Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7072
Gene name Gene Name - the full gene name approved by the HGNC.	TIA1 cytotoxic granule associated RNA binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TIA1
Synonyms (NCBI Gene) Gene synonyms aliases	ALS26, TIA-1, WDM
Disease Acronyms (UniProt) Disease acronyms from UniProt database	ALS26, WDM
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it pr

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SNP ID	Visualize variation	Clinical significance	Consequence
rs116621885	T>C	Benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Non coding transcript variant, missense variant, coding sequence variant, genic downstream transcript variant
rs747068278	C>T	Pathogenic	Missense variant, non coding transcript variant, genic downstream transcript variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000910	hsa-miR-15a-5p	Microarray	18362358
MIRT000909	hsa-miR-16-5p	Microarray	18362358
MIRT028191	hsa-miR-33a-5p	Sequencing	20371350
MIRT029253	hsa-miR-26b-5p	Microarray	19088304
MIRT043294	hsa-miR-331-3p	CLASH	23622248
MIRT036261	hsa-miR-1229-3p	CLASH	23622248
MIRT1424322	hsa-let-7a	CLIP-seq
MIRT1424323	hsa-let-7b	CLIP-seq
MIRT1424324	hsa-let-7c	CLIP-seq
MIRT1424325	hsa-let-7d	CLIP-seq
MIRT1424326	hsa-let-7e	CLIP-seq
MIRT1424327	hsa-let-7f	CLIP-seq
MIRT1424328	hsa-let-7g	CLIP-seq
MIRT1424329	hsa-let-7i	CLIP-seq
MIRT1424330	hsa-miR-1276	CLIP-seq
MIRT1424331	hsa-miR-1289	CLIP-seq
MIRT1424332	hsa-miR-1290	CLIP-seq
MIRT1424333	hsa-miR-1299	CLIP-seq
MIRT1424334	hsa-miR-188-5p	CLIP-seq
MIRT1424335	hsa-miR-30a	CLIP-seq
MIRT1424336	hsa-miR-30b	CLIP-seq
MIRT1424337	hsa-miR-30c	CLIP-seq
MIRT1424338	hsa-miR-30d	CLIP-seq
MIRT1424339	hsa-miR-30e	CLIP-seq
MIRT1424340	hsa-miR-3119	CLIP-seq
MIRT1424341	hsa-miR-3137	CLIP-seq
MIRT1424342	hsa-miR-3159	CLIP-seq
MIRT1424343	hsa-miR-3161	CLIP-seq
MIRT1424344	hsa-miR-3198	CLIP-seq
MIRT1424345	hsa-miR-3200-5p	CLIP-seq
MIRT1424346	hsa-miR-337-5p	CLIP-seq
MIRT1424347	hsa-miR-339-5p	CLIP-seq
MIRT1424348	hsa-miR-3660	CLIP-seq
MIRT1424349	hsa-miR-4252	CLIP-seq
MIRT1424350	hsa-miR-4294	CLIP-seq
MIRT1424351	hsa-miR-4309	CLIP-seq
MIRT1424352	hsa-miR-4311	CLIP-seq
MIRT1424353	hsa-miR-4458	CLIP-seq
MIRT1424354	hsa-miR-4477b	CLIP-seq
MIRT1424355	hsa-miR-4493	CLIP-seq
MIRT1424356	hsa-miR-4500	CLIP-seq
MIRT1424357	hsa-miR-4526	CLIP-seq
MIRT1424358	hsa-miR-4687-3p	CLIP-seq
MIRT1424359	hsa-miR-4720-3p	CLIP-seq
MIRT1424360	hsa-miR-4760-5p	CLIP-seq
MIRT1424361	hsa-miR-4762-5p	CLIP-seq
MIRT1424362	hsa-miR-4782-5p	CLIP-seq
MIRT1424363	hsa-miR-4804-3p	CLIP-seq
MIRT1424364	hsa-miR-507	CLIP-seq
MIRT1424365	hsa-miR-516b	CLIP-seq
MIRT1424366	hsa-miR-548al	CLIP-seq
MIRT1424367	hsa-miR-557	CLIP-seq
