Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7074
Gene name	TIAM Rac1 associated GEF 1
Gene symbol	TIAM1
Synonyms (NCBI Gene)	NEDLDSTIAM-1
Chromosome	21
Chromosome location	21q22.11
Summary	This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effect

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005565	hsa-miR-21-5p	Luciferase reporter assayMicroarrayNorthern blotqRT-PCR	20826792
MIRT005565	hsa-miR-21-5p	Luciferase reporter assayMicroarrayNorthern blotqRT-PCR	20826792
MIRT005565	hsa-miR-21-5p	Luciferase reporter assayMicroarrayNorthern blotqRT-PCR	20826792
MIRT005566	hsa-miR-31-5p	Luciferase reporter assayMicroarrayNorthern blotqRT-PCR	20826792
MIRT005566	hsa-miR-31-5p	Luciferase reporter assayMicroarrayNorthern blotqRT-PCR	20826792
MIRT005565	hsa-miR-21-5p	Luciferase reporter assay	23442323
MIRT018498	hsa-miR-335-5p	Microarray	18185580
MIRT052155	hsa-let-7b-5p	CLASH	23622248
MIRT046873	hsa-miR-221-3p	CLASH	23622248
MIRT040238	hsa-miR-615-3p	CLASH	23622248
MIRT039107	hsa-miR-769-3p	CLASH	23622248
MIRT038766	hsa-miR-93-3p	CLASH	23622248
MIRT037502	hsa-miR-744-5p	CLASH	23622248
MIRT053593	hsa-miR-10b-5p	Luciferase reporter assayqRT-PCRWestern blot	24481854
MIRT054278	hsa-miR-329-3p	Luciferase reporter assayqRT-PCRWestern blot	25654811
MIRT054278	hsa-miR-329-3p	Luciferase reporter assayqRT-PCRWestern blot	25654811
MIRT054429	hsa-miR-141-3p	Luciferase reporter assayqRT-PCRWestern blot	24551096
MIRT054429	hsa-miR-141-3p	Luciferase reporter assayqRT-PCRWestern blot	24551096
MIRT437579	hsa-miR-10a-5p	MicroarrayqRT-PCR	22815788
MIRT005565	hsa-miR-21-5p	MicroarrayqRT-PCR	22815788
MIRT437738	hsa-miR-342-3p	MicroarrayqRT-PCR	22815788
MIRT438887	hsa-miR-22-3p	Luciferase reporter assayWestern blot	23440286
MIRT438431	hsa-miR-29c-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	23142282
MIRT438887	hsa-miR-22-3p	Luciferase reporter assayWestern blot	23440286
MIRT438431	hsa-miR-29c-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	23142282
MIRT1424504	hsa-miR-1207-3p	CLIP-seq
MIRT1424505	hsa-miR-1245b-3p	CLIP-seq
MIRT1424506	hsa-miR-1248	CLIP-seq
MIRT1424507	hsa-miR-1262	CLIP-seq
MIRT1424508	hsa-miR-1323	CLIP-seq
MIRT1424509	hsa-miR-1537	CLIP-seq
MIRT1424510	hsa-miR-183	CLIP-seq
MIRT1424511	hsa-miR-19a	CLIP-seq
MIRT1424512	hsa-miR-19b	CLIP-seq
MIRT1424513	hsa-miR-21	CLIP-seq
MIRT1424514	hsa-miR-22	CLIP-seq
MIRT1424515	hsa-miR-29a	CLIP-seq
MIRT1424516	hsa-miR-29b	CLIP-seq
MIRT1424517	hsa-miR-29c	CLIP-seq
MIRT1424518	hsa-miR-3117-3p	CLIP-seq
MIRT1424519	hsa-miR-3122	CLIP-seq
MIRT1424520	hsa-miR-3134	CLIP-seq
MIRT1424521	hsa-miR-3138	CLIP-seq
