Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7082
Gene name	Tight junction protein 1
Gene symbol	TJP1
Synonyms (NCBI Gene)	ZO-1
Chromosome	15
Chromosome location	15q13.1
Summary	This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules betwee

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004341	hsa-miR-212-3p	Western blot	18162065
MIRT004341	hsa-miR-212-3p	Luciferase reporter assay	18162065
MIRT020884	hsa-miR-155-5p	Proteomics	18668040
MIRT051942	hsa-let-7b-5p	CLASH	23622248
MIRT050793	hsa-miR-17-5p	CLASH	23622248
MIRT042969	hsa-miR-324-3p	CLASH	23622248
MIRT039699	hsa-miR-615-3p	CLASH	23622248
MIRT438931	hsa-miR-105-5p	In situ hybridizationqRT-PCRLuciferase reporter assayWestern blotMicroarray	24735924
MIRT0004379	hsa-miR-105-5p	In situ hybridizationqRT-PCRLuciferase reporter assayWestern blotMicroarray	24735924
MIRT698475	hsa-miR-548ac	HITS-CLIP	23313552
MIRT698474	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT698473	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT698472	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT698471	hsa-miR-548z	HITS-CLIP	23313552
MIRT698470	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT698469	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT698468	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT698467	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT698466	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT698465	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT698464	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT698463	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT698461	hsa-miR-5700	HITS-CLIP	23313552
MIRT698462	hsa-miR-4731-3p	HITS-CLIP	23313552
MIRT698460	hsa-miR-4801	HITS-CLIP	23313552
MIRT698459	hsa-miR-802	HITS-CLIP	23313552
MIRT553632	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT553631	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT553630	hsa-miR-107	PAR-CLIP	21572407
MIRT553629	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT553628	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT553627	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT553626	hsa-miR-194-5p	PAR-CLIP	21572407
MIRT553625	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT732222	hsa-miR-212-5p	Luciferase reporter assayWestern blot	26692142
MIRT732222	hsa-miR-212-5p	Luciferase reporter assayWestern blot	26692142
MIRT735353	hsa-miR-4720-3p	Luciferase reporter assayWestern blottingIn situ hybridization	32314520
MIRT698475	hsa-miR-548ac	HITS-CLIP	23313552
MIRT698474	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT698473	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT698472	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT698471	hsa-miR-548z	HITS-CLIP	23313552
MIRT698470	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT698469	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT698468	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT698467	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT698466	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT698465	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT698464	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT698463	hsa-miR-5582-3p	HITS-CLIP	23313552
MIRT698461	hsa-miR-5700	HITS-CLIP	23313552
MIRT698462	hsa-miR-4731-3p	HITS-CLIP	23313552
MIRT698460	hsa-miR-4801	HITS-CLIP	23313552
MIRT698459	hsa-miR-802	HITS-CLIP	23313552