MIRT1424368	hsa-miR-583	CLIP-seq
MIRT1424369	hsa-miR-767-3p	CLIP-seq
MIRT1424370	hsa-miR-889	CLIP-seq
MIRT1424371	hsa-miR-892b	CLIP-seq
MIRT1424372	hsa-miR-98	CLIP-seq
MIRT1424373	hsa-miR-101	CLIP-seq
MIRT1424374	hsa-miR-1245b-3p	CLIP-seq
MIRT1424375	hsa-miR-1260	CLIP-seq
MIRT1424376	hsa-miR-1260b	CLIP-seq
MIRT1424377	hsa-miR-1264	CLIP-seq
MIRT1424378	hsa-miR-144	CLIP-seq
MIRT1424379	hsa-miR-188-3p	CLIP-seq
MIRT1424380	hsa-miR-19a	CLIP-seq
MIRT1424381	hsa-miR-19b	CLIP-seq
MIRT1424382	hsa-miR-2278	CLIP-seq
MIRT1424335	hsa-miR-30a	CLIP-seq
MIRT1424336	hsa-miR-30b	CLIP-seq
MIRT1424337	hsa-miR-30c	CLIP-seq
MIRT1424338	hsa-miR-30d	CLIP-seq
MIRT1424339	hsa-miR-30e	CLIP-seq
MIRT1424383	hsa-miR-3136-5p	CLIP-seq
MIRT1424341	hsa-miR-3137	CLIP-seq
MIRT1424384	hsa-miR-3156-3p	CLIP-seq
MIRT1424343	hsa-miR-3161	CLIP-seq
MIRT1424345	hsa-miR-3200-5p	CLIP-seq
MIRT1424385	hsa-miR-335	CLIP-seq
MIRT1424346	hsa-miR-337-5p	CLIP-seq
MIRT1424347	hsa-miR-339-5p	CLIP-seq
MIRT1424386	hsa-miR-3609	CLIP-seq
MIRT1424387	hsa-miR-4263	CLIP-seq
MIRT1424388	hsa-miR-4439	CLIP-seq
MIRT1424389	hsa-miR-4468	CLIP-seq
MIRT1424390	hsa-miR-4513	CLIP-seq
MIRT1424391	hsa-miR-4635	CLIP-seq
MIRT1424392	hsa-miR-4639-5p	CLIP-seq
MIRT1424393	hsa-miR-4668-3p	CLIP-seq
MIRT1424394	hsa-miR-4731-3p	CLIP-seq
MIRT1424395	hsa-miR-4738-3p	CLIP-seq
MIRT1424396	hsa-miR-4799-5p	CLIP-seq
MIRT1424397	hsa-miR-4801	CLIP-seq
MIRT1424398	hsa-miR-494	CLIP-seq
MIRT1424399	hsa-miR-520g	CLIP-seq
MIRT1424400	hsa-miR-520h	CLIP-seq
MIRT1424401	hsa-miR-526b	CLIP-seq
MIRT1424402	hsa-miR-548a-5p	CLIP-seq
MIRT1424403	hsa-miR-548ab	CLIP-seq
MIRT1424404	hsa-miR-548ah	CLIP-seq
MIRT1424405	hsa-miR-548ak	CLIP-seq
MIRT1424406	hsa-miR-548b-5p	CLIP-seq
MIRT1424407	hsa-miR-548c-5p	CLIP-seq
MIRT1424408	hsa-miR-548d-5p	CLIP-seq
MIRT1424409	hsa-miR-548h	CLIP-seq
MIRT1424410	hsa-miR-548i	CLIP-seq
MIRT1424411	hsa-miR-548j	CLIP-seq
MIRT1424412	hsa-miR-548w	CLIP-seq
MIRT1424413	hsa-miR-548y	CLIP-seq
MIRT1424414	hsa-miR-559	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT1424416	hsa-miR-599	CLIP-seq
MIRT2127191	hsa-miR-1343	CLIP-seq
MIRT2127192	hsa-miR-139-5p	CLIP-seq
MIRT2127193	hsa-miR-153	CLIP-seq
MIRT2127194	hsa-miR-2467-3p	CLIP-seq
MIRT2127195	hsa-miR-25	CLIP-seq
MIRT2127196	hsa-miR-27a	CLIP-seq
MIRT2127197	hsa-miR-27b	CLIP-seq
MIRT2127198	hsa-miR-299-5p	CLIP-seq
MIRT2127199	hsa-miR-3074-3p	CLIP-seq
MIRT2127200	hsa-miR-3074-5p	CLIP-seq
MIRT2127201	hsa-miR-3123	CLIP-seq
MIRT2127202	hsa-miR-3124-3p	CLIP-seq
MIRT2127203	hsa-miR-3163	CLIP-seq
MIRT2127204	hsa-miR-32	CLIP-seq
MIRT1424386	hsa-miR-3609	CLIP-seq
MIRT2127205	hsa-miR-363	CLIP-seq
MIRT2127206	hsa-miR-367	CLIP-seq
MIRT2127207	hsa-miR-3678-3p	CLIP-seq
MIRT2127208	hsa-miR-378g	CLIP-seq
