TIMP1 (TIMP metallopeptidase inhibitor 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7076
Gene name Gene Name - the full gene name approved by the HGNC.
TIMP metallopeptidase inhibitor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TIMP1
Synonyms (NCBI Gene) Gene synonyms aliases
CLGI, EPA, EPO, HCI, TIMP, TIMP-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HCI
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp11.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory ro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT006638 hsa-miR-519a-3p Luciferase reporter assay, qRT-PCR, Western blot 22262409
MIRT028755 hsa-miR-26b-5p Microarray 19088304
MIRT052992 hsa-miR-181a-5p Luciferase reporter assay, qRT-PCR, Western blot 22492871
MIRT437506 hsa-miR-1293 Luciferase reporter assay, Western blot 23943285
MIRT731726 hsa-miR-377-3p Luciferase reporter assay, qRT-PCR, Western blot 25998046
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
Transcription factor Regulation Reference
ASH1L Unknown 22488473
FOSB Repression 11337499
FOSB Unknown 10051488
FOSL2 Repression 11337499
JUND Unknown 10051488;11337499
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(41)
GO ID Ontology Definition Evidence Reference
GO:0001775 Process Cell activation IEA
GO:0002020 Function Protease binding IBA 21873635
GO:0002248 Process Connective tissue replacement involved in inflammatory response wound healing IEA
GO:0002576 Process Platelet degranulation TAS
GO:0005125 Function Cytokine activity IDA 3839290
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
305370 11820 ENSG00000102265
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01033
Protein name Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Protein function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8,
PDB 1D2B , 1OO9 , 1UEA , 2J0T , 3MA2 , 3V96 , 6MAV , 6N9D , 7S7L , 7S7M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00965 TIMP 22 → 199 Tissue inhibitor of metalloproteinase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  HIF-1 signaling pathway   Platelet degranulation
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (7)
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases rs869025224 25055964
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 16023759
Glomerulonephritis IGA Glomerulonephritis rs778043831 25133636
Show/Hide Text Mining Associations (379)
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Associate 34685701
Acne Vulgaris Associate 16185265
Acro Osteolysis Associate 35145077
Acute Disease Stimulate 32431079
Acute Kidney Injury Associate 33863396
Acute Lung Injury Associate 19159011
Acute On Chronic Liver Failure Associate 37816833
Adenocarcinoma Associate 17695477, 25674294, 30670912, 35328735
Adenocarcinoma Stimulate 33120770
Adenocarcinoma of Lung Associate 22761399, 25578494, 26366732, 33120770, 34323652, 34659209