MIRT553632	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT553631	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT553630	hsa-miR-107	PAR-CLIP	21572407
MIRT553629	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT553628	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT553627	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT553626	hsa-miR-194-5p	PAR-CLIP	21572407
MIRT553625	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT755766	hsa-miR-23a-3p	Luciferase reporter assayWestern blottingMicroarrayqRT-PCRImmunohistochemistry (IHC)in vitro cullelar assaysImmunofluorescenceELISA	37904170
MIRT1425746	hsa-miR-101	CLIP-seq
MIRT1425747	hsa-miR-103b	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425749	hsa-miR-1305	CLIP-seq
MIRT1425750	hsa-miR-137	CLIP-seq
MIRT1425751	hsa-miR-140-5p	CLIP-seq
MIRT1425752	hsa-miR-144	CLIP-seq
MIRT1425753	hsa-miR-145	CLIP-seq
MIRT1425754	hsa-miR-153	CLIP-seq
MIRT1425755	hsa-miR-191	CLIP-seq
MIRT1425756	hsa-miR-193a-3p	CLIP-seq
MIRT1425757	hsa-miR-193b	CLIP-seq
MIRT1425758	hsa-miR-200b	CLIP-seq
MIRT1425759	hsa-miR-200c	CLIP-seq
MIRT1425760	hsa-miR-23a	CLIP-seq
MIRT1425761	hsa-miR-23b	CLIP-seq
MIRT1425762	hsa-miR-23c	CLIP-seq
MIRT1425763	hsa-miR-3064-5p	CLIP-seq
MIRT1425764	hsa-miR-3133	CLIP-seq
MIRT1425765	hsa-miR-3200-3p	CLIP-seq
MIRT1425766	hsa-miR-337-3p	CLIP-seq
MIRT1425767	hsa-miR-3611	CLIP-seq
MIRT1425768	hsa-miR-361-5p	CLIP-seq
MIRT1425769	hsa-miR-3652	CLIP-seq
MIRT1425770	hsa-miR-3671	CLIP-seq
MIRT1425771	hsa-miR-369-3p	CLIP-seq
MIRT1425772	hsa-miR-374a	CLIP-seq
MIRT1425773	hsa-miR-374b	CLIP-seq
MIRT1425774	hsa-miR-376a	CLIP-seq
MIRT1425775	hsa-miR-376b	CLIP-seq
MIRT1425776	hsa-miR-3978	CLIP-seq
MIRT1425777	hsa-miR-4264	CLIP-seq
MIRT1425778	hsa-miR-4277	CLIP-seq
MIRT1425779	hsa-miR-429	CLIP-seq
MIRT1425780	hsa-miR-433	CLIP-seq
MIRT1425781	hsa-miR-4430	CLIP-seq
MIRT1425782	hsa-miR-4501	CLIP-seq
MIRT1425783	hsa-miR-4503	CLIP-seq
MIRT1425784	hsa-miR-4505	CLIP-seq
MIRT1425785	hsa-miR-4519	CLIP-seq
MIRT1425786	hsa-miR-4637	CLIP-seq
MIRT1425787	hsa-miR-4670-3p	CLIP-seq
MIRT1425788	hsa-miR-4676-5p	CLIP-seq
MIRT1425789	hsa-miR-4699-3p	CLIP-seq
MIRT1425790	hsa-miR-4760-5p	CLIP-seq
MIRT1425791	hsa-miR-4773	CLIP-seq
MIRT1425792	hsa-miR-4774-5p	CLIP-seq
MIRT1425793	hsa-miR-4777-5p	CLIP-seq
MIRT1425794	hsa-miR-495	CLIP-seq
MIRT1425795	hsa-miR-498	CLIP-seq
MIRT1425796	hsa-miR-501-3p	CLIP-seq
MIRT1425797	hsa-miR-502-3p	CLIP-seq
MIRT1425798	hsa-miR-510	CLIP-seq
MIRT1425799	hsa-miR-512-5p	CLIP-seq
MIRT1425800	hsa-miR-548aa	CLIP-seq
MIRT1425801	hsa-miR-548m	CLIP-seq
MIRT1425802	hsa-miR-575	CLIP-seq
MIRT1425803	hsa-miR-577	CLIP-seq
MIRT1425804	hsa-miR-592	CLIP-seq
MIRT1425805	hsa-miR-597	CLIP-seq
MIRT1425806	hsa-miR-607	CLIP-seq
MIRT1425807	hsa-miR-622	CLIP-seq
MIRT1425808	hsa-miR-892b	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425809	hsa-miR-1178	CLIP-seq
MIRT1425810	hsa-miR-1183	CLIP-seq
MIRT1425811	hsa-miR-1227	CLIP-seq
MIRT1425812	hsa-miR-1251	CLIP-seq
MIRT1425751	hsa-miR-140-5p	CLIP-seq
MIRT1425813	hsa-miR-142-3p	CLIP-seq
MIRT1425814	hsa-miR-323b-3p	CLIP-seq
MIRT1425815	hsa-miR-330-3p	CLIP-seq
MIRT1425816	hsa-miR-3545-5p	CLIP-seq
MIRT1425768	hsa-miR-361-5p	CLIP-seq
MIRT1425778	hsa-miR-4277	CLIP-seq
MIRT1425817	hsa-miR-4428	CLIP-seq
MIRT1425818	hsa-miR-4457	CLIP-seq
MIRT1425819	hsa-miR-4460	CLIP-seq
MIRT1425820	hsa-miR-455-5p	CLIP-seq
MIRT1425786	hsa-miR-4637	CLIP-seq
MIRT1425821	hsa-miR-4662a-5p	CLIP-seq
MIRT1425822	hsa-miR-4719	CLIP-seq
MIRT1425823	hsa-miR-4796-5p	CLIP-seq