MIRT2127209	hsa-miR-3919	CLIP-seq
MIRT2127210	hsa-miR-412	CLIP-seq
MIRT2127211	hsa-miR-4420	CLIP-seq
MIRT2127212	hsa-miR-4437	CLIP-seq
MIRT2127213	hsa-miR-4674	CLIP-seq
MIRT1424396	hsa-miR-4799-5p	CLIP-seq
MIRT1424364	hsa-miR-507	CLIP-seq
MIRT2127214	hsa-miR-511	CLIP-seq
MIRT2127215	hsa-miR-513a-5p	CLIP-seq
MIRT1424399	hsa-miR-520g	CLIP-seq
MIRT1424400	hsa-miR-520h	CLIP-seq
MIRT1424404	hsa-miR-548ah	CLIP-seq
MIRT2127216	hsa-miR-548u	CLIP-seq
MIRT1424367	hsa-miR-557	CLIP-seq
MIRT2127217	hsa-miR-570	CLIP-seq
MIRT2127218	hsa-miR-579	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT2127219	hsa-miR-626	CLIP-seq
MIRT2127220	hsa-miR-760	CLIP-seq
MIRT2127221	hsa-miR-873	CLIP-seq
MIRT2127222	hsa-miR-92a	CLIP-seq
MIRT2127223	hsa-miR-92b	CLIP-seq
MIRT2127191	hsa-miR-1343	CLIP-seq
MIRT2349042	hsa-miR-3120-3p	CLIP-seq
MIRT2127203	hsa-miR-3163	CLIP-seq
MIRT1424345	hsa-miR-3200-5p	CLIP-seq
MIRT2349043	hsa-miR-4325	CLIP-seq
MIRT1424392	hsa-miR-4639-5p	CLIP-seq
MIRT2349044	hsa-miR-4672	CLIP-seq
MIRT2349045	hsa-miR-4803	CLIP-seq
MIRT1424401	hsa-miR-526b	CLIP-seq
MIRT2349046	hsa-miR-545	CLIP-seq
MIRT2349047	hsa-miR-548c-3p	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT2127193	hsa-miR-153	CLIP-seq
MIRT2127195	hsa-miR-25	CLIP-seq
MIRT2127201	hsa-miR-3123	CLIP-seq
MIRT2127204	hsa-miR-32	CLIP-seq
MIRT1424345	hsa-miR-3200-5p	CLIP-seq
MIRT2127205	hsa-miR-363	CLIP-seq
MIRT2127206	hsa-miR-367	CLIP-seq
MIRT2127209	hsa-miR-3919	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT2349048	hsa-miR-642b	CLIP-seq
MIRT2127222	hsa-miR-92a	CLIP-seq
MIRT2127223	hsa-miR-92b	CLIP-seq
MIRT2642256	hsa-miR-1238	CLIP-seq
MIRT2642257	hsa-miR-1243	CLIP-seq
MIRT2642258	hsa-miR-1261	CLIP-seq
MIRT2642259	hsa-miR-1270	CLIP-seq
MIRT2642260	hsa-miR-1287	CLIP-seq
MIRT2127191	hsa-miR-1343	CLIP-seq
MIRT2127192	hsa-miR-139-5p	CLIP-seq
MIRT1424380	hsa-miR-19a	CLIP-seq
MIRT1424381	hsa-miR-19b	CLIP-seq
MIRT2642261	hsa-miR-2113	CLIP-seq
MIRT2642262	hsa-miR-23a	CLIP-seq
MIRT2642263	hsa-miR-23b	CLIP-seq
MIRT2642264	hsa-miR-23c	CLIP-seq
MIRT2127196	hsa-miR-27a	CLIP-seq
MIRT2127197	hsa-miR-27b	CLIP-seq
MIRT1424335	hsa-miR-30a	CLIP-seq
MIRT1424336	hsa-miR-30b	CLIP-seq
MIRT1424337	hsa-miR-30c	CLIP-seq
MIRT1424338	hsa-miR-30d	CLIP-seq
MIRT1424339	hsa-miR-30e	CLIP-seq
MIRT2349042	hsa-miR-3120-3p	CLIP-seq
MIRT2127202	hsa-miR-3124-3p	CLIP-seq
MIRT2642265	hsa-miR-3135b	CLIP-seq
MIRT1424383	hsa-miR-3136-5p	CLIP-seq
MIRT2642266	hsa-miR-3143	CLIP-seq
MIRT2642267	hsa-miR-3145-3p	CLIP-seq
MIRT2642268	hsa-miR-3148	CLIP-seq
MIRT1424343	hsa-miR-3161	CLIP-seq
MIRT1424346	hsa-miR-337-5p	CLIP-seq
MIRT2642269	hsa-miR-3646	CLIP-seq
MIRT2642270	hsa-miR-3649	CLIP-seq
MIRT2642271	hsa-miR-3654	CLIP-seq
