Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7078
Gene name Gene Name - the full gene name approved by the HGNC.
TIMP metallopeptidase inhibitor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TIMP3
Synonyms (NCBI Gene) Gene synonyms aliases
HSMRK222, K222, K222TA2, SFD
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SFD
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in res
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000954 hsa-miR-21-5p Luciferase reporter assay 18591254
MIRT000954 hsa-miR-21-5p Luciferase reporter assay 18591254
MIRT000954 hsa-miR-21-5p Luciferase reporter assay 18591254
MIRT000954 hsa-miR-21-5p Luciferase reporter assay 18591254
MIRT000954 hsa-miR-21-5p Western blot 18591254
Transcription factors
Transcription factor Regulation Reference
DNMT1 Repression 22982189
ELF3 Activation 12407165
SP1 Activation 15468069
SP1 Unknown 20056610
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IBA 21873635
GO:0002576 Process Platelet degranulation TAS
GO:0005515 Function Protein binding IPI 18344519, 18638486
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
188826 11822 ENSG00000100234
Protein
UniProt ID P35625
Protein name Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
Protein function Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular mat
PDB 3CKI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00965 TIMP 22 194 Tissue inhibitor of metalloproteinase Domain
Sequence
Sequence length 211
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Proteoglycans in cancer
MicroRNAs in cancer
  Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Glaucoma Glaucoma rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
Age-related macular degeneration Age related macular degeneration rs199474657, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152
View all (20 more)
26691988
Sorsby fundus dystrophy Sorsby pseudoinflammatory fundus dystrophy rs137853298, rs137853299, rs137853300, rs137853301
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 16926187 ClinVar
Fundus dystrophy, pseudoinflammatory, of sorsby FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY, OF SORSBY 8981947, 7894485, 8728699, 8634721, 7550309 ClinVar
Sorsby Fundus Dystrophy Sorsby fundus dystrophy GenCC
Acne Acne GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 16803511, 18831746, 23527119, 35701814
Adenocarcinoma Of Esophagus Associate 18516293
Adenocarcinoma of Lung Associate 32744429, 33126605, 36494333
Adenoma Oxyphilic Associate 31773698
Agnosia Associate 25065733
Alzheimer Disease Associate 39385222
Amyotrophic Lateral Sclerosis Associate 36768220
Aortic Aneurysm Abdominal Associate 11877705
Aortic Aneurysm Familial Abdominal 1 Associate 11877705
Aortic Aneurysm Thoracic Associate 30770620