MIRT1425794	hsa-miR-495	CLIP-seq
MIRT1425824	hsa-miR-520d-5p	CLIP-seq
MIRT1425825	hsa-miR-524-5p	CLIP-seq
MIRT1425826	hsa-miR-548g	CLIP-seq
MIRT1425827	hsa-miR-548p	CLIP-seq
MIRT1425828	hsa-miR-556-5p	CLIP-seq
MIRT1425829	hsa-miR-610	CLIP-seq
MIRT1425746	hsa-miR-101	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425809	hsa-miR-1178	CLIP-seq
MIRT1425810	hsa-miR-1183	CLIP-seq
MIRT1425811	hsa-miR-1227	CLIP-seq
MIRT2127555	hsa-miR-1228	CLIP-seq
MIRT2127556	hsa-miR-124	CLIP-seq
MIRT2127557	hsa-miR-1247	CLIP-seq
MIRT2127558	hsa-miR-1303	CLIP-seq
MIRT2127559	hsa-miR-132	CLIP-seq
MIRT2127560	hsa-miR-138	CLIP-seq
MIRT1425751	hsa-miR-140-5p	CLIP-seq
MIRT2127561	hsa-miR-141	CLIP-seq
MIRT1425813	hsa-miR-142-3p	CLIP-seq
MIRT1425752	hsa-miR-144	CLIP-seq
MIRT1425753	hsa-miR-145	CLIP-seq
MIRT1425755	hsa-miR-191	CLIP-seq
MIRT1425756	hsa-miR-193a-3p	CLIP-seq
MIRT1425757	hsa-miR-193b	CLIP-seq
MIRT2127562	hsa-miR-200a	CLIP-seq
MIRT2127563	hsa-miR-212	CLIP-seq
MIRT2127564	hsa-miR-224	CLIP-seq
MIRT1425760	hsa-miR-23a	CLIP-seq
MIRT1425761	hsa-miR-23b	CLIP-seq
MIRT1425762	hsa-miR-23c	CLIP-seq
MIRT1425763	hsa-miR-3064-5p	CLIP-seq
MIRT2127565	hsa-miR-3123	CLIP-seq
MIRT2127566	hsa-miR-3140-3p	CLIP-seq
MIRT2127567	hsa-miR-3149	CLIP-seq
MIRT2127568	hsa-miR-335	CLIP-seq
MIRT2127569	hsa-miR-342-3p	CLIP-seq
MIRT1425816	hsa-miR-3545-5p	CLIP-seq
MIRT1425767	hsa-miR-3611	CLIP-seq
MIRT1425768	hsa-miR-361-5p	CLIP-seq
MIRT2127570	hsa-miR-3620	CLIP-seq
MIRT2127571	hsa-miR-362-5p	CLIP-seq
MIRT1425769	hsa-miR-3652	CLIP-seq
MIRT2127572	hsa-miR-3653	CLIP-seq
MIRT2127573	hsa-miR-3658	CLIP-seq
MIRT2127574	hsa-miR-3662	CLIP-seq
MIRT2127575	hsa-miR-3667-3p	CLIP-seq
MIRT1425771	hsa-miR-369-3p	CLIP-seq
MIRT2127576	hsa-miR-3713	CLIP-seq
MIRT2127577	hsa-miR-3714	CLIP-seq
MIRT1425772	hsa-miR-374a	CLIP-seq
MIRT1425773	hsa-miR-374b	CLIP-seq
MIRT2127578	hsa-miR-3910	CLIP-seq
MIRT2127579	hsa-miR-3922-5p	CLIP-seq
MIRT2127580	hsa-miR-3973	CLIP-seq
MIRT2127581	hsa-miR-412	CLIP-seq
MIRT1425778	hsa-miR-4277	CLIP-seq
MIRT2127582	hsa-miR-4289	CLIP-seq
MIRT1425781	hsa-miR-4430	CLIP-seq
MIRT1425819	hsa-miR-4460	CLIP-seq
MIRT1425782	hsa-miR-4501	CLIP-seq
MIRT1425783	hsa-miR-4503	CLIP-seq
MIRT1425784	hsa-miR-4505	CLIP-seq
MIRT2127583	hsa-miR-450b-5p	CLIP-seq
MIRT2127584	hsa-miR-4511	CLIP-seq
MIRT2127585	hsa-miR-4517	CLIP-seq
MIRT2127586	hsa-miR-4536	CLIP-seq
MIRT1425820	hsa-miR-455-5p	CLIP-seq
MIRT1425786	hsa-miR-4637	CLIP-seq
MIRT2127587	hsa-miR-4652-3p	CLIP-seq
MIRT1425787	hsa-miR-4670-3p	CLIP-seq
MIRT2127588	hsa-miR-4696	CLIP-seq
MIRT1425789	hsa-miR-4699-3p	CLIP-seq
MIRT2127589	hsa-miR-4704-3p	CLIP-seq
MIRT2127590	hsa-miR-4705	CLIP-seq
MIRT2127591	hsa-miR-4709-3p	CLIP-seq
MIRT2127592	hsa-miR-4709-5p	CLIP-seq
MIRT2127593	hsa-miR-4717-3p	CLIP-seq
MIRT2127594	hsa-miR-4718	CLIP-seq
MIRT1425822	hsa-miR-4719	CLIP-seq
MIRT1425792	hsa-miR-4774-5p	CLIP-seq
MIRT1425794	hsa-miR-495	CLIP-seq
MIRT2127595	hsa-miR-500b	CLIP-seq
MIRT1425796	hsa-miR-501-3p	CLIP-seq
MIRT2127596	hsa-miR-501-5p	CLIP-seq
MIRT1425797	hsa-miR-502-3p	CLIP-seq
MIRT2127597	hsa-miR-502-5p	CLIP-seq
MIRT2127598	hsa-miR-506	CLIP-seq
MIRT2127599	hsa-miR-511	CLIP-seq
MIRT1425824	hsa-miR-520d-5p	CLIP-seq
MIRT2127600	hsa-miR-520g	CLIP-seq
MIRT2127601	hsa-miR-520h	CLIP-seq
MIRT1425825	hsa-miR-524-5p	CLIP-seq
MIRT2127602	hsa-miR-544	CLIP-seq
MIRT2127603	hsa-miR-548b-3p	CLIP-seq
MIRT1425826	hsa-miR-548g	CLIP-seq
MIRT1425801	hsa-miR-548m	CLIP-seq
MIRT2127604	hsa-miR-555	CLIP-seq