MIRT2642272	hsa-miR-3658	CLIP-seq
MIRT2642273	hsa-miR-3662	CLIP-seq
MIRT2642274	hsa-miR-382	CLIP-seq
MIRT2642275	hsa-miR-3942-3p	CLIP-seq
MIRT2349043	hsa-miR-4325	CLIP-seq
MIRT2642276	hsa-miR-4330	CLIP-seq
MIRT1424388	hsa-miR-4439	CLIP-seq
MIRT2642277	hsa-miR-4477a	CLIP-seq
MIRT2642278	hsa-miR-4511	CLIP-seq
MIRT1424390	hsa-miR-4513	CLIP-seq
MIRT2642279	hsa-miR-4639-3p	CLIP-seq
MIRT2642280	hsa-miR-4643	CLIP-seq
MIRT2642281	hsa-miR-4659a-3p	CLIP-seq
MIRT2642282	hsa-miR-4659b-3p	CLIP-seq
MIRT2642283	hsa-miR-4662a-3p	CLIP-seq
MIRT1424393	hsa-miR-4668-3p	CLIP-seq
MIRT2349044	hsa-miR-4672	CLIP-seq
MIRT2642284	hsa-miR-4683	CLIP-seq
MIRT2642285	hsa-miR-4698	CLIP-seq
MIRT2642286	hsa-miR-4728-3p	CLIP-seq
MIRT1424361	hsa-miR-4762-5p	CLIP-seq
MIRT2642287	hsa-miR-4775	CLIP-seq
MIRT2642288	hsa-miR-483-5p	CLIP-seq
MIRT1424364	hsa-miR-507	CLIP-seq
MIRT2127215	hsa-miR-513a-5p	CLIP-seq
MIRT1424401	hsa-miR-526b	CLIP-seq
MIRT2349046	hsa-miR-545	CLIP-seq
MIRT2642289	hsa-miR-548a-3p	CLIP-seq
MIRT2642290	hsa-miR-548ac	CLIP-seq
MIRT2642291	hsa-miR-548ae	CLIP-seq
MIRT2642292	hsa-miR-548aj	CLIP-seq
MIRT1424366	hsa-miR-548al	CLIP-seq
MIRT2642293	hsa-miR-548am	CLIP-seq
MIRT2642294	hsa-miR-548b-3p	CLIP-seq
MIRT2349047	hsa-miR-548c-3p	CLIP-seq
MIRT2642295	hsa-miR-548d-3p	CLIP-seq
MIRT2642296	hsa-miR-548e	CLIP-seq
MIRT2642297	hsa-miR-548f	CLIP-seq
MIRT2642298	hsa-miR-548g	CLIP-seq
MIRT2642299	hsa-miR-548x	CLIP-seq
MIRT2642300	hsa-miR-548z	CLIP-seq
MIRT2642301	hsa-miR-556-3p	CLIP-seq
MIRT1424367	hsa-miR-557	CLIP-seq
MIRT2642302	hsa-miR-561	CLIP-seq
MIRT2642303	hsa-miR-577	CLIP-seq
MIRT2127218	hsa-miR-579	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT2642304	hsa-miR-620	CLIP-seq
MIRT2349048	hsa-miR-642b	CLIP-seq
MIRT2642305	hsa-miR-802	CLIP-seq
MIRT1424370	hsa-miR-889	CLIP-seq
MIRT2642306	hsa-miR-942	CLIP-seq
MIRT2349048	hsa-miR-642b	CLIP-seq
MIRT2642257	hsa-miR-1243	CLIP-seq
MIRT2642258	hsa-miR-1261	CLIP-seq
MIRT2642259	hsa-miR-1270	CLIP-seq
MIRT2642260	hsa-miR-1287	CLIP-seq
MIRT2127191	hsa-miR-1343	CLIP-seq
MIRT2127192	hsa-miR-139-5p	CLIP-seq
MIRT1424380	hsa-miR-19a	CLIP-seq
MIRT1424381	hsa-miR-19b	CLIP-seq
MIRT2642261	hsa-miR-2113	CLIP-seq
MIRT2642262	hsa-miR-23a	CLIP-seq
MIRT2642263	hsa-miR-23b	CLIP-seq
MIRT2642264	hsa-miR-23c	CLIP-seq
MIRT2127196	hsa-miR-27a	CLIP-seq
MIRT2127197	hsa-miR-27b	CLIP-seq
MIRT1424335	hsa-miR-30a	CLIP-seq
MIRT1424336	hsa-miR-30b	CLIP-seq
MIRT1424337	hsa-miR-30c	CLIP-seq
MIRT1424338	hsa-miR-30d	CLIP-seq
MIRT1424339	hsa-miR-30e	CLIP-seq
MIRT2349042	hsa-miR-3120-3p	CLIP-seq
MIRT2642265	hsa-miR-3135b	CLIP-seq
MIRT1424383	hsa-miR-3136-5p	CLIP-seq
MIRT2642266	hsa-miR-3143	CLIP-seq
MIRT2642267	hsa-miR-3145-3p	CLIP-seq
MIRT1424343	hsa-miR-3161	CLIP-seq
MIRT1424346	hsa-miR-337-5p	CLIP-seq
