TK1 (thymidine kinase 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7083 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Thymidine kinase 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TK1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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TK2 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q25.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encod |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | P04183 | ||||||||||
| Protein name | Thymidine kinase, cytosolic (EC 2.7.1.21) | ||||||||||
| Protein function | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits | ||||||||||
| PDB | 1W4R , 1XBT , 2ORV , 2WVJ | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 234 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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