MIRT2127605	hsa-miR-582-5p	CLIP-seq
MIRT2127606	hsa-miR-605	CLIP-seq
MIRT2127607	hsa-miR-616	CLIP-seq
MIRT2127608	hsa-miR-654-3p	CLIP-seq
MIRT1425808	hsa-miR-892b	CLIP-seq
MIRT1425746	hsa-miR-101	CLIP-seq
MIRT1425747	hsa-miR-103b	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425809	hsa-miR-1178	CLIP-seq
MIRT1425810	hsa-miR-1183	CLIP-seq
MIRT2127555	hsa-miR-1228	CLIP-seq
MIRT2127556	hsa-miR-124	CLIP-seq
MIRT2127557	hsa-miR-1247	CLIP-seq
MIRT1425812	hsa-miR-1251	CLIP-seq
MIRT2349296	hsa-miR-1262	CLIP-seq
MIRT2349297	hsa-miR-1296	CLIP-seq
MIRT2127559	hsa-miR-132	CLIP-seq
MIRT2127560	hsa-miR-138	CLIP-seq
MIRT1425751	hsa-miR-140-5p	CLIP-seq
MIRT2127561	hsa-miR-141	CLIP-seq
MIRT1425813	hsa-miR-142-3p	CLIP-seq
MIRT1425752	hsa-miR-144	CLIP-seq
MIRT1425753	hsa-miR-145	CLIP-seq
MIRT1425754	hsa-miR-153	CLIP-seq
MIRT2349298	hsa-miR-185	CLIP-seq
MIRT1425755	hsa-miR-191	CLIP-seq
MIRT1425756	hsa-miR-193a-3p	CLIP-seq
MIRT1425757	hsa-miR-193b	CLIP-seq
MIRT2127562	hsa-miR-200a	CLIP-seq
MIRT1425758	hsa-miR-200b	CLIP-seq
MIRT1425759	hsa-miR-200c	CLIP-seq
MIRT2127563	hsa-miR-212	CLIP-seq
MIRT2127564	hsa-miR-224	CLIP-seq
MIRT1425760	hsa-miR-23a	CLIP-seq
MIRT1425761	hsa-miR-23b	CLIP-seq
MIRT1425762	hsa-miR-23c	CLIP-seq
MIRT2349299	hsa-miR-2909	CLIP-seq
MIRT1425763	hsa-miR-3064-5p	CLIP-seq
MIRT2127565	hsa-miR-3123	CLIP-seq
MIRT2349300	hsa-miR-3127-5p	CLIP-seq
MIRT1425764	hsa-miR-3133	CLIP-seq
MIRT2127566	hsa-miR-3140-3p	CLIP-seq
MIRT2349301	hsa-miR-3146	CLIP-seq
MIRT2127567	hsa-miR-3149	CLIP-seq
MIRT2349302	hsa-miR-3163	CLIP-seq
MIRT2349303	hsa-miR-3177-5p	CLIP-seq
MIRT2349304	hsa-miR-3182	CLIP-seq
MIRT1425814	hsa-miR-323b-3p	CLIP-seq
MIRT1425815	hsa-miR-330-3p	CLIP-seq
MIRT2127568	hsa-miR-335	CLIP-seq
MIRT1425766	hsa-miR-337-3p	CLIP-seq
MIRT2127569	hsa-miR-342-3p	CLIP-seq
MIRT1425816	hsa-miR-3545-5p	CLIP-seq
MIRT1425767	hsa-miR-3611	CLIP-seq
MIRT1425768	hsa-miR-361-5p	CLIP-seq
MIRT2127570	hsa-miR-3620	CLIP-seq
MIRT2127571	hsa-miR-362-5p	CLIP-seq
MIRT1425769	hsa-miR-3652	CLIP-seq
MIRT2127572	hsa-miR-3653	CLIP-seq
MIRT2127573	hsa-miR-3658	CLIP-seq
MIRT2127574	hsa-miR-3662	CLIP-seq
MIRT2127575	hsa-miR-3667-3p	CLIP-seq
MIRT1425771	hsa-miR-369-3p	CLIP-seq
MIRT2127576	hsa-miR-3713	CLIP-seq
MIRT2127577	hsa-miR-3714	CLIP-seq
MIRT1425772	hsa-miR-374a	CLIP-seq
MIRT1425773	hsa-miR-374b	CLIP-seq
MIRT2127578	hsa-miR-3910	CLIP-seq
MIRT2349305	hsa-miR-3918	CLIP-seq
MIRT2127579	hsa-miR-3922-5p	CLIP-seq
MIRT2127580	hsa-miR-3973	CLIP-seq
MIRT1425776	hsa-miR-3978	CLIP-seq
MIRT2127581	hsa-miR-412	CLIP-seq
MIRT2349306	hsa-miR-4253	CLIP-seq
MIRT1425777	hsa-miR-4264	CLIP-seq
MIRT1425778	hsa-miR-4277	CLIP-seq
MIRT2127582	hsa-miR-4289	CLIP-seq
MIRT1425779	hsa-miR-429	CLIP-seq
MIRT2349307	hsa-miR-4302	CLIP-seq
MIRT2349308	hsa-miR-4306	CLIP-seq
MIRT2349309	hsa-miR-4307	CLIP-seq
MIRT2349310	hsa-miR-4310	CLIP-seq
MIRT2349311	hsa-miR-4314	CLIP-seq
MIRT1425780	hsa-miR-433	CLIP-seq
MIRT1425781	hsa-miR-4430	CLIP-seq
MIRT2349312	hsa-miR-4436b-3p	CLIP-seq
MIRT1425819	hsa-miR-4460	CLIP-seq
MIRT1425782	hsa-miR-4501	CLIP-seq
MIRT1425783	hsa-miR-4503	CLIP-seq
MIRT1425784	hsa-miR-4505	CLIP-seq
MIRT2127584	hsa-miR-4511	CLIP-seq
MIRT1425785	hsa-miR-4519	CLIP-seq
MIRT1425786	hsa-miR-4637	CLIP-seq
MIRT2349313	hsa-miR-4644	CLIP-seq
MIRT2127587	hsa-miR-4652-3p	CLIP-seq
MIRT2349314	hsa-miR-4659a-3p	CLIP-seq
MIRT2349315	hsa-miR-4659b-3p	CLIP-seq
MIRT1425821	hsa-miR-4662a-5p	CLIP-seq
MIRT1425787	hsa-miR-4670-3p	CLIP-seq