MIRT2642269	hsa-miR-3646	CLIP-seq
MIRT2642271	hsa-miR-3654	CLIP-seq
MIRT2642272	hsa-miR-3658	CLIP-seq
MIRT2642273	hsa-miR-3662	CLIP-seq
MIRT2642274	hsa-miR-382	CLIP-seq
MIRT2642275	hsa-miR-3942-3p	CLIP-seq
MIRT2349043	hsa-miR-4325	CLIP-seq
MIRT2642276	hsa-miR-4330	CLIP-seq
MIRT1424388	hsa-miR-4439	CLIP-seq
MIRT2642277	hsa-miR-4477a	CLIP-seq
MIRT2642278	hsa-miR-4511	CLIP-seq
MIRT1424390	hsa-miR-4513	CLIP-seq
MIRT2642279	hsa-miR-4639-3p	CLIP-seq
MIRT2642280	hsa-miR-4643	CLIP-seq
MIRT2642281	hsa-miR-4659a-3p	CLIP-seq
MIRT2642282	hsa-miR-4659b-3p	CLIP-seq
MIRT2349044	hsa-miR-4672	CLIP-seq
MIRT2642284	hsa-miR-4683	CLIP-seq
MIRT2642285	hsa-miR-4698	CLIP-seq
MIRT2693176	hsa-miR-4711-3p	CLIP-seq
MIRT2642286	hsa-miR-4728-3p	CLIP-seq
MIRT1424361	hsa-miR-4762-5p	CLIP-seq
MIRT1424364	hsa-miR-507	CLIP-seq
MIRT2127215	hsa-miR-513a-5p	CLIP-seq
MIRT2349046	hsa-miR-545	CLIP-seq
MIRT2642289	hsa-miR-548a-3p	CLIP-seq
MIRT2642290	hsa-miR-548ac	CLIP-seq
MIRT2642291	hsa-miR-548ae	CLIP-seq
MIRT2642292	hsa-miR-548aj	CLIP-seq
MIRT1424366	hsa-miR-548al	CLIP-seq
MIRT2642293	hsa-miR-548am	CLIP-seq
MIRT2642294	hsa-miR-548b-3p	CLIP-seq
MIRT2642295	hsa-miR-548d-3p	CLIP-seq
MIRT2642296	hsa-miR-548e	CLIP-seq
MIRT2642297	hsa-miR-548f	CLIP-seq
MIRT2642298	hsa-miR-548g	CLIP-seq
MIRT2642299	hsa-miR-548x	CLIP-seq
MIRT2642300	hsa-miR-548z	CLIP-seq
MIRT2642301	hsa-miR-556-3p	CLIP-seq
MIRT1424367	hsa-miR-557	CLIP-seq
MIRT2642302	hsa-miR-561	CLIP-seq
MIRT2127218	hsa-miR-579	CLIP-seq
MIRT1424415	hsa-miR-582-5p	CLIP-seq
MIRT2693177	hsa-miR-592	CLIP-seq
MIRT1424416	hsa-miR-599	CLIP-seq
MIRT2642304	hsa-miR-620	CLIP-seq
MIRT2349048	hsa-miR-642b	CLIP-seq
MIRT2642305	hsa-miR-802	CLIP-seq
MIRT1424370	hsa-miR-889	CLIP-seq
MIRT2642306	hsa-miR-942	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	7544399, 12486009, 18164289
GO:0005634	Component	Nucleus	IDA	18164289
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24965446
GO:0005829	Component	Cytosol	IDA
GO:0006915	Process	Apoptotic process	IEA
GO:0008143	Function	Poly(A) binding	TAS	1934064
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	TAS
GO:0010494	Component	Cytoplasmic stress granule	IDA	21984414
GO:0010494	Component	Cytoplasmic stress granule	ISS
GO:0017148	Process	Negative regulation of translation	IEA
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	IEA
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	IDA	11106748
GO:0097165	Component	Nuclear stress granule	IDA	21984414
GO:1903608	Process	Protein localization to cytoplasmic stress granule	IMP	24965446
GO:1904037	Process	Positive regulation of epithelial cell apoptotic process	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603518	11802	ENSG00000116001

