Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7083
Gene name Gene Name - the full gene name approved by the HGNC.
Thymidine kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TK1
Synonyms (NCBI Gene) Gene synonyms aliases
TK2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encod
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016357 hsa-miR-193b-3p Microarray 20304954
MIRT029423 hsa-miR-26b-5p Microarray 19088304
MIRT048356 hsa-miR-103a-3p CLASH 23622248
MIRT038616 hsa-miR-186-3p CLASH 23622248
MIRT723919 hsa-miR-4639-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
MYB Activation 1944282
POU2AF1 Activation 15831936
POU2F1 Activation 15831936
POU2F2 Activation 15831936
SP1 Activation 10502302
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004797 Function Thymidine kinase activity IBA
GO:0004797 Function Thymidine kinase activity IDA 14697231, 22385435
GO:0004797 Function Thymidine kinase activity IEA
GO:0004797 Function Thymidine kinase activity TAS 3335503
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
188300 11830 ENSG00000167900
Protein
UniProt ID P04183
Protein name Thymidine kinase, cytosolic (EC 2.7.1.21)
Protein function Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits
PDB 1W4R , 1XBT , 2ORV , 2WVJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00265 TK 19 189 Thymidine kinase Family
Sequence
Sequence length 234
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
  Pyrimidine salvage
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