MIRT1425788	hsa-miR-4676-5p	CLIP-seq
MIRT2349316	hsa-miR-4685-5p	CLIP-seq
MIRT2349317	hsa-miR-4688	CLIP-seq
MIRT2349318	hsa-miR-4698	CLIP-seq
MIRT1425789	hsa-miR-4699-3p	CLIP-seq
MIRT2349319	hsa-miR-4700-3p	CLIP-seq
MIRT2349320	hsa-miR-4701-3p	CLIP-seq
MIRT2127589	hsa-miR-4704-3p	CLIP-seq
MIRT2127590	hsa-miR-4705	CLIP-seq
MIRT2127592	hsa-miR-4709-5p	CLIP-seq
MIRT2127593	hsa-miR-4717-3p	CLIP-seq
MIRT2349321	hsa-miR-4717-5p	CLIP-seq
MIRT2127594	hsa-miR-4718	CLIP-seq
MIRT1425822	hsa-miR-4719	CLIP-seq
MIRT1425790	hsa-miR-4760-5p	CLIP-seq
MIRT2349322	hsa-miR-4761-3p	CLIP-seq
MIRT2349323	hsa-miR-4762-3p	CLIP-seq
MIRT2349324	hsa-miR-4768-3p	CLIP-seq
MIRT1425791	hsa-miR-4773	CLIP-seq
MIRT1425792	hsa-miR-4774-5p	CLIP-seq
MIRT1425793	hsa-miR-4777-5p	CLIP-seq
MIRT2349325	hsa-miR-494	CLIP-seq
MIRT1425794	hsa-miR-495	CLIP-seq
MIRT1425795	hsa-miR-498	CLIP-seq
MIRT2127595	hsa-miR-500b	CLIP-seq
MIRT1425796	hsa-miR-501-3p	CLIP-seq
MIRT2127596	hsa-miR-501-5p	CLIP-seq
MIRT1425797	hsa-miR-502-3p	CLIP-seq
MIRT2127597	hsa-miR-502-5p	CLIP-seq
MIRT2127598	hsa-miR-506	CLIP-seq
MIRT1425798	hsa-miR-510	CLIP-seq
MIRT2127599	hsa-miR-511	CLIP-seq
MIRT1425799	hsa-miR-512-5p	CLIP-seq
MIRT1425824	hsa-miR-520d-5p	CLIP-seq
MIRT2127600	hsa-miR-520g	CLIP-seq
MIRT2127601	hsa-miR-520h	CLIP-seq
MIRT1425825	hsa-miR-524-5p	CLIP-seq
MIRT2127602	hsa-miR-544	CLIP-seq
MIRT2349326	hsa-miR-548ae	CLIP-seq
MIRT2349327	hsa-miR-548aj	CLIP-seq
MIRT2349328	hsa-miR-548am	CLIP-seq
MIRT2127603	hsa-miR-548b-3p	CLIP-seq
MIRT1425826	hsa-miR-548g	CLIP-seq
MIRT1425801	hsa-miR-548m	CLIP-seq
MIRT1425827	hsa-miR-548p	CLIP-seq
MIRT2349329	hsa-miR-548x	CLIP-seq
MIRT2127604	hsa-miR-555	CLIP-seq
MIRT2349330	hsa-miR-561	CLIP-seq
MIRT1425802	hsa-miR-575	CLIP-seq
MIRT1425803	hsa-miR-577	CLIP-seq
MIRT2127605	hsa-miR-582-5p	CLIP-seq
MIRT2349331	hsa-miR-591	CLIP-seq
MIRT2127606	hsa-miR-605	CLIP-seq
MIRT2127607	hsa-miR-616	CLIP-seq
MIRT2349332	hsa-miR-618	CLIP-seq
MIRT1425807	hsa-miR-622	CLIP-seq
MIRT1425808	hsa-miR-892b	CLIP-seq
MIRT1425809	hsa-miR-1178	CLIP-seq
MIRT2127555	hsa-miR-1228	CLIP-seq
MIRT1425753	hsa-miR-145	CLIP-seq
MIRT1425755	hsa-miR-191	CLIP-seq
MIRT1425760	hsa-miR-23a	CLIP-seq
MIRT1425761	hsa-miR-23b	CLIP-seq
MIRT1425762	hsa-miR-23c	CLIP-seq
MIRT2349300	hsa-miR-3127-5p	CLIP-seq
MIRT2349306	hsa-miR-4253	CLIP-seq
MIRT2349309	hsa-miR-4307	CLIP-seq
MIRT2349317	hsa-miR-4688	CLIP-seq
MIRT2127589	hsa-miR-4704-3p	CLIP-seq
MIRT1425790	hsa-miR-4760-5p	CLIP-seq
MIRT1425792	hsa-miR-4774-5p	CLIP-seq
MIRT2349331	hsa-miR-591	CLIP-seq
MIRT1425746	hsa-miR-101	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425752	hsa-miR-144	CLIP-seq
MIRT1425777	hsa-miR-4264	CLIP-seq
MIRT1425780	hsa-miR-433	CLIP-seq
MIRT1425793	hsa-miR-4777-5p	CLIP-seq
MIRT1425798	hsa-miR-510	CLIP-seq
MIRT1425799	hsa-miR-512-5p	CLIP-seq
MIRT1425801	hsa-miR-548m	CLIP-seq
MIRT1425803	hsa-miR-577	CLIP-seq
MIRT1425807	hsa-miR-622	CLIP-seq
MIRT1425746	hsa-miR-101	CLIP-seq
MIRT1425748	hsa-miR-105	CLIP-seq
MIRT1425752	hsa-miR-144	CLIP-seq
MIRT1425777	hsa-miR-4264	CLIP-seq
MIRT1425780	hsa-miR-433	CLIP-seq
MIRT1425793	hsa-miR-4777-5p	CLIP-seq
MIRT1425798	hsa-miR-510	CLIP-seq
MIRT1425799	hsa-miR-512-5p	CLIP-seq
MIRT2349326	hsa-miR-548ae	CLIP-seq
MIRT2349327	hsa-miR-548aj	CLIP-seq
MIRT2349328	hsa-miR-548am	CLIP-seq
MIRT2349329	hsa-miR-548x	CLIP-seq
MIRT1425803	hsa-miR-577	CLIP-seq
MIRT1425807	hsa-miR-622	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
AR	Activation	18535113
HDAC1	Repression	20580679