MIRT1424522	hsa-miR-3153	CLIP-seq
MIRT1424523	hsa-miR-3169	CLIP-seq
MIRT1424524	hsa-miR-335	CLIP-seq
MIRT1424525	hsa-miR-3647-3p	CLIP-seq
MIRT1424526	hsa-miR-3655	CLIP-seq
MIRT1424527	hsa-miR-3659	CLIP-seq
MIRT1424528	hsa-miR-3662	CLIP-seq
MIRT1424529	hsa-miR-3667-5p	CLIP-seq
MIRT1424530	hsa-miR-3691-3p	CLIP-seq
MIRT1424531	hsa-miR-3913-5p	CLIP-seq
MIRT1424532	hsa-miR-3924	CLIP-seq
MIRT1424533	hsa-miR-3936	CLIP-seq
MIRT1424534	hsa-miR-3942-3p	CLIP-seq
MIRT1424535	hsa-miR-4259	CLIP-seq
MIRT1424536	hsa-miR-4289	CLIP-seq
MIRT1424537	hsa-miR-4320	CLIP-seq
MIRT1424538	hsa-miR-4325	CLIP-seq
MIRT1424539	hsa-miR-4476	CLIP-seq
MIRT1424540	hsa-miR-4502	CLIP-seq
MIRT1424541	hsa-miR-4504	CLIP-seq
MIRT1424542	hsa-miR-450b-3p	CLIP-seq
MIRT1424543	hsa-miR-4662a-3p	CLIP-seq
MIRT1424544	hsa-miR-4668-5p	CLIP-seq
MIRT1424545	hsa-miR-4676-5p	CLIP-seq
MIRT1424546	hsa-miR-4684-3p	CLIP-seq
MIRT1424547	hsa-miR-4696	CLIP-seq
MIRT1424548	hsa-miR-4701-3p	CLIP-seq
MIRT1424549	hsa-miR-4759	CLIP-seq
MIRT1424550	hsa-miR-4762-3p	CLIP-seq
MIRT1424551	hsa-miR-4764-5p	CLIP-seq
MIRT1424552	hsa-miR-4795-5p	CLIP-seq
MIRT1424553	hsa-miR-4797-5p	CLIP-seq
MIRT1424554	hsa-miR-4802-3p	CLIP-seq
MIRT1424555	hsa-miR-499a-5p	CLIP-seq
MIRT1424556	hsa-miR-515-5p	CLIP-seq
MIRT1424557	hsa-miR-542-3p	CLIP-seq
MIRT1424558	hsa-miR-548aa	CLIP-seq
MIRT1424559	hsa-miR-548o	CLIP-seq
MIRT1424560	hsa-miR-575	CLIP-seq
MIRT1424561	hsa-miR-578	CLIP-seq
MIRT1424562	hsa-miR-590-5p	CLIP-seq
MIRT1424563	hsa-miR-617	CLIP-seq
MIRT1424564	hsa-miR-653	CLIP-seq
MIRT1424565	hsa-miR-758	CLIP-seq
MIRT1424513	hsa-miR-21	CLIP-seq
MIRT1424525	hsa-miR-3647-3p	CLIP-seq
MIRT1424528	hsa-miR-3662	CLIP-seq
MIRT1424538	hsa-miR-4325	CLIP-seq
MIRT2127226	hsa-miR-4642	CLIP-seq
MIRT1424545	hsa-miR-4676-5p	CLIP-seq
MIRT1424546	hsa-miR-4684-3p	CLIP-seq
MIRT2127227	hsa-miR-514	CLIP-seq
MIRT2127228	hsa-miR-514b-3p	CLIP-seq
MIRT1424560	hsa-miR-575	CLIP-seq
MIRT1424562	hsa-miR-590-5p	CLIP-seq
MIRT1424564	hsa-miR-653	CLIP-seq
MIRT1424510	hsa-miR-183	CLIP-seq
MIRT2349055	hsa-miR-2467-3p	CLIP-seq
MIRT1424515	hsa-miR-29a	CLIP-seq
MIRT1424516	hsa-miR-29b	CLIP-seq
MIRT1424517	hsa-miR-29c	CLIP-seq
MIRT1424524	hsa-miR-335	CLIP-seq
MIRT2349056	hsa-miR-3607-3p	CLIP-seq
MIRT1424526	hsa-miR-3655	CLIP-seq
MIRT1424527	hsa-miR-3659	CLIP-seq
MIRT1424533	hsa-miR-3936	CLIP-seq
MIRT1424534	hsa-miR-3942-3p	CLIP-seq
MIRT2349057	hsa-miR-4514	CLIP-seq
MIRT2349058	hsa-miR-4690-5p	CLIP-seq
MIRT2349059	hsa-miR-4692	CLIP-seq
MIRT1424555	hsa-miR-499a-5p	CLIP-seq
MIRT1424556	hsa-miR-515-5p	CLIP-seq
MIRT1424561	hsa-miR-578	CLIP-seq
MIRT1424563	hsa-miR-617	CLIP-seq
MIRT1424556	hsa-miR-515-5p	CLIP-seq