Protein

UniProt ID

P31483

Protein name

Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)

Protein function

RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:11106748, PubMed:12486009, PubMed:17488725, PubMed:8576255). Binds to U-rich sequences

PDB

2MJN , 3BS9 , 5ITH , 5O2V , 5O3J , 6ELD , 7VI4 , 7VI5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	9 → 77	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	108 → 178	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	216 → 280	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, small intestine, kidney, liver, lung, skeletal muscle, testes, pancreas, and ovary (at protein level). {ECO:0000269|PubMed:17488725}.

Sequence

MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAA
AALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTE
DIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTN
WATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQI
MEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQI
GYPQPYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGV
QPPQGQNGSMLPNQPSGYRVAGYETQ

Sequence length

386

Interactions

View interactions

	Reactome
			FGFR2 alternative splicing

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Distal myopathy	Distal myopathy, Welander type	rs398123028, rs140614802, rs559454746, rs769542442, rs1572140109
Welander distal myopathy	Welander Distal Myopathy, Welander distal myopathy, Swedish type	rs747068278	27282841, 23401021, 23348830, 29457785, 10482271, 28817800

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Distal amyotrophy	Distal amyotrophy	ClinVar
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis 26 with or without frontotemporal dementia	GenCC
Distal Myopathy	distal myopathy, Welander type	GenCC

Show/Hide Text Mining Associations (67)

