Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7077
Gene name Gene Name - the full gene name approved by the HGNC.
TIMP metallopeptidase inhibitor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TIMP2
Synonyms (NCBI Gene) Gene synonyms aliases
CSC-21K, DDC8
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006198 hsa-miR-519d-3p Luciferase reporter assay, Western blot 22262409
MIRT006639 hsa-miR-519c-3p Luciferase reporter assay, qRT-PCR, Western blot 22262409
MIRT006769 hsa-miR-200c-3p Luciferase reporter assay 22685266
Transcription factors
Transcription factor Regulation Reference
ETV4 Unknown 8810321
HIF1A Activation 17332917
JUN Unknown 8810321
NR4A1 Activation 22551568
PTTG1 Repression 19351864
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IBA 21873635
GO:0002020 Function Protease binding IPI 9573338
GO:0005178 Function Integrin binding IEA
GO:0005515 Function Protein binding IPI 12032297, 24112707, 28514442, 32296183
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
188825 11821 ENSG00000035862
Protein
UniProt ID P16035
Protein name Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Protein function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
PDB 1BR9 , 1GXD , 2TMP , 4ILW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00965 TIMP 25 203 Tissue inhibitor of metalloproteinase Domain
Sequence
Sequence length 220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Activation of Matrix Metalloproteinases
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Tumoral calcinosis Tumoral calcinosis rs104894343, rs104894344, rs745655924, rs137853086, rs375879489, rs761396172, rs137853087, rs137853091, rs137853088, rs137853089, rs137853090, rs766750282, rs760830864, rs786205250, rs267606841
View all (4 more)
24142982
Unknown
Disease term Disease name Evidence References Source
Myocardial infarction Myocardial Infarction 24358288 ClinVar
Eosinophilia Eosinophilia GWAS
Alzheimer disease Alzheimer disease GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 34756330
Acute Coronary Syndrome Stimulate 21273668
Acute Kidney Injury Associate 24675717, 28003188, 29145491, 30389130
Adenocarcinoma Inhibit 34060287
Adenocarcinoma of Lung Associate 26556867, 36494333
Adenoma Associate 23940598
Adenoma Pleomorphic Associate 25137137
AIDS Associated Nephropathy Associate 31275061
Airway Obstruction Associate 26126526
Albuminuria Associate 28805547