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	EXP	15721239
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	23109420
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IMP	20361982, 25684205
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	10835422
GO:0005515	Function	Protein binding	IPI	17440041, 21763699, 23109420, 23395182, 25684205, 32707033, 35914814
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	23109420
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23109420
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	IDA	20332120
GO:0007160	Process	Cell-matrix adhesion	IMP	20361982
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IBA
GO:0007264	Process	Small GTPase-mediated signal transduction	IDA	23109420
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	25032858
GO:0008289	Function	Lipid binding	IEA
GO:0010717	Process	Regulation of epithelial to mesenchymal transition	IDA	20826792
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	NAS	17086355
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IMP	20361982
GO:0016601	Process	Rac protein signal transduction	IDA	25032858
GO:0016601	Process	Rac protein signal transduction	IMP	20361982
GO:0019900	Function	Kinase binding	IPI	23109420
GO:0030335	Process	Positive regulation of cell migration	IDA	25032858
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035567	Process	Non-canonical Wnt signaling pathway	IDA	23109420
GO:0035567	Process	Non-canonical Wnt signaling pathway	ISS
GO:0044291	Component	Cell-cell contact zone	IDA	20361982
GO:0045202	Component	Synapse	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0050772	Process	Positive regulation of axonogenesis	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	NAS	24431302
GO:0065003	Process	Protein-containing complex assembly	IDA	23109420
GO:0070161	Component	Anchoring junction	IEA
GO:1904338	Process	Regulation of dopaminergic neuron differentiation	ISS

MIM	HGNC	e!Ensembl
600687	11805	ENSG00000156299

Q13009

Protein name

Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)

Protein function

Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell a

PDB

2D8I , 3KZD , 3KZE , 4GVC , 4GVD , 4K2O , 4K2P , 4NXP , 4NXQ , 4NXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	440 → 547	PH domain	Domain
PF18385	Tiam_CC_Ex	572 → 669	T-lymphoma invasion and metastasis CC-Ex domain	Domain
PF02196	RBD	766 → 839	Raf-like Ras-binding domain	Domain
PF00595	PDZ	845 → 925	PDZ domain	Domain
PF00621	RhoGEF	1044 → 1232	RhoGEF domain	Domain
PF00169	PH	1263 → 1395	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Sequence

MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS
TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA
ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS
LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN
SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG
ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT
TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP
GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD
GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT
AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI
LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS
SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT
EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV
VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP
KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN
RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS
NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS
PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE
LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK
LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL
RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA
DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL
SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP
ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS
KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK
ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS
GINGGLESASEEVIWVRREDFAPSRKLNTEI

Sequence length

1591

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Tight junction Regulation of actin cytoskeleton Proteoglycans in cancer		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodevelopmental disorder with language delay and seizures	Pathogenic	rs1249016772, rs760187500, rs759037691, rs1319513413	RCV002260889 RCV002260890 RCV002260891 RCV002260892