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002102	Component	Podosome	IEA
GO:0005515	Function	Protein binding	IPI	9707407, 11042084, 11734628, 12023291, 12154091, 16944923, 17015620, 17724469, 18823282, 19332538, 20164257, 20850437, 21402783, 22262837, 23885123, 25753039, 28661558, 29366904, 30992345, 31473225, 33961781
GO:0005516	Function	Calmodulin binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11734628
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11090614, 18337546
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005912	Component	Adherens junction	TAS	8486731
GO:0005921	Component	Gap junction	IEA
GO:0005921	Component	Gap junction	ISS
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IDA	11734628, 14757759, 18823282, 22006950
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	TAS	8486731
GO:0007043	Process	Cell-cell junction assembly	TAS	8486731
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	29771433
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	16427635
GO:0030036	Process	Actin cytoskeleton organization	IMP	25753039
GO:0030054	Component	Cell junction	IDA	28169360
GO:0030054	Component	Cell junction	TAS
GO:0030335	Process	Positive regulation of cell migration	IMP	25753039
GO:0031032	Process	Actomyosin structure organization	IMP	25753039
GO:0032991	Component	Protein-containing complex	IDA	25753039
GO:0034334	Process	Adherens junction maintenance	IMP	25753039
GO:0035633	Process	Maintenance of blood-brain barrier	NAS	30280653
GO:0036305	Process	Ameloblast differentiation	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	29771433
GO:0043296	Component	Apical junction complex	IDA	16427635
GO:0045177	Component	Apical part of cell	IDA	22006950
GO:0045216	Process	Cell-cell junction organization	IBA
GO:0045216	Process	Cell-cell junction organization	IMP	25753039
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0051493	Process	Regulation of cytoskeleton organization	IMP	25753039
GO:0051497	Process	Negative regulation of stress fiber assembly	ISS
GO:0070160	Component	Tight junction	IDA	22855531, 27037668, 30734065
GO:0070160	Component	Tight junction	IMP	24854121
GO:0070161	Component	Anchoring junction	IEA
GO:0071896	Process	Protein localization to adherens junction	IMP	25753039
GO:0090557	Process	Establishment of endothelial intestinal barrier	IBA
GO:0090557	Process	Establishment of endothelial intestinal barrier	IMP	23885123
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0150105	Process	Protein localization to cell-cell junction	IBA
GO:0150105	Process	Protein localization to cell-cell junction	IMP	25753039
GO:1901888	Process	Regulation of cell junction assembly	IMP	25753039
GO:1902396	Process	Protein localization to bicellular tight junction	IMP	25753039
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IMP	25753039
GO:1905605	Process	Positive regulation of blood-brain barrier permeability	IBA
GO:1905605	Process	Positive regulation of blood-brain barrier permeability	IMP	24854121
GO:2000049	Process	Positive regulation of cell-cell adhesion mediated by cadherin	IMP	25753039
GO:2000810	Process	Regulation of bicellular tight junction assembly	IMP	25753039

