Gene Gene information from NCBI Gene database.
Entrez ID 7057
Gene name Thrombospondin 1
Gene symbol THBS1
Synonyms (NCBI Gene)
THBSTHBS-1TSPTSP-1TSP1
Chromosome 15
Chromosome location 15q14
Summary The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type
miRNA miRNA information provided by mirtarbase database.
2132
miRTarBase ID miRNA Experiments Reference
MIRT001763 hsa-miR-30a-3p Luciferase reporter assayqRT-PCRWestern blot 16239240
MIRT001586 hsa-let-7b-5p pSILAC 18668040
MIRT001328 hsa-miR-1-3p pSILAC 18668040
MIRT004958 hsa-let-7a-5p qRT-PCR 17942906
MIRT004943 hsa-miR-98-5p qRT-PCR 17942906
Transcription factors Transcription factors information provided by TRRUST V2 database.
8
Transcription factor Regulation Reference
E2F1 Activation 20976175
NR1I2 Activation 21072196
SNAI1 Repression 19874710
TP53 Activation 10029407;10101800
TP53 Unknown 19826414
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
139
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001666 Process Response to hypoxia NAS 9304800
GO:0001786 Function Phosphatidylserine binding IDA 18940719
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 16150726
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 17996481
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
188060 11785 ENSG00000137801
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07996
Protein name Thrombospondin-1 (Glycoprotein G)
Protein function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species
PDB 1LSL , 1UX6 , 1Z78 , 1ZA4 , 2ERF , 2ES3 , 2OUH , 2OUJ , 3R6B , 5FOE , 7YYK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00093 VWC 318 372 von Willebrand factor type C domain Family
PF00090 TSP_1 383 428 Thrombospondin type 1 domain Domain
PF00090 TSP_1 439 489 Thrombospondin type 1 domain Domain
PF00090 TSP_1 496 546 Thrombospondin type 1 domain Domain
PF02412 TSP_3 727 762 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 762 785 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 786 821 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 821 844 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 845 882 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 883 918 Thrombospondin type 3 repeat Repeat
PF02412 TSP_3 919 954 Thrombospondin type 3 repeat Repeat
PF05735 TSP_C 972 1169 Thrombospondin C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: Expressed by platelets (at protein level) (PubMed:101549). Expressed by monocyte-derived immature and mature dendritic cells (at protein level) (PubMed:14568985). {ECO:0000269|PubMed:101549, ECO:0000269|PubMed:14568985}.
Sequence
MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR
IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV
SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD
VPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLL
TLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRK
VTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN
ATVPDGECCPRC
WPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQT
RTCHIQEC
DKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARE
TKACKKDAC
PINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQI
CNKQDC
PIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACF
NHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKN
AKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPN
LPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYN
HNPDQ
ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEH
NPDQ
LDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDN
DGIPDDKDNCRLVPNPDQ
KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRF
QMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDD
DYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNAL
WHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD
KTYAGGRLGLFVFSQEMVFFSDLKYECRD
P
Sequence length 1170
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Rap1 signaling pathway
p53 signaling pathway
Phagosome
Efferocytosis
PI3K-Akt signaling pathway
TGF-beta signaling pathway
Focal adhesion
ECM-receptor interaction
Cytoskeleton in muscle cells
Malaria
Human papillomavirus infection
Proteoglycans in cancer
MicroRNAs in cancer
Bladder cancer
  Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
20
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism spectrum disorder association rs796320749 RCV001291389
Clear cell carcinoma of kidney Likely benign rs201310923 RCV005907799
Lung cancer Likely benign rs201310923 RCV005907800
Malignant tumor of esophagus Likely benign rs201310923 RCV005907798
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Injuries Associate 32286426
Acidosis Lactic Stimulate 36562400
Acute Coronary Syndrome Associate 35109843
Adenocarcinoma Associate 20080664, 27513329
Adenocarcinoma of Lung Associate 35635202
Adenoma Islet Cell Associate 10411935
Anemia Sickle Cell Associate 11264185, 12663449
Aortic Aneurysm Abdominal Associate 34669362
Apical Hypertrophic Cardiomyopathy Stimulate 35328555
Arrhythmias Cardiac Associate 34670505