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Colon adenocarcinoma	Likely benign	rs144719094	RCV005938803
Gastric cancer	Uncertain significance	rs777513192	RCV005939259
Thyroid cancer, nonmedullary, 1	Likely benign	rs146229915	RCV005937040
TIAM1-related disorder	Uncertain significance; Likely benign; Benign	rs2085338785, rs146951286, rs2516979493, rs757091901, rs113219144, rs146369813, rs146645440, rs75483199, rs141775592, rs146784461, rs143304426, rs2070410, rs192535474, rs77092908, rs762194 View all (31 more)	RCV003966313 RCV004754985 RCV003399985 RCV003397735 RCV003919239 RCV003894777 RCV003906989 RCV003919864 RCV003921874 RCV003923899 RCV003923956 RCV003974363 RCV003897331 RCV003906908 RCV003967370 RCV003912086 RCV003977255 RCV003984468 RCV003909756 RCV003933846 RCV003942065 RCV003961521 RCV003959704 RCV003954904 RCV003917077 RCV003941637 RCV003931425 RCV003924304 RCV003937080 RCV003939417 RCV003934685 RCV003959034 RCV003947248 RCV003922080 RCV003924200 RCV003924216 RCV003926944 RCV003927008 RCV003979199 RCV003971670 RCV003971459 RCV003967028 RCV003976686 RCV003969074 RCV003972157 RCV003978171 RCV003915950

Show/Hide Text Mining Associations (45)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	24661909
Adenocarcinoma of Lung	Associate	24661909, 37748077
Amyotrophic Lateral Sclerosis	Associate	20801718
Breast Neoplasms	Associate	11328805, 20444703, 20819206, 35773411
Breast Neoplasms	Stimulate	27562113
Carcinoma	Associate	22302986
Carcinoma Ductal Breast	Associate	27562113
Carcinoma Hepatocellular	Associate	24551096, 25739101, 37047360
Carcinoma Intraductal Noninfiltrating	Stimulate	27562113
Carcinoma Non Small Cell Lung	Associate	37748077
Carcinoma Pancreatic Ductal	Associate	35844783
Carcinoma Renal Cell	Associate	20429013
Carcinoma Squamous Cell	Associate	26716504
Cholangiocarcinoma	Associate	26884821
Colonic Neoplasms	Associate	20826792
Colorectal Neoplasms	Associate	15655826, 19276682, 28347238, 34526059
Familial medullary thyroid carcinoma	Associate	33692755
Infections	Associate	20585556
Leukemia	Associate	17352239, 20215110
Leukemia Lymphoma Adult T Cell	Associate	20215110
Lung Neoplasms	Associate	22524833, 37748077
Lymphatic Metastasis	Associate	19276682, 22524833, 24661909, 26369827, 26884821
Lymphatic Metastasis	Stimulate	20429013
Lymphoma T Cell	Associate	24350867, 26959888
Neoplasm Metastasis	Associate	11274357, 15655826, 17003780, 22302986, 22524833, 26369827
Neoplasms	Associate	17003780, 18246045, 20429013, 20637541, 20819206, 22302986, 22524833, 23322732, 25973950, 26369827, 26959888, 27562113, 28423360, 37047360, 40303408
Neoplasms	Stimulate	23950931
Neuroblastoma	Associate	22367537, 28423360
Obesity	Associate	24136929
Osteosarcoma	Associate	25973950
Ovarian Neoplasms	Associate	32948241
Pancreatic Neoplasms	Associate	18472958, 23322732, 24136929, 40303408
Prostatic Hyperplasia	Associate	40392613
Prostatic Intraepithelial Neoplasia	Stimulate	17003780
Prostatic Neoplasms	Associate	17003780, 38246227
Prostatitis	Stimulate	17003780
Retinoblastoma	Associate	23950931
Spondylometaepiphyseal Dysplasia Short Limb Hand Type	Associate	37047360
Squamous Cell Carcinoma of Head and Neck	Associate	26369827
Squamous Intraepithelial Lesions	Stimulate	22443139
Stomach Neoplasms	Associate	18246045, 23534724, 38246227
Tertiary Lymphoid Structures	Associate	17003780
Thyroid cancer medullary	Associate	33692755
Triple Negative Breast Neoplasms	Associate	27902969
Uterine Cervical Neoplasms	Associate	30504727

TIAM1 (TIAM Rac1 associated GEF 1)