MIM	HGNC	e!Ensembl
601009	11827	ENSG00000104067

Q07157

Protein name

Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)

Protein function

TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a

PDB

2H2B , 2H2C , 2H3M , 2JWE , 2KXR , 2KXS , 2RCZ , 3CYY , 3LH5 , 3SHU , 3SHW , 3TSV , 3TSW , 3TSZ , 4OEO , 4OEP , 4Q2Q , 4YYX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	23 → 107	PDZ domain	Domain
PF00595	PDZ	186 → 261	PDZ domain	Domain
PF00595	PDZ	422 → 501	PDZ domain	Domain
PF07653	SH3_2	520 → 582	Variant SH3 domain	Domain
PF00625	Guanylate_kin	681 → 793	Guanylate kinase	Domain
PF00791	ZU5	1635 → 1727	ZU5 domain	Family

Tissue specificity

TISSUE SPECIFICITY: The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubu

Sequence

MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC
VSVLIDHF

Sequence length

1748

Interactions

View interactions

	KEGG		Reactome
	Adherens junction Tight junction Gap junction Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection		Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Likely benign	rs147136553	RCV005929330
Colon adenocarcinoma	Likely benign	rs147136553	RCV005929326
Familial cancer of breast	Likely benign	rs147136553	RCV005929325
Gastric cancer	Likely benign	rs147136553	RCV005929331
Lung cancer	Likely benign	rs147136553	RCV005929336
Malignant tumor of esophagus	Likely benign; Benign	rs147136553, rs45476796	RCV005929328 RCV005933201
Malignant tumor of urinary bladder	Likely benign	rs147136553	RCV005929327
Melanoma	Likely benign	rs147136553	RCV005929335
Nonpapillary renal cell carcinoma	Likely benign	rs147136553	RCV005929329
Ovarian serous cystadenocarcinoma	Likely benign	rs147136553	RCV005929332
Primary dilated cardiomyopathy	Uncertain significance	rs539329069	RCV004719304
Sarcoma	Benign	rs45476796	RCV005933202
See cases	Uncertain significance	rs148793257	RCV004584472
Thymoma	Benign	rs2229517	RCV005906532
Thyroid cancer, nonmedullary, 1	Likely benign	rs147136553	RCV005929334
TJP1-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs200912609, rs147136553, rs28420381, rs200389891, rs563006679, rs2229518, rs7166878, rs141536951, rs371236216, rs377130760, rs781101609, rs138589868, rs373357873, rs45476796, rs578151217 View all (17 more)	RCV003928904 RCV003980890 RCV003938926 RCV003924049 RCV003917288 RCV003979834 RCV003984756 RCV003984796 RCV003973874 RCV003911497 RCV003911890 RCV003943950 RCV003931785 RCV003939456 RCV003939543 RCV003924451 RCV003937130 RCV003937181 RCV003949546 RCV003961924 RCV003922192 RCV003931938 RCV003932244 RCV003934079 RCV003956816 RCV003954384 RCV003979064 RCV003964345 RCV003979227 RCV003976685 RCV003903211 RCV003905908 RCV003975586
Uterine carcinosarcoma	Likely benign	rs147136553	RCV005929333

