865	hsa-let-7i	CLIP-seq
MIRT2127630	hsa-miR-122	CLIP-seq
MIRT1425866	hsa-miR-1225-3p	CLIP-seq
MIRT1425867	hsa-miR-1226	CLIP-seq
MIRT2349358	hsa-miR-1227	CLIP-seq
MIRT1425868	hsa-miR-1233	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425871	hsa-miR-1914	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT2349359	hsa-miR-1972	CLIP-seq
MIRT1425873	hsa-miR-214	CLIP-seq
MIRT1425874	hsa-miR-2467-3p	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425876	hsa-miR-3120-3p	CLIP-seq
MIRT1425877	hsa-miR-3151	CLIP-seq
MIRT1425878	hsa-miR-3158-3p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425880	hsa-miR-3190	CLIP-seq
MIRT1425881	hsa-miR-3202	CLIP-seq
MIRT1425882	hsa-miR-3619-5p	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425885	hsa-miR-4257	CLIP-seq
MIRT1425886	hsa-miR-4261	CLIP-seq
MIRT1425887	hsa-miR-4265	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT1425889	hsa-miR-4271	CLIP-seq
MIRT1425891	hsa-miR-4290	CLIP-seq
MIRT1425892	hsa-miR-4291	CLIP-seq
MIRT1425893	hsa-miR-4296	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425895	hsa-miR-4322	CLIP-seq
MIRT1425897	hsa-miR-4417	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425899	hsa-miR-4428	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425902	hsa-miR-4458	CLIP-seq
MIRT1425903	hsa-miR-4476	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT1425906	hsa-miR-4493	CLIP-seq
MIRT1425907	hsa-miR-4500	CLIP-seq
MIRT1425908	hsa-miR-4519	CLIP-seq
MIRT1425909	hsa-miR-4530	CLIP-seq
MIRT1425910	hsa-miR-4640-5p	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425912	hsa-miR-4691-3p	CLIP-seq
MIRT2349360	hsa-miR-4717-5p	CLIP-seq
MIRT1425914	hsa-miR-4725-3p	CLIP-seq
MIRT1425915	hsa-miR-4725-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT1425917	hsa-miR-4726-5p	CLIP-seq
MIRT1425918	hsa-miR-4733-3p	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq
MIRT1425920	hsa-miR-4753-5p	CLIP-seq
MIRT1425921	hsa-miR-4761-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425923	hsa-miR-4800-5p	CLIP-seq
MIRT1425924	hsa-miR-486-3p	CLIP-seq
MIRT1425925	hsa-miR-504	CLIP-seq
MIRT1425927	hsa-miR-512-5p	CLIP-seq
MIRT1425928	hsa-miR-548v	CLIP-seq
MIRT2349361	hsa-miR-574-5p	CLIP-seq
MIRT1425929	hsa-miR-646	CLIP-seq
MIRT2349362	hsa-miR-648	CLIP-seq
MIRT1425930	hsa-miR-711	CLIP-seq
MIRT1425932	hsa-miR-761	CLIP-seq
MIRT1425933	hsa-miR-922	CLIP-seq
MIRT1425934	hsa-miR-98	CLIP-seq
MIRT1425872	hsa-miR-1915	CLIP-seq
MIRT1425875	hsa-miR-2964a-5p	CLIP-seq
MIRT1425879	hsa-miR-3185	CLIP-seq
MIRT1425883	hsa-miR-3929	CLIP-seq
MIRT1425888	hsa-miR-4270	CLIP-seq
MIRT2127639	hsa-miR-4300	CLIP-seq
MIRT1425894	hsa-miR-4302	CLIP-seq
MIRT1425898	hsa-miR-4419b	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425901	hsa-miR-4441	CLIP-seq
MIRT1425904	hsa-miR-4478	CLIP-seq
MIRT2127648	hsa-miR-4645-5p	CLIP-seq
MIRT2127649	hsa-miR-4673	CLIP-seq
MIRT1425911	hsa-miR-4690-5p	CLIP-seq
MIRT1425916	hsa-miR-4726-3p	CLIP-seq
MIRT2127653	hsa-miR-4728-5p	CLIP-seq
MIRT1425922	hsa-miR-4773	CLIP-seq
MIRT1425926	hsa-miR-505	CLIP-seq
MIRT2127659	hsa-miR-920	CLIP-seq
MIRT1425869	hsa-miR-18a	CLIP-seq
MIRT1425870	hsa-miR-18b	CLIP-seq
MIRT1425900	hsa-miR-4438	CLIP-seq
MIRT1425919	hsa-miR-4735-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYB	Activation	1944282
POU2AF1	Activation	15831936
POU2F1	Activation	15831936
POU2F2	Activation	15831936
SP1	Activation	10502302

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004797	Function	Thymidine kinase activity	IBA
GO:0004797	Function	Thymidine kinase activity	IDA	14697231, 22385435
GO:0004797	Function	Thymidine kinase activity	IEA
GO:0004797	Function	Thymidine kinase activity	TAS	3335503
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	3335503
GO:0008270	Function	Zinc ion binding	IDA	17407781
GO:0009157	Process	Deoxyribonucleoside monophosphate biosynthetic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	21900206, 22385435
GO:0046104	Process	Thymidine metabolic process	IBA
GO:0046104	Process	Thymidine metabolic process	IDA	22385435
GO:0046105	Process	Thymidine biosynthetic process	IDA	14697231
GO:0046872	Function	Metal ion binding	IEA
GO:0051289	Process	Protein homotetramerization	IDA	14697231
GO:0051289	Process	Protein homotetramerization	IPI	17407781
GO:0071897	Process	DNA biosynthetic process	IEA
GO:1904860	Process	DNA synthesis involved in mitotic DNA replication	IDA	14697231

Other IDs

• MIM: 188300
• HGNC: 11830
• e!Ensembl: ENSG00000167900

Protein

• UniProt ID: P04183
• Protein name: Thymidine kinase, cytosolic (EC 2.7.1.21)
• Protein function: Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits
• PDB: 1W4R, 1XBT, 2ORV, 2WVJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00265	TK	19 → 189	Thymidine kinase	Family

• Sequence:

  MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
  YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
  VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
  YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

• Sequence length: 234

Pathways

KEGG:

Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Reactome:

Pyrimidine salvage