Disease Name	Relationship Type	References
Associations from Text Mining
Abortion Spontaneous	Associate	38497425
Acquired Immunodeficiency Syndrome	Associate	8506945
Alzheimer Disease	Associate	30367664
Amyotrophic Lateral Sclerosis	Associate	23092511, 28817800, 29216908, 34291734, 34750982, 36112647
Anemia Aplastic	Associate	12614221
Arthritis Rheumatoid	Associate	17599736
Autism Spectrum Disorder	Associate	34410578
Breast Neoplasms	Associate	39940786
Carcinogenesis	Associate	26958940
Carcinoma Ovarian Epithelial	Associate	19641607
Cardiomyopathy Dilated	Associate	12921808
Churg Strauss Syndrome	Associate	37298167
Colorectal Neoplasms	Associate	21179245, 32449240
Distal Myopathies	Associate	28221306, 30348840, 35269506, 36112647, 39682710
Distal myopathy Nonaka type	Associate	34291734
Drug Related Side Effects and Adverse Reactions	Associate	10396241, 16242311, 23302373
Drug Related Side Effects and Adverse Reactions	Stimulate	26379152
Endometrial Neoplasms	Inhibit	25140393
Endometriosis	Associate	25140393
Enteropathy Associated T Cell Lymphoma	Associate	22654438, 26226842
Enterovirus Infections	Stimulate	31941779
Esophageal Squamous Cell Carcinoma	Associate	26958940
Frontotemporal Dementia	Associate	28817800, 29216908, 29886022
GATA2 Deficiency	Associate	23426534
Graves Disease	Associate	20675271
Hereditary leiomyomatosis and renal cell cancer	Associate	12149227, 26722524
HIV Infections	Associate	15905189
Hodgkin Disease	Associate	18647967, 19096012, 20065852, 26722524
Hodgkin Disease	Inhibit	8506945
Inflammation	Associate	27402301
Leukemia Hairy Cell	Associate	15073603
Leukemia Large Granular Lymphocytic	Associate	12648073, 9176382
Leukemia Large Granular Lymphocytic	Stimulate	8655683
Lung Diseases	Associate	18438838
Lupus Erythematosus Systemic	Associate	18438838, 39743791
Lymphocytosis	Associate	8655683
Lymphoma	Associate	16138337, 21274672, 9176382
Lymphoma B Cell	Associate	15073603, 9846961
Lymphoma Follicular	Associate	7510456
Lymphoma Large B Cell Diffuse	Associate	12149227, 17456059, 9846961
Lymphoma Large Cell Anaplastic	Associate	10029454, 10396241, 24805132
Lymphoma Non Hodgkin	Associate	23302373
Lymphoma T Cell	Associate	8655683, 9176382
Lymphoma T Cell Peripheral	Associate	8655683
Lymphomatoid Papulosis	Associate	10233858
Microsatellite Instability	Associate	10362805
Mitochondrial Diseases	Associate	30348840
Mouth Diseases	Associate	20191052
Muscular Atrophy Spinal	Associate	21189287
Muscular Dystrophies	Associate	35269506, 39682710
Mycosis Fungoides	Associate	10233858
Neoplasms	Associate	10029454, 12456216, 15073603, 17456059, 19096012, 22282309, 22931631, 23302373, 25674293, 26617911, 26958940, 29363227, 29615001, 33546043, 34275008, 35979577 View all (1 more)
Neoplasms	Inhibit	18959781
Neoplasms Cystic Mucinous and Serous	Associate	19641607
Neurodegenerative Diseases	Associate	30367664, 34291734, 36112647, 36638831
Osteoarthritis	Associate	36799242
Pituitary Diseases	Associate	32634346
Polycystic Ovary Syndrome	Associate	38497425
Polyuria	Associate	32634346
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	19016721, 8655683
Respiratory Distress Syndrome	Associate	27596159
Rheumatic Diseases	Associate	18438838
Scleroderma Systemic	Associate	18438838
Sleep Deprivation	Associate	7544399
Thyroid Diseases	Associate	20675271
Uterine Cervical Dysplasia	Stimulate	12121440
Uterine Cervical Neoplasms	Associate	9374383

TIA1 (TIA1 cytotoxic granule associated RNA binding protein)