Show/Hide Text Mining Associations (113)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acidosis	Associate	36768287
Acute Kidney Injury	Inhibit	24884882
Adenocarcinoma of Lung	Inhibit	37240145
Adenocarcinoma of Lung	Associate	38509005
Arthritis Infectious	Inhibit	18364044
Atherosclerosis	Stimulate	28901429
Azoospermia	Associate	30243299
Bell Palsy	Associate	15090575
Biliary Atresia	Associate	34392560
Bloom Syndrome	Associate	36293204
Brain Edema	Associate	28490769
Breast Neoplasms	Associate	11518717, 16140936, 22064657, 22193974, 24771004, 25733818, 26218882, 28683467, 30692208
Burns	Inhibit	18364044
Carcinogenesis	Associate	19144824, 29115525
Carcinoma Hepatocellular	Associate	12708492, 25609232, 29776350, 34443536
Carcinoma in Situ	Associate	17217619
Carcinoma Non Small Cell Lung	Inhibit	24294375
Carcinoma Non Small Cell Lung	Associate	24662916, 28508744
Carcinoma Renal Cell	Associate	19602254, 37790849
Carcinoma Squamous Cell	Associate	34216486
Carcinoma Squamous Cell	Inhibit	37240145
Cardiomyopathies	Stimulate	18056766
Cardiomyopathy Dilated	Inhibit	17760848
Cardiomyopathy Dilated	Stimulate	18056766
Cataract	Inhibit	33274006
Celiac Disease	Associate	27446827
Cerebral Hemorrhage	Associate	29771433
Cerebrocostomandibular Syndrome	Associate	18056766
Charcot Marie Tooth disease Type 1C	Inhibit	24445008
Colitis	Associate	31418947
Colorectal Neoplasms	Associate	12708492, 29115525, 30892955, 34965023, 35218185
Communicable Diseases	Associate	28118611
Congenital bilateral aplasia of vas deferens	Associate	26277102
Crohn Disease	Inhibit	30765731
Crohn Disease	Associate	39201543
Cystitis Interstitial	Associate	21352500
Cystitis Interstitial	Inhibit	24445008
Deafness	Associate	20505086
Drug Related Side Effects and Adverse Reactions	Associate	25733818
Edema	Associate	29771433
Endometrial Neoplasms	Associate	31456452
Endotoxemia	Associate	31330482
Enterocolitis Necrotizing	Inhibit	29276042
Eosinophilic Esophagitis	Associate	29032661
Eosinophilic Esophagitis	Inhibit	35239721
Fatty Liver	Associate	30345259
Fetal Growth Retardation	Associate	36293204, 36430274, 36768287
Fever	Inhibit	34162953
Gastroesophageal Reflux	Associate	29032661
Hantavirus Infections	Associate	21775443
Hashimoto Disease	Inhibit	22878044, 29924048
Heart Failure	Associate	17760848, 18056766
Heat Stroke	Associate	28490769
Hemangioma Cavernous Central Nervous System	Associate	21572340, 28181149
Hemolytic Uremic Syndrome	Inhibit	30301260
Hypoxia	Inhibit	27627890, 30755679, 33326735, 34162953, 36902491, 36982788
Hypoxia	Associate	29769799
Infections	Inhibit	21775443
Inflammation	Inhibit	27417573
Inflammation	Associate	28545409, 29776350, 32931139
Inflammatory Bowel Diseases	Associate	28545409
Intestinal Diseases	Associate	33381548
Intracranial Aneurysm	Associate	33974072
Irritable Bowel Syndrome	Associate	23042942, 33750831, 33843785, 40141298
Irritable Bowel Syndrome	Inhibit	39551069
Kidney Diseases	Associate	11073823, 21775443, 24475278
Liver Failure	Associate	30692208
Lung Neoplasms	Associate	21586512, 25027596, 35767221
Lung Neoplasms	Inhibit	37240145
Lymphatic Metastasis	Associate	34216486
Malaria Falciparum	Associate	24884882
Medulloblastoma	Associate	39628686
Melanoma	Associate	15855653, 36899895
Mental Disorders	Associate	33139732
Metabolic Syndrome	Associate	30345259
Mouth Neoplasms	Associate	34534039
Nasal Polyps	Associate	31839751, 37224640, 37382248
Nasal Polyps	Inhibit	37047067
Neoplasm Metastasis	Associate	11518717, 25609232, 35087173
Neoplasm Metastasis	Inhibit	12708492, 18386163
Neoplasms	Associate	15475928, 17585317, 18386163, 22064657, 22193974, 23390516, 24735924, 25027596, 29115525, 33159174, 34443536, 34445568, 38477086, 38509005, 39628686
Neoplasms	Inhibit	19184677, 37240145, 37790849
Nephrosis Lipoid	Associate	25683991
Neuroectodermal Tumors Primitive	Associate	15920547
Neurofibrosarcoma	Associate	32590748
Neuromyelitis Optica	Inhibit	32983166
Obesity	Inhibit	29438631
Osteochondrodysplasias	Inhibit	33381548
Pancreatic Neoplasms	Associate	35767221
Periodic fever familial autosomal dominant	Inhibit	39337254
Pleural Effusion	Associate	36769168
Polycystic Kidney Diseases	Inhibit	33974072
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Associate	15090575
Precancerous Conditions	Associate	34510826
Proteinuria	Associate	25683991
Psoriasis	Associate	19661441
Pulmonary Disease Chronic Obstructive	Inhibit	25745049
Rhinitis Allergic	Inhibit	35480562
Sarcoma Ewing	Associate	15920547
Sarcoma Synovial	Associate	14704716
Sleep Apnea Obstructive	Inhibit	32647186
Small Cell Lung Carcinoma	Associate	24959847
Status Asthmaticus	Associate	29843677
Stomach Neoplasms	Associate	37587724
Tooth Erosion	Associate	29558791
Uremia	Associate	30301260
Urinary Bladder Neoplasms	Associate	26800519, 33282635, 35087173
Urolithiasis	Inhibit	25329457
Uterine Cervical Neoplasms	Associate	36088372
Uveal melanoma	Associate	20861479
Virus Diseases	Associate	33158999
von Hippel Lindau Disease	Associate	19602254
Zinc Deficiency Neonatal due to Low Breast Milk Zinc	Associate	18716167

TJP1 (tight junction protein 1)